New Chemical Methodologies for Facilitated Biology-Oriented Synthesis

Department of Pharmacology, Toxicology and Therapeutic Chemistry

Faculty of Pharmacy and Food Sciences, UB

Rodolfo Lavilla Grifols
ORCID ID: 0000-0002-5006-9917
Tel +34 934024536

https://www.ub.edu/medicinalchemistrypharmacology/research-group/rodolfo-lavilla/

Principal investigator: • Rodolfo Lavilla
Researcher: • Ouldouz Ghashghaei
PhD student: • Marina Pedrola Teixell

 

Rodolfo-Lavilla-Grifols

Current
Research

Research Topics:

New Chemistry for BioMedical Applications.

Research in synthetic methodology of small molecules and biopolymers. Multicomponent reactions, heterocyclic and organometallic Chemistry for the Preparation of complex small molecules, situ-selective functionalization of biopolymers and preparation of functional Bioprobes.

Expertise in Organic Synthesis and Medicinal Chemistry. Preparation of Target Compounds, Combinatorial Libraries, Bioconjugates and Fluorescent tags.

Partner for Pharma/Biotech Companies in R+D Projects.

Selected
Publications

De Moliner, F.; Kielland, N.; Lavilla, R.; Vendrell, M. (2017). Modern Synthetic Avenues for the Preparation of Functional Fluorophores. Angewandte Chemie. 56(14), 3758-3769, 2017. doi.org/10.1002/anie.201609394

Mendive-Tapia, L.; Zhao, C.; Akram, A. R.; Preciado, S.; Albericio, F.; Lee, M.; Serrels, A.; Kielland, N.; Read, N. D.; Lavilla, R.; Vendrell, M. Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue. Nature Communications. 7(1), 2016. doi.org/10.1038/ncomms10940

Kishore, K. G.; Ghashghaei, O.; Estarellas, C.; Mestre, M. M.; Monturiol, C.; Kielland, N.; Kelly, J. M.; Francisco, A. F.; Jayawardhana, S.; Muñoz-Torrero, D.; Pérez, B.; Luque, F. J.; Gámez-Montaño, R.; Lavilla, R. (2016). Insertion of Isocyanides into N−Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. Angewandte Chemie. 55(31), 8994-8998. doi.org/10.1002/anie.201604109

Mendive-Tapia, L.; Preciado, S.; García, J.; Ramón, R.; Kielland, N.; Albericio, F.; Lavilla, R. New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues. Nature Communications. 6(1), 2015. doi.org/10.1038/ncomms8160

Pérez-Perarnau, A.; Preciado, S.; Palmeri, C. M.; Moncunill-Massaguer, C.; Iglesias-Serret, D.; González-Gironès, D. M.; Miguel, M. G.; Karasawa, S.; Sakamoto, S.; Cosialls, A. M.; Rubio-Patiño, C.; Saura-Esteller, J.; Ramón, R.; Caja, L.; Fabregat, I.; Pons, G.; Handa, H.; Albericio, F.; Gil, J.; Lavilla, R. (2014). A Trifluorinated Thiazoline Scaffold Leading to Pro-apoptotic Agents Targeting Prohibitins. Angewandte Chemie. 53(38), 10150-10154, 2014. doi.org/10.1002/anie.201405758

Selected
Publications

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Author

Identification

“Modern Synthetic Avenues for the Preparation of Functional Fluorophores” F. de Moliner, N. Kielland, Rodolfo Lavilla, Marc Vendrell. Angewandte Chemie International Edition. 2017, 56, 3758–3769; FI: 11.709

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Author

Identification

“Direct imaging of fungal infection in human pulmonary tissue with spacer-free BODIPY labelled antimicrobial peptides”L. Mendive-Tapia, C. Zhao, A. R. Akram, S. Preciado, F. Albericio, M. Lee, A. Serrels, N. Kielland, N. D. Read, K. Dhaliwal, R Lavilla, M. Vendrell.

Nature Commun. 2016, 7:10940

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Author

Identification

“Insertion of Isocyanides into N-Si bonds: Azine MultiComponent Reactions Leading to Potent Anti-parasitic Compounds” K. G. Kishore, O. Ghashghaei, C. Estarellas, M. M. Mestre, C. Monturiol, N. Kielland, J. M. Kelly, A. F. Francisco, S. Jayawardhana, D. Muñoz-Torrero, B. Pérez, F. J. Luque, R. Gámez-Montaño and Rodolfo Lavilla. Angewandte Chemie Int. Ed. 2016,55, 8994-8998.

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Author

Identification

“New Peptide Architectures through C-H Activation Stapling between Tryptophan -Phenylalanine/Tyrosine Residues”L. Mendive-Tapia, S. Preciado, J. García, R. Ramón, N. Kielland, F. Albericio and Rodolfo Lavilla. Nature Commun. 2015; 6: 7160.

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Author

Identification

“Novel trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins”A. Pérez-Perarnau, S. Preciado, C. Mariela Palmeri, C. Moncunill-Massaguer, D.l Iglesias-Serret, D. M. González-Gironès, M. Miguel, S. Karasawa, S.Sakamoto, A. M. Cosialls, C. Rubio-Patiño, J. Saura-Esteller, R. Ramón, L. Caja, I. Fabregat, G. Pons, H. Handa, F. Albericio, J. Gil and Rodolfo Lavilla. Angewandte Chemie Int. Ed. 2014, 53, 10150-10154.

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