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Researchers describe the complete epigenomes of the most frequent tumours

Manel Esteller, ICREA researcher in the IDIBELL and lecturer in the Faculty of Medicine and Health Sciences of the University of Barcelona.

Manel Esteller, ICREA researcher in the IDIBELL and lecturer in the Faculty of Medicine and Health Sciences of the University of Barcelona.

An example of three complete colon cancer epigenomes of a patient.

An example of three complete colon cancer epigenomes of a patient.

12/06/2017

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A team of researchers led by the lecturer Manel Esteller, ICREA researcher in the Bellvitge Biomedical Research Institute (IDIBELL) and the Faculty of Medicine and Health Sciences of the University of Barcelona, have characterized the complete epigenomes of the most common tumours, among which are the ones from colon cancer, lung cancer and breast cancer. The new study –an important step forward in the study of the origins and progress of these tumours published in the journal Oncogene- counts with the participation of Professor Modesto Orozco, from the Department of Biochemistry and Molecular Biomedicine of the Faculty of Biology of the UB, and member of IRB Barcelona and the platform Bioinformatics Barcelona (BIB), among other authors.

 

“This analysis has enabled us getting a first unbiased view of the tumour cells methylomes in solid tumours” says Manel Esteller, head of the Cancer Epigenetics and Biology Program (PEBC) in IDIBELL. “Not only proved that lots of anti-cancer genes’ activity has stopped specifically in cancer-affected organs, but we have also shown that there are other alterations in distant chromosomal areas, since in three-dimensional world of cells these sequences are in close relative positions”.



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