Signal transduction, cell cycle and cancer (Autophagy in health and disease). PI: Caroline Mauvezin

Caroline Mauvezin
PhD, Junior Group Leader
R2A researcher
caroline.mauvezin@ub.edu

Marta Garcia Cajide
Research assistant
mgarciac@ub.edu

Jordi Greoles Cano
Medical student
jordi.greoles@gmail.com

Mireia Bosch Calvet
Master's student
mboschca127@alumnes.ub.edu

Beatriz Garcia Monleón
Master's student
bgarcimo23@alumnes.ub.edu

I aim to guide young scientists to become independent thinkers and experts in cell biology and molecular biology techniques, as well as to master organization skills to efficiently work in the lab setting.

Every person, students, postdoc or technicians, joining the laboratory will be asked to acknowledge certain lines of conduct:

Be transparent: no one is perfect, everyone makes mistakes. If that happens, the best way you can deal with it is to be transparent and honest and report it so that results will be interpreted accordingly. We need to work in an atmosphere where we can trust and support each other.

Be independent: my goal is that everyone in the lab can “fly with their own wings”. After a supervised learning phase, you will be expected to be proactive and take responsibility for your research project. Project designing and sculpting will be done together, but you are expected to be the driving force for the advancement of the research.

Be a team player: although the lab members do not have to be your friends, and are definitely not your family, they are your teammates and each lab member is expected to treat others the way they want to be treated.

Those lines of conduct are designed to create a positive atmosphere in the lab, to nurture creativity and support enthusiasm and motivation for biomedical research.

Study of novel biomarkers for CIN-targeted breast cancer therapy (calibrate)

ReferèReferencencia: LABAE222994MAUV
Funding: AECC Scientific Foundation
Affiliate Institution: Universitat de Barcelona
From 01/12/2022 to 30/11/2025
PI: Caroline Mauvezin     

Estudio de la función de la autofagia en mitosis y su rol en la prevención de la inestabilidad cromosómica para el desarrollo de nuevas terapias contra el cáncer

Reference: PID2020-118768RJ-I00
Funding: Ministerio de Economía y Competitividad (MINECO-JIN)
Affiliate Institution: Universitat de Barcelona
From 01/11/2021 to 31/10/2024
PI: Caroline Mauvezin       

Identification of compounds for skin depigmentation based on modulation of autophagy

Reference: PID2020-118768RJ-I00
Funding: Bella Aurora Labs. S.A     
From 15/12/2021 to 15/08/2022
PI: Caroline Mauvezin

Identification of compounds for skin depigmentation based on modulation of autophagy

Reference: PID2020-118768RJ-I00
Funding: Bella Aurora Labs. S.A
From 02/10/2020 to 02/02/2021                           
PI: Albert Tauler and Caroline Mauvezin

For more information on the group's PI publications, visit the following links:

ORCID: 0000-0003-4220-7272

ResearcherID: B-5803-2016

Scopus: 35105510700

Carles Pons, Caroline Mauvezin. QATS: an ImageJ plugin for the quantification of toroidal nuclei in biological images. Bioinformatics, Volume 40, Issue 1, January 19, 2024, btae026. doi.org/10.1093/bioinformatics/btae026.

Almacellas E, Mauvezin C. Emerging roles of mitotic autophagy. J Cell Sci. 2022 Jun 1;135 (11): jcs255802. doi: 10.1242/ jcs.255802. Epub 2022 Jun 10. PMID: 35686549

Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of nuclear biomarkers for chromosomal instability. Methods Mol Biol. 2022;2445:117-125. doi: 10.1007/978-1-0716-2071-7_8. PMID: 34972989

Almacellas E, Garcia-Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells. Methods Mol Biol. 2022;2445:127-137. doi: 10.1007/978-1-0716-2071-7_9. PMID: 34972990

Klionsky D. et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi:10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability. Autophagy. 2021 Mar;17(3):796-813. doi: 10.1080/15548627.2020.1764727. Epub 2020 Jun 23. PMID: 32573315

Pelletier J, Riaño-Canalias F, Almacellas E, Mauvezin C, Samino S, Feu S, Menoyo S, Domostegui A, Garcia-Cajide M, Salazar R, Cortés C, Marcos R, Tauler A, Yanes O, Agell N, Kozma SC, Gentilella A, Thomas G. Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage. EMBO J. 2020 Jul 1;39(13):e103838. doi: 10.15252/embj.2019103838. Epub 2020 Jun 2. PMID: 32484960

Almacellas E, Pelletier J, Manzano A, Gentilella A, Ambrosio S, Mauvezin C, Tauler A. Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1. iScience. 2019 Oct 25;20:434-448. doi: 10.1016/j.isci.2019.09.040. Epub 2019 Oct 1. PMID: 31627130

Lőrincz P, Mauvezin C, Juhász G. Exploring autophagy in Drosophila. Cells. 2017 Jul 12;6(3):22. doi: 10.3390/cells6030022. PMID: 28704946

Mauvezin C, Neufeld TP. Autophagosomes take the Klp98-A train. Small GTPases. 2017 Jan 2;8(1):16-19. doi: 10.1080/21541248.2016.1184776. Epub 2016 May 4. PMID: 27142690

Klionsky D. et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi:10.1080/15548627.2015.1100356. PMID: 26799652

Mauvezin C, Neisch AL, Ayala CI, Kim J, Beltrame A, Braden CR, Gardner MK, Hays TS, Neufeld TP. Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila. J Cell Sci. 2016 Mar 1;129(5):971-82. doi: 10.1242/jcs.175224. Epub 2016 Jan 13. PMID: 26763909

Mauvezin C, Neufeld TP. Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion. Autophagy. 2015;11(8):1437-8. doi: 10.1080/15548627.2015.1066957. PMID: 26156798
Mauvezin C, Nagy P, Juhász G, Neufeld TP. Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015 May 11;6:7007. doi: 10.1038/ncomms8007. PMID: 25959678

Mauvezin C, Ayala C, Braden CR, Kim J, Neufeld TP. Assays to monitor autophagy in Drosophila. Methods. 2014 Jun 15;68(1):134-9. doi: 10.1016/j.ymeth.2014.03.014. Epub 2014 Mar 22. PMID: 24667416

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