{"id":5162,"date":"2023-04-14T11:44:36","date_gmt":"2023-04-14T09:44:36","guid":{"rendered":"https:\/\/www.ub.edu\/nurcamein\/?page_id=5162"},"modified":"2026-06-10T13:46:15","modified_gmt":"2026-06-10T11:46:15","slug":"vdr-vitamin-d-receptor","status":"publish","type":"page","link":"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/vdr-vitamin-d-receptor\/","title":{"rendered":"VDR (VITAMIN D RECEPTOR)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"5162\" class=\"elementor elementor-5162\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d983a9b e-flex e-con-boxed e-con e-parent\" data-id=\"d983a9b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b2343d8 e-con-full e-flex e-con e-child\" data-id=\"b2343d8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0b3590a elementor-hidden-mobile elementor-widget elementor-widget-breadcrumbs\" data-id=\"0b3590a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"breadcrumbs\"><span><span><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/\">Inicio<\/a><\/span><\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b861133 e-flex e-con-boxed e-con e-parent\" data-id=\"b861133\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f2e04bd e-con-full e-flex e-con e-child\" data-id=\"f2e04bd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-290b265 elementor-widget elementor-widget-heading\" data-id=\"290b265\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">VDR (VITAMIN D RECEPTOR)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cee523b e-flex e-con-boxed e-con e-parent\" data-id=\"cee523b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-94b0531 elementor-hidden-tablet elementor-hidden-mobile e-con-full e-flex e-con e-child\" data-id=\"94b0531\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5bc3b6c e-con-full e-flex e-con e-child\" data-id=\"5bc3b6c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;],&quot;sticky_offset&quot;:110,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t<div class=\"elementor-element elementor-element-0b1ccb8 e-con-full e-flex e-con e-child\" data-id=\"0b1ccb8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca4e8e3 elementor-widget elementor-widget-heading\" data-id=\"ca4e8e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><strong>NUCLEAR RECEPTORS<\/strong><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8052048 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8052048\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e93a99a elementor-widget elementor-widget-heading\" data-id=\"e93a99a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/ar-androgen-receptor\/\">AR (ANDROGEN RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1fd5277 elementor-widget elementor-widget-heading\" data-id=\"1fd5277\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/er-estrogen-receptor\/\">ER (ESTROGEN RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8d72b9 elementor-widget elementor-widget-heading\" data-id=\"a8d72b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/gr-glucocorticoid-receptors\/\">GR (GLUCOCORTICOID RECEPTORS)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa12ace elementor-widget elementor-widget-heading\" data-id=\"fa12ace\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/lxr-liver-x-receptor\/\">LXR (LIVER X RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36a8e21 elementor-widget elementor-widget-heading\" data-id=\"36a8e21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/ppar-peroxisomal-proliferator-activated-receptor\/\">PPAR (PEROXISOMAL PROLIFERATOR-ACTIVATED RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f62ba97 elementor-widget elementor-widget-heading\" data-id=\"f62ba97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/rxr-retinoid-x-receptor\/\">RXR (RETINOID X RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da6a59b elementor-widget elementor-widget-heading\" data-id=\"da6a59b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/tr-thyroid-hormone-receptor\/\">TR (THYROID HORMONE RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b648106 elementor-widget elementor-widget-heading\" data-id=\"b648106\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/vdr-vitamin-d-receptor\/\">VDR (VITAMIN D RECEPTOR)<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a7cc239 e-con-full e-flex e-con e-child\" data-id=\"a7cc239\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d52168 elementor-widget elementor-widget-text-editor\" data-id=\"5d52168\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Vitamin D receptors<\/strong>\u00a0(VDRs) probably mediate all vitamin D actions in higher vertebrates. VDRs are located predominantly in the nucleus of cells, where they act as transcription factors regulating the expression\/transcription of genes (<strong>genomic pathway<\/strong><strong>s<\/strong>) that control cell-specific biological functions. Furthermore, a small proportion of the VDRs are found in the cytosol, where they modulate various enzymes and signaling pathways (<strong>non-genomic pathways<\/strong>).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-99010bb elementor-widget elementor-widget-video\" data-id=\"99010bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/u559ZSxOttE&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-984ba0b elementor-widget elementor-widget-heading\" data-id=\"984ba0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ligands<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11f501e elementor-widget elementor-widget-text-editor\" data-id=\"11f501e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The main ligand of the VDRs is\u00a0<strong>1\u03b1, 25-dihydroxyvitamin D3<\/strong>\u00a0(1,25(OH)2D3\u00a0o\u00a0<strong>calcitriol<\/strong>), an active form of vitamin D in the animal kingdom. Calcitriol, synthesized in the kidney and various types of epithelial cells and the immune system, is actually a pleiotropic hormone with numerous regulatory actions in the body. Among them are the regulation of calcium and phosphate levels, and the biology and bone mineralization.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-07d8d29 elementor-widget elementor-widget-heading\" data-id=\"07d8d29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Classification<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0dcd7da elementor-widget elementor-widget-text-editor\" data-id=\"0dcd7da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>VDRs are a member of the\u00a0<strong>NR1 subfamily<\/strong>, the large nuclear receptor superfamily (NRs), along with the TRs and RARs.<\/p><p>In turn, based on their affinity for the ligand and their mode of action, they are classified as\u00a0<strong>Class II endocrine receptors<\/strong>, forming heterodimers with RXR.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8618170 elementor-widget elementor-widget-heading\" data-id=\"8618170\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Structure and interactions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7586edf elementor-widget elementor-widget-text-editor\" data-id=\"7586edf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>All members of the nuclear receptor superfamily share a general multi-domain structure. VDRs have the following domains:<\/p><ul><li><strong>A \/ B domain or Activation Function-1 (NTD \/ AF-1):<\/strong>\u00a0coactivator binding region in the N-terminal position, with ligand-dependent or independent gene transactivation function.<\/li><li><strong>C domain (DBD):<\/strong>\u00a0Highly conserved DNA binding region, containing two \u201czinc fingers\u201d that interact with specific nucleotide sequences in the target genes called hormone response elements (HRE motifs, in this case called Vitamin D Response Elements or VDREs). It also contributes to heterodimerization of the receptor.<\/li><li><strong>D domain or \u201chinge\u201d:<\/strong>\u00a0region that unites domains C and E and gives flexibility to the receptor.<\/li><li><strong>E \/ F domain (LBD \/ AF-2):<\/strong>\u00a0ligand-binding region and interaction with ligand-dependent coactivators and corepressors (AF-2 transactivation function), in C-terminal position.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fdb04e elementor-widget elementor-widget-image\" data-id=\"7fdb04e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/04\/VDR-5OW9-Nurcamein_Water-2-1024x1024.png\" class=\"attachment-large size-large wp-image-3368\" alt=\"\" srcset=\"https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/04\/VDR-5OW9-Nurcamein_Water-2.png 1024w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/04\/VDR-5OW9-Nurcamein_Water-2-300x300.png 300w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/04\/VDR-5OW9-Nurcamein_Water-2-150x150.png 150w, https:\/\/www.ub.edu\/nurcamein\/wp-content\/uploads\/2020\/04\/VDR-5OW9-Nurcamein_Water-2-768x768.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7eb03d1 elementor-widget elementor-widget-text-editor\" data-id=\"7eb03d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>VDR structure<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9440fcd elementor-widget elementor-widget-text-editor\" data-id=\"9440fcd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>VDRs mediate two types of actions of calcitriol:<\/p><h4>Genomic pathway<\/h4><p>Once calcitriol binds, VDR forms a heterodimer with some member of the retinoid X receptors (RXRs). The VDR-RXR heterodimer binds to vitamin D response elements (VDRE) located in the promoter, coding region, and introns, or sometimes far from the target genes, regulating their transcription rate.<\/p><p>The binding of the ligand to VDR modifies the conformation of its LBD region, usually promoting the release of transcriptional corepressants and the recruitment of coactivators and enzymes (histone acetylases \u2026) that modify the structure of chromatin, facilitating transcriptional activation of target genes.. In other cases the effect is the opposite, taking place transcriptional repression by mechanisms yet to be well known.<\/p><h4>Non-genomic pathway<\/h4><p>The binding of the ligand to the VDR cytosolic population triggers multiple intracellular signaling pathways or cascades, resulting in immediate responses independent of gene transcription in cells. These signaling pathways may also contribute to the ultimate modulation of target gene expression in the nucleus.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34ce7f3 elementor-widget elementor-widget-heading\" data-id=\"34ce7f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Expression<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28c23ed elementor-widget elementor-widget-text-editor\" data-id=\"28c23ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Although VDRs are widely distributed in the body, they are mainly expressed in those tissues involved in calcium and phosphate homeostasis regulation (intestine, bones, kidneys and parathyroid glands).<\/p><p>They can also be found in other cell types, such as dermal and organ fibroblasts, skin keratinocytes, epithelial cells, and numerous types of immune cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a73fcc elementor-widget elementor-widget-heading\" data-id=\"5a73fcc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Main functions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9aa8888 elementor-widget elementor-widget-text-editor\" data-id=\"9aa8888\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The functions of VDRs are key in the development, metabolism and general homeostasis of the organism. Classically, VDRs have been considered to mediate the effects of vitamin D on intestinal calcium absorption and bone tissue maintenance.<\/p><p>In addition, VDR \/vitamin D have a relevant role in the control of various functions and processes of the immune system and cell division. An anti-tumor protective action at various levels (antiproliferative, anti-angiogenic, anti-invasive \u2026) against various types of cancers has been also proposed.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46ef53c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"46ef53c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db39e65 elementor-widget elementor-widget-heading\" data-id=\"db39e65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">VDRs in the NuRCaMeIn Network <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a02979f elementor-widget elementor-widget-text-editor\" data-id=\"a02979f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><a href=\"https:\/\/www.iib.uam.es\/portal\/investigacion\/grupos?p_p_id=APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq&amp;p_p_lifecycle=0&amp;p_p_col_id=column-3&amp;p_p_col_count=1&amp;_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_id=33&amp;_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_idJefe=173&amp;_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_action=detail&amp;_APGIportlet_WAR_APIIBportlet_INSTANCE_2Veq_menu=intro\" target=\"_blank\" rel=\"noreferrer noopener\">Laboratorio del Dr. Alberto Mu\u00f1oz Terol del Instituto de Investigaciones Biom\u00e9dicas Alberto Sols<\/a><strong>\u00a0|<\/strong>\u00a0Centro mixto del Consejo Superior de Investigaciones Cient\u00edficas (CSIC) y la Universidad Aut\u00f3noma de Madrid (UAM).<\/li>\n \t<li><a href=\"https:\/\/www.ub.edu\/nurcamein\/en\/groups\/munoz-lab\/\" rel=\"noreferrer noopener\">Vitamin D and Colon Cancer<\/a>\u00a0<strong>|<\/strong>\u00a0Nurcamein<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-548b1ce elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"548b1ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-78adcf6 elementor-widget elementor-widget-heading\" data-id=\"78adcf6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">References<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57b93e5 elementor-widget elementor-widget-text-editor\" data-id=\"57b93e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5373853\/\" target=\"_blank\" rel=\"noreferrer noopener\">The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights, J. Wesley Pike\u00a0<em>et al.<\/em>\u00a0<\/a>| The Journal of Clinical Investigation<\/li><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6695859\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues,\u00a0Shaima Sirajudeen\u00a0<em>et al.<\/em>\u00a0<\/a>| International Journal of Molecular Sciences<\/li><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29981368\" target=\"_blank\" rel=\"noreferrer noopener\">Mechanisms of action of vitamin D in colon cancer,\u00a0<span class=\"content\"><span class=\"text given-name\">Gemma\u00a0Ferrer Mayorga<\/span>\u00a0<\/span><em>et al.<\/em>\u00a0<\/a>|\u00a0The Journal of Steroid Biochemistry and Molecular Biology<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>VDR (VITAMIN D RECEPTOR) NUCLEAR RECEPTORS AR (ANDROGEN RECEPTOR) ER (ESTROGEN RECEPTOR) GR (GLUCOCORTICOID RECEPTORS) LXR (LIVER X RECEPTOR) PPAR (PEROXISOMAL PROLIFERATOR-ACTIVATED RECEPTOR) RXR (RETINOID X RECEPTOR) TR (THYROID HORMONE RECEPTOR) VDR (VITAMIN D RECEPTOR) Vitamin D receptors\u00a0(VDRs) probably mediate all vitamin D actions in higher vertebrates. VDRs are located predominantly in the nucleus of [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"parent":5095,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"footnotes":""},"class_list":["post-5162","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>VDR (VITAMIN D RECEPTOR) - NuRCaMeIn<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ub.edu\/nurcamein\/en\/nuclear-receptors\/vdr-vitamin-d-receptor\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VDR (VITAMIN D RECEPTOR) - NuRCaMeIn\" \/>\n<meta property=\"og:description\" content=\"VDR (VITAMIN D RECEPTOR) NUCLEAR RECEPTORS AR (ANDROGEN RECEPTOR) ER (ESTROGEN RECEPTOR) GR (GLUCOCORTICOID RECEPTORS) LXR (LIVER X RECEPTOR) PPAR (PEROXISOMAL PROLIFERATOR-ACTIVATED RECEPTOR) RXR (RETINOID X RECEPTOR) TR (THYROID HORMONE RECEPTOR) VDR (VITAMIN D RECEPTOR) Vitamin D receptors\u00a0(VDRs) probably mediate all vitamin D actions in higher vertebrates. 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