Signal transduction, cell cycle and cancer (Autophagy in health and disease). PI: Caroline Mauvezin
Our laboratory stands at the interface of two prominent fields in cancer research, autophagy and cell division. We are interested in understanding the role of autophagy and lysosomes in cell cycle progression and in defining how this degradative process contributes to the maintenance of genomic stability.
KEYWORDS: Autophagy, cancer, chromosomal instability, cell cycle, lysosome biology.
Informative video: What if cells don’t divide correctly? The role of autophagy and lysosomes
Caroline Mauvezin
PhD, Junior Group Leader
R2A researcher
caroline.mauvezin@ub.edu
Marta Garcia Cajide
Research assistant
mgarciac@ub.edu
Jordi Greoles Cano
Medical student
jordi.greoles@gmail.com
Mireia Bosch Calvet
Master's student
mboschca127@alumnes.ub.edu
Beatriz Garcia Monleón
Master's student
bgarcimo23@alumnes.ub.edu
- Identification of the mechanisms by which autophagy protects against chromosomal instability in cancer cells.
- Promotion of the toroidal nucleus as useful biomarker of chromosomal instability.
I aim to guide young scientists to become independent thinkers and experts in cell biology and molecular biology techniques, as well as to master organization skills to efficiently work in the lab setting.
Every person, students, postdoc or technicians, joining the laboratory will be asked to acknowledge certain lines of conduct:
Be transparent: no one is perfect, everyone makes mistakes. If that happens, the best way you can deal with it is to be transparent and honest and report it so that results will be interpreted accordingly. We need to work in an atmosphere where we can trust and support each other.
Be independent: my goal is that everyone in the lab can “fly with their own wings”. After a supervised learning phase, you will be expected to be proactive and take responsibility for your research project. Project designing and sculpting will be done together, but you are expected to be the driving force for the advancement of the research.
Be a team player: although the lab members do not have to be your friends, and are definitely not your family, they are your teammates and each lab member is expected to treat others the way they want to be treated.
Those lines of conduct are designed to create a positive atmosphere in the lab, to nurture creativity and support enthusiasm and motivation for biomedical research.
Study of novel biomarkers for CIN-targeted breast cancer therapy (calibrate)
ReferèReferencencia: LABAE222994MAUV
Funding: AECC Scientific Foundation
Affiliate Institution: Universitat de Barcelona
From 01/12/2022 to 30/11/2025
PI: Caroline Mauvezin
Estudio de la función de la autofagia en mitosis y su rol en la prevención de la inestabilidad cromosómica para el desarrollo de nuevas terapias contra el cáncer
Reference: PID2020-118768RJ-I00
Funding: Ministerio de Economía y Competitividad (MINECO-JIN)
Affiliate Institution: Universitat de Barcelona
From 01/11/2021 to 31/10/2024
PI: Caroline Mauvezin
Identification of compounds for skin depigmentation based on modulation of autophagy
Reference: PID2020-118768RJ-I00
Funding: Bella Aurora Labs. S.A
From 15/12/2021 to 15/08/2022
PI: Caroline Mauvezin
Identification of compounds for skin depigmentation based on modulation of autophagy
Reference: PID2020-118768RJ-I00
Funding: Bella Aurora Labs. S.A
From 02/10/2020 to 02/02/2021
PI: Albert Tauler and Caroline Mauvezin
For more information on the group's PI publications, visit the following links:
ORCID: 0000-0003-4220-7272
ResearcherID: B-5803-2016
Scopus: 35105510700
Almacellas E, Mauvezin C. Emerging roles of mitotic autophagy. J Cell Sci. 2022 Jun 1;135 (11): jcs255802. doi: 10.1242/ jcs.255802. Epub 2022 Jun 10. PMID: 35686549
Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of nuclear biomarkers for chromosomal instability. Methods Mol Biol. 2022;2445:117-125. doi: 10.1007/978-1-0716-2071-7_8. PMID: 34972989
Almacellas E, Garcia-Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells. Methods Mol Biol. 2022;2445:127-137. doi: 10.1007/978-1-0716-2071-7_9. PMID: 34972990
Klionsky D. et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi:10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751
Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability. Autophagy. 2021 Mar;17(3):796-813. doi: 10.1080/15548627.2020.1764727. Epub 2020 Jun 23. PMID: 32573315
Pelletier J, Riaño-Canalias F, Almacellas E, Mauvezin C, Samino S, Feu S, Menoyo S, Domostegui A, Garcia-Cajide M, Salazar R, Cortés C, Marcos R, Tauler A, Yanes O, Agell N, Kozma SC, Gentilella A, Thomas G. Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage. EMBO J. 2020 Jul 1;39(13):e103838. doi: 10.15252/embj.2019103838. Epub 2020 Jun 2. PMID: 32484960
Almacellas E, Pelletier J, Manzano A, Gentilella A, Ambrosio S, Mauvezin C, Tauler A. Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1. iScience. 2019 Oct 25;20:434-448. doi: 10.1016/j.isci.2019.09.040. Epub 2019 Oct 1. PMID: 31627130
Lőrincz P, Mauvezin C, Juhász G. Exploring autophagy in Drosophila. Cells. 2017 Jul 12;6(3):22. doi: 10.3390/cells6030022. PMID: 28704946
Mauvezin C, Neufeld TP. Autophagosomes take the Klp98-A train. Small GTPases. 2017 Jan 2;8(1):16-19. doi: 10.1080/21541248.2016.1184776. Epub 2016 May 4. PMID: 27142690
Klionsky D. et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi:10.1080/15548627.2015.1100356. PMID: 26799652
Mauvezin C, Neisch AL, Ayala CI, Kim J, Beltrame A, Braden CR, Gardner MK, Hays TS, Neufeld TP. Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila. J Cell Sci. 2016 Mar 1;129(5):971-82. doi: 10.1242/jcs.175224. Epub 2016 Jan 13. PMID: 26763909
Mauvezin C, Neufeld TP. Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion. Autophagy. 2015;11(8):1437-8. doi: 10.1080/15548627.2015.1066957. PMID: 26156798
Mauvezin C, Ayala C, Braden CR, Kim J, Neufeld TP. Assays to monitor autophagy in Drosophila. Methods. 2014 Jun 15;68(1):134-9. doi: 10.1016/j.ymeth.2014.03.014. Epub 2014 Mar 22. PMID: 24667416
Mauvezin C, Nagy P, Juhász G, Neufeld TP. Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015 May 11;6:7007. doi: 10.1038/ncomms8007. PMID: 25959678
Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, Díaz-Ramos A, Hernández-Alvarez MI, Sebastián D, Mauvezin C, Palacín M, Zorzano A. Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J. 2013 Aug 28;32(17):2348-61. doi: 10.1038/emboj.2013.168. Epub 2013 Aug 6. PMID: 23921556
Mauvezin C, Sancho A, Ivanova S, Palacin M, Zorzano A. DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus. FEBS Lett. 2012 Sep 21;586(19):3179-86. doi: 10.1016/j.febslet.2012.06.032. Epub 2012 Jun 29. PMID: 22750142
Sancho A, Duran J, García-España A, Mauvezin C, Alemu EA, Lamark T, Macias MJ, DeSalle R, Royo M, Sala D, Chicote JU, Palacín M, Johansen T, Zorzano A. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. PLoS One. 2012;7(3): e34034. doi: 10.1371/ journal.pone.0034034. Epub 2012 Mar 28. PMID: 22470510
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