Research

Discovery of new bioactive agents by modification of known drugs using Multicomponent Reactions. Facilitated Access to Libraries of

For a summary of our research in the past 20 years, check out the following: Development of Heterocyclic Multicomponent Reactions…

Generation of functional probes by modern chemistry such as CH activation for modified tryptophan peptides and the preparation of fluorescent…

Direct synthetic access to compounds in 1-2 steps, to trigger Proapoptotic p-53 independent antitumoral activity, and Sdelectively targeting prohibitins (Collaboration…

  We focus our research in the study of the molecular mechanisms involved in behavioral abnormalities and cognitive decline, by using…

In this research line, our group is devoted to early preclinical evaluation of new compounds. Basically, we developed experimental strategies…

This constitutes a new research line initiated by Dr. Christian Griñán-Ferré, by using C. elegans, as well as several mice models…

P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of…

This is a more recent topic within our group. We have recently discovered that the lipophilic cavity of the sEH…

Within this project we designed, synthesized and evaluated novel polycyclic compounds as analogs of the clinically approved NMDA receptor antagonists…

Amantadine and rimantadine have been in clinical use as anti-influenza A virus agents for decades. The mechanism of action of…