RELEVANT PUBLICATIONS

Complet list

Giralt A, Hondares E, Villena JA, Ribas F, Díaz-Delfin J, Giralt M, Iglesias R, Villarroya F. PGC-1{alpha} controls the transcription of the SIRT3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem. 2011 Mar 27. [Epub ahead of print] Ghinis-Hozumi Y, González-Gallardo A, González-Dávalos L, Antaramian A, Villarroya F, Shimada A, Varela-Echavarría A, Mora O. Bovine sirtuins: Initial characterization and expression of Sirt1 and Sirt3 in liver, muscle, and adipose tissue. J Anim Sci. 2011 Mar 18. [Epub ahead of print] Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem. 2011 Feb 13. [Epub ahead of print] Côté HC, Gerschenson M, Walker UA, Miro O, Garrabou G, Hammond E, Villarroya J, Giralt M, Villarroya F, Cinque P, Garcia-Arumi E, Andreu AL, Pinti M, Cossarizza A.Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey. Mitochondrion. 2011 Feb 22. [Epub ahead of print] Domingo P, Cabeza MC, Pruvost A, Torres F, Salazar J, Del Mar Gutierrez M, Mateo MG, Fontanet A, Fernandez I, Domingo JC, Villarroya F, Vidal F, Baiget M. Association of thymidylate synthase gene polymorphisms with Stavudine triphosphate intracellular levels and lipodystrophy. Antimicrob Agents Chemother. 2011 Apr;55(4):1428-35. Epub 2011 Jan 31. Planavila A, Iglesias R, Giralt M, Villarroya F. Sirt1 acts in association with PPAR{alpha} to protect the heart from hypertrophy, metabolic dysregulation, and inflammation. Cardiovasc Res. 2010 Dec 22. [Epub ahead of print] Domingo P, Torres-Torronteras J, Pomar V, Giralt M, Domingo JC, Gutierrez Mdel M, Gallego-Escuredo JM, Mateo MG, Cano-Soldado P, Fernandez I, Pastor-Anglada M, Vidal F, Villarroya F, Andreu A, Marti R.Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. PLoS One. 2010 Nov 15;5(11):e13896. Gallego-Escuredo JM, Del Mar Gutierrez M, Diaz-Delfin J, Domingo JC, Mateo MG, Domingo P, Giralt M, Villarroya F. Differential effects of efavirenz and lopinavir/ritonavir on human adipocyte differentiation, gene expression and release of adipokines and pro-inflammatory cytokines. Curr HIV Res. 2010 Oct 1;8(7):545-53. Villarroya J, Diaz-Delfin J, Hyink D, Domingo P, Giralt M, Klotman PE, Villarroya F. HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. Antivir Ther. 2010;15(7):1021-8. Domingo P, Gallego-Escuredo JM, Domingo JC, Gutiérrez Mdel M, Mateo MG, Fernández I, Vidal F, Giralt M, Villarroya F. Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients. AIDS. 2010 Nov 13;24(17):2629-37. Giralt M, Díaz-Delfín J, Gallego-Escuredo JM, Villarroya J, Domingo P, Villarroya F. Lipotoxicity on the basis of metabolic syndrome and lipodystrophy in HIV-1-infected patients under antiretroviral treatment. Curr Pharm Des. 2010 Oct;16(30):3371-8. Domingo P, Villarroya F. Targets of metabolic toxicity of HIV antiretroviral drugs: the multiple roads to lipodystrophy and metabolic syndrome. Curr Pharm Des. 2010 Oct;16(30):3337-8. Negredo E, Massanella M, Puig J, Pérez-Alvarez N, Gallego-Escuredo JM, Villarroya J, Villarroya F, Moltó J, Santos JR, Clotet B, Blanco J. Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin Infect Dis. 2010 May 1;50(9):1300-8. Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F. Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 2010 Mar 3;11(3):206-12 Domingo P, Cabeza MC, Pruvost A, Salazar J, Gutierrez Mdel M, Mateo MG, Domingo JC, Fernandez I, Villarroya F, Muñoz J, Vidal F, Baiget M. Relationship between HIV/Highly active antiretroviral therapy (HAART)-associated lipodystrophy syndrome and stavudine-triphosphate intracellular levels in patients with stavudine-based antiretroviral regimens. Clin Infect Dis. 2010 Apr 1;50(7):1033-40. García-Rojas P, Antaramian A, González-Dávalos L, Villarroya F, Shimada A, Varela-Echavarría A, Mora O. Induction of PPAR{gamma} and PGC-1{alpha} by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue. J Anim Sci. 2010 Feb 12. [Epub ahead of print] Villarroya F, Domingo P, Giralt M. Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment. Biochim Biophys Acta. 2010 Mar;1801(3):392-399. Epub 2009 Sep 30. Garrabou G, Morén C, Gallego-Escuredo JM, Milinkovic A, Villarroya F, Negredo E, Giralt M, Vidal F, Pedrol E, Martínez E, Cardellach F, Gatell JM, Miró O. Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia. J Acquir Immune Defic Syndr. 2009 Dec 1;52(4):443-51. Camara Y, Mampel T, Armengol J, Villarroya F, Dejean L. UCP3 expression in liver modulates gene expression and oxidative metabolism in response to fatty acids, and sensitizes mitochondria to permeability transition. Cell Physiol Biochem. 2009;24(3-4):243-52. Epub 2009 Aug 3 Villarroya F, Domingo P, Giralt M. The importance of brown adipose tissue. N Engl J Med. 2009 Jul 23;361(4):417; author reply 418-21. Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F.SIRT1 controls the transcription of the PGC-1alpha gene in skeletal muscle through PGC-1alpha auto-regulatory loop and interaction with MyoD. J Biol Chem. 2009 Jun 24. [Epub ahead of print] Villarroya F, Bocos C, Giralt M, Ramos MP, Herrera E, Sevillano J, Gual M, Rosell M, Iglesias R.Pharmacological and gene modification-based models for studying the impact of perinatal metabolic disturbances in adult life. Adv Exp Med Biol. 2009;646:141-8. Girousse A, Tavernier G, Tiraby C, Lichtenstein L, Iacovoni JS, Mairal A, Villarroya F, Langin D.Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequences. Diabetologia. 2009 May 26. [Epub ahead of print] Villarroya J, Giralt M, Villarroya F. Mitochondrial DNA: An Up-and-coming Actor in White Adipose Tissue Pathophysiology. Obesity (Silver Spring). 2009 May 21. [Epub ahead of print] No abstract available. Giralt M, Domingo P, Villarroya F.HIV-1 Infection and the PPARgamma-Dependent Control of Adipose Tissue Physiology. PPAR Res. 2009;2009:607902. Epub 2008 Dec 1. Guallar JP, Rojas-Garcia R, Garcia-Arumi E, Domingo JC, Gallardo E, Andreu AL, Domingo P, Illa I, Giralt M, Villarroya F. Impaired expression of mitochondrial and adipogenic genes in adipose tissue from a patient with acquired partial lipodystrophy (Barraquer-Simons syndrome): a case report. J Med Case Reports. 2008 Aug 27;2:284. Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, Diaz-Delfin J, de Madariaga MA, Domingo JC. Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. J Leukoc Biol. 2008 Oct;84(4):1172-82. Epub 2008 Jul 16. Fourcade S, López-Erauskin J, Galino J, Duval C, Naudi A, Jove M, Kemp S, Villarroya F, Ferrer I, Pamplona R, Portero-Otin M, Pujol A. Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. Hum Mol Genet. 2008 Jun 15;17(12):1762-73. Epub 2008 Mar 14. Guallar JP, Gallego-Escuredo JM, Domingo JC, Alegre M, Fontdevila J, Martínez E, Hammond EL, Domingo P, Giralt M, Villarroya F. Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy. AIDS. 2008 Mar 12;22(5):575-84. Guallar JP, Cano-Soldado P, Aymerich I, Domingo JC, Alegre M, Domingo P, Villarroya F, Javier Casado F, Giralt M, Pastor-Anglada M. Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. Antivir Ther. 2007;12(6):853-63. Peraire J, Miró O, Saumoy M, Domingo P, Pedrol E, Villarroya F, Martínez E, López-Dupla M, Garrabou G, Sambeat MA, Deig E, Villarroya J, Chacón MR, López S, Fontanet A, Holmstrom M, Giralt M, Gatell JM, Vidal F. HIV-1-infected long-term non-progressors have milder mitochondrial impairment and lower mitochondrially-driven apoptosis in peripheral blood mononuclear cells than typical progressors. Curr HIV Res. 2007 Sep;5(5):467-73. Amat R, Solanes G, Giralt M, Villarroya F. SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription. J Biol Chem. 2007 Nov 23;282(47):34066-76. Epub 2007 Sep 20. Villarroya F, Domingo P, Giralt M. Lipodystrophy in HIV 1-infected patients: lessons for obesity research. Int J Obes (Lond). 2007 Dec;31(12):1763-76. Epub 2007 Jul 24. Review. Villarroya F, Domingo P, Giralt M. Mechanisms of antiretroviral-induced mitochondrial dysfunction in adipocytes and adipose tissue: in-vitro, animal and human adipose tissue studies. Curr Opin HIV AIDS. 2007 Jul;2(4):261-267. de Lange P, Feola A, Ragni M, Senese R, Moreno M, Lombardi A, Silvestri E, Amat R, Villarroya F, Goglia F, Lanni A. Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids. Endocrinology. 2007 Aug;148(8):4064-72. Epub 2007 May 3. Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, de Madariaga A, Domingo JC.9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development. J Immunol. 2007 May 15;178(10):6130-9. Chevillotte E, Giralt M, Miroux B, Ricquier D, Villarroya F. Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production. Diabetes. 2007 Apr;56(4):1042-50. Villarroya F, Iglesias R, Giralt M. PPARs in the Control of Uncoupling Proteins Gene Expression. PPAR Res. 2007;2007:74364. Giralt M, Domingo P, Guallar JP, Rodriguez de la Concepción ML, Alegre M, Domingo JC, Villarroya F.HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy. Antivir Ther. 2006;11(6):729-40. Duval C, Cámara Y, Hondares E, Sibille B, Villarroya F. Overexpression of mitochondrial uncoupling protein-3 does not decrease production of the reactive oxygen species, elevated by palmitate in skeletal muscle cells. FEBS Lett. 2007 Mar 6;581(5):955-61. Epub 2007 Feb 8. Hondares E, Pineda-Torra I, Iglesias R, Staels B, Villarroya F, Giralt M. PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1021-7. Epub 2007 Jan 25. Garrabou G, Soriano A, López S, Guallar JP, Giralt M, Villarroya F, Martínez JA, Casademont J, Cardellach F, Mensa J, Miró O. Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia. Antimicrob Agents Chemother. 2007 Mar;51(3):962-7. Epub 2006 Dec 28. Cámara Y, Duval C, Sibille B, Villarroya F. Activation of mitochondrial-driven apoptosis in skeletal muscle cells is not mediated by reactive oxygen species production. Int J Biochem Cell Biol. 2007;39(1):146-60. Epub 2006 Aug 17. Vidal F, Domingo JC, Guallar J, Saumoy M, Cordobilla B, Sánchez de la Rosa R, Giralt M, Alvarez ML, López-Dupla M, Torres F, Villarroya F, Cihlar T, Domingo P.In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.  Antimicrob Agents Chemother. 2006 Nov;50(11):3824-32. Epub 2006 Aug 28. Pedraza N, Rosell M, Villarroya J, Iglesias R, Gonzalez FJ, Solanes G, Villarroya F. Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression. Endocrinology. 2006 Oct;147(10):4695-704. Epub 2006 Jul 20. Guallar JP, Vilà MR, López-Gallardo E, Solano A, Domingo JC, Gámez J, Pineda M, Capablo JL, Domingo P, Andreu AL, Montoya J, Giralt M, Villarroya F. Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNA(Lys) point mutations in mitochondrial DNA. Mol Genet Metab. 2006 Nov;89(3):283-5. Epub 2006 Apr 17.

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