Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer’s disease (AD) being the most dominant, without efficacious drugs,…

Discovery of new bioactive agents by modification of known drugs using Multicomponent Reactions. Facilitated Access to Libraries of

Development of novel reactions involving basic heterocycles. Access to a variety of novel scaffolds for biomedical applications Reaction discovery and…

Generation of functional probes by modern chemistry such as CH activation for modified tryptophan peptides and the preparation of fluorescent…

Direct synthetic access to compounds in 1-2 steps, to trigger Proapoptotic p-53 independent antitumoral activity, and Sdelectively targeting prohibitins (Collaboration…

 We focus our research in the study of the molecular mechanisms involved in behavioral abnormalities and cognitive decline, by using…

Dr Ana Guerrero lead this research line, as a Ramón y Cajal position in the University of Barcelona. Even though…

This constitutes a new research line initiated by Dr. Christian Griñán-Ferré, by using C. elegans, as well as several mice models…

P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of…

This is a more recent topic within our group. We have recently discovered that the lipophilic cavity of the sEH…

Within this project we designed, synthesized and evaluated novel polycyclic compounds as analogs of the clinically approved NMDA receptor antagonists…

Amantadine and rimantadine have been in clinical use as anti-influenza A virus agents for decades. The mechanism of action of…

In the field of cancer therapeutics, we are working in three multidisciplinary projects in collaboration with excellent professionals. Increasing the…

Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense or T. brucei rhodesiense, and malaria, caused by Plasmodium species, are…

This project is the result of a collaboration with the group of Dr. Carles Galdeano. c-Myc degradation with PROTAC molecules…