{"id":51023,"date":"2024-10-15T10:19:35","date_gmt":"2024-10-15T08:19:35","guid":{"rendered":"https:\/\/www.ub.edu\/in2ub\/?p=51023"},"modified":"2024-10-15T10:20:22","modified_gmt":"2024-10-15T08:20:22","slug":"a-novel-treatment-for-uveal-melanoma-by-melatonin-loaded-nanostructured-lipid-carriers-has-been-described","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/in2ub\/a-novel-treatment-for-uveal-melanoma-by-melatonin-loaded-nanostructured-lipid-carriers-has-been-described\/","title":{"rendered":"A novel treatment for uveal melanoma by Melatonin loaded nanostructured lipid carriers has been described"},"content":{"rendered":"

Uveal melanoma is a highly aggressive intraocular tumour without effective therapeutic options. Now, a study lead by the Nanostructured systems for controlled drug delivery<\/a><\/u>\u00a0has shown the potential activity of Melatonin (MEL), a ubiquitously expressed endogenous molecule with oncostatic properties, when loaded into nanostructured lipid carriers (NLC). MEL-NLC displayed anti-inflammatory properties in vivo\u00a0and\u00a0cytotoxic potential in a uveal melanoma cell line\u00a0without affecting non-tumoral cells.\u00a0Preliminary biodistribution results also suggested their ability to reach the posterior segment of the eye, mainly the retina and the ciliary body, positioning them as a promising strategy for uveal melanoma treatment.<\/p>\n

Article<\/strong>: Melatonin loaded nanostructured lipid carriers for the treatment of uveal melanoma<\/a>. Bonilla-Vidal L.; Espina M.; Garc\u00eda M.L.; Cimino C.; Carbone C.; Baldom\u00e0 L.; Badia J.; Gliszczy\u0144ska A.; Souto E.B.; S\u00e1nchez-L\u00f3pez E. Journal of Drug Delivery Science and Technology, Volume 100, October 2024, Article number 106057<\/p>\n","protected":false},"excerpt":{"rendered":"

Uveal melanoma is a highly aggressive intraocular tumour without effective therapeutic options. Now, a study lead by the Nanostructured systems for controlled drug delivery\u00a0has shown the potential activity of Melatonin (MEL), a ubiquitously expressed endogenous molecule with oncostatic properties, when loaded into nanostructured lipid carriers (NLC). MEL-NLC displayed anti-inflammatory properties in vivo\u00a0and\u00a0cytotoxic potential in a…<\/p>\n","protected":false},"author":2,"featured_media":51024,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"\nA novel treatment for uveal melanoma by Melatonin loaded nanostructured lipid carriers has been described - IN\u00b2UB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/in2ub\/a-novel-treatment-for-uveal-melanoma-by-melatonin-loaded-nanostructured-lipid-carriers-has-been-described\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A novel treatment for uveal melanoma by Melatonin loaded nanostructured lipid carriers has been described - IN\u00b2UB\" \/>\n<meta property=\"og:description\" content=\"Uveal melanoma is a highly aggressive intraocular tumour without effective therapeutic options. Now, a study lead by the Nanostructured systems for controlled drug delivery\u00a0has shown the potential activity of Melatonin (MEL), a ubiquitously expressed endogenous molecule with oncostatic properties, when loaded into nanostructured lipid carriers (NLC). 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