This is a more recent topic within our group. We have recently discovered that the lipophilic cavity of the sEH is big enough for accommodating very large lipophilic units, such as that the diamantane (a). We have also discovery a few new families of very potent sEH inhibitors endowed with interesting DMPK properties (b). This project is in collaboration with the groups of Prof. Bruce D. Hammock and Christophe Morisseau (University of California Davis, Davis, USA), Prof. Manuel Vázquez-Carrera and Prof. Mercè Pallàs (UB), and Prof. Mabel Loza and José M. Brea (Universidad de Santiago de Compostela, Spain).

• Codony, S.; Valverde, E.; Leiva, R.; Brea, J.; Loza, M. I.; Morisseau, C.; Hammock, B. D.; Vázquez, S. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorg. Med. Chem. 2019, 27, 115078.
• Griñán-Ferré, C.; Codony, S.; Pujol, E.; Yang, J.; Leiva, R.; Escolano, C.; Puigoriol-Illamola, D.; Companys-Alemany, J.; Corpas, R.; Sanfeliu, C.; Pérez, B.; Loza, M. I.; Brea, J.; Morisseau, C.; Hammock, B. D.; Vázquez, S.; Pallàs, M.; Galdeano, C.Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease. Neurotherapeutics, 2020, 17, 1825-1835.
• Pallàs M, Vázquez S, Sanfeliu C, Galdeano C, Griñán-Ferré C. Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy. Biomolecules. 2020; 10(5):703. 
• Codony, S.; Pujol, E.; Pizarro, J.; Feixas, F.; Valverde, E.; Loza, M. I.; Brea, J. M.; Saez, E.; Oyarzabal, J.; Pineda-Lucena, A.; Pérez, B.; Pérez, C.; Rodríguez-Franco, M. I.; Leiva, R.; Osuna, S.; Morisseau, C.; Hammock, B. D.; Vázquez-Carrera, M.; Vázquez, S. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. J. Med. Chem., 63, 9237–9257.
• Martín-López, J.; Codony, S.; Bartra, C.; Morisseau, C.; Loza, M. I.; Sanfeliu, C.; Hammock, B. D.; Brea, J.; Vázquez, S. (Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity. Pharmaceuticals, 2021,  14, 1323.
• Codony, S.; Calvó-Tusell, C.; Valverde, E.; Osuna, S.; Morisseau, C.; Loza, M. I.; Brea, J.; Pérez, C.; Rodríguez-Franco, M. I.; Pizarro-Delgado, J.; Corpas, R.; Griñán-Ferré, C.; Pallàs, M.; Sanfeliu, C.; Vázquez-Carrera, M.; Hammock, B. D.; Feixas, F.; Vázquez, S. From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis. J. Med. Chem., 2021, 64, 5429–5446.
• Griñán-Ferré, C.; Companys-Alemany, J.; Jarné-Ferrer, J.; Codony, S.; González-Castillo, C.; Ortuño-Sahagún, D.; Vilageliu, L.; Grinberg, D.; Vázquez, S.; Pallàs, M. Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease. Int. J. Mol. Sci. 2021, 22, 3409.
• Codony, S.; Pont, C.; Griñán-Ferré, C.; Di Pede-Mattatelli, A.; Calvó-Tusell, C.; Feixas, F.; Osuna, S.; Jarné-Ferrer, J.; Naldi, M.; Bartolini, M.; Loza, M. I.; Brea, J.; Pérez, B.; Bartra, C.; Sanfeliu, C.; Juárez-Jiménez, J.; Morisseau, C.; Hammock, B. D.; Pallàs, M.; Vázquez, S.; Muñoz-Torrero, D. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease. J. Med. Chem. 2022, 65, 6, 4909–4925
• Sandra Codony, José M. Entrena, Carla Calvó-Tusell, Beatrice Jora, Rafael González-Cano, Sílvia Osuna, Rubén Corpas, Christophe Morisseau, Belén Pérez, Marta Barniol-Xicota, Christian Griñán-Ferré, Concepción Pérez, María Isabel Rodríguez-Franco, Antón L. Martínez, M. Isabel Loza, Mercè Pallàs, Steven H. L. Verhelst, Coral Sanfeliu, Ferran Feixas, Bruce D. Hammock, José Brea, Enrique J. Cobos, and Santiago Vázquez. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J. Med. Chem. 2022, 65, 20, 13660–13680
• Griñán-Ferré, Christian; Jarné-Ferrer, Júlia; Bellver-Sanchís, Aina; Codony, Sandra; Puigoriol-Illamola, Dolors; Sanfeliu, Coral; Oh, Yumin; Lee, Seulki; Vázquez, Santiago; Pallàs, Mercè. Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer’s disease therapeutics. CNS Neurosci Ther. 2023, 00:1–20.
• Peyman M, Barroso E, Turcu AL, Estrany F Jr, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother. 2023, 168:115667.