{"id":588,"date":"2022-04-13T11:05:00","date_gmt":"2022-04-13T11:05:00","guid":{"rendered":"https:\/\/www.ub.edu\/creatio\/wp\/?post_type=actualitat&#038;p=588"},"modified":"2023-08-11T10:15:57","modified_gmt":"2023-08-11T10:15:57","slug":"directrius_brain","status":"publish","type":"actualitat","link":"https:\/\/www.ub.edu\/creatio\/actualitat\/directrius_brain\/","title":{"rendered":"White Paper (Estudis Precl\u00ednics)"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" data-src=\"https:\/\/www.ub.edu\/creatio\/wp\/wp-content\/uploads\/2022\/08\/Portada-Brain-febrer-2022.jpg\" alt=\"\" class=\"wp-image-890 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" \/><noscript><img decoding=\"async\" src=\"https:\/\/www.ub.edu\/creatio\/wp\/wp-content\/uploads\/2022\/08\/Portada-Brain-febrer-2022.jpg\" alt=\"\" class=\"wp-image-890\"\/><\/noscript><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">El personal de Creatio ha participat al \u201cWhite Paper\u201d que descriu els desafiaments per transformar els aven\u00e7os substancials en ter\u00e0pia cel\u00b7lular en benefici per als pacients. L&#8217;informe s&#8217;ha publicat aquest mes a la prestigiosa revista Brain.&nbsp;&nbsp;<\/h3>\n\n\n\n<p>El Dr. Josep M. Canals, el Dr. Unai Perpi\u00f1a i la Dra. Cristina Salado van participar, com a representants de Creatio, amb la definici\u00f3 dels 7 reptes a superar per a la translaci\u00f3 cl\u00ednica de la ter\u00e0pia cel\u00b7lular a la malaltia de Huntington. L&#8217;informe, publicat a<a href=\"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awac086\/6545253\"> <\/a><a href=\"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awac086\/6545253\">Brain<\/a>, es centra en els grans aven\u00e7os de les ter\u00e0pies amb c\u00e8l\u00b7lules mare i el seu potencial per arribar als assaigs cl\u00ednics. Per aconseguir aquest objectiu, els experts assenyalen la necessitat abans d&#8217;harmonitzar processos a totes les etapes, des dels estudis precl\u00ednics fins a la seva aplicaci\u00f3 cl\u00ednica. Els reptes identificats van des de l&#8217;elecci\u00f3 dels models animals correctes, la producci\u00f3 a escala, el disseny d&#8217;assajos cl\u00ednics apropiats i els protocols de selecci\u00f3 de pacients fins a la gesti\u00f3 dels pacients despr\u00e9s del trasplantament. En les conclusions, els experts reforcen la import\u00e0ncia de la col\u00b7laboraci\u00f3 i harmonitzaci\u00f3 internacional per garantir que els coneixements adquirits als estudis precl\u00ednics puguin aplicar-se als assajos cl\u00ednics.&nbsp;<\/p>\n\n\n\n<p>Creatio, el Centre de Producci\u00f3 i Validaci\u00f3 de Ter\u00e0pies Avan\u00e7ades, \u00e9s membre de Stem Cells for Huntington Disease (<a href=\"https:\/\/www.sc4hd.org\/\">SC4HD<\/a>) i de l&#8217;European Huntington Disease Network Advanced Therapies Workshop Group (<a href=\"http:\/\/www.ehdn.org\/\">EHDN<\/a>), tots dos involucrats en el desenvolupament del \u00abWhite Paper.\u201d Ambdues xarxes internacionals reuneixen experts de diferents camps per compartir experi\u00e8ncies, desenvolupar protocols comuns i acordar les estrat\u00e8gies a seguir per al tractament de la malaltia de Huntington.&nbsp;&nbsp;<\/p>\n\n\n\n<p>El director de Creatio, el Dr. Josep M. Canals, es va mostrar esperan\u00e7at que aquest informe \u201cmarqui el cam\u00ed dels problemes que cal resoldre conjuntament per tractar la malaltia de Huntington, i no nom\u00e9s alleujar els seus s\u00edmptomes\u201d. El Dr. Canals va destacar que la medicina regenerativa en malalties neurodegeneratives es focalitza en la reparaci\u00f3. A difer\u00e8ncia dels tractaments farmacol\u00f2gics, la ter\u00e0pia cel\u00b7lular t\u00e9 com a objectiu recuperar les c\u00e8l\u00b7lules cerebrals ja perdudes, convertint-los en tractaments molt prometedors, ja que quan es diagnostica la malaltia el pacient t\u00e9 un dany neuronal significatiu que actualment no es pot revertir. Per tant, la ter\u00e0pia cel\u00b7lular ha de veure&#8217;s com una opci\u00f3 complement\u00e0ria per al tractament dels pacients de Huntington.&nbsp;<\/p>\n\n\n\n<p>La malaltia de Huntington \u00e9s un trastorn cerebral progressiu que provoca moviments descontrolats, problemes emocionals i p\u00e8rdua de la capacitat de pensament (cognici\u00f3). La major part dels casos s\u00f3n diagnosticats en edat adulta, entre els trenta i els quaranta anys, amb greus impactes associats a nivell social, econ\u00f2mic i emocional tant pels pacients com pels seus \u00e9ssers estimats. A m\u00e9s, els pacients de Huntington comparteixen les principals caracter\u00edstiques fisiopatol\u00f2giques de malalties neurodegeneratives multig\u00e8niques i\/o multifactorials m\u00e9s prevalents. Tenint en compte la disponibilitat de proves gen\u00e8tiques i m\u00faltiples models cel\u00b7lulars i animals, la malaltia de Huntington \u00e9s un excel\u00b7lent candidat per provar, optimitzar i implementar la ter\u00e0pia cel\u00b7lular. Per aquests motius, els autors d&#8217;aquest \u201cWhite Paper\u201d esperen que aquestes directrius tamb\u00e9 aplanin el cam\u00ed a altres trastorns neurodegeneratius complexos, com el Parkinson o l&#8217;Alzheimer.&nbsp;<\/p>\n","protected":false},"author":1,"featured_media":892,"template":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>White Paper (Estudis Precl\u00ednics) - Creatio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/creatio\/actualitat\/directrius_brain\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"White Paper (Estudis Precl\u00ednics) - Creatio\" \/>\n<meta property=\"og:description\" content=\"El personal de Creatio ha participat al \u201cWhite Paper\u201d que descriu els desafiaments per transformar els aven\u00e7os substancials en ter\u00e0pia cel\u00b7lular en benefici per als pacients. 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