Molecular basis of membrane traffic in mammalian cells - PI: Carles Enrich Bastús

Below are the names and email addresses of the members of each of the teams that make up the different lines of research of the research group:
 

• Team: Endocytosis and intracellular trafficking of proteins and cholesterol

Principal Investigator:

Carles Enrich Bastús (enrich@ub.edu)
Casanova 143
3a Planta Facultat de Medicina ala est
Tel.: 34-934021908
Fax. 34-934021907

Postdoctoral researchers:

Albert Luis Lu Lopez (alulopez@stanford.edu)              
Carles Rentero Alfonso (carles.rentero@ub.edu)
Teresa Royo Bargués (teresaroyo@ub.edu)

• Team: Lipid trafficking and metabolic disease

Principal Investigator:

Albert Pol Sorolla (apols@ub.edu)
Casanova 143
1ª planta Facultat de Medicina ala sud
CELLEX 1 Bloc A
Tel. 93 2275400 ext. 3358
Fax. 93 4021907

Postdoctoral researchers:

Marta Bosch Rodríguez (martabosch@ub.edu)
Albert Gubern Burset (albertgubern@gmail.com)

Predoctoral researchers:

Frederic Morales Paytubí (moralesfredericpaytuvi@gmail.com)

Laboratory technician:

Alba Fajardo González (albafajardogonzalez@gmail.com)

• Team: Signalling, cytoskeleton and cellular migration

Principal Investigator:

Francesc Tebar Ramon (tebar@ub.edu)
Casanova 143
1ª planta Facultat de Medicina ala sud
CELLEX 1 Bloc A
Tel. 93 2275400 ext. 3358
Fax. 93 4021907

Postdoctoral researchers:

Maria Calvo Adamúz (mariacalvo@ub.edu)

Predoctoral researchers:

Albert Chavero Pieres (albertchavero@gmail.com)

Laboratory location:

Lab. 1B
C/Casanova 143, 1ª planta Facultat de Medicina ala sud
Recepció CELLEX 1 Bloc A
Tel. 93 2275400 ext. 3358
Fax. 93 4021907

• Team: Endocytosis and intracellular trafficking of proteins and cholesterol (IP: Carles Enrich)

Our group is interested on the molecular mechanisms of membrane traffic in mammalian cells. This basic research is important for understanding a number of diseases including cancer, diabetes, and heart disease or liver disorders. We study the regulation of a variety of aspects of protein and cholesterol trafficking and signal transduction in the endocytic compartment. We focus on determining the role of annexin A6 in signalling, membrane trafficking and liver regeneration and glucose metabolism.

• Team: Lipid trafficking and metabolic disease (IP: Albert Pol)

Lipid droplets are organelles that collect, store and supply lipids in all eukaryotic cells. These organelles are also cellular hallmarks of prevalent diseases ranging from obesity to cancer. The cell biology of lipid droplets and its role in pathogenesis are still unclear. Our group is interested in the mechanisms of lipid droplet biogenesis and consumption. In this sense, the aim of our project is to characterize - in health and in disease - the cellular processes that are regulated or altered due to changes of the lipid fluxes existing in our cells. For instance, cholesterol accumulation promotes mitochondrial dysfunction and oxidative damage underlying in the pathogenesis of steatohepatitis, neurodegeneration and atherosclerosis. In this context, we are especially interested in how caveolin-1 regulates cholesterol trafficking and storage.

• Team: Signalling, cytoskeleton and cellular migration (IP: Francesc Tebar)

Our group is studying the signaling and trafficking of the epidermal growth factor receptor (EGFR) and the small GTPases KRas and Rac1. The signaling elicited by these proteins controls various important cellular processes such as proliferation, cell migration and mobility. EGFR signaling is initiated at the plasma membrane and remains in the endosomes, these signaling platforms can move to different cellular locations, thereby restricting spatial signaling and controlling different processes in the cell. Accordingly, many signaling proteins of EGFR have been detected in endosomes, among them KRas and Rac1. One of the objectives of the group is to study the involvement of the endocytic compartment on EGFR, KRas and Rac1 functionality.

• Correlative cryo-3D SIM and soft X-ray tomography to study the ER, mitochondria and cytoskeleton reorganization after repositioning of lysosomes to the periphery in AnxA6-depleted cells

Principal Investigator: Carlos Enrich
Cells ALBA Synchrotron BEAMLINE MISTRAL. Ref.2023077639
Period: 2024-...

• Enhanced contacts between lysosome and mitochondria as a key pathogenic pathway in neuronopathic Gaucher Disease

Principal Investigator: Silvana Zanlungo
Member of the research team: Carles Enrich (Professor convidat)
National Research and Development Agency (ANID), Chilean Fondecyt 1230337
Amount: 25.000.000 $CP
Period: 03/31/23-03/31/27

• Cell Compartments: trafficking and signaling in health and disease

Principal Investigator: Neus Agell
Member of the research team: Carles Enrich
Grups de Recerca de la Generalitat de Catalunya. 2021 SGR 00284
Amount; 60.000 €
Period: 2023-2025

• Role of SNX13 in an NPC1 bypass cholesterol egress pathway

Principal Investigator 1: Albert Lu; Principal Investigator 2: Francesc Tebar
Ara Parseghian Research Foundation
Amount: 100.000 US$
Period: 2023-2024

• Estudio y validación del mecanismo de acción de dos compuestos antineoplásicos: GG-1815 y DD07190-P1C

Principal investigators: Teresa Royo and Carlos Enrich
Research team: Francesc Tebar, Carles Rentero i Pol Sauqué
PROJECTS WITH COMPANIES (StartUp): SUBJECT THERAPEUTICS. IDIBAPS/Universidad de Barcelona.
SUIGENERIS FARMACOCOSMETICS SL. CIF: B64876311
Amount: 82.649 €
Period: 2022-2023

• Role of Annexin A6 in cholesterol transport through membrane contact sites (MCS) and exosome biology

MINISTERIO DE CIENCIA E INNOVACIÓN. BMC2020. PID2020-115910RB-I00
Principal Investigator 1: Carlos Enrich; Principal Investigator 2: Carles Rentero
Amount: 242.000 €
Period: 2021-2024

• Red Internacional para el estudio de la disfunción lisosomal en enfermedades neurodegenerativas

Principal Investigator: Silvana Zanlungo
Investigadores participantes: Ignacio Cancino, Bernardo Krause, Alejandra Álvarez, Carlos Enrich, Carles Rentero and Dominic Winter
AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO. Ministerio de Ciencia, Tecnología, Conocimiento e Innovación. Concurso FOVI 2023 (REDES). Gobierno de Chile.
Durada: 2024 - ...

• LRRK2 kinase and glucocerebrosidase (GCase) activity-mediated regulation of a lysosomal phospholipid, bis(monoacylglycerol)-phosphate (BMP)

Project #: MJFF-019043; Funding
The Michael J. Fox Foundation
Project coordinators: Kalpana Merchant (Northwestern University, US) and Albert Lu (IDIBAPS, University of Barcelona, Spain)
Amount: 200.000 US$
Period: 2021-2023

• Zonal distribution of the SARS CoV-2 receptor ACE2 and its partner TMPRSS2 in chronic liver disease

Principal Investigator: José Carlos Fernández-Checa
Team researchers: Carmen García Ruiz and Carlos Enrich
Funding Entity: scholarships of the Asociación Española para el Estudio del Hígado (AEEH): COVID-LIVER (2020). HCB/2020/1172
Amount: 30.000 €
Period: 2020-2022

• Ayuda del Vicerrectorado de Investigación de la Universidad de Barcelona

Principal investigator: Carles Enrich
Referència: AR0RM005
Amount: 10.000 €
Period: 2020-2021

• Iberoamerican Consortium for the Study of Liver Cirrhosis: A new avenue for therapeutics

Principal Investigator: Xavier Cubero (Coordinator, Madrid).
Team researchers: C Enrich (Barcelona), H Nakaya (Sao Paulo), NR Vargas (Buenos Aires) and RU Macías-Rodriguez (México)
Funding Entity: Unión Iberoamericana de Universidades. Financiación de proyectos de Investigación Interuniversitaria.
Period: 2019-2020

• Redes temáticas de investigación: Enfermedades Metabólicas y Cancer. RED2018-102799-T.

Principal Investigator: José Carlos Fernández-Checa
Team researchers: Total 9 groups
Funding Entity: Ministerio de Ciencia, Innovación y Universidades (2019)
Period: 2019-2022
Amount: 30.000 €

• Lipids and Synaptic Signaling in Health and Disease

Principal investigator: Alejandra Alvarez (Universidad de Chile)
Team researchers: Silvana Zanlungo, Carlos Enrich, Mónica Vazquez and Francisco Muñoz
Funding Entity: Concurso de apoyo a la formación de Redes Internacionales entre Centros de Investigación. CONICYT 2018
Period: 2018-2021
Amount: 15.900.000 CLP$.

• Contribución del compartimiento endocítico a la migración celular: Regulación por colesterol, annexin A6 y Rac1

Principal investigators: Carles Enrich and Francesc Tebar
Funding Entity: Ministerio de Economía y Competitividad. BFU2015-66785-P
Period: 01/01/2016-31/12/2019

• Organización compartimental y transporte

Principal investigators: Carles Enrich and Albert Pol (IP Coordinator: Vivek Malhotra)
Entitat Finançadora: Redes de Excelencia. REDES CONSOLIDER. 2016. Ministerio de Economía y Competitividad. BFU2016-81912-REDC (2017-2019)
Period: 01/01/2017-31/12/2019

• Mammalian lipid droplets: a central role in the organismal antibacterial response?

Principal investigator: Albert Pol
Funding Entity: Human Frontier Science Program (HFSP). RGP0020/2015
Period: 01/06/2015-31/05/2018

• Nuevas funciones de ACSL3, CAV1 y colesterol en el retículo endoplásmico: sensores homeostáticos que determinan la supervivencia o la muerte de las células.

Principal investigator: Albert Pol
Funding Entity: Ministerio de Economia y Competitividad. BFU2015-66401-R
Period: 01/01/2016-31/12/2018

• Lipid Droplet Overloading Promotes Pathogenesis and Progression of Type 2 Diabetes: Identifying New Therapeutic Targets and Applying Upgraded Therapies. 31/U/2016.

Principal investigator: Albert Pol
Funding Entity: Fundació Marató de TV3.
Period: 01/01/2017-31/12/2019

OTHER PROJECTS AND MOBILITY AID

Mobility of Teachers (International). Support from the University of Barcelona for the promotion of the Internalization of Centers of the University of Barcelona. Pontifical University of Chile. April 2022.

For more information for PI publications click in the link:
ORCID: https://orcid.org/0000-0003-0382-2993

Martinez-Campanario MC, Cortés M, Moreno-Lanceta A, Han L, Ninfali C, Domínguez V, Andrés-Manzano MJ, Farràs M, Esteve-Codina A, Enrich C, Díaz-Crespo FJ, Pintado B, Escolà-Gil JC, García de Frutos P, Andrés V, Melgar-Lesmes P, Postigo A. Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation. Nat Commun. 2023 Dec 14; 14(1): 8316. doi: 10.1038/ s41467-023-43896-7. PMID: 38097578

Cortés M, Brischetto A, Martinez-Campanario MC, Ninfali C, Domínguez V, Fernández S, Celis R, Esteve-Codina A, Lozano JJ, Sidorova J, Garrabou G, Siegert AM, Enrich C, Pintado B, Morales-Ruiz M, Castro P, Cañete JD, Postigo A. Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation. Nat Commun. 2023 Nov 17; 14(1): 7471. doi: 10.1038/ s41467-023-42277-4. PMID: 37978290

Ninfali C, Cortés M, Martínez-Campanario MC, Domínguez V, Han L, Tobías E, Esteve-Codina A, Enrich C, Pintado B, Garrabou G, Postigo A. The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2 Proc Natl Acad Sci U S A. 2023 Nov 14; 120(46): e2301120120. doi: 10.1073/ pnas.2301120120. Epub 2023 Nov 10. PMID: 37948583

Enrich, C., Lu, A., Tebar, F., Rentero, C., Grewal, T. Ca2+ and Annexins – Emerging Players for Sensing and Transferring Cholesterol and Phosphoinositides via Membrane Contact Sites. In: Rosenhouse-Dantsker, A. (eds) Cholesterol and PI(4,5)P2 in Vital Biological Functions. Adv Exp Med Biol. 2023; 1422:393-438. doi: 10.1007 /978-3-031-21547-6_15. PMID: 36988890 (Capítol de llibre)

Raquel Fucho, Estel Solsona-Vilarrasa, Sandra Torres, Susana Nuñez, Naroa Insausti-Urkia, Albert Edo, Maria Calvo, Anna Bosch, Gemma Martin, Carlos Enrich, Carmen Garcia-Ruiz and Jose Carlos Fernandez-Checa. Zonal expression of StARD1 and oxidative stress in alcoholic-related liver disease. J Lipid Res. 2023 Aug; 64(8):100413. doi: 10.1016/ j.jlr.2023.100413. Epub 2023 Jul 19. PMID: 37473919

Frederic Morales-Paytuví, Alba Fajardo, Carles Ruiz-Mirapeix, James Rae, Francesc Tebar, Marta Bosch, Carlos Enrich, Brett Collins, Robert Parton, and Albert Pol. Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation. J Cell Biol. 2023 Sep 4; 222(9): e202204020. doi: 10.1083/ jcb.202204020. Epub 2023 Aug 1. PMID: 37526691

Marta Fontcuberta-PiSunyer, Ainhoa García-Alamán, Èlia Prades, Noèlia Téllez, Hugo Alves-Figueiredo, Mireia Ramos-Rodríguez, Carlos Enrich, Rebeca Fernandez-Ruiz, Sara Cervantes, Laura Clua, Javier Ramón-Azcón, Christophe Broca, Anne Wojtusciszyn, Nuria Montserrat, Lorenzo Pasquali, Anna Novials, Joan-Marc Servitja, Josep Vidal, Ramon Gomis, Rosa Gasa. Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors. Commun Biol. 2023 Mar 24; 6(1):256. doi: 10.1038/ s42003-023-04627-2. PMID: 36964318

Samouillan V, Garcia E, Benitez AA, La Chica Lhoëst, MT, Dandurand J, Actis-Dato V, Guerra J, Escolà-Gil JC, Chiabrando G, Enrich C, & Llorente-Cortes V. Inhibitory effects of LRP1-based immunotherapy on cardiac extracellular matrix biophysical alterations induced by hypercholesterolemia. J Med Chem. 2023 May 11; 66(9): 6251-6262. doi: 10.1021/ acs.jmedchem.2c02103. Epub 2023 Apr 28. PMID: 37116069

Judith Cantó-Santos, Laura Valls-Roca, Ester Tobías, Francesc Josep García-García, Anna Esteve-Codina, Beatriz Martín-Mur, Mercedes Casado, Rafael Artuch, Estel Solsona-Vilarrasa, José Carlos Fernandez-Checa, Carmen García-Ruiz, Carles Rentero, Carlos Enrich, Pedro J. Moreno-Lozano, José César Milisenda, Francesc Cardellach, Josep M. Grau-Junyent, Glòria Garrabou. Unraveling Inclusion Body Myositis using a patient-derived fibroblasts model. J Cachexia Sarcopenia Muscle. 2023 Apr; 14(2): 964-977. doi: 10.1002/ jcsm.13178. Epub 2023 Mar 1. PMID: 36860172

Sanz-Garcia C, Nevzorova YA, Martínez-Naves E, Cubero FJ; Iberoamerican Consortium for the study of liver Cirrhosis, Hionides-Gutierrez A, Sañudo JR, Enrich C, Rentero C, Sancho-Bru P, Macías-Rodriguez RU, Ruiz-Margain A, Kershenobich-Stalnikowitz D, Vargas NR, Muñoz AE, Nakaya HI. Novel therapeutic avenues for the study of chronic liver disease and regeneration: The foundation of the Iberoamerican Consortium for the study of liver Cirrhosis. Gastroenterol Hepatol. 2023 Apr; 46(4):322-328. doi: 10.1016/ j.gastrohep.2022.05.012. Epub 2022 Jun 7. PMID: 35688395

Silvana Zanlungo, Carlos Enrich*, Volker Gerke, Emily R. Eden and María Isabel Colombo. Cell Compartments and Intracellular Trafficking of Lipids and Proteins: Impact on Biomedicine. Front Cell Dev Biol. 2022 Nov 24; 10:1087214. doi: 10.3389/ fcell.2022.1087214. eCollection 2022. PMID: 36506102

Mai Khanh Linh Nguyen, Jaimy Jose, Mohamed Whaba, Andrew J Hoy, Carlos Enrich, Carles Rentero, Thomas Grewal. Linking late endosomal cholesterol with cancer progression and anticancer drug resistance. Int J Mol Sci. 2022 Jun 29; 23(13): 7206. doi: 10.3390/ ijms23137206. PMID: 35806209.

Núria Bielsa, Mireia Casasampere, José Luis Abad, Carlos Enrich, Antonio Delgado, Gemma Fabriàs, José M Lizcano and Josefina Casas. Methuosis contributes to Jaspine-B-induced cell death. Int J Mol Sci. 2022 Jun 29; 23(13): 7257. doi: 10.3390/ ijms23137257. PMID: 35806262

Actis Dato V, Benitez-Amaro A, Garcia E, Claudi L, Iborra A, Escola-Gil JC, Samouillan V, Enrich C, Chiabrando G and Llorente-Cortés V. Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response. Biomed Pharmacother. 2022 Aug;152:113270. doi: 10.1016/j.biopha.2022.113270. Epub 2022 Jun 13. pmid: 35709652

Jaimy Jose, Monira Hoque, Johanna Engel, Syed S. Beevi, Mohamed Wahba, Mariya Georgieva, Kendelle Murphy, William E. Hughes, Blake J. Cochran, Albert Lu, Francesc Tebar, Andrew J Hoy, Paul Timpson, Kerry-Anne Rye, Carlos Enrich, Carles Rentero and Thomas Grewal. Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. Scientific Reports 2022 Jan 12; 12(1):596. doi: 10.1038/ s41598-021-04584-y. PMID: 35022465

Carlos Enrich, Albert Lu, Francesc Tebar, Carles Rentero and Thomas Grewal. Annexins bridging the gap: novel roles in membrane contact sites formation. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Des, 2021) doi: 10.3389/ fcell.2021.797949.

Lu A., Hsieh, F., Sharma, B.R., Vaighan S.R., Enrich, C. and Pfeffer S.R. CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export. J Cell Biol (Feb. 2022) 221 (2): e202105060. DOI: 10.1083/jcb.202105060

Sandra Torres, Estel Solsona-Vilarrasa, Susana Nuñez, Nuria Matías, Naroa Insausti-Urkia, Fernanda Castro, Mireia Casasempere, Gemma Fabriás, Josefina Casas, Carlos Enrich, Carmen Garcia-Ruiz, José C. Fernández-Checa. Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation. Redox Biology (2021) Jun 19;45: 102052. doi: 10.1016 /j.redox.2021.102052. PMID: 34175669

Thomas Grewal, Carles Rentero, Carlos Enrich, Mohamed Wahba, Carsten A. Raabe and Ursula Rescher. Annexins animal models - from fundamental principles to translational research. International Journal of Molecular Sciences (2021) Mar 26;22(7): 3439. doi: 10.3390/ ijms22073439. PMID: 33810523.

Bosch M, Parton RG, Pol A. Lipid droplets, bioenergetic fluxes, and metabolic flexibility. Seminars in Cell and Developmental Biology. 2020 Dec;108: 33-46. doi: 10.1016/ j.semcdb.2020.02.010. Epub 2020 Mar 4. PMID: 32146030

Pol A, Morales-Paytuví F, Bosch M, Parton RG. Non-caveolar caveolins - duties outside the caves. Journal of Cell Science. 2020 May 11;133(9): jcs241562. doi: 10.1242/ jcs.241562. PMID: 32393675

Parton RG, Bosch M, Steiner B, Pol A. Novel contact sites between lipid droplets, early endosomes, and the endoplasmic reticulum. Journal of Lipid Research. 2020 Nov;61(11): 1364. doi: 10.1194/ jlr.ILR120000876. Epub 2020 May 13. PMID: 32404335

Doolin T, Amir HM, Duong L, Rosenzweig R, Urban LA, Bosch M, Pol A. Gross SP, Siryaporn A. Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization. Nature Communications. 2020 Aug 4;11(1): 3888. doi: 10.1038/ s41467-020-17699-z. PMID: 32753666

Anna Alvarez-Guaita, Patricia Blanco-Muñoz, Elsa Meneses-Salas, Mohamed Wahba, Abigail H. Pollock, Jaimy Jose, Mercedes Casado, Marta Bosch, Rafael Artuch, Katharina Gaus, Albert Lu, Albert Pol, Francesc Tebar, Stephen E. Moss, Thomas Grewal, Carlos Enrich** Carles Rentero. Annexin A6 is critical to maintain glucose homeostasis and survival during liver regeneration in mice. Hepatology (2020) 72 (6), 2149-2164. doi: 10.1002/ hep.31232. PMID: 32170749.

Elsa Meneses-Salas, Ana García-Melero, Patricia Blanco-Muñoz, Jaimy Jose, Marie-Sophie Brenner, Albert Lu, Francesc Tebar, Thomas Grewal, Carles Rentero and Carlos Enrich*. Selective degradation permits a feedback loop controlling Annexin A6 and cholesterol levels in endolysosomes of NPC1 mutant cells. Cells (2020) May 7;9(5):E1152. doi: 10.3390/ cells9051152. PMID: 32392809.

Francesc Tebar, Albert Chavero, Carles Rentero, Albert Lu, Neus Agell, Carlos Enrich and Thomas Grewal. Pleiotropic roles of calmodulin in the regulation of KRas and Rac1 GTPases: functional diversity in health and disease. International Journal of Molecular Sciences (2020) 21 (10): 3680 doi: 10.3390/ijms21103680. PMID: 32456244.

Marta Bosch, Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocio Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M. Templin, James E. B. Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A. Del Pozo, Matthew J. Sweet, Patricia T. Bozza, Steven P. Gross, Robert G. Parton and Albert Pol. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science (2020) Oct 16;370(6514):eaay8085. 370.doi:10.1126/science.eaay8085. PMID: 33060333.

Elsa Meneses-Salas, Marta García-Forn, Marta Bosch, Jaimy Jose, Mohamed Wahba, Albert Pol, Francesc Tebar, Albert Lu, Andrés D. Klein, Silvana Zanlungo, Esther Pérez-Navarro, Thomas Grewal, Carlos Enrich** and Carles Rentero. Lack of Annexin A6 exacerbates liver dysfunction and reduced lifespan of NPC1-deficient mice. American Journal of Pathology (2020) S0002-9440 (20) 30564-2. doi.org/10.1016/j.ajpath.2020.12.009. PMID: 33345999.

Faten Abdelli, Karim Jellali, Estefanía Anguita, María González-Muñoz, Eduardo Villalobo, Ivan Madroñal, Juan Alcalde, Mamdouh Ben Ali, Jihene Elloumi-Mseddi, Ikram Jemel, Francesc Tebar, Carlos Enrich, Sami Aifa and Antonio Villalobo. The role of the calmodulin-binding and calmodulin-like domains of the epidermal growth factor receptor in tyrosine kinase activation. Journal of Cellular Physiology (2020) doi: 10.1002/jcp.30205. PMID: 33305427.

Hoque M, Elmaghrabi YA, Köse M, Meneses-Salas E, Blanco-Muñoz P, Beevi SS, Jose J, Conway JR, Swarbrick A, Timpson P, Tebar F, Enrich C, Rentero C, Grewal T. Annexin A6 improves anti-migratory properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells. Febs J. 2019 Dec 23. doi: 10.1111/ febs. 15186. [Epub ahead of print]

Enrich C, Rentero C, Grewal T, Futter CE, Eden ER. Cholesterol overload: contact sites to the rescue! Contact (Thousand Oaks). doi: 10.1177/ 2515256419893507. Author manuscript; available in PMC 2019 Dec 19. PMID: 31858076

Meneses-Salas E, García-Melero A, Kanerva K, Blanco-Muñoz P, Morales-Paytuvi F, Bonjoch J, Casas J, Egert A, Beevi SS, Jose J, Llorente-Cortés V, Rye K-A, Heeren J, Lu A, Pol A, Tebar F, Ikonen E, Grewal T, Enrich C**, Rentero C. Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells. Cell Mol Life Sci. 2019 Oct 29. doi: 10.1007/ s00018-019-03330-y. [Epub ahead of print]. PMID: 31664461

Grewal T, Enrich C, Rentero C, Buechler C. Annexins in adipose tissue: Novel players in obesity. Int J Mol Sci. 2019 Jul 13; 20(14). pii: E3449. doi: 10.3390 /ijms 20143449. PMID: 31337068

Solsona-Vilarrasa E, Fucho R, Torres S, Nuñez S, Nuño-Lámbarri N, Enrich C, García-Ruiz C, Fernández-Checa JC. Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes. Redox Biol. 2019 Jun; 24:101214. doi: 10.1016 /j.redox. 2019.101214. Epub 2019 May 9. PMID: 31108462

Cairns R, Fischer AW, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A, Buechler C, Hoy AJ, Heeren J, Enrich C, Rentero C, Grewal T. Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PLoS One. 2018 Aug 15;13(8): e0201310. doi: 10.1371 /journal.pone. 0201310. eCollection 2018. PMID: 30110341

Tebar F, Enrich C, Rentero C, Grewal T. GTPases Rac1 and Ras Signaling from Endosomes. Prog Mol Subcell Biol. 2018;57:65-105. doi: 10.1007/978-3-319- 96704-2_3. Review. PMID: 30097772

Soriano-Castell D, Chavero A, Rentero C, Bosch M, Vidal-Quadras M, Pol A, Enrich C, Tebar F. ROCK1 is a novel Rac1 effector to regulate tubular endocytic membrane formation during clathrin-independent endocytosis. Sci Rep 2017; Jul 31;7(1):6866. doi: 10.1038/ s41598-017- 07130-x.

Cairns R, Alvarez-Guaita A, Martínez-Saludes I, Wason SJ, Hanh J, Nagarajan SR, Hosseini-Beheshti E, Monastyrskaya K, Hoy AJ, Buechler C, Enrich C, Rentero C, Grewal T. Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Exp Cell Res 2017; Sep 15;358(2): 397-410. doi: 10.1016/ j.yexcr.2017.07.015.

Grewal T, Hoque M, Conway JRW, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C. Annexin A6-A multifunctional scaffold in cell motility. Cell Adh Migr 2017; May 4;11(3):288-304. doi: 10.1080/ 19336918. 2016. 1268318.

Fleta-Soriano E, Smutná K, Martínez JP, Lorca Oró C, Sadiq SK, Mirambeau G, Lopez-Iglesias C, Bosch M, Pol A, Brönstrup M, Diez J, Meyerhans A. The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition. Antimicrob Agents Chemother. 2017; Jul 25;61(8). pii: e00739-17. doi: 10.1128/AAC.00739-17.

Enrich C, Rentero C, Grewal T. Annexin A6 in the liver: From the endocytic compartment to cellular physiology. Biochim Biophys Acta 2017; Jun; 1864(6): 933-946. doi: 10.1016/ j.bbamcr. 2016.10.017.

Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC. Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 2017; Apr; 11:60-72. doi: 10.1016/ j.redox.2016.11.010.

Krautbauer S, Haberl EM, Eisinger K, Pohl R, Rein-Fischboeck L, Rentero C, Alvarez-Guaita A, Enrich C, Grewal T, Buechler C, Neumeier M. Annexin A6 regulates adipocyte lipid storage and adiponectin release. Mol Cell Endocrinol 2017; Jan 5;439: 419-430. doi: 10.1016/ j.mce. 2016.09.033.

Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F. ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. Nat Commun 2016; 7:13588. doi: 10.1038/ ncomms13588.

Sala-Vila A, Navarro-Lérida I, Bosch M, Calvo C, López JA, Calvo E, Ferguson C, Balsinde J, Enríquez JA, Giacomello M, Scorrano L, Parton RG, Vázquez J, Pol A, del Pozo MA. Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice. Sci Rep 2016; 6:27351. doi: 10.1038/ srep27351.

Cornely R, Pollock AH, Rentero C, Norris SE, Alvarez-Guaita A, Grewal T, Mitchell T, Enrich C, Moss SE, Parton RG, Rossy J, Gaus K. Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunol Cell Biol 2016; 94(6): 543-53. doi: 10.1038/ icb.2016.15.

García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway J R, Johnsen C H, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi Y A, Pol A, Tebar F, Murray R Z, Timpson P, Enrich C, Grewal T, Rentero C. Annexin A6 and late endosomal cholesterol modulates integrin recycling and cell migration. J Biol Chem 2016; 291(3): 1320-1335. doi: 10.1074/ jbc.M115.683557.

Bosch M, Fajardo A, Alcalá-Vida R, Fernández-Vidal A, Tebar F, Enrich C, Cardellach F, Pérez E, Pol A. Hepatic Primary and Secondary Cholesterol Deposition and Damage in Niemann-Pick Disease. Am J Pathol. 2016; 186 (3):517-23. doi: 10.1016/j.ajpath.2015.12.002.

Tran J, Magenau A, Rodriguez M, Rentero C, Royo T, Enrich C, Thomas SR, Grewal T, Gaus K. Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. PLoS One. 2016; 11(3): e0151556. doi: 10.1371/ journal.pone. 0151556.

Grewal T, Wason SJ, Enrich C, Rentero C. Annexins - insights from knockout mice. Biol Chem 2016; 397(10): 1031-53. doi: 10.1515/ hsz- 2016-0168.

Alvarez-Guaita A, Vila de Muga S, Owen DM , Williamson D, Magenau A, Garcia- Melero A, Reverter M, Hoque M, Cairns R, Cornely R, Tebar F, Grewal T, Gaus K, Ayala- Sanmartin J, Enrich C, Rentero C. Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. Br J Pharmacol. 2015; 172, 1677-1690.  doi: 10.1111/ bph.13022.

Herms A, Bosch M, Reddy B, Schieber N, Fajardo A, Rupérez C, Fernández-Vidal A, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun. 2015; 6:7176. doi: 10.1038/ ncomms8176.

Reales E, Bernabé-Rubio M, Casares- Arias J, Rentero C, Enrich C, Andrés G, Alonso MA. The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation. J Cell Sci 2015; 128, 2261-2270. doi: 10.1242/ jcs.164970.

Enrich C, Rentero C, Hierro A, Grewal T. Role of cholesterol in SNARE-mediated trafficking on intracellular membranes. J Cell Sci 2015; 128, 1071-1081. doi: 10.1242/ jcs.164459.

Hoque H, Rentero C, Conway JR, Timpson P, Murray RZ, Enrich C, Grewal T. The cross-talk of LDL-cholesterol with cell motility: insights from the Niemann Pick Type C1 mutation and altered integrin trafficking. Cell Adh Migr 2015; 9, 384-391. doi: 10.1080/ 19336918. 2015.1019996.

Gelabert-Baldrich M, Soriano-Castell D, Calvo M, Lu A, Vina-Vilaseca A, Rentero C, Pol A, Grinstein S, Enrich C, Tebar F. Dynamics of KRas on endosomes: involvement of acidic phospholipids in its association. FASEB J 2014;28: 3023-3037. doi: 10.1096/ fj.13-241158.

Reverter M, Rentero C, Garcia-Melero A, Hoque M, Vila de Muga S, Alvarez-Guaita A, Conway JR, Wood P, Cairns R, Lykopoulou L, Grinberg D, Vilageliu L, Bosch M, Heeren J, Blasi J, Timpson P, Pol A, Tebar F, Murray RZ, Grewal T, Enrich C. Cholesterol regulates Syntaxin 6 trafficking at trans-Golgi network endosomal boundaries. Cell Rep 2014; 7:883-897.  doi: 10.1016/ j.celrep.2014.03.043

Rodrigo-Torres D, Affo S, Coll M, Morales-Ibanez O, Millan C, Blaya D, Alvarez-Guaita A, Rentero C, Lozano JJ, Maestro MA, Solar M, Arroyo V, Caballeria J, van Grunsven LA, Enrich C, Gines P, Bataller R, Sancho-Bru P. The biliary epithelium gives rise to liver progenitor cells. Hepatology 2014;60: 1367-1377. doi: 10.1002/ hep.27078.

Pol A, Gross SP, Parton RG. Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. J Cell Biol 2014; 204:635-646. doi: 10.1083/ jcb.201311051.

Hoque M, Rentero C, Cairns R, Tebar F, Enrich C, Grewal T. Annexins - scaffolds modulating PKC localization and signaling. Cell Signal 2014; 26:1213-1225. doi: 10.1016/ j.cellsig.2014.02.012.

Tebar F, Gelabert-Baldrich M, Hoque M, Cairns R, Rentero C, Pol A, Grewal T, Enrich C. Annexins and endosomal signaling. Methods Enzymol 2014; 535:55-74. doi: 10.1016/ B978-0-12-397925- 4.00004-3.

Soler M, González-Bártulos M, Soriano-Castell D, Ribas X, Costas M, Tebar F, Massaguer A, Feliu L, Planas M. Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties. Org Biomol Chem. 2014; Mar 14;12(10): 1652-63. doi: 10.1039/ c3ob42422g.

• Congresses Presentations (oral and posters)

Depicting inclusion body myositis using a patient-derived fibroblast model.
Judith Cantó, Carlos Enrich, Gloria Garrabou. EUROMIT 2023. Bologna, Italy 11-15 June. Poster presentation

Increased lysosome-mitochondria Membrane Contact Sites and alteration in StARD3 cholesterol transporter levels in Gaucher Disease.
Claudia Parra-Ruiz, Laura Brito-Fernández, Alejandra R. Álvarez, Carlos Enrich, Silvana Zanlungo. Lysosomal Diseases. Gordon Research Conference. Connecting Function to Pathophysiology for Innovative Therapies. Castelldefels, Spain May 2023. Poster presentation

Unraveling the role of AnxA6 in cholesterol homeostasis of NPC1-deficient cells.
Marc Bernaus-Esqué, Carla Balagué-Dobón, Elsa Meneses-Salas, Francesc Tebar, Josep Maria Estanyol, Thomas Grewal, Carlos Enrich and Carles Rentero. Lysosomal Diseases. Gordon Research Conference. Connecting Function to Pathophysiology for Innovative Therapies. Castelldefels, Spain May 2023. Poster presentation

Increased lysosome-mitochondria membrane contact sites and stard3 cholesterol transporter levels in Gaucher disease.
Claudia Parra-Ruiz, Carlos Enrich, Laura Brito-Fernández, Alejandra R. Álvarez, Silvana Zanlungo. Chilean Society for Cell Biology – XXXIV Annual Meeting – December 12-16, 2022. Puerto Varas (Chile). Poster presentation

Loss of TBC1D15-mediated Rab7 inactivation reduces cholesterol accumulation in NPC1-deficient CHO cells.
Marc Bernaus, Elsa Meneses-Salas, Thomas Grewal, Carlos Enrich and Carles Rentero. ANNEXINS 2022. 11th International Conference on Annexins. Stockholm (Sweden). Poster presentation

A GWC screen to unravel new molecular mechanisms involved in EV uptake.
Victor Toribio, Albert Lu, Miguel Palma-Cobo, Carlos Enrich, Maria Yañez-Mó. ISEV2022 Annual Meeting. Lyon (France) 25-29-May. Oral presentation

Role of Annexin A6 in hepatic energetic metabolism in mice
ANNEXINS 2019. 10th International Conference on Annexin Biology. Carles Rentero, Patricia Blanco-Muñoz, Elsa Meneses-Salas, Thomas Grewal and Carlos Enrich. Poster and Oral Communication. *Short talk award to Carles Rentero

Annexin A6-mediated control of endosomal cholesterol export via TBC1D15/Rab7/StARD3 axis and its multiple cellular consequences
ANNEXINS 2019. 10th International Conference on Annexin Biology. Thomas Grewal, Jaimy Jose, Monira Hoque, Carles Rentero and Carlos Enrich. Invited speaker

AnxA6-mediated trafficking of SNAT4 regulates gluconeogenesis during liver regeneration
Patricia Blanco-Muñoz, Anna Garcia-Guaita, Elsa Meneses-Salas, Thomas Grewal, Carlos Enrich and Carles Rentero. CONSOLIDER-COAT-Annual Meeting 2019. Sant Feliu de Guixols, 28-29 May 2019. Poster presentation

Transmission electron microscopy reveals dramatic hepatic zonal changes upon chronic alcohol feeding
Raquel Fucho, Estel Solsona-Vilarrasa, Carlos Enrich, Carmen García-Ruiz and José C Fernández-Checa. EASL 2019. Vienna. Poster Presentation

The AnxA6/TBC1D15 complex controls Rab7-dependent late endosomal positioning and cholesterol export in NPC1 mutant cells
Elsa Meneses-Salas, Ana Garcia-Melero, Patricia Blanco-Muñoz, Thomas Grewal, Carles Rentero and Carlos Enrich. ASCB/EMBO 2018 meeting. San Diego CA. USA. Poster Presentation.

The scaffold protein Annexin A6 modulates the sensitivity of EGFR overexpressing cells towards EGFR tyrosine kinase inhibitors
Yasmin A. Elmaghrabi, Monira Hoque, Paul Timpson, Carles Rentero, Carlos Enrich, Thomas Grewal. 9th Garvan Signalling Symposium, 12-13 November 2018, The Garvan Institute of Medical Research, Sydney, Australia. Poster Presentation.

The scaffold protein Annexin A6 modulates the sensitivity of EGFR overexpressing cells towards EGFR tyrosine kinase inhibitors
Yasmin A. Elmaghrabi, Monira Hoque, Paul Timpson, Carles Rentero, Carlos Enrich, Thomas Grewal. The Sydney Cancer Conference 2018, Bridging research and practice, 11-12 October 2018, ICC Sydney, Australia. Poster Presentation.

Annexin A6 a novel gatekeeper to regulate the intracelular cholesterol homeostasis
Carlos Enrich, Elsa Meneses-Salas, Elina Ikonen, Thomas Grewal and Carles Rentero. The 2018 Golgi meeting: Membrane trafficking in cell organization and homeostasis. Sorrento, Italy, 15-19 October 2018. Poster Presentation

Role of Annexin A6, a calcium binding protein, in hepatic energetic metabolism in mice
Patricia Blanco-Muñoz, Anna Alvarez-Guaita, Elsa Meneses-Salas, Thomas Grewal, Carlos Enrich and Carles Rentero. XV International Meeting of the European Calcium Society. Hamburg, Germany, 9-13 September 2018. Selected for Oral presentation

Annexin A6 depletion rescues cholesterol egress in NPC1 mutant cells via formation of endosome-ER membrane contact sites
Thomas Grewal, Elsa Meneses-Salas, Ana Garcia-Melero, Patricia Blanco-Muñoz, Antonia Egert,  Syed S. Beevi, Carles Rentero and Carlos Enrich. XV International Meeting of the European Calcium Society. Hamburg, Germany, 9-13 September 2018. Selected for Oral presentation.

Annexin A6 depletion rescues cholesterol egress in NPC1 mutant cells via endosome-ER membrane contact formation
Thomas Grewal, Elsa Meneses-Salas, Ana Garcia-Melero, Patricia Blanco-Muñoz, Antonia Egert,  Syed S. Beevi, Carles Rentero and Carlos Enrich. 59th International Conference on the Bioscience of Lipids (ICBL). Lipid fluxes and metabolism – from fundamental mechanism to human disease. Helsinki, Finland, 4-7 September 2018. Poster Presentation.

Annexin A6 silencing reduces LE-cholesterol accumulation in NPC1 mutant cells
Elsa Meneses-Salas, Ana García-Melero, Patricia Blanco-Muñoz, Thomas Grewal, Carles Rentero and Carlos Enrich. CONSOLIDER-COAT-Annual Meeting 2018
Madrid, 7-8 March 2018. Poster Presentation

Glucose metabolism in Annexin A6 knock-out mice
Patricia Muñoz-Blanco, Anna Alvarez-Guaita, Elsa Meneses-Salas, Thomas Grewal, Carlos Enrich and Carles Rentero. CONSOLIDER-COAT-Annual Meeting 2018. Madrid, 7-8 March 2018. Poster Presentation

• Invited lectures

Pontificia Universidad Católica de Chile. Facultad de Ciencias Biológicas.
Santiago de Chile. Chile.
Proteómica funcional y estrategias experimentales para estudiar la regulación del transporte intracelular de lípidos y proteínas. Conferencia Invitada. Noviembre 2022.

XXXIII Annual Meeting of Sociedad de Biología Celular de Chile
Symposium: Lipids homeostasis and cell signalling
Recent advances of intracellular cholesterol transport and homeostasis
Puerto Varas (Chile). 25-29 November 2019
Invited speaker

ANNEXINS 2019. 10th International Conference on Annexin Biology
Annexin A6 depletion induces formation of membrane contact sites between endolysosomes and the endoplasmic reticulum in NPC1 mutant cells
Münster (Germany), September 2019.
Invited Speaker, Chair of session and Member of Scientific Board

Pontificia Universidad Católica de Chile. Facultad de Ciencias Biológicas
Santiago de Chile. Chile
Regulación del transporte intracelular del colesterol: consecuencias en la migración y fisiología celular
Conferencia Invitada. Abril 2018.

CONSOLIDER-COAT-Annual Meeting 2018
Annexin A6 a novel gatekeeper to regulate the intracellular cholesterol homeostasis
Madrid, 7-8 March 2018
Invited speaker

• Seminars given (invited)

CONSOLIDER-COAT-Annual Meeting 2019
Annexin A6 regulates Rab7 activity and LE-Chol transport
Sant Feliu de Guixols, 28-29 May 2019
Invited speaker

Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona
XIV Premi Gemma Rosell i Romero. X Setmana de la Recerca
“Mecanismes de transport intracel·lular del colesterol: canvi de paradigma i potencial terapèutic”
Conferencia invitada. Septiembre 2018

Pontificia Universidad Católica de Chile. Facultad de Medicina
Santiago de Chile. Chile
Los misterios de la regeneración hepática
Conferencia Invitada. Abril 2018

• Informative articles and reviews press

Summary of press comments on the article published in Cell Mol Life Sci, (2019):
Nova diana terapèutica contra les malalties causades per l’acumulació de lípids a les cèl·lules
https://www.ub.edu/web/ub/ca/
https://www.ub.edu/web/ub/ca/menu_eines/noticies/2019/11/053.html
Nueva diana terapéutica contra las enfermedades causadas por la acumulación de lípidos en las células
https://www.ub.edu/web/ub/es/index.html
https://www.ub.edu/web/ub/es/menu_eines/noticies/2019/11/053.html
A new therapeutic target against diseases caused by lipid accumulation in cells
https://www.ub.edu/web/ub/en/index.html
https://www.ub.edu/web/ub/en/menu_eines/noticies/2019/11/053.html
University of Sydney
https://sydney.edu.au/medicine-health/news-and-events/2019/11/18/researchers-overcome-cholesterol-overload-in-rare-genetic-disord.html

Summary of press comments on the article published in Cell Reports, 2014:
https://www.dropbox.com/s/x4bvbkxqdunmwf0/DOSSIER%20DE%20PREMSA%20-%20CELL%20REPORTS.pdf?dl=0
https://www.dropbox.com/s/h15a68vfsj4aghk/0000_ATEI_Colesterol_CAT_revisar5.mp4?dl=0
http://www.ub.edu/ubtv/video/migracion-celular
El Pais: http://sociedad.elpais.com/sociedad/2014/05/20/actualidad/1400608401_985898.html
https://www.ub.edu/web/ub/ca/menu_eines/noticies/2014/08/04.html

Revista Ronda Iberia. July 2014

El colesterol y la migración celular
NATIONAL GEOGRAPHIC. Explora Ciencia. Junio 2015.
http://www.nationalgeographic.com.es/ciencia/el-colesterol-y-la-migracion-celular_9295

Microscòpia de superresolució. Més enllà de les lleis de la física
Carles Rentero, Anna Álvarez-Guaita, Meritxell Reverter i Carles Enrich
OMNIS CELLULA (2012) 28, 10-15.

• Offers from the University of Barcelona:

Work UB

• Offers from the Research Group:

A one-year Postdoctoral position is available in the Cell Biology Unit of the Department of Biomedical Sciences, at the University of Barcelona School of Medicine. Please send curriculum vitae to: albertlu@ub.edu. Candidates with training and interest in cell and molecular biology are encouraged to apply as soon as possible.

More information.