{"id":5330,"date":"2024-12-14T22:26:43","date_gmt":"2024-12-14T21:26:43","guid":{"rendered":"https:\/\/www.ub.edu\/brainvitge\/?p=5330"},"modified":"2026-01-09T16:02:38","modified_gmt":"2026-01-09T15:02:38","slug":"audrey-de-paepe","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/brainvitge\/audrey-de-paepe\/","title":{"rendered":"Audrey De Paepe &#8211; Thesis defense"},"content":{"rendered":"<header class=\"article-header\">Audrey completed her Bachelor of Arts degree in Neuroscience at Pomona College in California in 2018. She was subsequently awarded a Fulbright fellowship to study multimodal neuroimaging in Huntington\u2019s disease with the Cognition &amp; Brain Plasticity Unit of IDIBELL and the University of Barcelona, under the supervision of Dr. Estela C\u00e1mara Mancha and Dr. Ruth De Diego-Balaguer. In 2020-2021, she completed the Master of Multidisciplinary Research in Experimental Sciences through the Barcelona Institute of Science and Technology, supervised by Dr. Laura Furlong and Dr. Alexis Giannoula.In 2021, Audrey enrolled in her PhD in Biomedicine (Neurosciences) at the Cognition &amp; Brain Plasticity Unit, while simultaneously completing studies in medicine at Columbia University Vagelos College of Physicians &amp; Surgeons. Her thesis is titled, <u>Mapping apathy in Huntington\u2019s disease: a combined dimensional neuroimaging approach<\/u>, and consists of four studies. The first investigated the link between the theoretical three-dimensional framework of apathy, demonstrating that cognitive and auto-activation deficit are related with reduced white matter microstructural connectivity in distinct corticostriatal tracts of interest, using diffusion tensor imaging. The second studied the relationship between longitudinal apathy and gray matter volume using voxel-based morphometry, highlighting the role of the middle cingulate cortex. The third assessed cross-sectional gray matter volume and apathy dimensions as elucidated through principal component analysis, revealing involvement of distinct cognitive, motor, and limbic territories. Finally, the fourth study extended these findings utilizing a Disease Trajectories unsupervised clustering framework to categorize longitudinal psychiatric signatures in Huntington\u2019s disease gene-expansion carriers.Audrey defended her PhD thesis in December 2024 as part of the Doctor of Philosophy Program at the University of Barcelona.<\/p>\n<\/header>\n<section class=\"entry-content cf\">\n<div class=\"maincontent m-all \">\n<h1 class=\"item-page-title-field\"><a href=\"https:\/\/www.ub.edu\/brainvitge\/seminar\/audrey-de-paepe-thesis-defense\/\"><span class=\"dont-break-out\">Mapping apathy in Huntington&#8217;s disease:<br \/>\na combined dimensional neuroimaging approach<\/span><\/a><\/h1>\n<p>&nbsp;<\/p>\n<p>Doctoral Programme in <em>Biomedecine<\/em>.<\/p>\n<p>Supervisor:\u00a0<a href=\"https:\/\/www.ub.edu\/brainvitge\/member\/camara_e\/\">Estela C\u00e0mara Mancha<\/a><\/p>\n<p>The thesis will be defended in:<\/p>\n<p>Facultat de Psicologia \u2013 Universitat de Barcelona<br \/>\nCampus Mundet<br \/>\nPg.Vall d\u2019Hebron 171<br \/>\nEdifici del Teatre<\/p>\n<h4><strong>December 12th, 2024<\/strong><\/h4>\n<h4><strong>Aula Antoni Caparr\u00f3s<\/strong><\/h4>\n<h4><strong>11:30h<\/strong><\/h4>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Audrey completed her Bachelor of Arts degree in Neuroscience at Pomona College in California in 2018. She was subsequently awarded a Fulbright fellowship to study multimodal neuroimaging in Huntington\u2019s disease&#8230;  <a class=\"excerpt-read-more\" href=\"https:\/\/www.ub.edu\/brainvitge\/audrey-de-paepe\/\" title=\"Read Audrey De Paepe &#8211; Thesis defense\">Read more &raquo;<\/a><\/p>\n","protected":false},"author":3,"featured_media":2574,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/posts\/5330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/comments?post=5330"}],"version-history":[{"count":3,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/posts\/5330\/revisions"}],"predecessor-version":[{"id":5339,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/posts\/5330\/revisions\/5339"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/media\/2574"}],"wp:attachment":[{"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/media?parent=5330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/categories?post=5330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ub.edu\/brainvitge\/wp-json\/wp\/v2\/tags?post=5330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}