Neurochemistry. PI: Manuel J. Rodríguez Allué


The Group of Neurochemistry has conducted research into simplified models of neurodegeneration of the CNS to better understand the cellular and molecular mechanisms underlying neurodegenerative processes in humans. During the last years we have focused our research in the study of the neuroinflammatory processes and synaptic plasticity impairment associated with movement disorders.

Further details can be reached at our webpage:


Manuel J Rodríguez Allué
PhD, Associate professor


Esther García García
Doctorate student


Carmen Andrade López
Laboratory technician


Nerea Chaparro Cabanillas
Master student

  • Role of microglia in the synaptic dysfunction processes present in Huntington's disease.

  • Study of the VPS13a protein function in basal ganglia neurons and its relevance in the movement disorders.

  • Non-invasive dynamic neural control by laser-based technology

PI: Merce Masana Nadal
European Union
2020 -2022

  • Training European teachers to integrate health in the school day

PI: Manuel J. Rodríguez Allué

  • Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis

PI: Jordi Alberch Vie, Manuel J Rodríguez Allué and Merce Masana Nadal
Fundació ChAC

  • Modulación de la dinámica de las redes neuronales como estrategia terapéutica para recuperar la disfunción de los ganglios basales en las enfermedades del movimiento

PI: Jordi Alberch Vie and Manuel J Rodríguez Allué
2018- 2020

For more information for PI publications click in the link:

Pérez-Sisqués L, Martín-Flores N, Masana M, Solana-Balaguer J, Llobet A, Romaní-Aumedes J, Canal M, Campoy-Campos G, García-García E, Sánchez-Fernández N, Fernández-García S, Gilbert JP, Rodríguez MJ, Man HY, Feinstein E, Williamson DL, Soto D, Gasull X, Alberch J, Malagelada C. RTP801 regulates motor cortex synaptic transmission and learning. (2021) Exp Neurol 342:113755. PMID: 33984337

Ding K, Yang J, Chin M, Sullivan L, Demirhan G, Violant-Holz V, Uvinha RR, Dai J, Xu X, Popeska B, Mladenova Z, Khan W, Kuan G, Balasekaran G, Smith GA on behalf of Global Community Health–COVID-19 Collaborative Research Team. Mental health among adults during the COVID-19 pandemic lockdown: A cross-sectional multi-country comparison. (2021). Int J Environ Res Public Health 18: 2686. PMID: 33800008

Violant-Holz V, Gallego-Jiménez MG, González-González CS, Muñoz-Violant S, Rodríguez MJ, Sansano-Nadal O, Guerra-Balic M. Psychological health and physical activity levels during the COVID-19 pandemic. A systematic review. (2020) Int J Environ Res Public Health 17: 9419. PMID: 33334073

Kim A, García-García E, Straccia M, Comella-Bolla A, Miguez A, Masana M, Alberch J, Canals JM, Rodríguez MJ. Reduced fractalkine levels lead to striatal synaptic plasticity deficits in Huntington's disease. Front Cell Neurosci. Jun 18;14:163. doi: 10.3389/ fncel.2020.00163. eCollection (2020). IF: 3,921. PMID: 32625064

Fernández-García S, Orlandi JG, García-Díaz Barriga GA, Rodríguez MJ, Masana M, Soriano J, Alberch J. Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease. BMC Biology 18:58. BMC Biol 18:58 (2020). (2020). IF: 6,723. PMID 32466798

Fernández-García S, Conde-Berriozabal S, García-García E Gort-Paniello C, Bernal-Casas D, García-Díaz Barriga G, López-Gil J, Muñoz-Moreno E, Sòria G, Campa L, Artigas , Rodriguez, MJ, Alberch J, Masana M. M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s Disease. doi: 10.7554/eLife.57017 (2020). IF: 6,830. PMID: 33016873

Vidal-Taboada JM, Pugliese M, Salvadó M, Gámez J, Mahy N, Rodríguez MJ. (2018). KATP Channel Expression and Genetic Polymorphisms Associated with Progression and Survival in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2018 Oct; 55(10): 7962-7972. doi: 10.1007/ s12035-018-0970-7. Epub 2018 Feb 28. IF: 4,586. PMID: 29492846

Rodriguez MJ, Mahy N. Neuron-microglia interactions in motor neuron degeneration. The inflammatory hypothesis in amyotrophic lateral sclerosis revisited. (2016) Curr Med Chem 23:4753-4772. IF: 3,249. PMID: 27881068

Martinez-Moreno M, Vidal-Taboada JM, Ortega FJ, Batlle M,  Mahy N, Rodriguez MJ. Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus” (2016) Neurosciece 333:229-243. IF: 3,277. doi: 10.1016/j.neuroscience.2016.07.032. Epub 2016 Jul 25. PMID: 27471195

Espinosa-Parrilla J, Pugliese M, Mahy N, Rodríguez MJ. Neuroprotection: A new therapeutic approach of relapsing remitting multiple sclerosis, cap 13 en Trending topics in Multiple sclerosis; p. 307-328. Ed. González-Quevedo A. (2016) InTech, Rijeka. ISBN 978-953-51-4678-0

Vidal-Taboada JM, López-López A, Salvado M, Lorenzo L, García C, Mahy N, Rodriguez MJ, Gámez J. UNC13A confers risk for sporadic ALS and influences survival in a Spanish cohort. J Neurol. 2015 Oct; 262(10): 2285-92. doi: 10.1007/ s00415-015-7843-z. Epub 2015 Jul 11. PMID: 26162714, IF: 3,408

Batlle M, Ferri L, Andrade C, Ortega J, Vidal-Taboada JM, Pugliese M, Mahy N, and Rodríguez MJ. Astroglia-microglia crosstalk during neurodegeneration in the rat hippocampus. Biomed Res Int. 2015; 2015: 102419. doi: 10.1155/ 2015/102419. Epub 2015 Apr 21. PMID: 25977914. IF: 2,134

Espinosa-Parrilla JF, Martínez-Moreno M, Gasull X, Mahy N, and Rodríguez MJ. The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity. Mol Cell Neurosci. 2015 Jan;64: 104-15. doi: 10.1016/ j.mcn.2014.12. 004. Epub 2014 Dec 12. PMID: 25497271. IF: 3.597

Bosch MN, Pugliese M, Andrade C, Gimeno-Bayón J, Mahy N, and Rodríguez MJ. Aβ immunotherapy reduces amyloid plaques and astroglial reaction in aged domestic dogs. Neurodegener Dis. 2015; 15(1): 24-37. doi: 10.1159/ 000368672. Epub 2014 Dec 20. PMID: 25531153. IF: 2.937

Virgili N, Mancera P, Chanvillard C, Wegner A, Wappenhans B, Rodríguez MJ, Infante-Duarte C,  Espinosa-Parrilla JF, Pugliese M. Diazoxide attenuates autoimmune encephalomyelitis and modulates lymphocyte proliferation and dendritic cell functionality. J Neuroimmune Pharmacol. 2014 Sep; 9(4): 558-68. doi: 10.1007/ s11481-014- 9551-3. Epub 2014 Jun 18. PMID: 24939091. IF: 4,110

López-López A, Gámez J, Syriani E, Morales M, Salvado M, Rodríguez MJ, Mahy N, and Vidal-Taboada JM. CX3CR is a modifying gene of survival and progression in Amyotrophic Lateral Sclerosis. PLoS One. 2014; 9(5): e96528. Published online 2014 May 7. doi: 10.1371/ journal.pone.0096528. PMID: 4013026. IF: 3,234

Gimeno-Bayón J, López-López A, Rodríguez MJ, and Mahy N. Glucose pathways adaptation supports acquisition of activated microglia phenotype. J Neurosci Res. 2014 Jun; 92(6): 723-31. doi: 10.1002/ jnr.23356. Epub 2014 Feb 7. PMID: 24510633. IF: 2,594

Ortega FJ, Vukovic J, Rodríguez MJ, and Bartlett PF. Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells. Glia. 2014 Feb; 62(2): 247-58. doi: 10.1002/ glia.22603. Epub 2013 Dec 6. PMID: 24311472. IF: 6,031

Rodríguez MJ, Martínez-Moreno, M, Ortega FJ, and Mahy N. Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue. Oxid Med Cell Longev. 2013; 2013:194546. doi: 10.1155/ 2013/ 194546. Epub 2013 Jun 16. PMID:23844272. IF: 3,363

Ortega FJ, Jolkkonen J, and Rodríguez MJ. Microglia is an active player in how glibenclamide improves stroke outcome. J Cereb Blood Flow Metab. 2013 Jul; 33(7): 1138–1139. Published online 2013 May 1. doi: 10.1038/ jcbfm.2013.72. PMID: 3705445. IF: 5,339

Bosch MN, Gimeno-Bayón J, Rodríguez MJ, Pugliese M, and Mahy N. Rapid improvement of canine cognitive dysfunction with immunotherapy designed for Alzheimer's disease. Curr Alzheimer Res. 2013 Jun; 10(5): 482-93. PMID: 23566345. IF: 3,796

Ortega FJ, Jolkkonen J, Mahy N, and Rodríguez MJ. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2013 Mar; 33(3): 356-64. doi: 10.1038/ jcbfm.2012.166. Epub 2012 Nov 14. PMID: 23149556. IF: 5,339

Ortega FJ, Gimeno-Bayon J, Espinosa-Parrilla JF, Carrasco JL, Batlle M, Pugliese M, Mahy N, and Rodríguez MJ. ATP-depenent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats. Exp Neurol. 2012 May; 235(1): 282-96. doi: 10.1016/ j.expneurol.2012.02. 010. Epub 2012 Feb 24. PMID: 22387180. IF: 4,645.

Djazouli-Alim FZ, Rodríguez MJ, Lebaili N, Andrade C and Mahy N. Adaptation of Camelus dromedarius pars nervosa of the hypophysis to winter and summer living conditions. Folia Histochem Cytobiol. 2012 Jul 4;50(2): 203-12. PMID: 22763958. IF: 1,101

Bosch MN, Pugliese M, Gimeno-Bayón J, Rodríguez MJ, Mahy N. Dogs with cognitive dysfunction syndrome: a natural model of alzheimer’s disease. Curr Alzheimer Res. 2012 Mar; 9(3): 298-314. PMID: 21875411. IF: 3,676

Ortega FJ, Vidal-Taboada JM, Mahy N, Rodríguez MJ. Molecular mechanisms of acute brain injury and ensuing neurodegeneration, Cap 7 en Brain Damage - Bridging between basic research and clinics; p. 163-186. Ed. González-Quevedo A. (2012) InTech, Rijeka. ISBN 979-953-307-461-9. DOI: 10.5772/37401

Virgili N, Espinosa-Parrilla JF, Mancera P, Pasten-Zamorano A, Gimeno-Bayón J, Rodríguez MJ, Mahy N, Pugliese M. Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis. J Neuroinflammation. 2011 Nov 2; 8:149. doi: 10.1186/ 1742-2094-8-149. PMID: 22047130. IF: 3,827

Gonzalo-Ruiz A, Delso M, Carrero I, Gonzalo-Vicente P, Sanz-Anquela JM, Rodríguez MJ, Arévalo-Serrano J. A rat model of oligomeric forms of beta-amyloid (Aß) peptide: neuronal loss, synaptic alteration, astrogliosis, and calcium-binding proteins activation in vivo. European Journal of anatomy, ISSN-e 1136-4890, Vol. 15, Nº. 1, 2011, pàg. 47-72.

Vidal-Taboada JM, Mahy N, Rodríguez MJ. Microglia, calcification and Neurodegenerative Diseases, Cap 13 en Neurodegenerative Diseases – Processes, Prevention, Protection and Monitoring; p. 301-322. Ed. Chuen-Chung Chang. (2011) InTech, Rijeka. ISBN 979-953-307-041-3

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