Design and synthesis of novel disease-modifying anti-Alzheimer compounds
Healthy ageing is becoming increasingly threatened by a number of age-related neurodegenerative diseases, including Alzheimer’s disease (AD). AD causes loss…
Healthy ageing is becoming increasingly threatened by a number of age-related neurodegenerative diseases, including Alzheimer’s disease (AD). AD causes loss…
Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer’s disease (AD) being the most dominant, without efficacious drugs,…
New work published in Aging and Disease by Bellver-Sanchis et al. Abstract: Epigenetic alterations are a fundamental pathological hallmark of…
Discovery of new bioactive agents by modification of known drugs using Multicomponent Reactions. Facilitated Access to Libraries of
Development of novel reactions involving basic heterocycles. Access to a variety of novel scaffolds for biomedical applications Reaction discovery and…
Generation of functional probes by modern chemistry such as CH activation for modified tryptophan peptides and the preparation of fluorescent…
Direct synthetic access to compounds in 1-2 steps, to trigger Proapoptotic p-53 independent antitumoral activity, and Sdelectively targeting prohibitins (Collaboration…
We focus our research in the study of the molecular mechanisms involved in behavioral abnormalities and cognitive decline, by using…
Dr Ana Guerrero lead this research line, as a Ramón y Cajal position in the University of Barcelona. Even though…
This constitutes a new research line initiated by Dr. Christian Griñán-Ferré, by using C. elegans, as well as several mice models…
P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of…