{"id":5146,"date":"2023-04-14T11:29:20","date_gmt":"2023-04-14T09:29:20","guid":{"rendered":"https:\/\/www.ub.edu\/nurcamein\/?page_id=5146"},"modified":"2026-06-10T13:43:12","modified_gmt":"2026-06-10T11:43:12","slug":"rxr-retinoid-x-receptor","status":"publish","type":"page","link":"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/rxr-retinoid-x-receptor\/","title":{"rendered":"RXR (RETINOID X RECEPTOR)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"5146\" class=\"elementor elementor-5146\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d9ee3d1 e-flex e-con-boxed e-con e-parent\" data-id=\"d9ee3d1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a634924 e-con-full e-flex e-con e-child\" data-id=\"a634924\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53d778e elementor-hidden-mobile elementor-widget elementor-widget-breadcrumbs\" data-id=\"53d778e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"breadcrumbs\"><span><span><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/\">Inicio<\/a><\/span><\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-edf9dcb e-flex e-con-boxed e-con e-parent\" data-id=\"edf9dcb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-48074d0 e-con-full e-flex e-con e-child\" data-id=\"48074d0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-914e5cf elementor-widget elementor-widget-heading\" data-id=\"914e5cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">RXR (RETINOID X RECEPTOR)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2bcf96c e-flex e-con-boxed e-con e-parent\" data-id=\"2bcf96c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cedde44 elementor-hidden-tablet elementor-hidden-mobile e-con-full e-flex e-con e-child\" data-id=\"cedde44\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-d83f6dc e-con-full e-flex e-con e-child\" data-id=\"d83f6dc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;],&quot;sticky_offset&quot;:110,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t<div class=\"elementor-element elementor-element-7fefb4f e-con-full e-flex e-con e-child\" data-id=\"7fefb4f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9d66261 elementor-widget elementor-widget-heading\" data-id=\"9d66261\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><strong>NUCLEAR RECEPTORS<\/strong><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc60613 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"bc60613\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-baffadb elementor-widget elementor-widget-heading\" data-id=\"baffadb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/ar-androgen-receptor\/\">AR (ANDROGEN RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-166571d elementor-widget elementor-widget-heading\" data-id=\"166571d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/er-estrogen-receptor\/\">ER (ESTROGEN RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba3e193 elementor-widget elementor-widget-heading\" data-id=\"ba3e193\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/gr-glucocorticoid-receptors\/\">GR (GLUCOCORTICOID RECEPTORS)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-053f50c elementor-widget elementor-widget-heading\" data-id=\"053f50c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/lxr-liver-x-receptor\/\">LXR (LIVER X RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b04e1b elementor-widget elementor-widget-heading\" data-id=\"6b04e1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/ppar-peroxisomal-proliferator-activated-receptor\/\">PPAR (PEROXISOMAL PROLIFERATOR-ACTIVATED RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96b4dfe elementor-widget elementor-widget-heading\" data-id=\"96b4dfe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/rxr-retinoid-x-receptor\/\">RXR (RETINOID X RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57e1279 elementor-widget elementor-widget-heading\" data-id=\"57e1279\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/tr-thyroid-hormone-receptor\/\">TR (THYROID HORMONE RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a52a77 elementor-widget elementor-widget-heading\" data-id=\"7a52a77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/vdr-vitamin-d-receptor\/\">VDR (VITAMIN D RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8be8e30 e-con-full e-flex e-con e-child\" data-id=\"8be8e30\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f95235c elementor-widget elementor-widget-text-editor\" data-id=\"f95235c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>X retinoid receptors (RXRs)<\/strong>\u00a0are nuclear receptors that function as homodimers or heterodimers with other nuclear receptors, playing an important role in cell proliferation and cell death, development, metabolism, and cell differentiation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9f090e elementor-widget elementor-widget-video\" data-id=\"e9f090e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/cK1loDPBHoQ&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b2d8d4 elementor-widget elementor-widget-heading\" data-id=\"5b2d8d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ligands<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-743bfdf elementor-widget elementor-widget-text-editor\" data-id=\"743bfdf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Among ligands capable of activating RXRs there are unsaturated fatty acids (such as docosahexaenoic acid) and derivatives of vitamin A (specifically, 9-cis retinoic acid). However, the low endogenous levels of these molecules in certain tissues has motivated the search for alternative natural ligands. Recently, 9-cis-13,14-dihydroretinoic acid or C24: 5 long chain fatty acid have been proposed as new endogenous regulators of RXR.<\/p><p>It is worth noting the rexinoids or the RXR synthetic ligands, as well. Among them is bexarotene, used as a drug in different types of cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77c592b elementor-widget elementor-widget-heading\" data-id=\"77c592b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Classification<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75b468d elementor-widget elementor-widget-text-editor\" data-id=\"75b468d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>RXRs are members of the\u00a0<strong>NR2 subfamily<\/strong>, which in turn is part of the large nuclear receptor superfamily.<\/p><p>Based on their affinity for the ligand and its mode of action, RXRs are classified as \u201cadopted\u201d and Type II receptors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c24292 elementor-widget elementor-widget-heading\" data-id=\"9c24292\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Structure and interactions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10f1dc5 elementor-widget elementor-widget-text-editor\" data-id=\"10f1dc5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>All members of the nuclear receptor family share a general multi-domain\u00a0structure. RXRs are made up of the following domains:<\/p><ul><li><strong>A\/B domain (NTD\u00a0<i>N terminal domain\u00a0<\/i>\/ AF-1):<\/strong>\u00a0coactivators binding region in the N-terminal position, with DNA transactivation function (AF-1), being able to operate dependently or independently of the ligand.<\/li><li><strong>C domain (DBD,\u00a0<i>DNA binding domain<\/i>):<\/strong>\u00a0Highly conserved DNA binding region, containing two \u201czinc fingers\u201d that interact with specific hormonal response elements (HREs motifs), and mediating receptor dimerization .<\/li><li><strong>D domain or \u201chinge region\u201d:<\/strong>\u00a0region that unites domains C and E, and which gives flexibility to the receptor.<\/li><li><strong>E \/ F domain (LBD \/ AF-2):<\/strong>\u00a0region of ligand binding and interaction with coactivators and corepressors (ligand-dependent AF-2 transactivation function), in C-terminal position.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-250f4ed elementor-widget elementor-widget-image\" data-id=\"250f4ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-1024x1024.png\" class=\"attachment-large size-large wp-image-3376\" alt=\"\" srcset=\"https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-1024x1024.png 1024w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-300x300.png 300w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-150x150.png 150w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-768x768.png 768w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-1536x1536.png 1536w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/03\/RXRTETRA-1G5Y-Nurcamein_Water-2048x2048.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3acd27 elementor-widget elementor-widget-text-editor\" data-id=\"d3acd27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>RXR structure |\u00a0Presumably an autorepressed not transcriptionaly competent RXR form.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-58d27b1 elementor-widget elementor-widget-text-editor\" data-id=\"58d27b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>RXRs form heterodimers with receptors of the NR1 subfamily (such as TR, LXR, PPAR, VDR or RAR), in a \u201cpermissive\u201d and \u201cnon-permissive\u201d way.\u00a0<strong>Permissive<\/strong>\u00a0heterodimers are those that can be activated by an RXR agonist ligand on its own or by the ligands of the other receptor that forms the complex (heterodimers with PPAR or LXR, for example). The\u00a0<strong>non-permissive<\/strong>\u00a0are those heterodimers that can only be activated by the ligand of the receptor with which RXR forms the dimer (VDR, TR or RAR for example).<\/p><p>As with other Type II nuclear receptors, in the absence of ligand the RXR heterodimer is linked to the DNA HREs motifs, which in turn are associated with corepressor proteins that repress gene expression.<\/p><p>The binding of an agonist ligand to the receptor induces a conformational change in the LBD domain, resulting in the dissociation of corepressors and the recruitment of coregulator complexes that activate the promoter and the transcription of the target genes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76b495a elementor-widget elementor-widget-heading\" data-id=\"76b495a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Expression<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b5b00f3 elementor-widget elementor-widget-text-editor\" data-id=\"b5b00f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>There are three types of RXR (RXR\u03b1 or NR2B1, RXR\u03b2 or NR2B2 and RXR\u03b3 or NR2B3) that, in turn, have two isoforms with partially redundant functions. Despite the fact that RXRs are expressed in almost all body tissues, the expression of each of the isotypes depends on the cell type:<\/p><ul><li><strong>RXR\u03b11\/\u03b12:<\/strong><b>\u00a0present in the liver, lung, muscle, kidney, intestine epidermis and myeloid cells.<\/b><\/li><li><strong>RXR\u03b21\/\u03b22:<\/strong>\u00a0they are distributed ubiquitously.<\/li><li><strong>RXR\u03b31\/\u03b32<\/strong><strong>:<\/strong>\u00a0both variants are the main isoforms of muscle tissue (skeletal and cardiac). Furthermore,\u00a0<strong>RXR\u03b31<\/strong>\u00a0has been identified in the brain.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41e1d5e elementor-widget elementor-widget-heading\" data-id=\"41e1d5e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Main functions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a5c66a elementor-widget elementor-widget-text-editor\" data-id=\"3a5c66a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>RXRs play a critical role due to their ability to associate with other nuclear receptors and the expression of one or more of the three isoforms (RXR\u03b1, \u03b2 and \u03b3) in each cell type of the organism. Their functions are key, above all, in the control of development processes and homeostasis. Since they are lipid sensors, they play an important role in the communication between metabolism and the immune response. Given this function, they could be an interesting therapeutic target for the treatment of diseases of immunological and metabolic origin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-599f4e3 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"599f4e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36d0402 elementor-widget elementor-widget-heading\" data-id=\"36d0402\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">RXRs in the NuRCaMeIn Network<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08d733d elementor-widget elementor-widget-text-editor\" data-id=\"08d733d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><a href=\"https:\/\/www.cnic.es\/en\/investigacion\/nuclear-receptor-signaling\" target=\"_blank\" rel=\"noreferrer noopener\">Nuclear Receptor Signaling Laboratory<\/a>\u00a0<strong>|<\/strong>\u00a0Centro Nacional de Investigaciones Cardiovasculares de Madrid.<\/li>\n \t<li><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/groups\/ricote-lab\/\" rel=\"noreferrer noopener\">RXRs in Metabolic and Cardiovascular Diseases<\/a>\u00a0<strong>|<\/strong>\u00a0Nurcamein<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70f36ec elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"70f36ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e7863cf elementor-widget elementor-widget-heading\" data-id=\"e7863cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">References<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-368a2f7 elementor-widget elementor-widget-text-editor\" data-id=\"368a2f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6121510\/\" target=\"_blank\" rel=\"noreferrer noopener\">Retinoid X Receptor Antagonists, Masaki Watanabe\u00a0<em>et al.<\/em>\u00a0<\/a>| International Journal of Molecular Sciences<\/li><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27320333\" target=\"_blank\" rel=\"noreferrer noopener\">Retinoid X Receptor Selective Agonists and their Synthetic Methods, Carl E. Wagner\u00a0<em>et al.<\/em>\u00a0<\/a>|\u00a0Current Topics in Medicinal Chemistry<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>RXR (RETINOID X RECEPTOR) NUCLEAR RECEPTORS AR (ANDROGEN RECEPTOR) ER (ESTROGEN RECEPTOR) GR (GLUCOCORTICOID RECEPTORS) LXR (LIVER X RECEPTOR) PPAR (PEROXISOMAL PROLIFERATOR-ACTIVATED RECEPTOR) RXR (RETINOID X RECEPTOR) TR (THYROID HORMONE RECEPTOR) VDR (VITAMIN D RECEPTOR) X retinoid receptors (RXRs)\u00a0are nuclear receptors that function as homodimers or heterodimers with other nuclear receptors, playing an important role [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"parent":5095,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"footnotes":""},"class_list":["post-5146","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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