Acetylcholinesterase: A versatile template to coin potent modulators of multiple therapeutic targets
Luque, F. J.; Muñoz-Torrero, D. Acc. Chem. Res. 2024, 57, 450-467
March 14, 2024
Publications
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Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability
Román-Álamo, L.; Avalos-Padilla, Y.; Bouzón-Arnáiz, I.; Iglesias, V.; Fernández-Lajo, J.; Monteiro, J. M.; Rivas, L.; Fisa, R.; Riera, C.; Andreu,…
March 14, 2024
Reaction Space Charting as a Tool in Organic Chemistry Research and Development
Eloy Lozano Baró, Pau Nadal Rodríguez, Jordi Juárez-Jiménez, Ouldouz Ghashghaei*, Rodolfo Lavilla* https://doi.org/10.1002/adsc.202301205 The chemical and reaction spaces are incredibly…
February 15, 2024
Exploring the reactivity of bicyclic α-iminophosphonates to access new imidazoline I2 receptor ligands
Andrea Bagán, Sònia Abás, Judith Palà-Pujadas, Alba Irisarri, Christian Griñán-Ferré, Mercè Pallàs, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belén…
November 14, 2023
Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease
Andrea Bagán, Sergio Rodriguez-Arévalo, Teresa Taboada-Jara , Christian Griñán-Ferré, Mercè Pallàs, Iria Brocos-Mosquera, Luis F. Callado, José A. Morales-García, Belén…
November 14, 2023
Design and Synthesis of AMPK Activators and GDF15 Inducers
Meijian Zhang, Andrea Bagán, Donna Martínez, Emma Barroso, Xavier Palomer, Santiago Vázquez, Carmen Escolano*, Manuel Vázquez-Carrera* Molecules 2023, 28(14), 5468;…
November 14, 2023
Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D.…
November 10, 2023
The Prohibitin-Binding Compound Fluorizoline Induces the Pro-inflammatory Cytokines Interleukin-8 and Interleukin-6 through the Activation of JNK and p38 MAP Kinases
Ismael Sánchez-Vera, José Saura-Esteller, Sonia Núñez-Vázquez, Ana M Cosialls, Ouldouz Ghashghaei, Rodolfo Lavilla, Gabriel Pons, Joan Gil, Daniel Iglesias-Serret DOI: 10.1016/j.bcp.2023.115860…
November 1, 2023
Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer’s disease therapeutics
Griñán-Ferré, Christian; Jarné-Ferrer, Júlia; Bellver-Sanchís, Aina; Codony, Sandra; Puigoriol-Illamola, Dolors; Sanfeliu, Coral; Oh, Yumin; Lee, Seulki; Vázquez, Santiago; Pallàs, Mercè DOI: 10.1111/cns.14511 Neuroinflammation is widely recognized as a significant…
October 1, 2023
Design and Synthesis of AMPK Activators and GDF15 Inducers
Zhang, Meijian; Bagan, Andrea; Martinez, Donna; Barroso, Emma; Palomer, Xavier; Vazquez, Santiago; Escolano, Carmen; Vazquez-Carrera, Manuel DOI: 10.3390/molecules28145468 Targeting growth differentiation factor 15 (GDF15) is a recent…
July 1, 2023
A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR
Μarianna Stampolaki, Anja Hoffmann, Kumar Tekwani, Kyriakos Georgiou, Christina Tzitzoglaki, Chunlong Ma, Stefan Becker, Patrick Schmerer, Kristin Döring, Ioannis Stylianakis, Andreea L. Turcu, Jun Wang, Santiago Vázquez, Loren B. Andreas, Michaela Schmidtke, Antonios Kolocouris DOI:…
June 1, 2023
Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds
Pau Nadal Rodríguez, Ouldouz Ghashghaei*, Anna M. Schoepf, Sam Benson, Marc Vendrell, Rodolfo Lavilla* https://doi.org/10.1002/ange.202303889 Charting the chemical reaction space…
May 20, 2023
G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease by Bellver-Sanchis et al.
New work published in Aging and Disease by Bellver-Sanchis et al. Abstract: Epigenetic alterations are a fundamental pathological hallmark of…
May 2, 2023
The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI
Sánchez-Vera, I.; Núñez-Vázquez, S.; Saura-Esteller, J.; Cosialls, A.M.; Heib, J.; Nadal Rodríguez, P.; Ghashghaei, O.; Lavilla, R.; Pons, G.; Gil,…
April 30, 2023
Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells
Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas and Jose C. Perales. https://www.nature.com/articles/s41419-022-05177-x
February 25, 2023
Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats
Elena Hernández-Hernández , Sandra Ledesma-Corvi, Fernando Yáñez-Gómez, Celia Garau, Laura Gálvez-Melero, Andrea Bagán , Carmen Escolano , M. Julia García-Fuster…
February 25, 2023
Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06
Andrea Bagán , José A. Morales-García, Christian Griñán-Ferré, Caridad Díaz , José Pérez del Palacio, Maria C. Ramos, Francisca Vicente,…
February 25, 2023
The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures
Bouzón-Arnáiz, I.; Avalos-Padilla, Y.; Biosca, A.; Caño-Prades, O.; Román-Álamo, L.; Valle, J.; Andreu, D.; Moita, D.; Prudêncio, M.; Arce, E.…
February 13, 2023
Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions
Trejo, Angela, Carme Masdeu, Irene Serrano-Pérez, Marina Pedrola, Narcís Juanola, Ouldouz Ghashghaei, Guadalupe Jiménez-Galisteo, Rodolfo Lavilla, Francisco Palacios, Concepción Alonso,…
January 15, 2023
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites
Marianna Stampolaki, Satish R. Malwal, Nadine Alvarez-Cabrera, Zijun Gao, Mohammad Moniruzzaman, Svitlana O. Babii, Nikolaos Naziris, André Rey-Cibati, Mariana Valladares-Delgado,…
January 1, 2023
Amantadine variant – aryl conjugates that inhibit multiple M2 mutant – amantadine resistant influenza a viruses
Influenza A viruses can cause a serious future threat due to frequent mutations. Amantadine and rimantadine drugs inhibit influenza A…
December 1, 2022
A Multicomponent Reaction Platform towards Multimodal Near-Infrared BODIPY Dyes for STED and Fluorescence Lifetime Imaging
Antonio Fernandez, Nicola Kielland, Ashraff Makda, Neil O. Carragher, M. Carmen González-García, Laura Espinar-Barranco, Juan A. González-Vera, Angel Orte, Rodolfo…
November 1, 2022
Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist
In Alzheimer’s disease pathology, several neuronal processes are dysregulated by excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic agents…
October 1, 2022
Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice
Companys-Alemany, Julia; Roig-Soriano, Joan; Turcu, Andreea L.; Chillon, Miguel; Vazquez, Santiago; Pallas, Merce; Grinan-Ferre, Christian DOI: 10.1097/WNR.0000000000001825 N-methyl-D-aspartate (NMDA) receptor antagonists mediate adult neurogenic effects.…
October 1, 2022