{"id":994,"date":"2020-10-09T16:59:00","date_gmt":"2020-10-09T16:59:00","guid":{"rendered":"https:\/\/www.ub.edu\/creatio\/wp\/?post_type=actualitat&#038;p=994"},"modified":"2022-08-03T17:02:52","modified_gmt":"2022-08-03T17:02:52","slug":"review","status":"publish","type":"actualitat","link":"https:\/\/www.ub.edu\/creatio\/en\/news\/review\/","title":{"rendered":"Review: Immune Response in Patients (Advanced Therapies)"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" data-src=\"https:\/\/www.ub.edu\/creatio\/wp\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-1024x687.png\" alt=\"Revisi\u00f3 Cient\u00edfica_Resposta Immune Pacients_Ter\u00e0pies Avan\u00e7ades\" class=\"wp-image-991 lazyload\" width=\"659\" height=\"442\" data-srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-1024x687.png 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-300x201.png 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-768x515.png 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades.png 1396w\" data-sizes=\"(max-width: 659px) 100vw, 659px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 659px; --smush-placeholder-aspect-ratio: 659\/442;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.ub.edu\/creatio\/wp\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-1024x687.png\" alt=\"Revisi\u00f3 Cient\u00edfica_Resposta Immune Pacients_Ter\u00e0pies Avan\u00e7ades\" class=\"wp-image-991\" width=\"659\" height=\"442\" srcset=\"https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-1024x687.png 1024w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-300x201.png 300w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades-768x515.png 768w, https:\/\/www.ub.edu\/creatio\/wp-content\/uploads\/2022\/08\/Revisio-Cientifica_Resposta-Immune-Pacients_Terapies-Avancades.png 1396w\" sizes=\"(max-width: 659px) 100vw, 659px\" \/><\/noscript><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Cell therapy as a strategy to treat neurodegenerative diseases was first applied in humans in the 1980s. Since then, researchers and doctors around the world have continued to join forces to improve this treatment, which aims to replace affected neurons as well as enhance endogenous proliferation of new ones. <\/h3>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.3389\/fncel.2020.00250\">The latest review published by Creatio team<\/a>, first-authored by the researcher Cristina Salado-Manzano, describes a detailed analysis of the mechanisms that promote Parkinson&#8217;s and Huntington&#8217;s diseases, which justify intracerebral transplantation since these diseases have no cure.<\/p>\n\n\n\n<p>There is a crucial factor so that the transplanted tissue can integrate into the brain and be functional: the patient&#8217;s own immune response. In this work, the potential of cell therapy to reestablish the affected neural circuits in neurodegenerative diseases is demonstrated, although the immunosuppression pharmacological regimen, as well as the immune response biomarkers, would need to be further homogenized to improve the therapy.<\/p>\n\n\n\n<p>The last part of this very complete review is a gift for those biomedicine lovers with special passion for biotech; would it be possible to develop an <em>in vitro <\/em>immunogenicity testing platform that allows to evaluate the activation of the immune system of a given cellular product, before even going to preclinical testing in animals? Advanced techniques and brilliant ideas will give an answer. Without a doubt, a good read that offers a thorough overview of a complex strategy that carries encouraging potential for the treatment of neurodegeneration.<\/p>\n\n\n\n<p>Cristina Salado-Manzano has been a PhD Student of the European Union\u2019s Horizon 2020 Research and Innovation Programme under the Marie Sk\u0142odowska-Curie grant agreement no 722779, <a href=\"http:\/\/training4crm.com\/\">Training4CRM<\/a>.<\/p>\n","protected":false},"author":1,"featured_media":991,"template":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Review: Immune Response in Patients (Advanced Therapies) - Creatio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/creatio\/en\/news\/review\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Review: Immune Response in Patients (Advanced Therapies) - Creatio\" \/>\n<meta property=\"og:description\" content=\"Cell therapy as a strategy to treat neurodegenerative diseases was first applied in humans in the 1980s. 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