Novel P2X7 receptor antagonists.

P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of Science & Technology, Gwangju, South Korea) and Prof. David Soto (UB) we have recently discovered new families of P2X7 receptor antagonists (a) and the first P2X7 and NMDA receptors dual antagonists (b).

  • Barniol-Xicota, M.; Kwak, S.-H.; Lee, S.-D.; Caseley, E.; Valverde, E.; Jiang, L.-H.; Kim, Y.-C.; Vázquez, S. Escape form adamantane: scaffold optimization of novel P2X7 antagonists featuring complex polycycles. Bioorg. Med. Chem. Lett. 2018, 27, 759-763.
  • Karoutzou, O; Kwak, S.-H.; Lee, S.-D.; Martínez-Falguera, D.; Sureda, F. X.; Vázquez, S.; Kim, Y.-C.; Barniol-Xicota, M. Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. Molecules 2018, 23, 230.

Diagnostics with Modern Chemical Probes

Generation of functional probes by modern chemistry such as CH activation for modified tryptophan peptides and the preparation of fluorescent…

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Neurodegeneration in ageing and neurodegenerative diseases

 We focus our research in the study of the molecular mechanisms involved in behavioral abnormalities and cognitive decline, by using…

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Design, synthesis and evaluation of new polycyclic inhibitors of the M2 channel of the influenza A virus.

Amantadine and rimantadine have been in clinical use as anti-influenza A virus agents for decades. The mechanism of action of…

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New imidazoline I2 receptor ligands

The imidazoline I2 receptors (I2-IRs) are altered in the brain of Alzheimer’s disease patients and I2-IR ligands may have therapeutic…

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