{"id":834,"date":"2025-06-16T17:30:19","date_gmt":"2025-06-16T17:30:19","guid":{"rendered":"https:\/\/www.ub.edu\/cmd_lab\/?p=834"},"modified":"2025-06-16T17:30:31","modified_gmt":"2025-06-16T17:30:31","slug":"new-preprint-alert-2","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/cmd_lab\/new-preprint-alert-2\/","title":{"rendered":"New PrePrint Alert!"},"content":{"rendered":"<p data-start=\"289\" data-end=\"581\">Our latest preprint is now available on <a href=\"https:\/\/lnkd.in\/dTKqdXiu\"><strong data-start=\"219\" data-end=\"231\">ChemRxiv<\/strong><\/a>!<\/p>\n<p data-start=\"289\" data-end=\"581\">In this study, we investigate how <strong data-start=\"323\" data-end=\"418\">hydrogen bonds contribute to the stability of molecular glue (MG)-induced ternary complexes<\/strong>. Our findings show that the <strong data-start=\"447\" data-end=\"486\">strengthening of polar interactions<\/strong> is a consistent physicochemical mechanism that supports the action of chemically diverse MGs.<\/p>\n<p data-start=\"583\" data-end=\"766\">Based on these insights, we propose a <strong data-start=\"621\" data-end=\"649\">new conceptual framework<\/strong> to better understand and classify molecular glues according to their <strong data-start=\"719\" data-end=\"738\">structural role<\/strong> within the ternary complex.<\/p>\n<p data-start=\"583\" data-end=\"766\">We hope this work provides valuable guidance for the <strong data-start=\"824\" data-end=\"854\">rational design of new MGs<\/strong> and accelerates their application in both <strong data-start=\"897\" data-end=\"911\">biomedical<\/strong> and <strong data-start=\"916\" data-end=\"936\">biotechnological<\/strong> fields.<\/p>\n<p data-start=\"946\" data-end=\"1146\">Congratulations to <strong data-start=\"887\" data-end=\"914\">Patricia Blanco Gabella<\/strong> for leading this study, and thanks to <strong data-start=\"953\" data-end=\"1013\">Varbina Ivanova, \u00c1lvaro Serrano-Morr\u00e1s, and Julian Fuchs<\/strong> for their important contributions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our latest preprint is now available on ChemRxiv! In this study, we investigate how hydrogen bonds contribute to the stability of molecular glue (MG)-induced ternary complexes. Our findings show that the strengthening of polar interactions is a consistent physicochemical mechanism that supports the action of chemically diverse MGs. Based on these insights, we propose a [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":835,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/posts\/834"}],"collection":[{"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/comments?post=834"}],"version-history":[{"count":2,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/posts\/834\/revisions"}],"predecessor-version":[{"id":837,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/posts\/834\/revisions\/837"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/media\/835"}],"wp:attachment":[{"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/media?parent=834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/categories?post=834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ub.edu\/cmd_lab\/wp-json\/wp\/v2\/tags?post=834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}