{"id":4530,"date":"2026-02-25T13:06:46","date_gmt":"2026-02-25T13:06:46","guid":{"rendered":"https:\/\/www.ub.edu\/creatio\/?post_type=actualitat&#038;p=4530"},"modified":"2026-02-25T14:26:50","modified_gmt":"2026-02-25T14:26:50","slug":"nam","status":"publish","type":"actualitat","link":"https:\/\/www.ub.edu\/creatio\/en\/news\/nam\/","title":{"rendered":"VISI-ON-BRAIN Project (NAMs)"},"content":{"rendered":"\n<ul>\n<li>Project coordinated by the University of Barcelona through Creatio \u2013 the Production and Validation Center of Advanced Therapies<\/li>\n<\/ul>\n\n\n\n<p><strong>Barcelona, 25 February 2026<\/strong> \u2014 Universitat de Barcelona today announced the launch of VISI-ON-BRAIN (Cutting-edge Human In Vitro and In Silico Biomedical Tools on Brain Disorders), a Horizon Europe project funded with over \u20ac4.5 million under the Marie Sk\u0142odowska-Curie Actions \u2013 Doctoral Networks (MSCA-DN). Over 48 months (2026\u20132029), the consortium will train 15 doctoral researchers to develop and apply next-generation human in vitro and in silico approaches for complex brain disorders, including Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s disease.<\/p>\n\n\n\n<p>The project arrives as biomedical R&amp;D and policy shift decisively toward innovation without animal use and toward human-relevant, mechanistically anchored evidence, driven by concerns about translation, cost, and late-stage clinical attrition. In Europe, this includes a Commission Roadmap to phase out animal testing in chemical safety assessments and Parliament calls to accelerate the transition with clearer objectives and timelines. In the United States, the FDA has outlined a stepwise plan to reduce animal testing in preclinical safety studies and expand New Approach Methodologies (NAMs), including computational and advanced in vitro systems.<\/p>\n\n\n\n<p>Neuroscience makes this transition mission-critical: neurodegenerative therapeutic agents development has seen exceptionally high failure rates, underscoring the need for models that better reflect human biology and disease trajectories. The EU\u2019s broader competitiveness push\u2014via the Commission\u2019s Strategy for European Life Sciences (\u201cChoose Europe for life sciences\u201d) and the European Biotech Act\u2014reinforces this direction by strengthening translation from lab to market, boosting innovation uptake, and accelerating pathways from research to real-world impact.<\/p>\n\n\n\n<p>VISI-ON-BRAIN is designed to close the translational gap by building an integrated pipeline of predictive, reproducible, clinically anchored experimental and computational tools, while training researchers who can operate at the interface of biology, data, engineering and regulatory relevance.<\/p>\n\n\n\n<p><strong>A pan-European, intersectoral training and research platform<\/strong><\/p>\n\n\n\n<p>The programme brings together 15 academic, clinical, and industrial partners across eight European countries, enabling doctoral researchers to combine wet-lab innovation with advanced modeling, analytics, and translational validation. The project is coordinated by the University of Barcelona through Creatio \u2013 Production and Validation Center of Advanced Therapies (Spain). The beneficiary consortium includes: Danmarks Tekniske Universitet (Denmark), Prinses M\u00e1xima Centrum voor Kinderoncologie (Netherlands), Eberhard Karls Universit\u00e4t T\u00fcbingen (Germany), Lunds Universitet (Sweden), Cardiff University and King\u2019s College London (United Kingdom), Consiglio Nazionale delle Ricerche (Italy), Starlab Barcelona SL (Spain) and FRESCI (Spain). Associated partners are: Universit\u00e0 degli Studi di Milano-Bicocca (Italy), Utrecht University (Netherlands), VERIGRAFT AB (Sweden), Ospedale San Raffaele SRL (Italy), and the European Commission Joint Research Centre (Italy).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"742\" data-src=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-1024x742.jpg\" alt=\"\" class=\"wp-image-4531 lazyload\" data-srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-1024x742.jpg 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-300x217.jpg 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-768x557.jpg 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-1536x1114.jpg 1536w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-scaled.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/742;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"742\" src=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-1024x742.jpg\" alt=\"\" class=\"wp-image-4531\" srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-1024x742.jpg 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-300x217.jpg 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-768x557.jpg 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-1536x1114.jpg 1536w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Consortium-picture-4-scaled.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><figcaption class=\"wp-element-caption\">From left to right and in ascending order, the experts Josep M. Canals (coordinador del proyecto europeo VISI-ON-BRAIN), Albert Giralt, Andrea Faedo y Daniel del Toro; Henrik Ahlenius, Marco Straccia y Nicholas Allen; Milena Mennecozzi, Delilah Hendriks y Jordi Abante; Aureli Soria-Frisch, Benedetta Artegiani y Arto Heiskanen; Saioa Ortiz, Andrea Comella, Jenny Emn\u00e9us y Vania Broccoli; Raimund Strehl y Dafnis Batall\u00e9.<\/figcaption><\/figure>\n\n\n\n<p><strong>Why it matters: from \u201cmore data\u201d to \u201cbetter evidence.\u201d<\/strong><\/p>\n\n\n\n<p>Brain disorders are a major global health challenge and a substantial societal and economic burden. VISI-ON-BRAIN will accelerate human-relevant, decision-grade tools that enable earlier, more reliable go\/no-go decisions, de-risk translation, and improve the efficiency of therapeutic discovery and development. Beyond the science, it is a workforce and competitiveness investment\u2014training doctoral researchers who can move easily between academia, clinical research, and industry, helping scale NAMs from promising methods to validated, deployable practice aligned with evolving regulatory expectations.<\/p>\n\n\n\n<p>Funded by the European Union under the Marie Sk\u0142odowska-Curie grant agreement N. 101227124. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"410\" data-src=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-1024x410.png\" alt=\"\" class=\"wp-image-4532 lazyload\" data-srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-1024x410.png 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-300x120.png 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-768x307.png 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2.png 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/410;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"410\" src=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-1024x410.png\" alt=\"\" class=\"wp-image-4532\" srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-1024x410.png 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-300x120.png 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2-768x307.png 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/Funded-by-the-European-Union-2.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"364\" data-src=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-1024x364.png\" alt=\"\" class=\"wp-image-4533 lazyload\" data-srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-1024x364.png 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-300x107.png 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-768x273.png 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-1536x546.png 1536w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3.png 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/364;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"364\" src=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-1024x364.png\" alt=\"\" class=\"wp-image-4533\" srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-1024x364.png 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-300x107.png 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-768x273.png 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3-1536x546.png 1536w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2026\/02\/2602-VOB-logo-rgb-horizontal-positivo-3.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/figure>\n","protected":false},"author":1,"featured_media":4524,"template":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - 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