{"id":4595,"date":"2026-06-04T12:59:56","date_gmt":"2026-06-04T10:59:56","guid":{"rendered":"https:\/\/www.ub.edu\/allo3d\/?page_id=4595"},"modified":"2026-06-04T12:59:58","modified_gmt":"2026-06-04T10:59:58","slug":"recerca","status":"publish","type":"page","link":"https:\/\/www.ub.edu\/allo3d\/ca\/recerca\/","title":{"rendered":"Recerca"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1l4q7ll-6f2f374973e5ead6b2fca90d52974a80\">\n.avia-section.av-1l4q7ll-6f2f374973e5ead6b2fca90d52974a80{\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/www.ub.edu\/allo3d\/wp-content\/uploads\/2024\/04\/fondo5network-1500x430.png);\nbackground-position:50% 50%;\nbackground-attachment:scroll;\n}\n.avia-section.av-1l4q7ll-6f2f374973e5ead6b2fca90d52974a80 .av-section-color-overlay{\nopacity:0.5;\nbackground-color:#000000;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-1l4q7ll-6f2f374973e5ead6b2fca90d52974a80 main_color avia-section-default avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-full-stretch avia-bg-style-scroll av-section-color-overlay-active container_wrap sidebar_right'  data-section-bg-repeat='stretch'><div class=\"av-section-color-overlay-wrap\"><div class=\"av-section-color-overlay\"><\/div><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-4595'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lu6xwpd4-ea9c02f0bf12b9035ab9d7c2e4067fe9\">\n#top .av-special-heading.av-lu6xwpd4-ea9c02f0bf12b9035ab9d7c2e4067fe9{\npadding-bottom:10px;\ncolor:#ffffff;\n}\nbody .av-special-heading.av-lu6xwpd4-ea9c02f0bf12b9035ab9d7c2e4067fe9 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-lu6xwpd4-ea9c02f0bf12b9035ab9d7c2e4067fe9 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-lu6xwpd4-ea9c02f0bf12b9035ab9d7c2e4067fe9 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-lu6xwpd4-ea9c02f0bf12b9035ab9d7c2e4067fe9 av-special-heading-h1 custom-color-heading blockquote modern-quote  avia-builder-el-1  avia-builder-el-no-sibling '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Recerca<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-12qereh-b531adb61cffd28e4e4c013764fb55a9\">\n.avia-section.av-12qereh-b531adb61cffd28e4e4c013764fb55a9{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n.avia-section.av-12qereh-b531adb61cffd28e4e4c013764fb55a9 .av-extra-border-element .av-extra-border-inner{\nbackground-color:#ffffff;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-12qereh-b531adb61cffd28e4e4c013764fb55a9 main_color avia-section-large avia-no-border-styling  avia-builder-el-2  el_after_av_section  el_before_av_section  avia-bg-style-scroll av-arrow-down-section container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-4595'><div class='entry-content-wrapper clearfix'>\n<section  class='av_textblock_section av-lxji6qnl-62b8802c00e70df5c30b46e6be50b048 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>El nostre grup es centra en entendre com la din\u00e0mica conformacional de les biomacromol\u00e8cules afecta les relacions estructura-activitat. Ens interessa el desenvolupament de noves estrat\u00e8gies terap\u00e8utiques per a les malalties cardiometab\u00f2liques (CVD) i altres factors de risc com la diabetis tipus 2 i l&#8217;obesitat.<\/h3>\n<\/div><\/section>\n<div class='flex_column_table av-3c19w9-01d453045375e1e2c9956a94cdb21118 sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3c19w9-01d453045375e1e2c9956a94cdb21118\">\n.flex_column.av-3c19w9-01d453045375e1e2c9956a94cdb21118{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-3c19w9-01d453045375e1e2c9956a94cdb21118 av_one_half  avia-builder-el-4  el_after_av_textblock  el_before_av_one_half  first flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-36j89l-ea87f122dd0abe0ba6634ae92245daed\">\n#top .av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed{\npadding-bottom:0;\ncolor:#000000;\nfont-size:30px;\n}\nbody .av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed .av-special-heading-tag{\nfont-size:30px;\n}\n.av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed .special-heading-inner-border{\nborder-color:#000000;\n}\n.av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-36j89l-ea87f122dd0abe0ba6634ae92245daed .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-36j89l-ea87f122dd0abe0ba6634ae92245daed av-special-heading-h2 custom-color-heading blockquote modern-quote  avia-builder-el-5  el_before_av_hr  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Diabetis<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-v22eyx-162341d2cb9dda7a910d26edfe845d49\">\n#top .hr.av-v22eyx-162341d2cb9dda7a910d26edfe845d49{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-v22eyx-162341d2cb9dda7a910d26edfe845d49 .hr-inner{\nwidth:50px;\nborder-color:#000000;\n}\n<\/style>\n<div  class='hr av-v22eyx-162341d2cb9dda7a910d26edfe845d49 hr-custom  avia-builder-el-6  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-t128rt-ac8935bf11c255c557bca6d04c8eac6c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>L&#8217;AMPK \u00e9s una prote\u00efna quinasa de serina\/treonina que exerceix un paper clau en l&#8217;home\u00f2stasi energ\u00e8tica cel\u00b7lular.<\/h3>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-qxi4e1-80df6d3008aab4c14125f923ea87e722 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>\u00c9s un complex heterotrim\u00e8ric compost per una subunitat catal\u00edtica (\u03b1) i dos components reguladors (\u03b2 i \u03b3). Aquests components estan codificats per m\u00faltiples gens, cosa que d\u00f3na lloc a dues isoformes \u03b1, dues \u03b2 i tres \u03b3 que formen fins a 12 complexos diferents. Aquests complexos presenten una expressi\u00f3 dependent del teixit i mostren difer\u00e8ncies notables en la seva activitat espec\u00edfica i en la seva sensibilitat als activadors al\u00b7lost\u00e8rics.<\/p>\n<p>La regulaci\u00f3 de l&#8217;AMPK es controla amb precisi\u00f3 mitjan\u00e7ant diversos mecanismes: al\u00b7lost\u00e8ric, indirecte i directe. L&#8217;activaci\u00f3 directa de l&#8217;AMPK s&#8217;aconsegueix mitjan\u00e7ant moduladors que s&#8217;uneixen al lloc al\u00b7lost\u00e8ric de f\u00e0rmacs i metab\u00f2lits (ADaM), situat a la interf\u00edcie entre les subunitats \u03b1 i \u03b2, promovent aix\u00ed un mecanisme d&#8217;activaci\u00f3 independent de la fosforilaci\u00f3 de la Thr172. Per exemple, la uni\u00f3 de l&#8217;activador tenopiridona A-769662 incrementa l&#8217;activitat de l&#8217;AMPK m\u00e9s de 90 vegades quan la Ser108 del domini CBM de la subunitat \u03b2 est\u00e0 fosforilada. En els darrers anys s&#8217;han descrit diversos activadors directes de l&#8217;AMPK. Sorprenentment, alguns presenten una marcada selectivitat d&#8217;isoforma, mentre que d&#8217;altres no en tenen i, per tant, s&#8217;anomenen panactivadors. El disseny de compostos selectius que actuen sobre isoformes espec\u00edfiques de la subunitat AMPK constitueix un focus d&#8217;investigaci\u00f3 important, a causa de l&#8217;especificitat de la seva distribuci\u00f3 tissular. Per tant, cal cercar nous activadors de l&#8217;AMPK amb potencial terap\u00e8utic per al tractament de malalties metab\u00f2liques, que presentin efectes beneficiosos tant vasculars com metab\u00f2lics.<\/p>\n<p>M\u00e9s espec\u00edficament, els nostres objectius principals d&#8217;aquesta l\u00ednia de recerca s\u00f3n i) obtenir un model complet d&#8217;AMPK a2b2g1, directament relacionat amb la diabetis tipus 2, ii) dissenyar un modulador espec\u00edfic per al model d&#8217;AMPK a2b2g1 directament relacionat amb la diabetis tipus 2, i iii) finalment, el nostre projecte a llarg termini est\u00e0 relacionat amb el desenvolupament d&#8217;un AMPK, que posteriorment es pot extrapolar a altres sistemes complexos.<\/p>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-10ufwzd-47ac1daf0c9929bdcdb06b55b5fe92c5\">\n.flex_column.av-10ufwzd-47ac1daf0c9929bdcdb06b55b5fe92c5{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-10ufwzd-47ac1daf0c9929bdcdb06b55b5fe92c5 av_one_half  avia-builder-el-9  el_after_av_one_half  avia-builder-el-last  flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-sub-av-h6xvop-37b2d423e8c3681dd8e0cce6d19f04ef\">\n.av-hotspot-image-container .av-image-hotspot.av-ggfvjt-c581c280dfcdc456d8432eb004ffbeae{\ntop:42.7%;\nleft:62.7%;\n}\n.av-hotspot-image-container .av-image-hotspot.av-ggfvjt-c581c280dfcdc456d8432eb004ffbeae .av-image-hotspot_inner{\nbackground-color:#481d36;\ncolor:#ffffff;\n}\n.av-hotspot-image-container .av-image-hotspot.av-ggfvjt-c581c280dfcdc456d8432eb004ffbeae .av-image-hotspot-pulse{\nbackground-color:#481d36;\n}\n.av-hotspot-image-container .av-image-hotspot.av-dripzd-bbf4fdd58464e9ddb9f50a2429252be2{\ntop:19.4%;\nleft:19.9%;\n}\n.av-hotspot-image-container .av-image-hotspot.av-dripzd-bbf4fdd58464e9ddb9f50a2429252be2 .av-image-hotspot_inner{\nbackground-color:#481d36;\ncolor:#ffffff;\n}\n.av-hotspot-image-container .av-image-hotspot.av-dripzd-bbf4fdd58464e9ddb9f50a2429252be2 .av-image-hotspot-pulse{\nbackground-color:#481d36;\n}\n.av-hotspot-image-container .av-image-hotspot.av-c3zl7d-d65320c9ba76eae1bf240b6e7688d6bc{\ntop:82.5%;\nleft:71%;\n}\n.av-hotspot-image-container .av-image-hotspot.av-c3zl7d-d65320c9ba76eae1bf240b6e7688d6bc .av-image-hotspot_inner{\nbackground-color:#481d36;\ncolor:#ffffff;\n}\n.av-hotspot-image-container .av-image-hotspot.av-c3zl7d-d65320c9ba76eae1bf240b6e7688d6bc .av-image-hotspot-pulse{\nbackground-color:#481d36;\n}\n<\/style>\n<div  class='av-hotspot-image-container av-h6xvop-37b2d423e8c3681dd8e0cce6d19f04ef  avia-builder-el-10  avia-builder-el-no-sibling  av-hotspot-numbered av-mobile-fallback-active  av-non-fullwidth-hotspot-image'  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class='av-hotspot-container'><div class='av-hotspot-container-inner-cell'><div class='av-hotspot-container-inner-wrap'><div class='av-image-hotspot av-ggfvjt-c581c280dfcdc456d8432eb004ffbeae av-image-hotspot-1 ' data-avia-tooltip-position='bottom' data-avia-tooltip-alignment='centered' data-avia-tooltip-class='av-tt-default-width av-tt-pos-below av-tt-align-centered  av-mobile-fallback-active  main_color av-tt-hotspot' data-avia-tooltip='&lt;p&gt;&lt;strong&gt;Lloc ADaM:&lt;\/strong&gt; butxaca d&#8217;uni\u00f3 al\u00b7lost\u00e8rica on s&#8217;uneixen els moduladors directes.&lt;\/p&gt;\n'><div class='av-image-hotspot_inner'>1<\/div><div class='av-image-hotspot-pulse'><\/div><\/div><div class='av-image-hotspot av-dripzd-bbf4fdd58464e9ddb9f50a2429252be2 av-image-hotspot-2 ' data-avia-tooltip-position='bottom' data-avia-tooltip-alignment='centered' data-avia-tooltip-class='av-tt-default-width av-tt-pos-below av-tt-align-centered  av-mobile-fallback-active  main_color av-tt-hotspot' data-avia-tooltip='&lt;p&gt;&lt;strong&gt;Domini CBM:&lt;\/strong&gt; a la subunitat \u00df, on es troba pSer108.&lt;\/p&gt;\n'><div class='av-image-hotspot_inner'>2<\/div><div class='av-image-hotspot-pulse'><\/div><\/div><div class='av-image-hotspot av-c3zl7d-d65320c9ba76eae1bf240b6e7688d6bc av-image-hotspot-3 ' data-avia-tooltip-position='top' data-avia-tooltip-alignment='centered' data-avia-tooltip-class='av-tt-default-width av-tt-pos-above av-tt-align-centered  av-mobile-fallback-active  main_color av-tt-hotspot' data-avia-tooltip='&lt;p&gt;&lt;strong&gt;P-loop al domini quinasa:&lt;\/strong&gt; una porci\u00f3 estructural important per al disseny d&#8217;adhesius moleculars al\u00b7lost\u00e8rics.&lt;\/p&gt;\n'><div class='av-image-hotspot_inner'>3<\/div><div class='av-image-hotspot-pulse'><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3601 avia-img-lazy-loading-not-3601 avia_image' src=\"https:\/\/www.ub.edu\/allo3d\/wp-content\/uploads\/2024\/06\/AMPK_Kat-845x684.jpg\" alt='' title='AMPK_Kat'  height=\"684\" width=\"845\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.ub.edu\/allo3d\/wp-content\/uploads\/2024\/06\/AMPK_Kat-845x684.jpg 845w, https:\/\/www.ub.edu\/allo3d\/wp-content\/uploads\/2024\/06\/AMPK_Kat-495x400.jpg 495w\" sizes=\"(max-width: 845px) 100vw, 845px\" \/><\/div><\/div><\/div><div class='av-hotspot-fallback-tooltip av-image-hotspot-1 '><div class=\"av-hotspot-fallback-tooltip-count\">1<div class=\"avia-arrow\"><\/div><\/div><div class=\"av-hotspot-fallback-tooltip-inner clearfix\"><p>\n<strong>Lloc ADaM:<\/strong> butxaca d&#8217;uni\u00f3 al\u00b7lost\u00e8rica on s&#8217;uneixen els moduladors directes.<\/p>\n<\/div><\/div><div class='av-hotspot-fallback-tooltip av-image-hotspot-2 '><div class=\"av-hotspot-fallback-tooltip-count\">2<div class=\"avia-arrow\"><\/div><\/div><div class=\"av-hotspot-fallback-tooltip-inner clearfix\"><p>\n<strong>Domini CBM:<\/strong> a la subunitat \u00df, on es troba pSer108.<\/p>\n<\/div><\/div><div class='av-hotspot-fallback-tooltip av-image-hotspot-3 '><div class=\"av-hotspot-fallback-tooltip-count\">3<div class=\"avia-arrow\"><\/div><\/div><div class=\"av-hotspot-fallback-tooltip-inner clearfix\"><p>\n<strong>P-loop al domini quinasa:<\/strong> una porci\u00f3 estructural important per al disseny d&#8217;adhesius moleculars al\u00b7lost\u00e8rics.<\/p>\n<\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><div class='av-extra-border-element border-extra-arrow-down'><div class='av-extra-border-outer'><div class='av-extra-border-inner'><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1jrddjt-9c55408822e88a64c7889b454fd1722d\">\n.avia-section.av-1jrddjt-9c55408822e88a64c7889b454fd1722d{\nbackground-color:#f8f8f8;\nbackground-image:unset;\n}\n.avia-section.av-1jrddjt-9c55408822e88a64c7889b454fd1722d .av-extra-border-element .av-extra-border-inner{\nbackground-color:#f8f8f8;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-1jrddjt-9c55408822e88a64c7889b454fd1722d main_color avia-section-large avia-no-border-styling  avia-builder-el-11  el_after_av_section  el_before_av_section  avia-bg-style-scroll av-arrow-down-section container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  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.av-image-hotspot.av-netq09-4b1d5a57099129497d0becda5de0a8a4{\ntop:45.6%;\nleft:46.1%;\n}\n.av-hotspot-image-container .av-image-hotspot.av-netq09-4b1d5a57099129497d0becda5de0a8a4 .av-image-hotspot_inner{\nbackground-color:#481d36;\ncolor:#ffffff;\n}\n.av-hotspot-image-container .av-image-hotspot.av-netq09-4b1d5a57099129497d0becda5de0a8a4 .av-image-hotspot-pulse{\nbackground-color:#481d36;\n}\n.av-hotspot-image-container .av-image-hotspot.av-mpd0gp-f5e7b0e0d78c37c2e4400583991f5edb{\ntop:5.5%;\nleft:69.6%;\n}\n.av-hotspot-image-container .av-image-hotspot.av-mpd0gp-f5e7b0e0d78c37c2e4400583991f5edb .av-image-hotspot_inner{\nbackground-color:#481d36;\ncolor:#ffffff;\n}\n.av-hotspot-image-container .av-image-hotspot.av-mpd0gp-f5e7b0e0d78c37c2e4400583991f5edb .av-image-hotspot-pulse{\nbackground-color:#481d36;\n}\n.av-hotspot-image-container .av-image-hotspot.av-kmywfd-6b10d0357fdbfe215b9e8254c92f33a8{\ntop:54%;\nleft:70.4%;\n}\n.av-hotspot-image-container .av-image-hotspot.av-kmywfd-6b10d0357fdbfe215b9e8254c92f33a8 .av-image-hotspot_inner{\nbackground-color:#481d36;\ncolor:#ffffff;\n}\n.av-hotspot-image-container .av-image-hotspot.av-kmywfd-6b10d0357fdbfe215b9e8254c92f33a8 .av-image-hotspot-pulse{\nbackground-color:#481d36;\n}\n<\/style>\n<div  class='av-hotspot-image-container av-lusixp9d-f937dcb0bfcc674294a911b69a3e0913  avia-builder-el-13  avia-builder-el-no-sibling  av-hotspot-numbered av-mobile-fallback-active  av-non-fullwidth-hotspot-image'  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class='av-hotspot-container'><div class='av-hotspot-container-inner-cell'><div class='av-hotspot-container-inner-wrap'><div class='av-image-hotspot av-netq09-4b1d5a57099129497d0becda5de0a8a4 av-image-hotspot-1 ' data-avia-tooltip-position='bottom' data-avia-tooltip-alignment='centered' data-avia-tooltip-class='av-tt-default-width av-tt-pos-below av-tt-align-centered  av-mobile-fallback-active  main_color av-tt-hotspot' data-avia-tooltip='&lt;p&gt;&lt;strong&gt;Lloc d&#8217;uni\u00f3 de la colina:&lt;\/strong&gt; La colina, un nutrient essencial, es troba juntament amb el bucle de ciste\u00efna que es mostra en groc.&lt;\/p&gt;\n'><div class='av-image-hotspot_inner'>1<\/div><div class='av-image-hotspot-pulse'><\/div><\/div><div class='av-image-hotspot av-mpd0gp-f5e7b0e0d78c37c2e4400583991f5edb av-image-hotspot-2 ' data-avia-tooltip-position='bottom' data-avia-tooltip-alignment='centered' data-avia-tooltip-class='av-tt-default-width av-tt-pos-below av-tt-align-centered  av-mobile-fallback-active  main_color av-tt-hotspot' data-avia-tooltip='&lt;p&gt;&lt;b&gt;Glycyl&lt;\/b&gt;&lt;b&gt; radical &lt;\/b&gt;&lt;b&gt;domain&lt;\/b&gt;&lt;b&gt;: &lt;\/b&gt;&lt;span class=&quot;HwtZe&quot; lang=&quot;es&quot;&gt;&lt;span class=&quot;jCAhz ChMk0b&quot;&gt;&lt;span class=&quot;ryNqvb&quot;&gt;contiene el &lt;em&gt;glycyl loop,&lt;\/em&gt; que se sugiere que fluct\u00faa entre una conformaci\u00f3n abierta y una cerrada.&lt;\/span&gt;&lt;\/span&gt;&lt;\/span&gt;&lt;\/p&gt;\n'><div class='av-image-hotspot_inner'>2<\/div><div class='av-image-hotspot-pulse'><\/div><\/div><div class='av-image-hotspot av-kmywfd-6b10d0357fdbfe215b9e8254c92f33a8 av-image-hotspot-3 ' data-avia-tooltip-position='bottom' data-avia-tooltip-alignment='centered' data-avia-tooltip-class='av-tt-default-width av-tt-pos-below av-tt-align-centered  av-mobile-fallback-active  main_color av-tt-hotspot' data-avia-tooltip='&lt;p&gt;&lt;strong&gt;Posible \u00e1rea de aproximaci\u00f3n de CutD:&lt;\/strong&gt; hemos planteado la hip\u00f3tesis de que la enzima activadora CutD deber\u00eda aproximarse a esta regi\u00f3n para iniciar la reacci\u00f3n radicalaria.&lt;\/p&gt;\n'><div class='av-image-hotspot_inner'>3<\/div><div class='av-image-hotspot-pulse'><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3606 avia-img-lazy-loading-not-3606 avia_image' src=\"https:\/\/www.ub.edu\/allo3d\/wp-content\/uploads\/2024\/06\/CutCch_PyMOL-e1725546795758-845x684.png\" alt='' title='CutC+ch_PyMOL'  height=\"684\" width=\"845\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><div class='av-hotspot-fallback-tooltip av-image-hotspot-1 '><div class=\"av-hotspot-fallback-tooltip-count\">1<div class=\"avia-arrow\"><\/div><\/div><div class=\"av-hotspot-fallback-tooltip-inner clearfix\"><p>\n<strong>Lloc d&#8217;uni\u00f3 de la colina:<\/strong> La colina, un nutrient essencial, es troba juntament amb el bucle de ciste\u00efna que es mostra en groc.<\/p>\n<\/div><\/div><div class='av-hotspot-fallback-tooltip av-image-hotspot-2 '><div class=\"av-hotspot-fallback-tooltip-count\">2<div class=\"avia-arrow\"><\/div><\/div><div class=\"av-hotspot-fallback-tooltip-inner clearfix\"><p>\n<b>Glycyl<\/b><b> radical <\/b><b>domain<\/b><b>: <\/b><span class=\"HwtZe\" lang=\"es\"><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">contiene el <em>glycyl loop,<\/em> que se sugiere que fluct\u00faa entre una conformaci\u00f3n abierta y una cerrada.<\/span><\/span><\/span><\/p>\n<\/div><\/div><div class='av-hotspot-fallback-tooltip av-image-hotspot-3 '><div class=\"av-hotspot-fallback-tooltip-count\">3<div class=\"avia-arrow\"><\/div><\/div><div class=\"av-hotspot-fallback-tooltip-inner clearfix\"><p>\n<strong>Posible \u00e1rea de aproximaci\u00f3n de CutD:<\/strong> hemos planteado la hip\u00f3tesis de que la enzima activadora CutD deber\u00eda aproximarse a esta regi\u00f3n para iniciar la reacci\u00f3n radicalaria.<\/p>\n<\/div><\/div><\/div><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1iak0h5-4ef952ded09b0480965f14dd299d516d\">\n.flex_column.av-1iak0h5-4ef952ded09b0480965f14dd299d516d{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-1iak0h5-4ef952ded09b0480965f14dd299d516d av_one_half  avia-builder-el-14  el_after_av_one_half  avia-builder-el-last  flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81\">\n#top .av-special-heading.av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81{\npadding-bottom:0;\nfont-size:30px;\n}\nbody .av-special-heading.av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81 .av-special-heading-tag{\nfont-size:30px;\n}\n.av-special-heading.av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81 .av-subheading{\nfont-size:14px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-1gfwyqh-baa69611466ed016de8eaa1f1fe7bd81 av-special-heading-h2 blockquote modern-quote  avia-builder-el-15  el_before_av_hr  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Malalties Cardiovasculars<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1dw14y1-6e12d3651a2cd8e16ee525d72bb0affd\">\n#top .hr.av-1dw14y1-6e12d3651a2cd8e16ee525d72bb0affd{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-1dw14y1-6e12d3651a2cd8e16ee525d72bb0affd .hr-inner{\nwidth:50px;\nborder-color:#000000;\n}\n<\/style>\n<div  class='hr av-1dw14y1-6e12d3651a2cd8e16ee525d72bb0affd hr-custom  avia-builder-el-16  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-1df7utl-2badb17b95ae30823507d64b512d37fe '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Estudis recents han demostrat que les alteracions compositives i funcionals del microbioma intestinal tenen un impacte a les malalties metab\u00f2liques i cardiovasculars.<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-1biffl5-a11911e4831d898d8b5b149a1f2c5d4b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><div>\n<div class=\"contingut\">\n<p>Tot i que aquestes troballes ressalten el paper crucial de l&#8217;eix intest\u00ed-cor, els resultats han revelat la rellev\u00e0ncia de la microbiota en la generaci\u00f3 de metab\u00f2lits espec\u00edfics, com la trimetilamina (TMA), amb efectes fisiopatol\u00f2gics.<\/p>\n<p>Aquesta l\u00ednia de recerca t\u00e9 com a objectiu explorar una nova estrat\u00e8gia terap\u00e8utica per al tractament de les malalties cardiovasculars (ECV), mitjan\u00e7ant la recerca d&#8217;un enzim prometedor implicat en la regulaci\u00f3 de la funci\u00f3 vascular: el tur\u00f3 trimetilamina (TMA)-llisa, CutC, ubicat a la microbiota intestinal humana. L&#8217;objectiu final \u00e9s dissenyar un modulador d&#8217;aquest enzim que ens permeti comprendre millor l&#8217;eix intest\u00ed-cor a les MCV i, m\u00e9s espec\u00edficament, regular l&#8217;efecte de la disbiosi de la microbiota intestinal en aquests pacients; \u00e9s a dir, dissenyar un compost modificador.<\/p>\n<p>M\u00e9s espec\u00edficament, els nostres principals objectius en aquesta l\u00ednia de recerca s\u00f3n: i) comprendre el mecanisme de reacci\u00f3 al lloc actiu de CutC mitjan\u00e7ant estudis QM\/MM; ii) obtenir l&#8217;estructura 3D de CutD per explorar la formaci\u00f3 del complex CutC:CutD, i iii) dissenyar un inhibidor per evitar la formaci\u00f3 dels metab\u00f2lits TMA i TMAO. Aquest darrer pas podria incloure el disseny d&#8217;un inhibidor no covalent i\/o covalent aprofitant les diferents vies que connecten el lloc actiu amb l&#8217;espai extern.<\/p>\n<\/div>\n<\/div>\n<div><\/div>\n<\/div><\/section><\/p><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><div class='av-extra-border-element border-extra-arrow-down'><div class='av-extra-border-outer'><div class='av-extra-border-inner'><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-chuzll-cbd21c8d421d982b29a3e30b9a0a425b\">\n.avia-section.av-chuzll-cbd21c8d421d982b29a3e30b9a0a425b{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n.avia-section.av-chuzll-cbd21c8d421d982b29a3e30b9a0a425b .av-extra-border-element .av-extra-border-inner{\nbackground-color:#ffffff;\n}\n<\/style>\n<div id='av_section_4'  class='avia-section av-chuzll-cbd21c8d421d982b29a3e30b9a0a425b main_color avia-section-large avia-no-border-styling  avia-builder-el-19  el_after_av_section  el_before_av_section  avia-bg-style-scroll av-arrow-down-section container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-4595'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-bfjj3t-568e796c6f2824b0581a04399976639f sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-bfjj3t-568e796c6f2824b0581a04399976639f\">\n.flex_column.av-bfjj3t-568e796c6f2824b0581a04399976639f{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-bfjj3t-568e796c6f2824b0581a04399976639f av_one_half  avia-builder-el-20  el_before_av_one_half  avia-builder-el-first  first flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3\">\n#top .av-special-heading.av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3{\npadding-bottom:0;\nfont-size:30px;\n}\nbody .av-special-heading.av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3 .av-special-heading-tag{\nfont-size:30px;\n}\n.av-special-heading.av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3 .av-subheading{\nfont-size:14px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-lujnpg6r-47d176be751ddaeeebe4b2ecf84709e3 av-special-heading-h2 blockquote modern-quote  avia-builder-el-21  el_before_av_hr  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Obesitat vs Malaltia d\u2019Alzheimer<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-92om95-06a7df6ff02ef7ba0f7630467eb6c470\">\n#top .hr.av-92om95-06a7df6ff02ef7ba0f7630467eb6c470{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-92om95-06a7df6ff02ef7ba0f7630467eb6c470 .hr-inner{\nwidth:50px;\nborder-color:#000000;\n}\n<\/style>\n<div  class='hr av-92om95-06a7df6ff02ef7ba0f7630467eb6c470 hr-custom  avia-builder-el-22  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-lujnpq1p-f9b4b1e416ab4b29c72be0354d92c3a1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>El paper de la resist\u00e8ncia a la leptina en l&#8217;obesitat \u00e9s ben conegut.<\/h3>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lujnpx5g-c65ce9dd72dd804c0ee006dded9abb28 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><div>\n<div class=\"contingut\">\n<p>Tot i aix\u00f2, encara no s&#8217;ha dilucidat el paper neuroprotector que exerceixen seq\u00fc\u00e8ncies espec\u00edfiques de la prote\u00efna leptina davant de dues prote\u00efnes caracter\u00edstiques de la malaltia d&#8217;Alzheimer.<\/p>\n<p>La malaltia dAlzheimer (EA) \u00e9s la forma m\u00e9s comuna de dem\u00e8ncia. Actualment, no hi ha cura per a l&#8217;EA i hi ha molt poques ter\u00e0pies disponibles per alleujar els s\u00edmptomes. Els f\u00e0rmacs basats en p\u00e8ptids ofereixen nombrosos avantatges, com la seva alta selectivitat, pot\u00e8ncia i baixa toxicitat. Els nostres col\u00b7laboradors han demostrat recentment que els p\u00e8ptids de leptina s\u00f3n agents terap\u00e8utics potencials en la lluita contra l&#8217;EA. Aix\u00f2 va proporcionar la primera evid\u00e8ncia contundent dels efectes neuroprotectors de petits p\u00e8ptids derivats de la leptina, cosa que representa una possible via d&#8217;aven\u00e7. No obstant aix\u00f2, els p\u00e8ptids de leptina no es poden administrar en forma de comprimits, ja que es degraden r\u00e0pidament al sistema digestiu. Per traduir aquestes troballes en un aven\u00e7 terap\u00e8utic, calen millores que estabilitzin aquestes mol\u00e8cules, permetent una administraci\u00f3 senzilla per a l&#8217;usuari final i mantenint l&#8217;activitat biol\u00f2gica. Al projecte Pep-AD-designer, proposem un enfocament iteratiu que combina la qu\u00edmica sint\u00e8tica i computacional amb bioassaigs in vitro per dissenyar nous p\u00e8ptids bioactius basats en leptina amb farmacocin\u00e8tica millorada. Mitjan\u00e7ant aquest enfocament interdisciplinari, el projecte Pep-AD-designer abordar\u00e0 les limitacions dels p\u00e8ptids terap\u00e8utics basats en leptina per apropar aquesta tecnologia a assaigs cl\u00ednics i proves in vivo robustes, transformant aix\u00ed el desenvolupament de f\u00e0rmacs biol\u00f2gics. Finalment preveiem el desenvolupament d&#8217;un m\u00e8tode patentable i efica\u00e7 per estabilitzar ter\u00e0pies biol\u00f2giques.<\/p>\n<p>El nostre objectiu actual \u00e9s comprendre el mecanisme d&#8217;acci\u00f3 d&#8217;aquests p\u00e8ptids espec\u00edfics contra l&#8217;autoagregaci\u00f3 de les prote\u00efnes Ab-amiloide i tau. Aquest projecte es desenvolupa en col\u00b7laboraci\u00f3 amb la Prof. C. Pubill-Ulldemolins, investigadora principal del Projecte Generaci\u00f3 de Coneixement 2023 (PID2022-142623OA-I00). Supervisem els estudis computacionals que es faran servir per millorar el disseny d&#8217;aquests p\u00e8ptids amb propietats farmacocin\u00e8tiques optimitzades.<\/p>\n<\/div>\n<\/div>\n<div><\/div>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-f3et5-7cbeb23b39fceffcead1f856cd559f3e\">\n.flex_column.av-f3et5-7cbeb23b39fceffcead1f856cd559f3e{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\nbackground-color:#fcfcff;\n}\n<\/style>\n<div  class='flex_column av-f3et5-7cbeb23b39fceffcead1f856cd559f3e av_one_half  avia-builder-el-25  el_after_av_one_half  avia-builder-el-last  flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m1f02rk4-866b7d38b316d025b407646d101fb675\">\n.avia-image-container.av-m1f02rk4-866b7d38b316d025b407646d101fb675 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-m1f02rk4-866b7d38b316d025b407646d101fb675 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-m1f02rk4-866b7d38b316d025b407646d101fb675 av-styling- avia-align-center  avia-builder-el-26  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3924 avia-img-lazy-loading-not-3924 avia_image ' src=\"https:\/\/www.ub.edu\/allo3d\/wp-content\/uploads\/2024\/09\/Video_Alzheimer.gif\" alt='' title='Video_Alzheimer'  height=\"720\" width=\"1216\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><div class='av-extra-border-element border-extra-arrow-down'><div class='av-extra-border-outer'><div class='av-extra-border-inner'><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-vu4czt-5cd21bdd7d024205629bb9bc4f842ba6\">\n.avia-section.av-vu4czt-5cd21bdd7d024205629bb9bc4f842ba6{\nbackground-color:#f8f8f8;\nbackground-image:unset;\n}\n.avia-section.av-vu4czt-5cd21bdd7d024205629bb9bc4f842ba6 .av-extra-border-element .av-extra-border-inner{\nbackground-color:#f8f8f8;\n}\n<\/style>\n<div id='av_section_5'  class='avia-section av-vu4czt-5cd21bdd7d024205629bb9bc4f842ba6 main_color avia-section-small avia-no-border-styling  avia-builder-el-27  el_after_av_section  el_before_av_section  avia-bg-style-scroll av-arrow-down-section container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-4595'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-m1eune1x-37a5642e402477358dcf089f8b258c66 sc-av_one_half av-break-at-tablet-flextable av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m1eune1x-37a5642e402477358dcf089f8b258c66\">\n.flex_column.av-m1eune1x-37a5642e402477358dcf089f8b258c66{\nborder-radius:0px 0px 0px 0px;\npadding:5px 27px 27px 27px;\n}\n<\/style>\n<div  class='flex_column av-m1eune1x-37a5642e402477358dcf089f8b258c66 av_one_half  avia-builder-el-28  el_before_av_one_half  avia-builder-el-first  first av-break-at-tablet flex_column_table_cell av-equal-height-column av-align-middle  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-e7kkg9-b0066adfd4660b150dd2626bbf269a57\">\n#top .av-special-heading.av-e7kkg9-b0066adfd4660b150dd2626bbf269a57{\nmargin:10px 0 0 0;\npadding-bottom:0;\nfont-size:40px;\n}\nbody .av-special-heading.av-e7kkg9-b0066adfd4660b150dd2626bbf269a57 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-e7kkg9-b0066adfd4660b150dd2626bbf269a57 .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-e7kkg9-b0066adfd4660b150dd2626bbf269a57 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-e7kkg9-b0066adfd4660b150dd2626bbf269a57 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-e7kkg9-b0066adfd4660b150dd2626bbf269a57 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-e7kkg9-b0066adfd4660b150dd2626bbf269a57 av-special-heading-h2 blockquote modern-quote  avia-builder-el-29  el_before_av_hr  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >QM Skills<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-c2b5a1-517942226b935f1dae21d5453bb78bea\">\n#top .hr.av-c2b5a1-517942226b935f1dae21d5453bb78bea{\nmargin-top:10px;\nmargin-bottom:10px;\n}\n.hr.av-c2b5a1-517942226b935f1dae21d5453bb78bea .hr-inner{\nwidth:50px;\nborder-color:#000000;\n}\n<\/style>\n<div  class='hr av-c2b5a1-517942226b935f1dae21d5453bb78bea hr-custom  avia-builder-el-30  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-ap5dux-4c66267ea29e783f18e7b6bbd89217ab '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Utilitzem c\u00e0lculs de mec\u00e0nica qu\u00e0ntica (QM) per a la caracteritzaci\u00f3 completa de mol\u00e8cules org\u00e0niques petites, com ara l&#8217;optimitzaci\u00f3 de m\u00ednims, la determinaci\u00f3 d&#8217;estats de transici\u00f3 o el c\u00e0lcul de diverses propietats fisicoqu\u00edmiques en dissolvents gasosos i impl\u00edcits.<\/p>\n<p>Aix\u00ed mateix, hem fet servir c\u00e0lculs semiemp\u00edrics qu\u00e0ntics, DFT i m\u00e8todes post-HF per comprendre la interacci\u00f3 entre diferents interaccions no covalents o la determinaci\u00f3 de mecanismes de reacci\u00f3.<\/p>\n<p>A m\u00e9s, gr\u00e0cies a l&#8217;estudi de diverses metal\u00b7loprote\u00efnes i prote\u00efnes intr\u00ednsecament desordenades (IDP), hem desenvolupat un coneixement fonamental de la reparametritzaci\u00f3 de sistemes complexos, cosa que ens permet modificar espec\u00edficament algunes caracter\u00edstiques del camp de for\u00e7a.<\/p>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ggl0qh-a6887e2d8929b610b0a7b542df5084eb\">\n.flex_column.av-ggl0qh-a6887e2d8929b610b0a7b542df5084eb{\nborder-radius:0px 0px 0px 0px;\npadding:27px 27px 27px 27px;\n}\n<\/style>\n<div  class='flex_column av-ggl0qh-a6887e2d8929b610b0a7b542df5084eb av_one_half  avia-builder-el-32  el_after_av_one_half  avia-builder-el-last  av-break-at-tablet flex_column_table_cell av-equal-height-column av-align-middle  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ecs3zt-f06852424385045b10d75424319e9759\">\n#top .av-special-heading.av-ecs3zt-f06852424385045b10d75424319e9759{\npadding-bottom:0;\nfont-size:40px;\n}\nbody .av-special-heading.av-ecs3zt-f06852424385045b10d75424319e9759 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-ecs3zt-f06852424385045b10d75424319e9759 .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-ecs3zt-f06852424385045b10d75424319e9759 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-ecs3zt-f06852424385045b10d75424319e9759 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-ecs3zt-f06852424385045b10d75424319e9759 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-ecs3zt-f06852424385045b10d75424319e9759 av-special-heading-h2 blockquote modern-quote  avia-builder-el-33  el_before_av_hr  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >MM Skills<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-cigmx5-cafde52b9005b36735228892b07ef643\">\n#top .hr.av-cigmx5-cafde52b9005b36735228892b07ef643{\nmargin-top:10px;\nmargin-bottom:10px;\n}\n.hr.av-cigmx5-cafde52b9005b36735228892b07ef643 .hr-inner{\nwidth:50px;\nborder-color:#000000;\n}\n<\/style>\n<div  class='hr av-cigmx5-cafde52b9005b36735228892b07ef643 hr-custom  avia-builder-el-34  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-anm349-44ee6df2b8fa30b7cfb2873acb07fa1e '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Utilitzem simulacions de mec\u00e0nica molecular (MM) per caracteritzar la din\u00e0mica de les prote\u00efnes en abs\u00e8ncia i pres\u00e8ncia de petites mol\u00e8cules org\u00e0niques o p\u00e8ptids. El nostre objectiu principal \u00e9s comprendre la din\u00e0mica estructural de sistemes heter\u00f2mers complexos per entendre el seu efecte sobre l&#8217;activitat. Amb aquesta informaci\u00f3, busquem dissenyar un nou compost bioactiu que identifiqui els punts clau del lloc actiu o dissenyar noves estrat\u00e8gies terap\u00e8utiques basades en cavitats al\u00b7lost\u00e8riques que determinin la comunicaci\u00f3 en xarxa.<\/p>\n<p>A m\u00e9s, hem centrat la nostra atenci\u00f3 en el proc\u00e9s de plegament i agregaci\u00f3 de petits p\u00e8ptids, i en la uni\u00f3 de lligands petits a les interaccions prote\u00efna-prote\u00efna (IPP), on el grup ha utilitzat \u00e0mpliament t\u00e8cniques de mostreig millorat, com ara FEP, metadin\u00e0mica o aMD.<\/p>\n<\/div><\/section><\/p><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><div class='av-extra-border-element border-extra-arrow-down'><div class='av-extra-border-outer'><div class='av-extra-border-inner'><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mpyjemr9-a87f91f1edf50435edbcea9890aa2ca0\">\n.avia-section.av-mpyjemr9-a87f91f1edf50435edbcea9890aa2ca0{\nbackground-color:#f8f8f8;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_6'  class='avia-section av-mpyjemr9-a87f91f1edf50435edbcea9890aa2ca0 main_color avia-section-no-padding avia-no-border-styling  avia-builder-el-36  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-4595'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-av_one_half-6c34a2a159d2a1e1723ba25c388010c5 sc-av_one_half av-break-at-tablet-flextable av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-6c34a2a159d2a1e1723ba25c388010c5\">\n.flex_column.av-av_one_half-6c34a2a159d2a1e1723ba25c388010c5{\nborder-radius:0px 0px 0px 0px;\npadding:5px 27px 27px 27px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-6c34a2a159d2a1e1723ba25c388010c5 av_one_half  avia-builder-el-37  el_before_av_one_half  avia-builder-el-first  first av-break-at-tablet flex_column_table_cell av-equal-height-column av-align-middle  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mpzdr9dd-936a80746c047e6cf408bc01965f2800\">\n.avia-progress-bar-container.av-mpzdr9dd-936a80746c047e6cf408bc01965f2800 .progress{\nheight:10px;\n}\n<\/style>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-sub-av-mpzdr9dd-936a80746c047e6cf408bc01965f2800\">\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdqblp-823b1a8e12d22467b7df6f9035c0c136 .bar{\nwidth:100%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdqmfg-e85a4e48da18a7f96f6c2867c94b1efb .bar{\nwidth:100%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdqs89-22f8f75922b69f66946841c70a95e323 .bar{\nwidth:90%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdr7zf-f85c332ccf1ffb7979ad608489a6829f .bar{\nwidth:70%;\n}\n<\/style>\n<div  class='avia-progress-bar-container av-mpzdr9dd-936a80746c047e6cf408bc01965f2800 av-flat-bar av-animated-bar av-small-bar avia_animate_when_almost_visible  avia-builder-el-38  avia-builder-el-no-sibling '><div class='avia-progress-bar av-mpzdqblp-823b1a8e12d22467b7df6f9035c0c136 icon-bar-no theme-color-bar theme-color-bar icon-bar-no'><div class=\"progressbar-title-wrap\"><div class='progressbar-icon'><span class='progressbar-char' aria-hidden='true' data-av_icon='' data-av_iconfont='entypo-fontello'><\/span><\/div><div class='progressbar-title'>Caracteritzaci\u00f3 de petits compostos<\/div><\/div><div class=\"progressbar-percent\" data-timer=\"2200\"><span class='av-bar-counter __av-single-number' data-number='100'>0<\/span>%<\/div><div class=\"progress\"><div class=\"bar-outer\"><div class='bar' data-progress='100'><\/div><\/div><\/div><\/div><div class='avia-progress-bar av-mpzdqmfg-e85a4e48da18a7f96f6c2867c94b1efb icon-bar-no theme-color-bar theme-color-bar icon-bar-no'><div class=\"progressbar-title-wrap\"><div class='progressbar-icon'><span class='progressbar-char' aria-hidden='true' data-av_icon='' data-av_iconfont='entypo-fontello'><\/span><\/div><div class='progressbar-title'>Cooperativitat entre interaccions no covalents<\/div><\/div><div class=\"progressbar-percent\" data-timer=\"2200\"><span class='av-bar-counter __av-single-number' data-number='100'>0<\/span>%<\/div><div class=\"progress\"><div class=\"bar-outer\"><div class='bar' data-progress='100'><\/div><\/div><\/div><\/div><div class='avia-progress-bar av-mpzdqs89-22f8f75922b69f66946841c70a95e323 icon-bar-no theme-color-bar theme-color-bar icon-bar-no'><div class=\"progressbar-title-wrap\"><div class='progressbar-icon'><span class='progressbar-char' aria-hidden='true' data-av_icon='' data-av_iconfont='entypo-fontello'><\/span><\/div><div class='progressbar-title'>Estudi de mecanismes de reacci\u00f3<\/div><\/div><div class=\"progressbar-percent\" data-timer=\"2200\"><span class='av-bar-counter __av-single-number' data-number='90'>0<\/span>%<\/div><div class=\"progress\"><div class=\"bar-outer\"><div class='bar' data-progress='90'><\/div><\/div><\/div><\/div><div class='avia-progress-bar av-mpzdr7zf-f85c332ccf1ffb7979ad608489a6829f icon-bar-no theme-color-bar theme-color-bar icon-bar-no'><div class=\"progressbar-title-wrap\"><div class='progressbar-icon'><span class='progressbar-char' aria-hidden='true' data-av_icon='' data-av_iconfont='entypo-fontello'><\/span><\/div><div class='progressbar-title'>Parametritzaci\u00f3 de metalocompostos<\/div><\/div><div class=\"progressbar-percent\" data-timer=\"2200\"><span class='av-bar-counter __av-single-number' data-number='70'>0<\/span>%<\/div><div class=\"progress\"><div class=\"bar-outer\"><div class='bar' data-progress='70'><\/div><\/div><\/div><\/div><\/div><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-74a35ad45c4f1be0827eb32da699bb47\">\n.flex_column.av-av_one_half-74a35ad45c4f1be0827eb32da699bb47{\nborder-radius:0px 0px 0px 0px;\npadding:27px 27px 27px 27px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-74a35ad45c4f1be0827eb32da699bb47 av_one_half  avia-builder-el-39  el_after_av_one_half  avia-builder-el-last  av-break-at-tablet flex_column_table_cell av-equal-height-column av-align-middle  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mpzdsevd-f723162f61822447375eab8117de1201\">\n.avia-progress-bar-container.av-mpzdsevd-f723162f61822447375eab8117de1201 .progress{\nheight:10px;\n}\n<\/style>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-sub-av-mpzdsevd-f723162f61822447375eab8117de1201\">\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdqblp-823b1a8e12d22467b7df6f9035c0c136 .bar{\nwidth:100%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdqmfg-e85a4e48da18a7f96f6c2867c94b1efb .bar{\nwidth:100%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdqs89-22f8f75922b69f66946841c70a95e323 .bar{\nwidth:90%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdr7zf-f85c332ccf1ffb7979ad608489a6829f .bar{\nwidth:70%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdrjj4-ffe7099df252fb9fc81d24fbf497974a .bar{\nwidth:100%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzdrron-29b6c9faf083bdaacfdfdb8d7bf799f2 .bar{\nwidth:100%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzds0ro-a0cdf040801f0f31e4bbd790ecac69fc .bar{\nwidth:90%;\n}\n#top .avia-progress-bar-container .avia-progress-bar.av-mpzds4tr-824b0af17678aa194dcffe65f6d74a50 .bar{\nwidth:70%;\n}\n<\/style>\n<div  class='avia-progress-bar-container av-mpzdsevd-f723162f61822447375eab8117de1201 av-flat-bar av-animated-bar av-small-bar avia_animate_when_almost_visible  avia-builder-el-40  avia-builder-el-no-sibling '><div class='avia-progress-bar av-mpzdrjj4-ffe7099df252fb9fc81d24fbf497974a icon-bar-no theme-color-bar theme-color-bar icon-bar-no'><div class=\"progressbar-title-wrap\"><div class='progressbar-icon'><span class='progressbar-char' aria-hidden='true' data-av_icon='' data-av_iconfont='entypo-fontello'><\/span><\/div><div class='progressbar-title'>Simulacions MD<\/div><\/div><div class=\"progressbar-percent\" 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