A Medicinal Chemist's Guide to Molecular Interactions
Caterina Bissantz, Bernd Kuhn and Martin Stahl
DOI: 10.1021/jm100112j |
Cheminformatic Tools for Medicinal Chemists
Steven W. Muchmore, Jeremy J. Edmunds, Kent D. Stewart and Philip J. Hajduk DOI: 10.1021/jm100164z |
Molecular Shape and Medicinal Chemistry: A Perspective
Anthony Nicholls, Georgia B. McGaughey, Robert P. Sheridan, Andrew C. Good, Gregory Warren, Magali Mathieu, Steven W. Muchmore, Scott P. Brown, J. Andrew Grant, James A. Haigh, Neysa Nevins, Ajay N. Jain and Brian Kelley
DOI: 10.1021/jm900818s |
Understanding and Predicting Druggability. A High-Throughput Method for Detection of Drug Binding Sites
Peter Schmidtke and Xavier Barril
DOI: 10.1021/jm100574m |
Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency
Christopher W. Murray, Maria G. Carr, Owen Callaghan, Gianni Chessari, Miles Congreve, Suzanna Cowan, Joseph E. Coyle, Robert Downham, Eva Figueroa, Martyn Frederickson, Brent Graham, Rachel McMenamin, M. Alistair O'Brien, Sahil Patel, Theresa R. Phillips, Glyn Williams, Andrew J. Woodhead and Alison J.-A. Woolford
DOI: 10.1021/jm100059d |
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin
Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess, Amita M. Chaudhari, Michael G. Darcy, Carla A. Donatelli, Juan I. Luengo, Ken A. Newlander, Cynthia A. Parrish, Lance H. Ridgers, Martha A. Sarpong, Stanley J. Schmidt, Glenn S. Van Aller, Jeffrey D. Carson, Melody A. Diamond, Patricia A. Elkins, Christine M. Gardiner, Eric Garver, Seth A. Gilbert, Richard R. Gontarek, Jeffrey R. Jackson, Kevin L. Kershner, Lusong Luo, Kaushik Raha, Christian S. Sherk, Chiu-Mei Sung, David Sutton, Peter J. Tummino, Ronald J. Wegrzyn, Kurt R. Auger and Dashyant Dhanak
DOI: 10.1021/ml900028r |
Fragment Screening by Surface Plasmon Resonance
Iva Navratilova and Andrew L. Hopkins
DOI: 10.1021/ml900002k |
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist
Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami, Masahiro Ito, Masami Suzuki, Yoshiyuki Tsujihata, Ryo Ito, Ayako Harada, Koji Takeuchi, Nobuhiro Suzuki, Junichi Miyazaki, Takashi Santou, Tomoyuki Odani, Naoyuki Kanzaki, Miyuki Funami, Toshimasa Tanaka, Akifumi Kogame, Shinichiro Matsunaga, Tsuneo Yasuma and Yu Momose
DOI: 10.1021/ml1000855 |
Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist
Alexander Pasternak, Stephen D. Goble, Mary Struthers, Pasquale P. Vicario, Julia M. Ayala, Jerry Di Salvo, Ruth Kilburn, Thomas Wisniewski, Ju.lie A. DeMartino, Sander G. Mills and Lihu Yang DOI: 10.1021/ml900009d |
Synthesis and SAR of Benzisothiazole- and Indolizine-β-d-glucopyranoside Inhibitors of SGLT2
Huiqiang Zhou, Dana P. Danger, Steven T. Dock, Lora Hawley, Shane G. Roller, Chari D. Smith and Anthony L. Handlon DOI: 10.1021/ml900010b |