{"id":51624,"date":"2025-06-13T14:20:22","date_gmt":"2025-06-13T12:20:22","guid":{"rendered":"https:\/\/www.ub.edu\/in2ub\/?p=51624"},"modified":"2025-06-13T14:25:42","modified_gmt":"2025-06-13T12:25:42","slug":"new-therapeutic-strategy-is-designed-to-help-lower-cholesterol-levels","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/in2ub\/new-therapeutic-strategy-is-designed-to-help-lower-cholesterol-levels\/","title":{"rendered":"New therapeutic strategy is designed to help lower cholesterol levels"},"content":{"rendered":"<p>A study led by by experts Carles J. Ciudad and Ver\u00f2nica No\u00e9, from <a href=\"https:\/\/www.ub.edu\/in2ub\/grup-de-recerca\/cancer-therapy-group\/\" target=\"_blank\" rel=\"noopener\">Cancer therapy group<\/a> and researchers from the University of Oregon presents a new therapeutic tool capable of regulating blood cholesterol levels and thus opening up new perspectives in the fight against atherosclerosis caused by the accumulation of lipid plaques in the artery walls.<\/p>\n<p>Specifically, the team has designed a strategy to inhibit the expression of PCSK9, a protein that plays a decisive role in modulating plasma levels of low-density lipoprotein cholesterol (LDL-C). The new method, based on the use of molecules known as polypurine hairpins (PPRH), facilitates the uptake of cholesterol by cells and prevents it from accumulating in the arteries without causing the side effects of the most common statin-based medication.<\/p>\n<p>The study has been supported by projects of the Spanish Ministry of Science, Innovation and Universities (MICINN) and the National Institutes of Health (NIH) of the United States.<\/p>\n<p><strong>Reference article:<\/strong><\/p>\n<section class=\"cuerpo-texto container-xl mb-5\">\n<div class=\"novedad-cuerpo\">\n<p>L\u00f3pez-Aguilar, Ester; Pacheco-Vel\u00e1zquez, Silvia; Busquets, M. Ant\u00f2nia; Hay, Joshua; Mueller, Paul A.; Fazio, Sergio; Ciudad, Carlos J.; No\u00e9, Ver\u00f2nica; Pamir, Nathalie.\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295225002382\" target=\"_blank\" rel=\"noopener\">\u00abInhibition of PCSK9 with Polypurine reverse Hoogsteen hairpins: A novel gene therapy approach\u00bb<\/a>.\u00a0<em>Biochemical Pharmacology<\/em>, May 2025. DOI: 10.1016\/j.bcp.2025.116976.<\/p>\n<\/div>\n<\/section>\n<p>&nbsp;<\/p>\n<p>Read more at <a href=\"https:\/\/web.ub.edu\/en\/web\/actualitat\/w\/strategy-cholesterol-levels\" target=\"_blank\" rel=\"noopener\">UB News.<\/a><\/p>\n<p>Image: Prof. Ver\u00f2nica No\u00e9 and Prof. Carles J. Ciudad, professors at the UB\u2019s Faculty of Pharmacy and Food Sciences and the Institute of Nanoscience and Nanotechnology (IN2UB): <a href=\"https:\/\/www.ub.edu\/in2ub\/grup-de-recerca\/cancer-therapy-group\/\" target=\"_blank\" rel=\"noopener\">Cancer therapy group.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study led by by experts Carles J. Ciudad and Ver\u00f2nica No\u00e9, from Cancer therapy group and researchers from the University of Oregon presents a new therapeutic tool capable of regulating blood cholesterol levels and thus opening up new perspectives in the fight against atherosclerosis caused by the accumulation of lipid plaques in the artery&#8230;<\/p>\n","protected":false},"author":2,"featured_media":51625,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New therapeutic strategy is designed to help lower cholesterol levels - IN\u00b2UB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/in2ub\/new-therapeutic-strategy-is-designed-to-help-lower-cholesterol-levels\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New therapeutic strategy is designed to help lower cholesterol levels - IN\u00b2UB\" \/>\n<meta property=\"og:description\" content=\"A study led by by experts Carles J. Ciudad and Ver\u00f2nica No\u00e9, from Cancer therapy group and researchers from the University of Oregon presents a new therapeutic tool capable of regulating blood cholesterol levels and thus opening up new perspectives in the fight against atherosclerosis caused by the accumulation of lipid plaques in the artery...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ub.edu\/in2ub\/new-therapeutic-strategy-is-designed-to-help-lower-cholesterol-levels\/\" \/>\n<meta property=\"og:site_name\" content=\"IN\u00b2UB\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-13T12:20:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-13T12:25:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ub.edu\/in2ub\/wp-content\/uploads\/2025\/06\/equipfarmacia_2025.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"720\" \/>\n\t<meta property=\"og:image:height\" content=\"480\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"IN2UB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"IN2UB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ub.edu\/in2ub\/new-therapeutic-strategy-is-designed-to-help-lower-cholesterol-levels\/\",\"url\":\"https:\/\/www.ub.edu\/in2ub\/new-therapeutic-strategy-is-designed-to-help-lower-cholesterol-levels\/\",\"name\":\"New therapeutic strategy is designed to help lower cholesterol levels - 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