Stepwise structural simplification of the dihydroxyanthraquinone moiety of a multitarget rhein-based anti-Alzheimer lead to improve drug metabolism and pharmacokinetic properties

Overexpression in Plasmodium falciparum of an intrinsically disordered segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate

Ávalos-Padilla, Y.; Bouzón-Arnáiz, I.; Ramírez, M.; Camarero-Hoyos, C.; Orozco-Quer, M.; Arce, E.M.; Muñoz-Torrero, D.; Fernàndez-Busquets, X. Front. Cell. Infect. Microbiol.…

Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women

Borrallo-Lopez, L.; Guzman, L.; Romero, N.G.; Sampietro, A.; Mallo-Abreu, A.; Guardia-Escote, L.; Teixidó, E.; Flick, B.; Fernàndez-Busquets, X.; Muñoz-Torrero, D.;…

Proteome aggregation in cells derived from amyotrophic lateral sclerosis patients for personalized drug evaluation

Pérez de la Lastra Aranda, C.; Tosat-Bitrián, C.; Porras, G.; Dafinca, R.; Muñoz-Torrero, D.; Talbot, K.; Martín-Requero, Á.; Martínez, A.;…

Leveraging the aggregated protein dye YAT2150 for malaria chemotherapy

Camarero-Hoyos, C.; Bouzón-Arnáiz, I.; Avalos-Padilla, Y.; Fallica, A.N.; Román-Álamo, L.; Ramírez, M.; Portabella, E.; Cuspinera, O.; Currea-Ayala, D.; Orozco-Quer, M.;…

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