Rodolfo Lavilla

Rodolfo Lavilla

Rodolfo Lavilla is full Professor of Organic and Medicinal Chemistry at the Faculty of Pharmacy. Rodolfo studied Pharmacy and did a Master in Medicnal Chemistry at the Universoity of Barcelona. Then he received is PhD in Pharmacy at the University of Barcelona under the supervison of Prof. Mercedes Alvarez and made a postdoctoral stay in the University of California, San Diego (Adisor Prof. Ernest Wenkert) and afterwards joined faculty in the University of Barcelona and started an independent career. He has published over 120 research papers, review articles, book chapters and patents., and has given over 50 invited lectures in international congresses and research departments all over the world. His major research interests deal with reactivity issues in heterocyclic chemistry, multicomponent reactions and the organometallic chemistry of peptides; looking for applications in biological and medicinal chemistry programs. He has active collaborations with pharmaceutical companies in medchem projects. He has directed 12 PhD (4 with extrordinary awards) and around 35 Ms theses, and tutored over 25 postdoctoral fellows. Mentoring is an important activity in the group, and several past memebrs are holding relevant positions in industry and academia. Rodolfo serves as reviewer for several Research Agencies (Catalunya, Basque Country, Castilla y León, Spain, France, Flanders, Latvia, Netherlands, Argentina, USA, etc.) and also for more than 40 scientific journals (Royal Society of Chemistry, American Chemical Society, Wiley-WCH, Bentham, etc)

TEAM

Dr. Ouldouz Ghashghaei
Assistant Professor

Dr. Anna Maria Schoepf
Erwin-Schroedinger Postdoctoral Fellow

Pau Nadal Rodríguez
PhD student 

Dr. Ouldouz Ghashghaei

received her BSc in Chemistry and MSc in Organic Chemistry/Polymer Science from Sharif University of Technology (SUT). She received a second MSc and her PhD (2017) in Experimental and Industrial Organic Chemistry, under supervision of Prof. Lavilla at Barcelona Science Park (PCB). During her PhD, she developed novel isocyanide-based multicomponent reactions to access bioactive heterocyclic compounds. She also had a short stay in the laboratories of Prof. Ramon Eritja at the Institute for Advanced Chemistry of Catalonia (IQAC). Since 2017 she is a postdoctoral scientist at Lavilla group, having participated in several collaborative projects with industrial and academic partners. She has also done a short postdoc in Medicinal Chemistry under supervision of Prof. Diego Muñoz-Torrero. In December 2020, she joined the project PsorTREX2 as the posdoctoral medicinal chemist. Her research is mainly focused on developing new methodologies to assemble complex heterocyclic systems and fluorescent probes for biomedical applications.

 

Dr. Anna Maria Schoepf

joined the Lavilla group in April 2022 as a postdoctoral Erwin-Schroedinger-Fellow. She studied pharmacy at the University of Innsbruck and subsequently worked as a licensed pharmacist and pharmacy manager in Austria and Argentina. This was followed by a PhD in the field of Medicinal Chemistry at the University of Innsbruck, where she spent four years as a University Assistant at the Center for Chemistry and Biomedicine. Her doctoral studies focused on the development of small molecules to overcome the resistance in chronic myeloid leukemia and other malignancies. Following this, Anna moved to the Institute of Cancer Research in London as a postdoctoral researcher, where she worked on a Hit-to-Lead project in the group of Dr Gurdip Bhalay to develop inhibitors of a novel RNA helicase in cooperation with Merck KGaA.

 

 

Pau Nadal Rodríguez

is a Pharmacy graduate from University of Barcelona. As an undergraduate, he spent some time as a research assistant in Prof. Escolano’s research group. After graduation, he joined Glaxo Smith Kline (Stevenage, UK) through a one-year Industrial Placement, where he worked in the MedChem department as a synthetic chemist, and gained extensive insight into the Pharmaceutical R&D field in general and the drug discovery process in particular.

He started his PhD under the supervision of Dr. Carmen Escolano and Dr. Rodolfo Lavilla in October 2020. His thesis is framed within the study of Ugi-type multicomponent reactions, with the objective of obtaining new compounds with potential biological activity.


Alumni:

  • Marina Pedrola (PhD, 2022)
  • Alejandro Diaz (M.S, 2022)

Drugs from Drugs

Discovery of new bioactive agents by modification of known drugs using Multicomponent Reactions. Facilitated Access to Libraries of

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Heterocyclic Multicomponent Reactions

For a summary of our research in the past 20 years, check out the following: Development of Heterocyclic Multicomponent Reactions…

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Diagnostics with Modern Chemical Probes

Generation of functional probes by modern chemistry such as CH activation for modified tryptophan peptides and the preparation of fluorescent…

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Holistic approach to anti-knock agents: A high-throughput screening of aniline-like compounds

Antonio Viayna, Ouldouz Ghashghaei, David Vílchez, CarolinaEstarellas, Manuel López, Jesús Gómez-Catalán, Rodolfo Lavilla, Jesús Delgado, F. Javier Luque The increasing…

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A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy-Induced Cancer Cell Death

Nicole D. Barth, Lorena Mendive-Tapia, Ramon Subiros-Funosas, Ouldouz Ghashghaei, Rodolfo Lavilla, Laura Maiorino, Xue-Yan He, Ian Dransfield, Mikala Egeblad, Marc…

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New Trimethoprim-Like Molecules: Bacteriological Evaluation and Insights into Their Action

Marta Jorba, Marina Pedrola, Ouldouz Ghashghaei, Rocío Herráez, Lluis Campos-Vicens, Franciso Javier Luque ,Rodolfo Lavilla, Miguel Viñas This work reports…

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Selected Projects

Multicomponent Reactions: Discovery, Development and Applications in Biomedicine (2019-2022).
Ministerio de Ciencia e Innovación, Spain: PID2019-107991RB-I00
95.000 €. Principal Investigator

Facilitated prepararion of relevant compoun in biology (2015-2019).
DGICYT (Ministerio Economía y Competitividad, Spain): CTQ2015-67870-P
139.100 €. Principal Investigator.

Identification, synthesis and toxicological evaluation of new antidetonating molecule (2018-2019)
Fundació Bosch i Gimpera (U. Barcelona). Licenced research .FBG 309799.
98.780€. Principal Investigator. Coordinator: F. J. Luque (U. Barcelona).

Deciphering pathogen-host interactions in the pathogenesis of cryptococcosis using optical methods and in vivo imaging techniques. (2016-2018).
ERA NET. DGICYT (Ministerio Economía y Competitividad, Spain-EU)). PCIN-2015-224.
46.000 €. Principal Investigator. Coordinator U.Himerich (U. Leuven, BE).

Development of new LRR8 / VRAC chloride channel inhibitors, a new key element in ischemia (2018-2020).
Fundació La Marató de TV3 (Spain). 247/C/2017
299.936,53 €. Principal Investigator. Coordinator R. Estévez Povedano (IDIBELL).

Funds to empower quality research groups (2017-2019).
Comissionat per a Universitats i Recerca (Generalitat de Catalunya, Spain): SGR-DGR 1439
65.896 €. Researcher. Principal Investigator F. Albericio (U. Barcelona)

Development of pharmacological chaperones for the treatment of rare neurometabolic diseases (2013-2015).
Secretaría de Estado de Investigación, desarrollo e innovación (Spain). Subprograma INNPACTO. IPT-2012-0561-010000
114.186 €. Principal Investigator. Coordinator M. Martinell (Minoryx Therapeutics SL).

DIGITAL – Diagnosis, follow-up and treatment of patients with genetic diseases included in neonatal screening programs and other rare metabolic diseases” (2014-2017).
Secretaría de Estado de Investigación, desarrollo e innovación (Spain). Retos Colaboración 2014: RTC-2014-2412-1.
101.728 €. Principal Investigator. Coordinator M. Martinell (Minoryx Therapeutics SL).

Marine natural products privileged structures for the discovery and administration of new drugs (2013-2015).
Comisión Interministerial de Ciencia y Tecnología (Spain) (CTQ2012-30930). 738.000,00 €. Researcher. Principal Investigator: F. Albericio (U. Barcelona)

Patents

Fluorogenic compounds, processes of preparation thereof and methods of use.
Marc Vendrell Escobar, Ramón Subiros Funosas, Lorena Mendive Tapia, Fernando Albericio Palomera, Rodolfo Lavilla Grifols, Rodolfo; Nick D. Read. PCT (Intl. Appl. 2016) WO 2016207626

Obtaining process, composition and use of modified peptide comprising at least one arylated tryptophan with anti-microbial activity.
Gonzalez, Rodrigo; Grifols, Rodolfo Lavilla; Cascone, Osvaldo; Palomera, Fernando Albericio; Iannucci, Nancy B. Argentinian patent Appl AR 97488 A1 20160316 (2016).

Heteroarylaminoioquinolines, methods for their preparation and therapeutic uses thereof. García Collazo, A. M.; Martinell Pedemonte, M.; Revés Vilaplana, M.; Lavilla Grifols, R.; Rodríguez Pascau, L.; Cubero Jordá, E. European patent Office. WO 2016/120808 A1 : PCT/IB2016/050413 (2016)

Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof. Barril Alonso, X.; García Collazo, A. M.; Aymamí Bofarull, J.; Revés Vilaplana, M.; Lavilla Grifols, R.; Martinell Pedemonte, M. European patent Office. EP 13382314.6 1454. PCT: EP2014/066392. (2014).

Collaborations

Prof. Raul Estévez Povedano, IDIBELL Barcelona, Medicinal Chemistry (anion channel blockers)
Prof. Joan Gil, U. Barcelona, IDIBELL, Cancer (selective apoptosis)
Prof. Rongrong Hu, South China U. Tech. Material Science (functional organic compounds)
Prof. F. Javier Luque, U. Barcelona. Computational Chemistry (reaction mechanisms)
Prof Dolores Velasco, U. Barcelona. Photophysics (photoswitchable probes)
Prof. Marc Vendrell, U. Edinburgh. Biological Chemistry (fluorescent probes)
Prof. Miquel Viñas, U. Barcelona, IDIBELL, Medicinal Chemistry (antibiotic resistance)
Prof. Thomas Haarmann-Stemmann, Leibniz Research Institute
for Environmental Medicine, Medicinal Chemistry (AhR signalling)

 

Contact

Dr. Rodolfo Lavilla

rlavilla@ub.edu
Laboratory of Medicinal Chemistry
Faculty of Pharmacy and Food Sciences
University of Barcelona & Institute of Biomedicine (IBUB)
Tel. 93 4024532