Biochemistry and Molecular Biology

Presentation

The unit of Biochemistry and Molecular Biology do teaching in the degrees of Medicine, Biomedical Engineering, Nursing-Clinic and Biomedical Sciences. The subjects of Basic Biochemistry, Molecular Biology, Biochemistry of Systems at the Degree of Medicine, Chemistry and Biochemistry at the degree of Biomedical Engineering, Biochemistry at the Nursing-Clinical Degree and Cell Biology of Pathology an Clinical and Analytical Biochemistry at the Biomedical Sciences degree. The unit also participates in University of Barcelona coordinated and interuniversity master's degrees (Neurosciences, Translational Medicine, Advanced Immunology ...).

Regarding research the unit has different groups with interests in the fields of neuroscience (Neurochemistry, Neuroinflammation, Molecular mechanisms in neurological/neurodegenerative diseases and identification of novel therapeutic targets), Immunology and Hepatic Pathology (Translational Research in New Strategies for Diagnosis and Treatment of Hepatic Disease).

Bedini Chesa, Josep Lluis Assistant medical professor jlbedini@clinic.cat
Cadefau Surroca, Joan Aureli Assistant professor 3P  jcadefau@ub.edu 
De Sousa Valente, Juan Tony Assistant professor 3P valentedesousa@ub.edu 
Jiménez Povedano, Wladimiro Full professor wjimenez@ub.edu 
Malagelada Grau, Cristina Associate professor cristina.malagelada@ub.edu 
Marin Soria, Jose Luis  Assistant medical prof. 1P  JLMARIN@clinic.cat
Martí Puig, Eulàlia  Associate professor eulalia.marti@ub.edu
Martín Andorrà, Margarita
(Head Unit, phone 934024541)
Associated professor martin_andorra@ub.edu 
Mira Vallet, Aurea Assistant professor 1P AMIRA@clinic.cat
Morales Ruiz, Manuel Assistant professor 3P  morales@clinic.cat
Pérez Sisques, Letícia Assistant professor 3P leticiaperezsisques@ub.edu
Pugliese, Marco Assistant professor 3P marcopugliese@ub.edu 
Rodríguez Allue, Manuel José Associate professor marodriguez@ub.edu
Saura Martí, Josep Associate professor josepsaura@ub.edu 
Serrano Candelas, Eva Assistant professor eva.serrano.candelas@ub.edu

Nuevas estrategias Terapeúticas contra la enfermedad del hígado graso no alcohólico y la fibrosis hepática experimental: Nanoparticulas de óxido de cerio y bloqueo de PTTG1 mediante ARNip
By: Sílvia Carvajal Restoy
Directors: Wladimiro Jiménez Povedano and Guillermo Fernández Varo
Doctorate in Translational Medicine
Universitat de Barcelona (2020)

New insights in mast cell function triggered by FcεRI, KIT and MRGPRX2 receptors
By: Arnau Navinés Ferrer
Director: Margarita Martín Andorrà
Universitat de Barcelona (11/2019)

Brain Immune Response as therapeutic target ni the treatment of Parkinson’s disease
By: Neus Rabaneda Lombarte
Directors: Josep Saura Martí (co-directed by Carme Solà Subirana, CSIC)
Universitat de Barcelona (07/2019)

A comprehensive multiomics approach towards understanding obsessive-compulsive disorder

By:  Laura Domenech Salgado
Director: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra (2018)

Prenatal and Postnatal exposure to tobacco smoking and molecular signatures in children
By: Marta Vives Usano
Director: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra (2018)

Evaluation of noncoding RNAs in Parkinson’s disease Center
By: Joan Pallares Albanell
Director: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra (2017)

Cerca i identificació de nous biomarcadors de fibrosi hepàtica per mitjà de tècniques proteòmiques
By: Santiago Marfà Bruix
Director: Wladimiro Jimenez Povedano
Universitat de Barcelona (02/2017)

Deleció condicional de C/EBPβ en cél·lules de la micròglia. Nova eina per a l’estudi i la modulació de l’activació glial en models de neurodegeneració

By: Marta Pulido Salgado

Directors: Josep Saura and Carme Solà

Universitat de Barcelona (2016)

 

Nuevos tratamientos contra la hipertensión portal en la cirrosis hepàtica experimental en la cirrosis experimental: 1/ Nanoparticulas de oxido de cerio y 2/ Agonismo parcial del receptor V1a de la vasopresina
By: Denise Oró Bozzini
Director: Wladimiro Jimenez Povedano
Universitat de Barcelona (10/2016)

La proteïna adaptadora 3BP2 com a regulador de l'activitat cel·lular a través dels receptors de membrana Fcepsilon RI i KIT
By: Erola Ainsua Enrich
Director: Margarita Martín Andorrà
Qualification: Excellent
Universitat de Barcelona (2014)

Activació dels canals KATP com estratègia neuroprotectora pel tractament de malalties autoimmunes desmielinitzants
By: Noemí Virgili Treserres
Directors: Marco Pugliese and Juan F. Espinosa Parrilla
Qualification: Excellent Cum Laude 
Universitat de Barcelona (26.06.2014)

Nuevos mecanismos de regulación hepática mediados por miR-33 y el receptor de las lipoproteínas de baja densidad
By: Montse Pauta Puig
Director: Manuel Morales Ruiz
Facultat de Medicina, Universitat de Barcelona (13/09/2013)

Mecanismes moleculars de secreció miocàrdica: remodelat ventricular and secreció del pèptid natriurètic tipus B
By: Gregori Casals Mercadé
Director: Wladimiro Jimenez Povedano
Universitat de Barcelona (02/2013)

Insight into the Disease Processes of Fragile X Premutation Carriers Associated Pathologies. Expression-profile characerization and identification of a novel pathogenic mechanism
By: Elisabet Mateu Huertas
Director: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra (2013)

Efecte de l’activació del canal K(ATP) al perfil d’expressió microglial durant la neurodegeneració a l’hipocamp de la rata
By: Margot Martínez Moreno
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (05/2013)

C/EBPβ and C/EBPδ in neuroinflammation

By: Marco Straccia
Directors: Josep Saura and Carme Solà
Universitat Autónoma de Barcelona (2012)

Caracterización de la Disfunción vascular sanguínea y linfática en la cirrosis hepática: Evaluación de la inhibición del factor de crecimiento placentario y del óxido nítrico como estrategias terapéuticas
By: Jordi Ribera Sabaté
Director: Manuel Morales Ruiz
Facultat de Medicina, Universitat de Barcelona (28/11/2012)

Desenvolupament d’una teràpia anti-amiloide per a la malaltia d’Alzheimer en el gos amb disfunció cognitiva
By:  Maria Neus Bosch Pont
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (06/2012)

KATP Channel blockade instructs microglia to foster brain repair and neurogenesis after stroke
By: Francisco Javier Ortega González,
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (04/2012)

Prostaglandina E2 en la activación osmótica inducida por manitol en el mastocito
By: Ivonne Marisol Torres
Director: Margarita Martín Andorrà
Qualification obtained: Excellent cum laude
Universitat de Barcelona (2011)

Modulació de l’activació microglial com estratègia neuroreparadora

By: Nuria Gresa Arribas
Directors: Carme Solà and Josep Saura
Universitat de Barcelona (2011)

Characterization of the contribution of small non-coding RNA deregulation to Parkinson’s disease patogénesis
By: Elena Miñones Moyano
Director: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat de Barcelona (2011)

Full characterization of the small RNA transcriptote using novel comptutational methods for hight-throughput sequencing data: study of miRNA variability in eukaryote organsims
By: Lorena del Valle Pantano Rubiño
Director: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra (2011)

Vps13a distribution in the brain of a Huntington’s disease mouse model
By: Maria Carreras Caballé
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2021)

Via NF-kB com a diana terapèutica en els dèficits cognitius de la Malaltia de Huntington associats a astrocitosi reactiva
By: Maria Oliveró Viña
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2021)

Localización tisular y distribución neuronal de la coreína en el cerebro de ratón
By: Nerea Chaparro Cabanillas
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2020)

Targeting microglial TREM2 as an Alzheimer’s disease therapy
By: Júlia Ollé Grau
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2020)

New targets to control KIT-dependent cell signals
By: Óscar Laguía Candelaria
Director: Margarita Martín Andorrà
Universitat de Barcelona (2019)

Glial activation and its mechanism of control in Parkinson's disease
By: Neus Rabaneda Lombarte
Director: Josep Saura Martí
Bachelor's: Medicina, Universitat de Barcelona (2019)

Molecular basis of Huntington's Disease: Susceptibility of Medium Spiny Neurons
By: Anna Pelach Pueyo
Director: Manuel J Rodríguez Allué
Facultat de Farmàcia, Universitat de Barcelona (2019)

MRGPRX2: a new explanation for anaphylactoid reactions to perioperative drugs
By: Sergio Aguilar López
Director: Margarita Martín Andorrà
Universitat de Barcelona (2018)

Experimental Neurotoxic and genetic models of Parkinson’s
By: Josep Garré Cristau
Director: Josep Saura Martí
Bachelor's: Medicina, Universitat de Barcelona (2018)

Estudi de la resposta glial induïda per micropartícules de sílice nanoporoses (II)

By: Paula Carreras Domínguez

Director: Josep Saura Martí

Bachelor's: Biotecnologia, Universitat de Barcelona (2018)

 

Caracterització de cultius de cèl·lules microglia-like a partir de monòcits humans adults

By: Clara Alba Rey

Director: Josep Saura Martí

Bachelor's: Ciències Biomèdiques, Universitat de Barcelona (2018)

 

Natural targets to combat weakness in neuromuscular disease

By: Anna Sanchez Àvila

Director: Josep Saura Martí

Bachelor's: Ciències Biomèdiques, Universitat de Barcelona (2018)

 

T cells: the key to recovery after stroke? A critical Review
By: Míriam Mayor Echave-Sustaeta
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2018)

La esclerosis lateral amiotrófica y sus mecanismos patológicos de agregación proteica
By: Miguel Pérez Nieto
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2018)

Dysregulation of Gene expression deregulation in heart and skeletal muscle of Huntington’s disease induced mice
By: Clara Farrés Álvarez
Director: Eulàlia Martí Puig
Bachelor's de Biologia Humana, Universitat Pompeu Fabra (2018)

New mirnas involved ingastrointestinal stromal tumor cells viability
By: Cindy Gabriela Mancía
Director: Margarita Martín Andorrà
Universitat de Barcelona (2017)

Estudi de la resposta glial induïda per micropartícules de sílice nanoporoses

By: Júlia Sala Jarque

Director: Josep Saura Martí

Bachelor's: Biotecnologia, Universitat de Barcelona (2017)

 

Mechanisms of neuroinflammation in amyotrophic lateral sclerosis (ALS)
By: Nil Albiol Zamora
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2017)

New molecules involved in the signaling of oncogenic receptors KIT and pdgfrα
By: Cristina Belda Marín
Director: Margarita Martín Andorrà
Universitat de Barcelona (2016)

Role of ATP-dependent potassium channels in reactive microglia in amyotrophic lateral sclerosis (ALS)
By: Carolina Roqueta Bachelor's
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2016)

Unravelling non-coding RNA mechanisms in neurodegenerative conditions
By: Clara Domingo Sabugo
Director: Eulàlia Martí Puig
Bachelor's: Ciències Biomèdiques, Universitat de Barcelona (2016)

Novel neuroprotective therapies for multiple sclerosis: an updated review
By: Albert Cortés Bullich
Director: Marco Pugliese
Qualification: 8,9
Universitat de Barcelona (2015-2016)

OMALIZUMAB: Where do we come from? Where are we going?
By: Ignacio Molina Molina
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)

Obtaining a 3BP2 proline rich domain deleted mutant. Implications in ligands binding.
By: Oriol Careta Borrás
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)

ATP-sensitive potassium channel (KATP) and L-type voltage-gated calcium channel (L-VGCC) coupling in BV-2 microglial cells
By: Carla Barona
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2014)

3BP2 adaptor molecule role in Kit oncogènic downregulation in gastrointestinal stromal tumor (GIST) cells. Implications in therapy
By: Ignacio Bon Romero
Director: Margarita Martín Andorrà
Universitat de Barcelona (2014)

La interacció entre Myo1f i 3BP2 en Mastòcits Humans.
By: Cristina Luque Bailén
Director: Margarita Martín Andorrà
Universitat de Barcelona (2014)

Gene expression profile and phenotype characterization of macrophages transformed by liver cancer cells: an approach for modelling tumor-associated macrophages
By: Alejandro Martínez Navarro
Director: Pedro Melgar Lesmes
Qualification: 9.0
Master in Advanced Immunology
Facultat de Medicina i Ciències de la Salut (07/2021)

Approaching the role of chorein in neurons and establishing a cellular model of chorea-acanthocytosis disease
By: Nerea Chaparro Cabanillas
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut (2021)

Cerium Oxide Nanoparticles as a Potential Experimental Treatment for Bleomicyn-Induced Acute Respiratory Distress Syndrome in Rats
By: Alejandro Vidal.
Qualification: 8,40/10
Director: Wladimiro Jiménez
Facultat de Medicina i Ciències de la Salut (2020-2021)

Modulation of macrophages using matrix-embedded endothelial cells to reduce liver fibrosis
By: Laura Piñeiro Alonso
Director: Pedro Melgar Lesmes
Qualification: 8,2
Master in Advanced Immunology
Facultat de Medicina i Ciències de la Salut (09/2020)

Characterization of human microglia-like cells and studies on C/EBP transcription factors 
By: Elia Micoli
Directors: Josep Saura and Enrico Tongiorgi
Master in Neurosciences, University of Trieste (2020)

LNA-CTG administration as a therapeutic approach in Huntington’s disease
By: Maria Solaguren Beascoa
Director: Eulàlia Martí Puig
Universitat de Barcelona (2019)

KARS, a new target in anaphylaxis
By: Pau Ribó Molina
Director: Margarita Martín Andorrà
Universitat de Barcelona (2019)

Human monocyte-derived microglia-like cells: culture characterization and role of C/EBP transcription factors in neuroinflammatory response

By: Andrea Llaves López
Director: Josep Saura Martí

Master of Translational Medicine. Universidad de Barcelona (2019)

 

Potential effect of Cerium Oxide Nanoparticles in an experimental model of NAFLD
By: Shayan Shahbazi Dastjerdeh. Qualification: 8,30/10
Directors: Guillermo Fernández Varo, Gregori Casals and Wladimiro Jiménez
IX Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2018-2019)

MiR-1246 and miR-5100 target MITF and decrease GIST cell viability
By: Cindy Gabriela Mancía
Director: Margarita Martín Andorrà
Universitat de Barcelona (2018)

Targeted matrix metalloproteinase 9 overexpression in macrophages promotes a phenotype switch boosting fibrosis resolution
By: Aureli Luquero Gómez
Directors: Pedro Melgar Lesmes and Wladimiro Jiménez
Qualificació: 8,7 (Matrícula d'honor)
Master of Advanced Immunology, Univ. de Barcelona/Univ.Autònoma de Barcelona (2018)

Distribución de la coreína en el cerebro de ratón
By: Álvaro Llorens Rastrollo
Director: Manuel J Rodríguez Allué
Facultat de Biologia, Universitat de Barcelona (2018)

Selection and validation of novel drugs based on system biology target discovery to ameliorate symptoms in Huntington's disease
By: Esther García García
Director: Manuel J Rodríguez Allué
Facultat de Farmàcia, Universitat de Barcelona (2018)

lInvolvement of small RNAs in the pathophysiology of Huntington’s disease: focus on sCAG species
By: Anna Guisado Corcoll
Director: Eulàlia Martí Puig (co-supervisad amb Dr. Esther Perez-Navarro)

Master in Neurosciences, Univeristat de Barcelona (2018)

New tools for single-cell diagnostic of liver càncer
By: Adriana Mora Barrabés
Directors: Pedro Melgar Lesmes and Wladimiro Jiménez
Qualificació: 7,2
VIII Master of Translational Medicine
MSc-CELLEX, Universitat de Barcelona (2018)

Stimulation of functional liver regeneration in cirrhotic livers through intrahepatic vascular normalization and modulation of Akt targets
By: Raúl del Rey Vergara
Director: Manuel Morales Ruiz
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2018)

Analysis of molecules involved in KIT regulation in a new cellular model for mastocytosis
By: Alexis Eduardo Pérez Paredes
Director: Margarita Martín Andorrà
Universitat de Barcelona (2017)

Microglia-like cells as a neuroinflammation model for Parkinson’s Disease
By: Gerard Aguilar Pérez
Director: Josep Saura Martí

Master of Translational Medicine, Universitat de Barcelona (2017)

 

Long non-coding RNA in Parkinson’s Disease
By: Manisha Arumalla
Director: Eulàlia Martí Puig
Master in Genetics and Genomics, Universitat de Barcelona (2017)

RNA toxicity in Huntington’s disease
By: Cristina Navarrete Hernandez
Director: Eulàlia Martí Puig
Master in Genetics and Genomics, Universitat de Barcelona (2017)

Evaluation of antioxidant and anti-steatotic effects of cerium oxide nanoparticles as promising therapeutic agent in the non-alcoholic fatty liver
By: Marina Parra Robert
Directors: Gregori Casals and Wladimiro Jiménez
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2017)

Effect of cerium oxide nanoparticles on oxidative stress and cellular oxysterols production
By: Núria Massana Martinell
Director: Gregori Casals and Wladimiro Jiménez
Master in Laboratory of Clinical Analysis, Universitat Pompeu Fabra (2017)

Functional Characterization of DDX15 gene deficiency
By: Irene Portolés Plaza
Director: Manuel Morales Ruiz
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2017)

Human microglia-like cells as a neuroinflammation model for Parkinson’s Disease. Characterization of alpha-synuclein effects in human microglia-like cells
By: Carla Belmonte Mateos
Director: Josep Saura Martí

Master of Neurosciences. Universitat de Barcelona (2016)

 

Effects of nanoporous silica particles on glial cells
By: Elisa García Lara
Director: Josep Saura Martí

Master of Translational Medicine. Universitat de Barcelona (2016)

 

Analysis of casein kinase II expression in hepatic stellate cells and its possible role in hepatic inflammation and fibrosis
By: Meritxell Perramón Corominas
Directors: Guillermo Fernández Varo and Wladimiro Jiménez
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2016)

Study of the role of the adaptor protein 3BP2 in k562 cells. A chronic myelogenous leukaemia cellular model
By: Ignacio Bon Romero
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)

Estudio in vitro del Omalizumab (anti-IgE) en Urticaria Crónica
By: Elizabeth Proaño
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)

Preparation of microglia-like cell cultures from human peripheral blood monocytes. Preliminary study of C/EBPβ and C/EBPδ expression

By: Anaïs Marsal Cots

Director: Josep Saura Martí

Master of Neurosciences. Universitat de Barcelona (2015)

 

Analysis of gene expression perturbations in Huntington’s disease models after administration of LNA-oligonucleotides complementary to the CAG repeat.
By: Zeus Aranda Remon
Director: Eulàlia Martí Puig
Master in Biomedical Research, Universitat Pompeu Fabra (2015)

3BP2, KIT and Myo1f in Mast cell migration and activation
By: Arnau Navinés Ferrer
Director: Margarita Martín Andorrà
Universitat de Barcelona (2014)

Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition
By: Blai Morales Romero
Director: Manuel Morales Ruiz
IV Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2014)

Expression and regulation of AVPR2 and AQP-2 genes in Hepatic Stellate Cells (HSCs)
By: Berta Serra Navarro
Directors: Guillermo Fernández Varo and Wladimiro Jiménez
IV Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2014)

Gene expression deregulation induced by locked nucleic acids targeting small CAG-repeated RNAs (LNA-asCAG) in R6/2 mouse model for huntington’s disease
By: Gartze Mentxaca Miranda
Director: Eulàlia Martí Puig
Master in Biomedical Research, Universitat Pompeu Fabra (2014)

Deregulation of non-coding RNAs in Parkinson’s Disease
By: Joan Pallarès Albanell
Director: Eulàlia Martí Puig
Master in Biomedical Research, Universitat Pompeu Fabra (2013) 

Characterization of the pathological role of downstream targets of Akt in liver disease
By: Cristina Alarcón Vila
Director: Manuel Morales Ruiz
III Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2013)

Los factores de transcripción C/EBPs en la EAE, un modelo animal de Esclerosis Múltiple

By: María José Andón

Director: Josep Saura and Tony Valente

Master of Neurosciencies. Universitat de Barcelona (2012)

 

Efecto de un agonista parcial de la vasopresina en la hemodinámica sistémica y la presión portal en ratas con cirrosis y ascitis
By: Silvia Carvajal Restoy
Directors: Guillermo Fernández Varo and Wladimiro Jiménez
II Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2012)

Transduction of dominant-negative soluble PDGFRβ improves hepatic hepatic collagen, systemic hemodynamics and portal pressure in fibrotics rats
By: Denise Oró Bozzini
Directors: Guillermo Fernández Varo and Wladimiro Jiménez
II Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2012)

Generació de ratolins deficients per al factor de transcripció C/EBPβ en cèl·lules de micròglia mitjançant el sistema Cre/LoxP
By: Marta Pulido Salgado

Director: Josep Saura Martí
Master of Biomedicine. Universitat de Barcelona (2011)

Cerium Oxide Nanoparticles as a Potential Experimental Treatment for Bleomicyn-Induced Acute Respiratory Distress Syndrome in Rats
Per: Alejandro Vidal. Nota: 8,40/10
Director: Wladimiro Jiménez
Facultat de Medicina i Ciències de la Salut (2020-2021)

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