Dc. Ricote Group

RXRs in Metabolic and Cardiovascular Diseases

Mercedes Ricote holds a PhD in Biology from the Universidad Complutense de Madrid. After her postdoctoral stay at the Burnham Institute and the University of California, San Diego (La Jolla, California, USA), she joined the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid in 2004 as group leader. During her time at CNIC, she significantly contributed to the cardiovascular field. In 2023, Dr. Ricote took a new step in her career by joining the Centro Nacional de Biotecnología del Consejo Superior de Investigaciones Científicas (CNB-CSIC). The group’s projects focus on investigating the regulation of gene expression at the transcriptional and epigenetic level of macrophages in different tissues, especially in the heart, liver and brain, with special emphasis on their potential medical utility for the treatment of metabolic and inflammatory diseases. The work carried out by our group in recent years has contributed to elucidate the role of nuclear receptors in macrophage homeostasis, metabolism, and inflammation. In addition, she has recently initiated a new research direction examining the transmission of signals between mothers and neonates and their impact on the control of energy homeostasis.

About Us

  • Principal investigator:
    Mercedes Ricote Pacheco
  • Predoctoral:
    Laura Martín Aguado
    Marta Piñeiro Pérez
  • Laboratory Technician:
    Patricia Cozar López
    Sandra López Gil
Grupo Mercedes Ricote 2025

What Do We Research?

Publications

  1. Ting SM, Zhao X, Sun G, Ricote M, Aronowski J. J Neurosci
    (2025) Sep 10;45(37): e0248252025
  2. Paredes A, Justo-Méndez R, Jiménez-Blasco D, Núñez V, Calero I, Villalba-Orero M, Alegre-Martí A, Fischer T, Gradillas A, Sant’Anna VAR, Were F, Huang Z, Hernansanz-Agustín P, Contreras C, Martínez F, Camafeita E, Vázquez J, Ruiz-Cabello J, Area-Gómez E, Sánchez-Cabo F, Treuter E, Bolaños JP, Estébanez-Perpiñá E, Rupérez FJ, Barbas C, Enríquez JA, Ricote M.
    Nature. (2023) Jun;618(7964):365-373
  3. Menéndez-Gutiérrez MP, Porcuna J, Nayak R, Paredes A, Niu H, Núñez V, Paranjpe A, Gómez MJ, Bhattacharjee A, Schnell DJ, Sánchez-Cabo F, Welch JS, Salomonis N, Cancelas JA, Ricote M
    Blood. (2023) Feb 9;141(6):592-608
  4. Di Martino O, Ferris MA, Hadwiger G, Sarkar S, Vu A, Menéndez-Gutiérrez MP, Ricote M, Welch JS
    Haematologica (2022) Feb 1;107(2):417-426
  5. Paredes A, Santos-Clemente R, Ricote M
    Int J Mol Sci. (2021) Jul 21;22(15):7775
  6. Font-Díaz J, Jiménez-Panizo A, Caelles C, Vivanco MD, Pérez P, Aranda A, Estébanez-Perpiñá E, Castrillo A, Ricote M, Valledor AF
    Semin Cancer Biol. (2021) Aug;73:58-75
  7. Porcuna J, Menéndez-Gutiérrez MP, Ricote M
    Curr Opin Pharmacol. (2020) May 8; 53: 27-34
  8. Casanova-Acebes M, Menéndez-Gutiérrez MP, Porcuna J, Álvarez-Errico D, Lavin Y, García A, Kobayashi S, Le Berichel J, Núñez V, Were F, Jiménez-Carretero D, Sánchez-Cabo F, Merad M, Ricote M
    Nat Commun. (2020) Apr 3;11(1):1655, 2020
  9. Walter W, Sánchez-Cabo F, Ricote M
    Bioinformatics (2015) Sep 1;31(17):2912-4
  10. Menéndez-Gutiérrez, M.P., Rőszer, T., Fuentes, L., Núñez, V., Amelia Escolano A., Redondo, J.M., De Clerck, N., Metzger, D., Valledor, A.F., Ricote, M
    J. Clin. Invest. (2015) Feb; 125 (2):809-823