Discovered a regulatory mechanism of antisense DNA
Human genes are always expressed as in Western writing: from left to right. So, when we speak about the activity of our genome, in fact, we refer to the expression of genes in this sense of the double-stranded DNA. However, for some while, it is known the existence of some 'rebel' DNA sequences that are activated in reverse: from right to left. They are known as antisense transcripts and their functions remain little known.
Human genes are always expressed as in Western writing: from left to right. So, when we speak about the activity of our genome, in fact, we refer to the expression of genes in this sense of the double-stranded DNA. However, for some while, it is known the existence of some 'rebel' DNA sequences that are activated in reverse: from right to left. They are known as antisense transcripts and their functions remain little known.
Article reference:
R. Boque-Sastre, M. Soler, C. Oliveira-Mateos, A. Portela, C. Moutinho, S. Sayols, A. Villanueva, M. Esteller and S. Guil. "Head-to-head antisense transcription and R-loop formation promotes transcriptional activation". Proceedings of the National Academy of Sciences. Doi: 10.1073/pnas.1421197112, 2015.