{"id":9,"date":"2018-12-28T12:49:42","date_gmt":"2018-12-28T11:49:42","guid":{"rendered":"http:\/\/www.ub.edu\/ibub\/?page_id=9"},"modified":"2020-02-13T15:22:15","modified_gmt":"2020-02-13T14:22:15","slug":"technology-transfer-opportunities","status":"publish","type":"page","link":"https:\/\/www.ub.edu\/ibub\/technology-transfer-opportunities\/","title":{"rendered":"Technology Transfer Opportunities"},"content":{"rendered":"\t\t
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Technology Transfer Opportunities<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Biochemical and Biomedical
Transfer Opportunities<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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services<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Animal Models:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cancer<\/p>

Cardiovascular diseases<\/p>

Diabetes and Obesity<\/p>

Drosophila and CNS diseases<\/p>

Inflammation<\/p>

Intrapancreatic PDAC models<\/p>

PPARbeta\/delta knock out models<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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In Vivo Studies:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Anti-inflammatory and toxicology drug validation<\/p>

Cardiovascular performance, ecocardiography, treadmill<\/p>

Impact of drugs on development using Drosophila<\/p>

Infrared thermography<\/p>

Metabolic phenotyping of rodent models Stereotaxis<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Cell-Based Studies:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Analysis of the mechanisms of action of anticancer drugs<\/p>

Barrier models for drug absorption screening and drug-transporter interactions<\/p>

Cell immortalization (fibroblasts, adipocytes,…)<\/p>

In vitro assays of bacterial infection and immunosuppression<\/p>

Mitochondrial metabolism and respiration<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Structural Approaches and \u201cOMICS\u201d Services:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biophysics assays: surface plasmon resonance\/Biacore studies and competition assays<\/p>

Computational biology and bioinformatics applied to genomes and gene\/protein networks<\/p>

Generation of high-quality leads for drug discovery<\/p>

Metabolomics and computational analysis of metabolic fluxes<\/p>

Protein crystallography, lead identification and validation<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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know-how<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Gene-protein networks integration, data management and visualization<\/p>

Infrared thermography for metabolic studies<\/p>

Mechanisms of action of anticancer drugs<\/p>

Mitochondrial metabolism and respiration<\/p>

Multiomics modelling<\/p>

Pharmacogenetics of anticancer drugs<\/p>

Pharmacological evaluation of drugs in metabolic-related diseases<\/p>

Protein structure-function relationship analysis and structural biology<\/p>

Signal transduction pathways and disease<\/p>

Targeted metabolomics<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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*Conventional cell, biochemical, protein and molecular biology approaches available in most laboratories at IBUB. <\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Chemistry and Pharmacy
Transfer Opportunities<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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services<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biophysical characterization of ligand-protein complexes<\/p>

Computational structure-based drug discovery: druggability, virtual screening, hit\/lead optimisation<\/p>

Design and synthesis of chemical libraries and scaffolds<\/p>

Design and synthesis of prodrugs<\/p>

Experimental determination of physicochemical properties<\/p>

Expert advice on new synthetic routes for organic compounds<\/p>

Expert advice on the determination of ADMET properties<\/p>

Expert opinion about chemical patents, infractions risks, etc.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Expert opinion on chemical manufacturing sites<\/p>

Fragment-based drug discovery: fragment screening, fragment evolution<\/p>

Hit to lead optimization<\/p>

HPLC and\/or HPLC\/MS of APIs, drugs and mixtures<\/p>

Molecular modelling of biomolecules for structure-function relationships<\/p>

Optimization and scale-up of routes of synthesis for APIs<\/p>

Search of molecules in libraries of compounds<\/p>

Structural elucidation and synthesis of metabolites\u0003<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Structural elucidation, isolation and synthesis of impurities of active pharmaceutical ingredients (APIs)<\/p>

Synthesis and conjugation of Fluorophores and Small molecule Bioprobes<\/p>

Synthesis of labelled compounds<\/p>

Synthesis of peptides and oligonucleotides (DNA, RNA)<\/p>

Synthesis of peptides-oligonucleotides conjugates<\/p>

Theoretical studies in structure-activity relationships<\/p>

Primary cultures of specialized cell types (adipocytes, hepatocytes, neurons, intestinal barrier, macrophages, cardiomyocites…)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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know-how<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Synthesis of bioactive compounds<\/p>\n

Assays for the physicochemical characterization of compounds: lipophilicity \/ hydrophilicity (log Po\/w, log D, log D7.4, CHI, log D vs pH, CHI vs pH); Acidity (pKa), isoelectric point; solubility (log S0, log Sk, pH-dependent solubility), interactions with proteins (Kb, DHB).<\/p>\n

Biophysical methods for ligand-protein characterization (DSF, SPR, ITC, fluorescence).\u0003 Chromatographical estimation of biological properties: aquatic toxicity (LC50, CNAR), skin permeability (kp), and soil-water distribution (log KOC).<\/p>\n

Computational determination of physicochemical properties of bioactive drugs<\/p>\n

Computational methods for drug discovery Design and development of \u201chigh throughput\u201d methods for the determination of physicochemical parameters (log Po\/w, log D, CHI, pKa, log S).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Flow-chemistry (hydrogenation, coupling-reactions)<\/p>

Freeze-drying<\/p>

Patented compounds with biological activity<\/p>

Reactions under special conditions (Flow, Microwave irradiation, Photoredox, High dilution, etc.)<\/p>

Reactions with gas (H2, CO, NH3, O3, etc.)<\/p>

Solid-phase synthesis of peptides and oligonucleotides (DNA, RNA): synthesis and isolation.<\/p>

Synthesis of antibiotics, antivirals and antitumor compounds<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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[+] Download Biochemical and Biomedical Transfer Opportunities Catalog<\/a><\/h4>

[+] Download Chemistry and Pharmacy Transfer Opportunities Catalog<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Technology Transfer Opportunities Biochemical and BiomedicalTransfer Opportunities services Animal Models: Cancer Cardiovascular diseases Diabetes and Obesity Drosophila and CNS diseases Inflammation Intrapancreatic PDAC models PPARbeta\/delta knock out models In Vivo Studies: Anti-inflammatory and toxicology drug validation Cardiovascular performance, ecocardiography, treadmill Impact of drugs on development using Drosophila Infrared thermography Metabolic phenotyping of rodent models Stereotaxis … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-9","page","type-page","status-publish"],"acf":[],"yoast_head":"\nTechnology Transfer Opportunities - IBUB - Institut de Biomedicina de la Universitat de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/ibub\/technology-transfer-opportunities\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Technology Transfer Opportunities - IBUB - Institut de Biomedicina de la Universitat de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Technology Transfer Opportunities Biochemical and BiomedicalTransfer Opportunities services Animal Models: Cancer Cardiovascular diseases Diabetes and Obesity Drosophila and CNS diseases Inflammation Intrapancreatic PDAC models PPARbeta\/delta knock out models In Vivo Studies: Anti-inflammatory and toxicology drug validation Cardiovascular performance, ecocardiography, treadmill Impact of drugs on development using Drosophila Infrared thermography Metabolic phenotyping of rodent models Stereotaxis ... 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