Novel P2X7 receptor antagonists.
P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of…
April 3, 2020
Research
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Design, synthesis and evaluation of novel soluble epoxide hydrolase (sEH) inhibitors for inflammatory diseases.
This is a more recent topic within our group. We have recently discovered that the lipophilic cavity of the sEH…
April 3, 2020
Design, synthesis and evaluation of new polycyclic antagonists of the NMDA receptors
Within this project we designed, synthesized and evaluated novel polycyclic compounds as analogs of the clinically approved NMDA receptor antagonists…
April 3, 2020
Design, synthesis and evaluation of new polycyclic inhibitors of the M2 channel of the influenza A virus.
Amantadine and rimantadine have been in clinical use as anti-influenza A virus agents for decades. The mechanism of action of…
April 2, 2020