The research has been possible thanks to the funds given by the Association for International Cancer Research (United Kingdom), the Lymphoma Research Foundation (USA) and the Institute of Health Carlos III (Spain); it illustrates how new genome sequencing technologies are revolutionizing the study and knowledge of several types of cancer. For the last three years, the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukaemia has sequenced the genome of hundreds of patients of this frequent leukaemia; researchers have identified new mechanisms of tumour progression and new targets for therapeutic intervention. These studies enable to apply genomic studies to clinical practice in order to improve cancer patients’ diagnosis and treatment.
S. Beà, R. Valdés-Mas, A. Navarro, I. Salaverria, D. Martín-Garcia, P. Jares, E. Giné, M. Pinyol, C. Royo, F. Nadeu, L. Conde, M. Juan, G. Clot, P. Vizán, L. Di Croce, D. A. Puente, M. López-Guerra, A. Moros, G. Roue, M. Aymerich, N. Villamor, Ll. Colomo, A. Martínez, A. Valera, J. I. Martín-Subero, V. Amador, L. Hernández, M. Rozman, A. Enjuanes, P. Forcada, A. Muntañola, E. M. Hartmann, M. J. Calasanz, A. Rosenwald, G. Ott, J. M. Hernández-Rivas, W. Klapper, R. Siebert, A. Wiestner, W. H. Wilson, D. Colomer, A. López-Guillermo, C. López-Otín, X. S. Puente, and E. Campo."Landscape of somatic mutations and clonal evolution in mantle cell lymphoma". Proceedings of the National Academy of Sciences (PNAS), October 2013. doi: 10.1073/pnas.1314608110