{"id":51562,"date":"2025-05-12T11:39:41","date_gmt":"2025-05-12T09:39:41","guid":{"rendered":"https:\/\/www.ub.edu\/in2ub\/?p=51562"},"modified":"2025-05-12T11:41:50","modified_gmt":"2025-05-12T09:41:50","slug":"calorimetric-force-spectroscopy-establishes-a-groundbreaking-approach-to-studying-nucleic-acids","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/in2ub\/ca\/calorimetric-force-spectroscopy-establishes-a-groundbreaking-approach-to-studying-nucleic-acids\/","title":{"rendered":"Calorimetric force spectroscopy establishes a groundbreaking approach to studying nucleic acids"},"content":{"rendered":"<p>DNA hybridization is a fundamental molecular reaction in biotechnology. To understand how this helix forms and stays stable, it&#8217;s important to know how temperature affects the process. Until now, it was often assumed that certain thermodynamic parameters, such as heat capacity, didn\u2019t change with temperature, but this isn\u2019t entirely accurate.<\/p>\n<p>In this study, a UB team, led by<strong> Prof.\u00a0 F\u00e8lix Ritort<\/strong>,\u00a0<a href=\"https:\/\/www.ub.edu\/in2ub\/grup-de-recerca\/biomolecule-and-small-system-physics\/\" target=\"_blank\" rel=\"noopener\">The Small Biosystems Lab<\/a>,\u00a0in collaboration with Sapienza University of Rome and the expert Steven B. Smith Engineering, Los Lunas, NM, USA, have used a highly precise technique that &#8220;unzips&#8221; individual DNA molecules while rapidly changing the temperature. This allowed them to more accurately measure how the DNA\u2019s heat capacity (a key parameter) changes depending on its sequence.<\/p>\n<p>This new approach, called calorimetric force spectroscopy, opens the door to more detailed studies not only of DNA, but also of modified molecules and other nucleic acids like RNA or or DNA\/RNA hybrids.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-57340-5\" target=\"_blank\" rel=\"noopener\">DNA calorimetric force spectroscopy at single base pair resolution<\/a>.\u00a0<em>Rissone P.; Rico-Pasto M.; Smith S.B.; Ritort F.\u00a0<\/em><strong>Nature Communications<\/strong>. Volume 16, Article number: 2688 (2025).<\/p>\n<p>Fig. | Single-molecule calorimetric force-spectroscopy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA hybridization is a fundamental molecular reaction in biotechnology. To understand how this helix forms and stays stable, it&#8217;s important to know how temperature affects the process. Until now, it was often assumed that certain thermodynamic parameters, such as heat capacity, didn\u2019t change with temperature, but this isn\u2019t entirely accurate. In this study, a UB&#8230;<\/p>\n","protected":false},"author":2,"featured_media":51566,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Calorimetric force spectroscopy establishes a groundbreaking approach to studying nucleic acids - IN\u00b2UB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/in2ub\/calorimetric-force-spectroscopy-establishes-a-groundbreaking-approach-to-studying-nucleic-acids\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calorimetric force spectroscopy establishes a groundbreaking approach to studying nucleic acids - IN\u00b2UB\" \/>\n<meta property=\"og:description\" content=\"DNA hybridization is a fundamental molecular reaction in biotechnology. To understand how this helix forms and stays stable, it&#8217;s important to know how temperature affects the process. Until now, it was often assumed that certain thermodynamic parameters, such as heat capacity, didn\u2019t change with temperature, but this isn\u2019t entirely accurate. 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