Discovery of (3-Phenylcarbamoyl-3,4-dihydro‑2H‑pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties

Andrea Bagán, Alba López-Ruiz, Sònia Abás, M. Carmen Ruiz-Cantero, Foteini Vasilopoulou, Teresa Taboada-Jara, Christian Griñán-Ferré, Mercè Pallàs, Carolina Muguruza, Rebeca Diez-Alarcia, Luis F. Callado, José M. Entrena, Enrique J. Cobos, Belén Pérez, José A. Morales-García, Elies Molins, Steven De Jonghe, Dirk Daelemans, José Brea, Cristina Val, M. Isabel Loza, Elena Hernández-Hernández, Jesús A. García-Sevilla, M. Julia García-Fuster, Caridad Díaz, Rosario Fernández-Godino, Olga Genilloud, Milan Beljkaš, Slavica Oljačić, Katarina Nikolic, Carmen Escolano

Journal of Medicinal Chemistry 2025, 68, 2551-2573

DOI: 10.1021/acs.jmedchem.4c01644