P2X7 receptor antagonists are of interest in inflammatory and neurodegenerative diseases. In collaboration with Prof. Yong-Chul Kim (Gwangju Institute of Science & Technology, Gwangju, South Korea) and Prof. David Soto (UB) we have recently discovered new families of P2X7 receptor antagonists (a) and the first P2X7 and NMDA receptors dual antagonists (b).
- Barniol-Xicota, M.; Kwak, S.-H.; Lee, S.-D.; Caseley, E.; Valverde, E.; Jiang, L.-H.; Kim, Y.-C.; Vázquez, S. Escape form adamantane: scaffold optimization of novel P2X7 antagonists featuring complex polycycles. Bioorg. Med. Chem. Lett. 2018, 27, 759-763.
- Karoutzou, O; Kwak, S.-H.; Lee, S.-D.; Martínez-Falguera, D.; Sureda, F. X.; Vázquez, S.; Kim, Y.-C.; Barniol-Xicota, M. Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. Molecules 2018, 23, 230.
