{"id":7958,"date":"2024-05-08T10:38:28","date_gmt":"2024-05-08T08:38:28","guid":{"rendered":"https:\/\/www.ub.edu\/nurcamein\/?p=7958"},"modified":"2024-05-09T12:03:17","modified_gmt":"2024-05-09T10:03:17","slug":"publicado-un-nuevo-articulo-del-grupo-del-profesor-alberto-munoz-donde-se-describe-el-papel-de-la-vitamina-d-en-la-diferenciacion-del-epitelio-del-colon-humano","status":"publish","type":"post","link":"https:\/\/www.ub.edu\/nurcamein\/es\/blog-es\/publicado-un-nuevo-articulo-del-grupo-del-profesor-alberto-munoz-donde-se-describe-el-papel-de-la-vitamina-d-en-la-diferenciacion-del-epitelio-del-colon-humano\/","title":{"rendered":"Publicado un nuevo art\u00edculo del grupo del Prof. Alberto Mu\u00f1oz donde se describe el papel de la vitamina D en la diferenciaci\u00f3n del epitelio del colon humano"},"content":{"rendered":"\n

El grupo del Prof. Alberto Mu\u00f1oz<\/a>, en colaboraci\u00f3n con investigadores del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), la Universidad de Cantabria y el Hospital Universitario La Paz, ha publicado un nuevo art\u00edculo en la revista \u201cCell Death & Disease<\/a>\u201d titulado:\u00a0Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids<\/strong>.<\/p>\n\n\n\n

Por primera vez se define el efecto de la vitamina D sobre la capacidad de diferenciaci\u00f3n de las c\u00e9lulas del epitelio del colon hacia sus dos principales linajes: c\u00e9lulas enteroc\u00edticas y mucosecretoras. Este trabajo se ha realizado en organoides, que son estructuras tridimensionales generadas a partir de c\u00e9lulas troncales del epitelio col\u00f3nico obtenidas de biopsias de pacientes con c\u00e1ncer de colon, siendo, por tanto, un modelo celular que reproduce de forma precisa las caracter\u00edsticas del tejido. Mediante an\u00e1lisis transcript\u00f3micos y ultraestructurales, los autores demuestran que la vitamina D inhibe la diferenciaci\u00f3n regulada por las rutas de Notch y BMP en las c\u00e9lulas del epitelio col\u00f3nico.<\/p>\n\n\n\n

Puedes leer el art\u00edculo completo accediendo al siguiente enlace.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

La revista Cell Death & Disease ha publicado un nuevo art\u00edculo en el que participa el doctor Alberto Mu\u00f1oz.<\/p>\n","protected":false},"author":22,"featured_media":7965,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[516],"class_list":["post-7958","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-es","tag-grupo-dr-munoz"],"yoast_head":"\nNuevo art\u00edculo del grupo del profesor Alberto Mu\u00f1oz - NuRCaMeIn<\/title>\n<meta name=\"description\" content=\"La revista Cell Death & Disease ha publicado un nuevo art\u00edculo en el que participa el grupo del profesor Alberto Mu\u00f1oz.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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