This is a more recent topic within our group. We have recently discovered that the lipophilic cavity of the sEH is big enough for accommodating very large lipophilic units, such as that the diamantane (a). We have also discovery a few new families of very potent sEH inhibitors endowed with interesting DMPK properties (b). This project is in collaboration with the groups of Prof. Bruce D. Hammock and Christophe Morisseau (University of California Davis, Davis, USA), Prof. Manuel Vázquez-Carrera and Prof. Mercè Pallàs (UB), and Prof. Mabel Loza and José M. Brea (Universidad de Santiago de Compostela, Spain).
- Codony, S.; Valverde, E.; Leiva, R.; Brea, J.; Loza, M. I.; Morisseau, C.; Hammock, B. D.; Vázquez, S. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorg. Med. Chem. 2019, 27, 115078.
- Griñán-Ferré, C.; Codony, S.; Pujol, E.; Yang, J.; Leiva, R.; Escolano, C.; Puigoriol-Illamola, D.; Companys-Alemany, J.; Corpas, R.; Sanfeliu, C.; Pérez, B.; Loza, M. I.; Brea, J.; Morisseau, C.; Hammock, B. D.; Vázquez, S.; Pallàs, M.; Galdeano, C.Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease. Neurotherapeutics, 2020, 17, 1825-1835.
- Codony, S.; Pujol, E.; Pizarro, J.; Feixas, F.; Valverde, E.; Loza, M. I.; Brea, J. M.; Saez, E.; Oyarzabal, J.; Pineda-Lucena, A.; Pérez, B.; Pérez, C.; Rodríguez-Franco, M. I.; Leiva, R.; Osuna, S.; Morisseau, C.; Hammock, B. D.; Vázquez-Carrera, M.; Vázquez, S. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. J. Med. Chem., 63, 9237–9257.
- Martín-López, J.; Codony, S.; Bartra, C.; Morisseau, C.; Loza, M. I.; Sanfeliu, C.; Hammock, B. D.; Brea, J.; Vázquez, S. (Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity. Pharmaceuticals, 2021, 14, 1323.
- Codony, S.; Calvó-Tusell, C.; Valverde, E.; Osuna, S.; Morisseau, C.; Loza, M. I.; Brea, J.; Pérez, C.; Rodríguez-Franco, M. I.; Pizarro-Delgado, J.; Corpas, R.; Griñán-Ferré, C.; Pallàs, M.; Sanfeliu, C.; Vázquez-Carrera, M.; Hammock, B. D.; Feixas, F.; Vázquez, S. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. J. Med. Chem., 2021, 64, 5429–5446.
