{"id":1091,"date":"2020-03-26T06:00:00","date_gmt":"2020-03-26T06:00:00","guid":{"rendered":"https:\/\/www.ub.edu\/creatio\/wp\/?post_type=actualitat&p=1091"},"modified":"2022-08-05T06:06:00","modified_gmt":"2022-08-05T06:06:00","slug":"producciocart","status":"publish","type":"actualitat","link":"https:\/\/www.ub.edu\/creatio\/actualitat\/producciocart\/","title":{"rendered":"Producci\u00f3 CAR-T Assaig Cl\u00ednic (Ter\u00e0pies Avan\u00e7ades)"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Des del seu inici el 2016, el projecte ARI<\/a> (Assist\u00e8ncia Recerca Intensiva) liderat per l’Hospital Cl\u00ednic de Barcelona ha rebut el suport i la contribuci\u00f3 de Creatio. <\/h3>\n\n\n\n

El projecte ARI, nascut fruit del somni de l\u2019Ari Bened\u00e9 -una adolescent a qui se li va diagnosticar leuc\u00e8mia limfobl\u00e0stica aguda que ens va deixar el 2 de setembre de 2016-, es va convertir en un projecte complet pel desenvolupament d’una estrat\u00e8gia d’immunoter\u00e0pia utilitzant c\u00e8l\u00b7lules CAR T dissenyades contra el c\u00e0ncer de la sang. Aquesta estrat\u00e8gia terap\u00e8utica utilitza les pr\u00f2pies c\u00e8l\u00b7lules immunit\u00e0ries T del pacient i redirigeix \u200b\u200bla seva citotoxicitat a partir de la seva modificaci\u00f3 gen\u00e8tica per expressar un receptor d’antigen quim\u00e8ric (CAR) contra les c\u00e8l\u00b7lules canceroses. La modificaci\u00f3 gen\u00e8tica es pot aconseguir infectant les c\u00e8l\u00b7lules T amb part\u00edcules lentivirals que contenen la informaci\u00f3 gen\u00e8tica que codifica pel CAR, la qual \u00e9s l’etapa on va intervenir Creatio. Amb les seves instal\u00b7lacions d’avantguarda i el seu personal expert, Creatio ha estat el responsable de la producci\u00f3 de les part\u00edcules lentivirals de grau cl\u00ednic pel projecte ARI. Les part\u00edcules, doncs, es van emprar per infectar les c\u00e8l\u00b7lules T pr\u00e8viament extretes i seleccionades dels 28 pacients participants en l’assaig cl\u00ednic en un sistema tancat semiautom\u00e0tic en el punt d’atenci\u00f3 m\u00e8dica. Com a tal, cada lot de c\u00e8l\u00b7lules CAR T constitueix un producte \u00fanic fet per a un sol pacient. Els resultats de tot el proc\u00e9s de producci\u00f3 i caracteritzaci\u00f3 dels 28 productes de c\u00e8l\u00b7lules CAR T han estat publicats a Frontiers in Immunology<\/em><\/a> per l’equip de l’Hospital Cl\u00ednic dirigit pel Dr. Manel Juan, sent els cient\u00edfics de Creatio co-autors de l’article. L’estudi mostra que la fabricaci\u00f3 de c\u00e8l\u00b7lules CAR T es pot completar en un temps limitat, el que millora la qualitat del producte i la seva persist\u00e8ncia en els pacients despr\u00e9s del trasplantament. Tamb\u00e9, es va demostrar que l’efici\u00e8ncia de transducci\u00f3 del lentivirus estava en un bon rang tant per a controls sans com per a pacients. A m\u00e9s, les c\u00e8l\u00b7lules CAR-T produ\u00efdes van mostrar una distribuci\u00f3 fenot\u00edpica apropiada i una potent efic\u00e0cia antitumoral. Els resultats de l’assaig cl\u00ednic han estat molt prometedors fins al moment i encara ara es recopilen, els quals es publicaran en un futur pr\u00f2xim.<\/p>\n\n\n\n

Creatio est\u00e0 entusiasmat amb els resultats i confia que, despr\u00e9s de d\u00e8cades d’esfor\u00e7os, aviat arribaran temps emocionants per a una nova generaci\u00f3 de medicaments que comprenguin c\u00e8l\u00b7lules, gens i teixits, tots ells agrupats sota el paraigua conegut com a productes medicinals de ter\u00e0pia avan\u00e7ada (ATMP, de l\u2019angl\u00e8s Advanced Therapy Medicinal Products<\/em>). L\u2019experi\u00e8ncia de Creatio en la producci\u00f3 cl\u00ednica de part\u00edcules lentivirals es posa a disposici\u00f3 de la comunitat investigadora per prosperar cap al futur de la medicina.<\/p>\n","protected":false},"author":1,"featured_media":1092,"template":"","class_list":["post-1091","actualitat","type-actualitat","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nProducci\u00f3 CAR-T Assaig Cl\u00ednic (Ter\u00e0pies Avan\u00e7ades) - Creatio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/creatio\/actualitat\/producciocart\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Producci\u00f3 CAR-T Assaig Cl\u00ednic (Ter\u00e0pies Avan\u00e7ades) - Creatio\" \/>\n<meta property=\"og:description\" content=\"Des del seu inici el 2016, el projecte ARI (Assist\u00e8ncia Recerca Intensiva) liderat per l’Hospital Cl\u00ednic de Barcelona ha rebut el suport i la contribuci\u00f3 de Creatio. 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