SEMINARIS DE LA FACULTAT DE GEOLOGIA I L'INSTITUT DE CIÈNCIES DE LA TERRA 'JAUME ALMERA'
Marc Descamps, Unité Matériaux et Transformations, CNRS; Université Lille1, França

About 80% of the drugs are formulated in the solid state which can be crystalline or amorphous (glassy). The molecular nature of these solids - either active substances or excipients - gives them specific properties: low melting point, low molecular and crystalline symmetry, easy vitrification (difficulty of recrystallization) and also a great sensitivity to the external disturbances. The industrial formulation processes impose strong constraints which involve dynamic aspects in addition to temperature or pressure variations. These specific perturbations are, for example, the frequency of the shocks during grinding or the rate of desolvatation during atomizations (spray drying) or freeze-drying. The dynamic aspects are also clearly important during extrusions. These materials which are driven by dynamic stresses often undergo modifications of their physical state. One can observe amorphizations or on the contrary recrystallizations.

Dia: 18 de Gener de 2012
Hora: 12 h.
Lloc: Sala d'actes de l'Institut Jaume Almera