{"id":2471,"date":"2022-11-17T08:33:38","date_gmt":"2022-11-17T08:33:38","guid":{"rendered":"https:\/\/www.ub.edu\/creatio\/?post_type=actualitat&#038;p=2471"},"modified":"2023-08-11T10:15:47","modified_gmt":"2023-08-11T10:15:47","slug":"jrc-ecvam","status":"publish","type":"actualitat","link":"https:\/\/www.ub.edu\/creatio\/actualitat\/jrc-ecvam\/","title":{"rendered":"Creatio participa en el monogr\u00e0fic de m\u00e8todes alternatius per la JRC (Estudis Precl\u00ednics)"},"content":{"rendered":"\n<p><em>El Dr. Canals, director de Creatio, en col\u00b7laboraci\u00f3 amb un grup d&#8217;experts en Productes Medicinals de Ter\u00e0pia Avan\u00e7ada (en angl\u00e8s <\/em><em>Advanced Therapy Medicinal Products, ATMPs<\/em><em>), va dur a terme un estudi exhaustiu sobre l&#8217;estat dels models no animals m\u00e9s avan\u00e7ats utilitzats en la recerca biom\u00e8dica per testar la immunogenicitat.<\/em>\u00a0<\/p>\n\n\n\n<p>Els ATMP, que inclouen ter\u00e0pia g\u00e8nica, ter\u00e0pia cel\u00b7lular, ter\u00e0pia de teixits i ter\u00e0pies combinades, s\u00f3n tractaments prometedors per a les malalties on la medicina convencional ha fracassat. Aquests poden anar des del c\u00e0ncer, disfuncions locomotores, afeccions cardiovasculars, malalties neurodegeneratives fins a trastorns gen\u00e8tics rars. Malauradament, aquestes ter\u00e0pies prometedores poden provocar alguns efectes secundaris no desitjats que compensen les seves propietats curatives.&nbsp;<\/p>\n\n\n\n<p>La immunogenicitat, l&#8217;hoste rebutja el trasplantament o les c\u00e8l\u00b7lules injectades, \u00e9s un efecte negatiu com\u00fa dels ATMP. Les ag\u00e8ncies reguladores s\u00f3n les responsables d&#8217;avaluar el risc d&#8217;immunogenicitat de les noves ter\u00e0pies abans de l&#8217;aprovaci\u00f3. Malauradament, la majoria de les proves estandarditzades existents utilitzen rosegadors i altres mam\u00edfers, els quals no imiten les caracter\u00edstiques de l&#8217;entorn hum\u00e0. Els m\u00e8todes alternatius com els cultius de c\u00e8l\u00b7lules humanes o els models humans en 3D es consideren un bon substitut per validar aquestes ter\u00e0pies innovadores. Per aquest motiu, el Joint Research Council (JRC), el centre de ci\u00e8ncia i coneixement de la Comissi\u00f3 Europea (CE), va rebre l&#8217;enc\u00e0rrec d&#8217;avaluar l&#8217;estat dels m\u00e8todes alternatius que proven la immunogenicitat dels ATMP.&nbsp;<\/p>\n\n\n\n<p>Creatio, un centre de producci\u00f3 i validaci\u00f3 d&#8217;ATMP amb m\u00e9s de 10 anys d&#8217;experi\u00e8ncia, t\u00e9 un comprom\u00eds a llarg termini amb la reducci\u00f3 de l&#8217;\u00fas innecessari d&#8217;animals en la recerca biom\u00e8dica. Juntament amb el JRC, el Dr. Canals va participar en l\u2019estudi dels m\u00e8todes existents amb un equip d&#8217;experts internacionals d&#8217;Espanya, Fran\u00e7a i It\u00e0lia. Els resultats van posar de manifest un desequilibri entre la gran quantitat d&#8217;assaigs cl\u00ednics amb ATMP i el baix nombre d&#8217;articles centrats en m\u00e8todes alternatius per provar la immunogenicitat (nom\u00e9s el 0,22% del total). A m\u00e9s, la majoria d&#8217;aquests models no van ser innovadors, la majoria utilitza proves de laboratori ben establertes (majorit\u00e0riament c\u00e8l\u00b7lules T de cultiu primari 2D) i amb una notable prevalen\u00e7a per una an\u00e0lisi de contingut i rendiment baix i\/o mitj\u00e0.\u00a0<\/p>\n\n\n\n<p>El Dr. Canals ha destacat que \u00ab<em>aquesta an\u00e0lisi mostra que hi ha una clara necessitat insatisfeta d\u2019utilitzar m<\/em><em>\u00e8todes alternatius fiables<\/em><em>. Aix\u00f2 dificulta la possibilitat que els ATMP en desenvolupament arribin als pacients. La comunitat cient\u00edfica ha de prioritzar el desenvolupament de m\u00e8todes alternatius innovadors i personalitzats<\/em>\u00ab. El grup expert creu que el desenvolupament de les plataformes amb experi\u00e8ncia en l\u2019\u00e0mbit de les ATMP seria un factor clau per definir els models rellevants no animals per a q\u00fcestions cient\u00edfiques espec\u00edfiques, mentre maximitzen les necessitats i les oportunitats juntament amb els desenvolupadors de proves.&nbsp;<\/p>\n\n\n\n<p>Consulta l\u2019informe:&nbsp;&nbsp;<\/p>\n\n\n\n<p><a href=\"https:\/\/publications.jrc.ec.europa.eu\/repository\/handle\/JRC126997\">Canals, J., Romania, P., Belio-Mairal, P., Nic, M., Dibusz, K., Novotny, T., Busquet, F., Rossi, F., Straccia, M., Daskalopoulos, E., Dura, A., Gribaldo, L. and Whelan, M., Advanced Non-animal Models in Biomedical Research, EUR 30334\/4 EN, Publications Office of the European Union, Luxembourg, 2022, ISBN 978-92-76-49092-0, doi:10.2760\/153339, JRC126997.&nbsp;<\/a><\/p>\n","protected":false},"author":1,"featured_media":2518,"template":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - 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