Research

Research

Discovery of innovative drugs against viral respiratory infections

Leiva R, Barniol-Xicota M, Codony S, Ginex T, Vanderlinden E, Montes M, Caffrey M, Luque FJ, Naesens L, Vázquez S. Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion. J Med Chem. 2018 Jan 11;61(1):98-118.

Research

Novel P2X7 receptor antagonists.

P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of…

Design, synthesis and evaluation of novel soluble epoxide hydrolase (sEH) inhibitors for inflammatory diseases.

This is a more recent topic within our group. We have recently discovered that the lipophilic cavity of the sEH…

Discovery of innovative drugs against viral respiratory infections

Design, synthesis and evaluation of new polycyclic antagonists of the NMDA receptors

Within this project we designed, synthesized and evaluated novel polycyclic compounds as analogs of the clinically approved NMDA receptor antagonists…