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Audrey De Paepe – Thesis defense

Audrey completed her Bachelor of Arts degree in Neuroscience at Pomona College in California in 2018. She was subsequently awarded a Fulbright fellowship to study multimodal neuroimaging in Huntington’s disease with the Cognition & Brain Plasticity Unit of IDIBELL and the University of Barcelona, under the supervision of Dr. Estela Cámara Mancha and Dr. Ruth De Diego-Balaguer. In 2020-2021, she completed the Master of Multidisciplinary Research in Experimental Sciences through the Barcelona Institute of Science and Technology, supervised by Dr. Laura Furlong and Dr. Alexis Giannoula.In 2021, Audrey enrolled in her PhD in Biomedicine (Neurosciences) at the Cognition & Brain Plasticity Unit, while simultaneously completing studies in medicine at Columbia University Vagelos College of Physicians & Surgeons. Her thesis is titled, Mapping apathy in Huntington’s disease: a combined dimensional neuroimaging approach, and consists of four studies. The first investigated the link between the theoretical three-dimensional framework of apathy, demonstrating that cognitive and auto-activation deficit are related with reduced white matter microstructural connectivity in distinct corticostriatal tracts of interest, using diffusion tensor imaging. The second studied the relationship between longitudinal apathy and gray matter volume using voxel-based morphometry, highlighting the role of the middle cingulate cortex. The third assessed cross-sectional gray matter volume and apathy dimensions as elucidated through principal component analysis, revealing involvement of distinct cognitive, motor, and limbic territories. Finally, the fourth study extended these findings utilizing a Disease Trajectories unsupervised clustering framework to categorize longitudinal psychiatric signatures in Huntington’s disease gene-expansion carriers.Audrey defended her PhD thesis in December 2024 as part of the Doctor of Philosophy Program at the University of Barcelona.

Mapping apathy in Huntington’s disease:
a combined dimensional neuroimaging approach

 

Doctoral Programme in Biomedecine.

Supervisor: Estela Càmara Mancha

The thesis will be defended in:

Facultat de Psicologia – Universitat de Barcelona
Campus Mundet
Pg.Vall d’Hebron 171
Edifici del Teatre

December 12th, 2024

Aula Antoni Caparrós

11:30h