Articles in International Journals

 


A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.

Maggio V, Cánovas V, Félix AJ, Gómez V, de Torres I, Semidey ME, Morote J, Noé V, Ciudad CJ, Paciucci R.

Cancer Lett. 2019 Jun 28;452:158-167. doi: 10.1016/j.canlet.2019.03.019


Parallel Clamps and Polypurine Hairpins (PPRH) for Gene Silencing and Triplex-Affinity Capture: Design, Synthesis, and Use.

Aviñó A, Eritja R, Ciudad CJ, Noé V.

Curr Protoc Nucleic Acid Chem. 2019 Mar 26:e78. doi: 10.1002/cpnc.78


Silencing PD-1 and PD-L1: the potential of PolyPurine Reverse Hoogsteen hairpins for the elimination of tumor cells.

Ciudad CJ, Medina Enriquez MM, Félix AJ, Bener G, Noé V.

Immunotherapy. 2019 Apr;11(5):369-372. doi: 10.2217/imt-2018-0215.


Cancer immunotherapy using PolyPurine Reverse Hoogsteen hairpins targeting the PD-1/PD-L1 pathway in human tumor cells.

Medina Enríquez MM, Félix AJ, Ciudad CJ, Noé V.

PLoS One. 2018 Nov 6;13(11):e0206818. doi: 10.1371/journal.pone.0206818. eCollection 2018.

PMID: 30399174 Free Article


Functional Pharmacogenomics and toxicity of PolyPurine Reverse Hoogsteen hairpins directed against survivin in human cells.

Félix AJ, Ciudad CJ, Noé V.

Biochem Pharmacol. 2018 Jun 22. pii: S0006-2952(18)30233-8. doi: 10.1016/j.bcp.2018.06.020. [Epub ahead of print]

PMID: 29940174


Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health‐Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

Gemma Navarro, Eva Martínez-Pinilla, Raquel Ortiz, Véronique Noé, Carlos J. Ciudad & Rafael Franco.

Comprehensive Reviews in Food Science and Food Safety Vol.17 (2018)


Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome.

Benito A, Polat IH, Noé V, Ciudad CJ, Marin S, Cascante M.

Oncotarget. 2017 Oct 7;8(63):106693-106706. doi: 10.18632/oncotarget.21601. eCollection 2017 Dec 5.

PMID: 29290982


A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression.

Navarro G, Martínez-Pinilla E, Sánchez-Melgar A, Ortiz R, Noé V, Martín M, Ciudad C, Franco R.

PLoS One. 2017 Apr 25;12(4):e0176067. doi: 10.1371/journal.pone.0176067. eCollection 2017.

PMID: 28441400


Polypurine Reverse Hoogsteen Hairpins as a Gene Silencing Tool for Cancer.

Ciudad CJ, Rodríguez L, Villalobos X, Félix AJ, Noé V.

Curr Med Chem. 2017;24(26):2809-2826. doi: 10.2174/0929867324666170301114127. Review.

PMID: 28260512


Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma.

Miguel A, Sendra L, Noé V, Ciudad CJ, Dasí F, Hervas D, Herrero MJ, Aliño SF.

Onco Targets Ther. 2017 Jan 23;10:503-514. doi: 10.2147/OTT.S104393. eCollection 2017.

PMID: 28176947


Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes.

Solé A, Delagoutte E, Ciudad CJ, Noé V, Alberti P.

Sci Rep. 2017 Jan 9;7:39898. doi: 10.1038/srep39898.

PMID: 28067256


Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells.

Bener G, J Félix A, Sánchez de Diego C, Pascual Fabregat I, Ciudad CJ, Noé V.

BMC Immunol. 2016 Sep 26;17(1):32.

PMID: 27671753


Correction of point mutations at the endogenous locus of the dihydrofolate reductase gene using repair-PolyPurine Reverse Hoogsteen hairpins in mammalian cells.

Solé A, Ciudad CJ, Chasin LA, Noé V.

Biochem Pharmacol. 2016 Jun 15;110-111:16-24. doi: 10.1016/j.bcp.2016.04.002. Epub 2016 Apr 7.

PMID: 27063945


Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines.

Villalobos X, Rodríguez L, Solé A, Lliberós C, Mencia N, Ciudad CJ, Noé V.

Nucleic Acid Ther. 2015 Jun 4. [Epub ahead of print]

PMID: 26042602


Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition.

Ciudad-Roberts A, Camarasa J, Ciudad CJ, Pubill D, Escubedo E.

Br J Pharmacol. 2015 Oct;172(20):4970-84. doi: 10.1111/bph.13266. Epub 2015 Oct 9.

PMID: 26228024


Health benefits of walnut polyphenols: An exploration beyond their lipid profile.

Sánchez-González C, Ciudad C, Noé V, Izquierdo-Pulido M.

Crit Rev Food Sci Nutr. 2015 Dec 29:0. [Epub ahead of print]

PMID: 26713565


Urolithin A causes p21 up-regulation in prostate cancer cells.

Sánchez-González C, Ciudad CJ, Izquierdo-Pulido M, Noé V.

Eur J Nutr. 2015 May 12. [Epub ahead of print]

PMID: 25962506


Improved design of PPRHs for gene silencing.

Rodríguez L, Villalobos X, Solé A, Lliberós C, Ciudad CJ, Noé V.

Mol Pharm. 2015 Mar 2;12(3):867-77. doi: 10.1021/mp5007008. Epub 2015 Jan 23.


Repair of single-point mutations by polypurine reverse Hoogsteen hairpins.

Solé A, Villalobos X, Ciudad CJ, Noé V.

Hum Gene Ther Methods. 2014 Oct;25(5):288-302. doi: 10.1089/hgtb.2014.049. Epub 2014 Oct 14.

PMID: 25222154 [PubMed - in process]

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Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells.

Sánchez-González C, Ciudad CJ, Noé V, Izquierdo-Pulido M.

Food Funct. 2014 Oct 22;5(11):2922-30. doi: 10.1039/c4fo00542b.

PMID: 25214070 [PubMed - in process]

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Stability and Immunogenicity Properties of the Gene-Silencing Polypurine Reverse Hoogsteen Hairpins.

Villalobos X, Rodríguez L, Prévot J, Oleaga C, Ciudad CJ, Noé V.

Mol Pharm. 2013 Nov 27. [Epub ahead of print]

PMID: 24251728


Validation of miRNA-mRNA interactions by electrophoretic mobility shift assays.

Solé A, Mencia N, Villalobos X, Noé V, Ciudad CJ.

BMC Res Notes. 2013 Nov 12;6(1):454. [Epub ahead of print]PMID: 24215842

[PubMed - as supplied by publisher]

Free Article



Polypurine reverse Hoogsteen hairpins as a gene therapy tool against survivin in human prostate cancer PC3 cells in vitro and in vivo.

Rodríguez L, Villalobos X, Dakhel S, Padilla L, Hervas R, Hernández JL, Ciudad CJ, Noé V.

Biochem Pharmacol. 2013 Sep 23. doi:pii: S0006-2952(13)00603-5. 10.1016/j.bcp.2013.09.013. [Epub ahead of print]


Therapeutic Targeting of Tumor Growth and Angiogenesis with a Novel Anti-S100A4 Monoclonal Antibody.

Hernández JL, Padilla L, Dakhel S, Coll T, Hervas R, Adan J, Masa M, Mitjans F, Martinez JM, Coma S, Rodríguez L, Noé V, Ciudad CJ, Blasco F, Messeguer R.

PLoS One. 2013 Sep 4;8(9):e72480. doi: 10.1371/journal.pone.0072480.


The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells.

Barros S, Mencia N, Rodríguez L, Oleaga C, Santos C, Noé V, Ciudad CJ.

PLoS One. 2013 May 13;8(5):e63276. doi: 10.1371/journal.pone.0063276. Print 2013.


Cocoa flavanol metabolites activate HNF-3β, Sp1, and NFY-mediated transcription of apolipoprotein AI in human cells.

Oleaga C, Ciudad CJ, Izquierdo-Pulido M, Noé V.

Mol Nutr Food Res. 2013 Jun;57(6):986-95. doi: 10.1002/mnfr.201200507. Epub 2013 Jan 7.


Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics.

Oleaga C, Welten S, Belloc A, Solé A, Rodriguez L, Mencia N, Selga E, Tapias A, Noé V, Ciudad CJ.

Biochem Pharmacol. 2012 Dec 15;84(12):1581-91. doi: 10.1016/j.bcp.2012.09.014. Epub 2012 Sep 25.


Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.

Oleaga C, Ciudad CJ, Noé V, Izquierdo-Pulido M.

Oxid Med Cell Longev. 2012;2012:390385. doi: 10.1155/2012/390385. Epub 2012 Aug 7.


Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression.

Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F.

Gene. 2012 Oct 25;508(2):199-205. doi: 10.1016/j.gene.2012.07.074. Epub 2012 Aug 7.


New π-arene ruthenium(II) piano-stool complexes with nitrogen ligands.

Grau J, Noe V, Ciudad C, Prieto MJ, Font-Bardia M, Calvet T, Moreno V.

J Inorg Biochem. 2012 Apr;109:72-81. doi: 10.1016/j.jinorgbio.2012.01.003. Epub 2012 Jan 20.


Underexpression of miR-224 in methotrexate resistant human colon cancer cells.

Mencia N, Selga E, Noé V, Ciudad CJ.

Biochem Pharmacol. 2011 Aug 16. [Epub ahead of print]


CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract.

Oleaga C, García M, Solé A, Ciudad CJ, Izquierdo-Pulido M, Noé V.

Eur J Nutr. 2011 Aug 6. [Epub ahead of print]


A lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber induces genetic and metabolic alterations in colon mucosa of female C57BL/6J mice.

Lizarraga D, Vinardell MP, Noé V, van Delft JH, Alcarraz-Vizán G, van Breda SG, Staal Y, Günther UL, Reed MA, Ciudad CJ, Torres JL, Cascante M.

J Nutr. 2011 Sep;141(9):1597-604.


Gene expression profiles in rat mesenteric lymph nodes upon supplementation with conjugated linoleic acid during gestation and suckling.

Selga E, Pérez-Cano FJ, Franch A, Ramírez-Santana C, Rivero M, Ciudad CJ, Castellote C, Noé V.

BMC Genomics. 2011 Apr 11;12:182.


Coding Polypurine Hairpins Cause Target-Induced Cell Death in Breast Cancer Cells.

de Almagro MC, Mencia N, Noé V, Ciudad CJ.

Hum Gene Ther. 2011 Feb 16.


UDP-glucuronosyltransferase 1A6 overexpression in breast cancer cells resistant to methotrexate.

de Almagro MC, Selga E, Thibaut R, Porte C, Noé V, Ciudad CJ.

Biochem Pharmacol. 2011 Jan 1;81(1):60-70.


Overexpression of S100A4 in human cancer cell lines resistant to methotrexate.

Mencía N, Selga E, Rico I, de Almagro MC, Villalobos X, Ramirez S, Adan J, Hernández JL, Noé V, Ciudad CJ.

BMC Cancer. 2010 Jun 1;10:250.


Networking of differentially expressed genes in human cancer cells resistant to methotrexate.

Selga E, Oleaga C, Ramírez S, de Almagro MC, Noé V, Ciudad CJ.

Genome Med. 2009 Sep 4;1(9):83.

PMID: 19732436 [PubMed - in process] Free PMC Article


Polypurine hairpins directed against the template strand of DNA knock down the expression of mammalian genes.

de Almagro MC, Coma S, Noé V, Ciudad CJ.

J Biol Chem. 2009 Apr 24;284(17):11579-89. Epub 2009 Mar 3.

PMID: 19261618 [PubMed - indexed for MEDLINE] Free PMC Article


Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands.

Helena Garcia M, Morais TS, Florindo P, Piedade MF, Moreno V, Ciudad C, Noe V.

J Inorg Biochem. 2009 Mar;103(3):354-61. Epub 2009 Jan 6.


Regulation of Sp1 by cell cycle related proteins.

Tapias A, Ciudad CJ, Roninson IB, Noé V.

Cell Cycle. 2008 Sep 15;7(18):2856-67. Epub 2008 Sep 24.

PMID: 18769160 [PubMed - indexed for MEDLINE] Free PMC Article


Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells.

Selga E, Morales C, Noé V, Peinado MA, Ciudad CJ.

BMC Med Genomics. 2008 Aug 11;1:35.

PMID: 18694510 [PubMed] Free PMC Article


Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity.

Riera X, Moreno V, Ciudad CJ, Noe V, Font-Bardía M, Solans X.

Bioinorg Chem Appl. 2007:98732.

PMID: 18364995 [PubMed - in process] Free PMC Article


Transcriptional regulation of the 5'-flanking region of the human transcription factor Sp3 gene by NF-1, c-Myb, B-Myb, AP-1 and E2F.

Tapias A, Ciudad CJ, Noé V.

Biochim Biophys Acta. 2008 May;1779(5):318-29. Epub 2008 Mar 10.


Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis.

Selga E, Noé V, Ciudad CJ.

Biochem Pharmacol. 2008 Jan 15;75(2):414-26. Epub 2007 Sep 8.


Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue.

Salas A, Noé V, Ciudad CJ, Romero MM, Remesar X, Esteve M.

BMC Genomics. 2007 Aug 28;8:292.

PMID: 17725831 [PubMed - indexed for MEDLINE] Free PMC Article


Differentially expressed genes between high-risk human papillomavirus types in human cervical cancer cells.

Vazquez-Ortiz G, García JA, Ciudad CJ, Noé V, Peñuelas S, López-Romero R, Mendoza-Lorenzo P, Piña-Sánchez P, Salcedo M.

Int J Gynecol Cancer. 2007 Mar-Apr;17(2):484-91. Epub 2007 Feb 14.


Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer.

Ramos-Montoya A, Lee WN, Bassilian S, Lim S, Trebukhina RV, Kazhyna MV, Ciudad CJ, Noé V, Centelles JJ, Cascante M.

Int J Cancer. 2006 Dec 15;119(12):2733-41.


Strand displacement of double-stranded DNA by triplex-forming antiparallel purine-hairpins.

Coma S, Noé V, Eritja R, Ciudad CJ.

Oligonucleotides. 2005 Dec;15(4):269-83.


Gene identification by cDNA arrays in HPV-positive cervical cancer.

Vázquez-Ortíz G, Ciudad CJ, Piña P, Vazquez K, Hidalgo A, Alatorre B, Garcia JA, Salamanca F, Peralta-Rodriguez R, Rangel A, Salcedo M.

Arch Med Res. 2005 Sep-Oct;36(5):448-58.


Characterization of the 5'-flanking region of the human transcription factor Sp3 gene.

Tapias A, Monasterio P, Ciudad CJ, Noé V.

Biochim Biophys Acta. 2005 Aug 15;1730(2):126-36.


Anti-migratory and anti-angiogenic effect of p16: a novel localization at membrane ruffles and lamellipodia in endothelial cells.

Alhaja E, Adan J, Pagan R, Mitjans F, Cascalló M, Rodríguez M, Noé V, Ciudad CJ, Mazo A, Vilaró S, Piulats J.

Angiogenesis. 2004;7(4):323-33. Epub 2005 May 9.


Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells.

Peñuelas S, Noé V, Ciudad CJ.

FEBS J. 2005 Feb;272(3):696-710.


Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells.

Fonseca C, Moreira JN, Ciudad CJ, Pedroso de Lima MC, Simões S.

Eur J Pharm Biopharm. 2005 Feb;59(2):359-66.


Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH.

Peñuelas S, Noé V, Morales R, Ciudad CJ.

Med Sci Monit. 2005 Jan;11(1):BR6-12.


A highly efficient electroporation method for the transfection of endothelial cells.

Hernández JL, Coll T, Ciudad CJ.

Angiogenesis. 2004;7(3):235-41.


Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.

Blasco F, Peñuelas S, Cascalló M, Hernández JL, Alemany C, Masa M, Calbó J, Soler M, Nicolás M, Pérez-Torras S, Gómez A, Tarrasón G, Noé V, Mazo A, Ciudad CJ, Piulats J.

Oncology. 2004;67(3-4):277-90.


Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

Angulo E, Noé V, Casadó V, Mallol J, Gomez-Isla T, Lluis C, Ferrer I, Ciudad CJ, Franco R.

J Neurochem. 2004 Nov;91(3):547-57.


Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells.

Noé V, Peñuelas S, Lamuela-Raventós RM, Permanyer J, Ciudad CJ, Izquierdo-Pulido M.

J Nutr. 2004 Oct;134(10):2509-16.

PMID: 15465739 [PubMed - indexed for MEDLINE] Free Article


Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism.

Llaverias G, Vázquez-Carrera M, Sánchez RM, Noé V, Ciudad CJ, Laguna JC, Alegret M.

J Lipid Res. 2004 Nov;45(11):2015-24. Epub 2004 Aug 16.

PMID: 15314095 [PubMed - indexed for MEDLINE] Free Article


Use of siRNAs and antisense oligonucleotides against survivin RNA to inhibit steps leading to tumor angiogenesis.

Coma S, Noe V, Lavarino C, Adán J, Rivas M, López-Matas M, Pagan R, Mitjans F, Vilaró S, Piulats J, Ciudad CJ.

Oligonucleotides. 2004;14(2):100-13.