{"id":562,"date":"2020-02-25T16:01:15","date_gmt":"2020-02-25T16:01:15","guid":{"rendered":"https:\/\/carlescurutchet.wordpress.com\/?p=562"},"modified":"2021-12-02T13:23:33","modified_gmt":"2021-12-02T11:23:33","slug":"new-article-in-angewandte-chemie-cooperative-labelling-of-amyloids","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/cplab\/2020\/02\/25\/new-article-in-angewandte-chemie-cooperative-labelling-of-amyloids\/","title":{"rendered":"New article in Angewandte Chemie: Cooperative labelling of amyloids"},"content":{"rendered":"<p>In humans, amyloid aggregation is related to up to\u00a0thirty-six degenerative protein misfolding disorders, including non-neurologic\u00a0and neurologic illnesses, such as type 2 diabetes or Alzheimer\u2019s and\u00a0Parkinson\u2019s diseases. Amyloids are characterized by their capacity to bind Congo red (CR), one of the most used amyloid-specific dyes. The structural features of CR binding were unknown for years. In this study, we combined spectroscopic data with\u00a0molecular docking, molecular dynamics, and excitonic quantum\/molecular mechanics calculations to examine and rationalize CR binding to amyloids concluding that CR binds to amyloid fibrils with the long axis oblique\u00a0to the fibril axis and the plane radial to the fibril core, following a cooperative mechanism characterized by the\u00a0formation of a 1:1 stoichiometric complex. For more information check this <a href=\"https:\/\/doi.org\/10.1002\/anie.201916630\">link<\/a>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"  wp-image-563 aligncenter\" src=\"https:\/\/www.ub.edu\/cplab\/wp-content\/uploads\/2020\/02\/anie201916630-toc-0001-m.jpg\" alt=\"anie201916630-toc-0001-m.jpg\" width=\"264\" height=\"230\" srcset=\"https:\/\/www.ub.edu\/cplab\/wp-content\/uploads\/2020\/02\/anie201916630-toc-0001-m.jpg 388w, https:\/\/www.ub.edu\/cplab\/wp-content\/uploads\/2020\/02\/anie201916630-toc-0001-m-300x261.jpg 300w\" sizes=\"auto, (max-width: 264px) 100vw, 264px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In humans, amyloid aggregation is related to up to\u00a0thirty-six degenerative protein misfolding disorders, including non-neurologic\u00a0and neurologic illnesses, such as type 2 diabetes or Alzheimer\u2019s and\u00a0Parkinson\u2019s diseases. Amyloids are characterized by their capacity to bind Congo red (CR), one of the most used amyloid-specific dyes. The structural features of CR binding were unknown for years. In&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,6,9,10],"tags":[],"class_list":["post-562","post","type-post","status-publish","format-standard","hentry","category-chemistry","category-excited-states","category-publications","category-qm-mm"],"_links":{"self":[{"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/posts\/562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/comments?post=562"}],"version-history":[{"count":1,"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/posts\/562\/revisions"}],"predecessor-version":[{"id":627,"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/posts\/562\/revisions\/627"}],"wp:attachment":[{"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/media?parent=562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/categories?post=562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ub.edu\/cplab\/wp-json\/wp\/v2\/tags?post=562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}