Rodolfo Lavilla

Rodolfo Lavilla

Rodolfo Lavilla is full Professor of Organic and Medicinal Chemistry at the Faculty of Pharmacy. Rodolfo studied Pharmacy and did a Master in Medicnal Chemistry at the Universoity of Barcelona. Then he received is PhD in Pharmacy at the University of Barcelona under the supervison of Prof. Mercedes Alvarez and made a postdoctoral stay in the University of California, San Diego (Adisor Prof. Ernest Wenkert) and afterwards joined faculty in the University of Barcelona and started an independent career. He has published over 120 research papers, review articles, book chapters and patents., and has given over 50 invited lectures in international congresses and research departments all over the world. His major research interests deal with reactivity issues in heterocyclic chemistry, multicomponent reactions and the organometallic chemistry of peptides; looking for applications in biological and medicinal chemistry programs. He has active collaborations with pharmaceutical companies in medchem projects. He has directed 12 PhD (4 with extrordinary awards) and around 35 Ms theses, and tutored over 25 postdoctoral fellows. Mentoring is an important activity in the group, and several past memebrs are holding relevant positions in industry and academia. Rodolfo serves as reviewer for several Research Agencies (Catalunya, Basque Country, Castilla y León, Spain, France, Flanders, Latvia, Netherlands, Argentina, USA, etc.) and also for more than 40 scientific journals (Royal Society of Chemistry, American Chemical Society, Wiley-WCH, Bentham, etc)

TEAM

Ouldouz Ghashghaei
P
ostDoc

Marina Pedrola
PhD student

Shadi Keihankhadiv
PhD student

Narcís Juanola
Master student

Ouldouz Ghashghaei
received her degree in Chemistry and a Master in Organic Chemistry/Polymer Science from Sharif University of Technology. She received a second Master (2013) and her PhD (2017) in Experimental and Industrial Organic Chemistry, both under supervision of Prof. Lavilla at Faculty of Pharmacy-UB and Barcelona Science Park. During her PhD, she focused on developing novel isocyanide-based multicomponent reactions to access bioactive heterocyclic compounds. She also had a short stay in the laboratories of Prof. Ramon Eritja at the Institute for Advanced Chemistry of Catalonia (IQAC).

Since 2017, she is a postdoctoral scientist at Lavilla group, developing fluorescent probes for bioimaging and also new methodologies to assemble complex polyheterocycles with applications in biomedicine. She has also done a six-month postdoc in Medicinal Chemistry under supervision of Prof. Diego Muñoz-Torrero and has participated in several collaborative projects of the group with industrial and academic partners.

 

Marina Pedrola
performed her degree in Pharmacy at the University of Barcelona, followed by a master in Organic Chemistry. Currently, she is a predoctoral student of the Organic Chemistry program. She is mainly interested in medicinal chemistry and, besides, the study of new methodologies involving heterocycles reactivity.

 

 

 

 

 

Shadi Keihankhadiv
Performed her degree in Applied Chemistry at Islamic Azad University of Lahijan, followed by a master at Islamic Azad University of Pharmaceutical Science. Since October 2020, she is a predoctoral student of the Organic Chemistry program at University of Barcelona. She will be mainly focusing on new multicomponent reactions and isocyanides.

 

 

 

 

Drugs from Drugs

Discovery of new bioactive agents by modification of known drugs using Multicomponent Reactions. Application to antibiotics, CNS agents, antitumoral compounds,…

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Multicomponent reactions

Development of novel reactions involving basic heterocycles. Access to a variety of novel scaffolds.  Reaction discovery and study of the…

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Diagnostics with modern chemical methodology

Generation of functional probes by modern chemistry such as CH activation for modified tryptophan peptides and the preparation of fluorescent…

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Direct imaging of fungal infection in human pulmonary tissue with spacer-free BODIPY labelled antimicrobial peptides.

Mendive-Tapia, L.; Zhao, C.; Akram, A. R.; Preciado, S.; Albericio, F.; Lee, M.; Serrels, A.; Kielland, N.; Read, N. D.;…

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Insertion of Isocyanides into N-Si bonds: Azine MultiComponent Reactions Leading to Potent Anti-parasitic Compounds.

Kishore, K. G. Ghashghaei, O.; Estarellas, C.; Mestre, M. M.; Monturiol, C.; Kielland, N.; Kelly, J. M.; Francisco, A. F.;…

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Constrained Cyclopeptides: Biaryl Formation through Pd-catalyzed C-H Activation in Peptides. Structural Control of the Cyclization vs Cyclodimerization Outcome.

Mendive-Tapia, L.; Bertran, A.; García, J.; Acosta, G.; Albericio, F.; Lavilla. R. Chemistry, a European Journal. 2016, 22(37), 13114-13119; DOI:…

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Selected Projects

Multicomponent Reactions: Discovery, Development and Applications in Biomedicine (2019-2022).
Ministerio de Ciencia e Innovación, Spain: PID2019-107991RB-I00
95.000 €. Principal Investigator

Facilitated prepararion of relevant compoun in biology (2015-2019).
DGICYT (Ministerio Economía y Competitividad, Spain): CTQ2015-67870-P
139.100 €. Principal Investigator.

Identification, synthesis and toxicological evaluation of new antidetonating molecule (2018-2019)
Fundació Bosch i Gimpera (U. Barcelona). Licenced research .FBG 309799.
98.780€. Principal Investigator. Coordinator: F. J. Luque (U. Barcelona).

Deciphering pathogen-host interactions in the pathogenesis of cryptococcosis using optical methods and in vivo imaging techniques. (2016-2018).
ERA NET. DGICYT (Ministerio Economía y Competitividad, Spain-EU)). PCIN-2015-224.
46.000 €. Principal Investigator. Coordinator U.Himerich (U. Leuven, BE).

Development of new LRR8 / VRAC chloride channel inhibitors, a new key element in ischemia (2018-2020).
Fundació La Marató de TV3 (Spain). 247/C/2017
299.936,53 €. Principal Investigator. Coordinator R. Estévez Povedano (IDIBELL).

Funds to empower quality research groups (2017-2019).
Comissionat per a Universitats i Recerca (Generalitat de Catalunya, Spain): SGR-DGR 1439
65.896 €. Researcher. Principal Investigator F. Albericio (U. Barcelona)

Development of pharmacological chaperones for the treatment of rare neurometabolic diseases (2013-2015).
Secretaría de Estado de Investigación, desarrollo e innovación (Spain). Subprograma INNPACTO. IPT-2012-0561-010000
114.186 €. Principal Investigator. Coordinator M. Martinell (Minoryx Therapeutics SL).

DIGITAL – Diagnosis, follow-up and treatment of patients with genetic diseases included in neonatal screening programs and other rare metabolic diseases” (2014-2017).
Secretaría de Estado de Investigación, desarrollo e innovación (Spain). Retos Colaboración 2014: RTC-2014-2412-1.
101.728 €. Principal Investigator. Coordinator M. Martinell (Minoryx Therapeutics SL).

Marine natural products privileged structures for the discovery and administration of new drugs (2013-2015).
Comisión Interministerial de Ciencia y Tecnología (Spain) (CTQ2012-30930). 738.000,00 €. Researcher. Principal Investigator: F. Albericio (U. Barcelona)

Patents

Fluorogenic compounds, processes of preparation thereof and methods of use.
Marc Vendrell Escobar, Ramón Subiros Funosas, Lorena Mendive Tapia, Fernando Albericio Palomera, Rodolfo Lavilla Grifols, Rodolfo; Nick D. Read. PCT (Intl. Appl. 2016) WO 2016207626

Obtaining process, composition and use of modified peptide comprising at least one arylated tryptophan with anti-microbial activity.
Gonzalez, Rodrigo; Grifols, Rodolfo Lavilla; Cascone, Osvaldo; Palomera, Fernando Albericio; Iannucci, Nancy B. Argentinian patent Appl AR 97488 A1 20160316 (2016).

Heteroarylaminoioquinolines, methods for their preparation and therapeutic uses thereof. García Collazo, A. M.; Martinell Pedemonte, M.; Revés Vilaplana, M.; Lavilla Grifols, R.; Rodríguez Pascau, L.; Cubero Jordá, E. European patent Office. WO 2016/120808 A1 : PCT/IB2016/050413 (2016)

Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof. Barril Alonso, X.; García Collazo, A. M.; Aymamí Bofarull, J.; Revés Vilaplana, M.; Lavilla Grifols, R.; Martinell Pedemonte, M. European patent Office. EP 13382314.6 1454. PCT: EP2014/066392. (2014).

Collaborations

Prof. Raul Estévez Povedano, IDIBELL Barcelona, Medicinal Chemistry (anion channel blockers)
Prof. Joan Gil, U. Barcelona, IDIBELL, Cancer (selective apoptosis)
Prof. Rongrong Hu, South China U. Tech. Material Science (functional organic compounds)
Prof. F. Javier Luque, U. Barcelona. Computational Chemistry (reaction mechanisms)
Prof Dolores Velasco, U. Barcelona. Photophysics (photoswitchable probes)
Prof. Marc Vendrell, U. Edinburgh. Biological Chemistry (fluorescent probes)
Prof. Miquel Viñas, Barcelona, IDIBELL, Medicinal Chemistry (antibiotic resistance)

 

Contact

Dr. Rodolfo Lavilla

rlavilla@ub.edu
Laboratory of Medicinal Chemistry
Faculty of Pharmacy and Food Sciences
University of Barcelona & Institute of Biomedicine (IBUB)
Tel. 93 4024532