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On the binding of cinmetacin and indomethacin to human serum albumin
Posted June 8th, 2010 by pschmidtke
| Title | On the binding of cinmetacin and indomethacin to human serum albumin |
| Publication Type | Journal Article |
| Year of Publication | 1986 |
| Authors | Montero, MT, Pouplana R, Valls O, Garcia S |
| Journal | The Journal of pharmacy and pharmacology |
| Volume | 38 |
| Issue | 12 |
| Pagination | 925 - 927 |
| Date Published | 1986/12// |
| Keywords | Acids/blood;, Albumin/metabolism, Binding;, Dialysis;, Humans;, Indoleacetic, Indomethacin/blood;, Kinetics;, Protein, Serum |
| Abstract | The binding of two non-steroidal anti-inflammatory drugs, indomethacin and cinmetacin, to human serum albumin was studied by dynamic dialysis at 37 degrees C and pH 7.4. Cinmetacin is bound more than indomethacin. The affinity constant for the primary binding site is 4.28 X 10(6) M-1 for cinmetacin and 1.4 X 10(6) M-1 for indomethacin. The protein binding of indomethacin is decreased in the presence of cinmetacin. |
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