{"id":2162,"date":"2022-03-22T13:41:15","date_gmt":"2022-03-22T12:41:15","guid":{"rendered":"http:\/\/www.ub.edu\/ibub\/?p=2162"},"modified":"2022-03-22T13:41:18","modified_gmt":"2022-03-22T12:41:18","slug":"correct-mitochondrial-function-prevents-muscle-loss-during-ageing","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/ibub\/correct-mitochondrial-function-prevents-muscle-loss-during-ageing\/","title":{"rendered":"Correct mitochondrial function prevents muscle loss during ageing"},"content":{"rendered":"\n

Loss of muscle mass and power related to ageing \u2014sarcopenia\u2014 is a \ndegenerative process that reduces the quality of life and increases the \ndependency levels of the elderly. Studies indicate that this muscle \natrophy is related to chronic inflammation. When and why does this \ninflammation take place?<\/strong><\/p>\n\n\n\n

\"\"
Mitochondria are the organelles that work on the energy metabolism of the cell. <\/figcaption><\/figure><\/div>\n\n\n\n

An article published in the journal Aging Cell<\/em><\/a> reveals the inflammatory process that drives muscle atrophy is related to the accumulation of damaged mitochondria in cells. Also, the increase in BNIP3 levels \u2014a protein linked to the clearance of damaged mitochondria\u2014 is related to a better muscle ageing. <\/p>\n\n\n\n

The study is led by the experts Antonio Zorzano, professor at the Faculty of Biology<\/a>, head of the Laboratory of Complex Metabolic Diseases and Mitochondria in IRB Barcelona<\/a> and head of the research group of the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM<\/a>), and David Sebasti\u00e1n, lecturer at the Faculty of Pharmacy and Food Sciences<\/a> and member of the IRB Barcelona and CIBERDEM.<\/p>\n\n\n\n

The study was conducted with culture cells and mice models, as well \nas human samples from young and older people. Other collaborators in the\n study were the teams from the Institute of Biomedicine of the \nUniversity of Barcelona (IBUB<\/a>), the Health Park Sant Joan de D\u00e9u and the Carlos III Health Institute, among others.<\/p>\n\n\n\n

\"\"
The inflammatory process that drives muscle atrophy is related to the accumulation of damaged mitochondria in cells. <\/figcaption><\/figure><\/div>\n\n\n\n

Mitochondria \u2014power plants of cells\u2014 play an essential role in \ncellular physiology. \u201cIf the BNIP3 levels of the protein are low at \nadvanced ages, more damaged mitochondria accumulate. This triggers \ninflammatory processes that cause muscle atrophy\u201d, says lecturer David \nSebasti\u00e1n.<\/p>\n\n\n\n

However, \u201cthe reason why some people show higher levels of BNIP3 than\n others is still unknown\u201d, adds Andrea Irazoki, first author of the \narticle, lecturer at the Faculty of Biology and member of IRB Barcelona \nand CIBERDEM.<\/p>\n\n\n\n

\u201cIn this study, we intend to clarify the mechanisms that lead to the development of sarcopenia and look for tools to promote a healthy ageing regarding the muscles\u201d, concludes Professor Antonio Zorzano.<\/p>\n\n\n\n

UB NEW<\/strong> [+]<\/a> IRB NEW [+]<\/a> <\/strong><\/p>\n\n\n\n

\"\"
The study was conducted with culture cells and mice models, as well as human samples from young and older people. <\/figcaption><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"

Loss of muscle mass and power related to ageing \u2014sarcopenia\u2014 is a degenerative process that reduces the quality of life and increases the dependency levels of the elderly. Studies indicate that this muscle atrophy is related to chronic inflammation. When and why does this inflammation take place? An article published in the journal Aging Cell … Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":2165,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2162","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"\nCorrect mitochondrial function prevents muscle loss during ageing - IBUB - Institut de Biomedicina de la Universitat de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/ibub\/correct-mitochondrial-function-prevents-muscle-loss-during-ageing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Correct mitochondrial function prevents muscle loss during ageing - IBUB - Institut de Biomedicina de la Universitat de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Loss of muscle mass and power related to ageing \u2014sarcopenia\u2014 is a degenerative process that reduces the quality of life and increases the dependency levels of the elderly. Studies indicate that this muscle atrophy is related to chronic inflammation. When and why does this inflammation take place? An article published in the journal Aging Cell ... 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