Investigación traslacional en nuevas estrategias de diagnóstico y tratamiento de la enfermedad hepática. IP: Wladimiro Jimenez

Wladimiro Jimenez
PhD Profesor Catedrático de Universidad
wjimenez@ub.edu

Manuel Morales Ruiz
PhD Profesor Asociado
morales@clinic.cat

Guillermo Fernández Varo
PhD Investigador CIBERehd
guillermo.fernandez@ciberehd.org

Jordi Ribera Sabaté
PhD Investigador CIBERehd
jordi.ribera@ciberehd.org

Gregori Casals Mercadal
PhD Especialista Senior, Hospital Clínic
casals@clinic.cat

Esther Fernández Galán
Especialista, Hospital Clínic
esfernandez@clinic.cat

Marina Parra Robert
Especialista, Hospital Clínic
mparra@clinic.cat

Pedro Melgar Lesmes
PhD Investigador Postdoctoral Ramon y Cajal
pmelgar@ub.edu

Carmen Belén González
Técnica de Laboratorio, IDIBAPS
cbgonzalez@clinic.cat

Alazne Moreno Lanceta

Investigadora Becaria FPI, IDIBAPS
amorenol@clinic.cat

Mirieia Medrano Bosch
Becaria predoctoral FPU
mmedranobosch@ub.edu

Elena Lecue Costas
Investigadora Predoctoral, IDIBAPS
elecuecostas@gmail.com

Meritxell Perramon Corominas
Investigadora Predoctoral, IDIBAPS
meri.perramon@gmail.com

• Identificación de biomarcadores no invasivos de lesión hepática y de nuevas vías de señalización de procesos fibroproliferatius hepáticos.
• Evaluación de nuevas estrategias para inhibir la actividad hapatocitaria de FoxO1 o para modificar la actividad de dianas específicas de Akt que tienen un potencial terapéutico para estimular la regeneración hepática funcional en hígados cirróticos.
• Establecer nuevas terapias para la normalización de la vasculatura intrahepática en hígados cirróticos.
• Evaluar el potencial terapéutico de las nanopartículas de óxido de cerio en modelos experimentales de hepatocarcinoma y esteatosis hepática.
• Evaluar la utilidad de los implantes matriciales de colágeno que contiene células endoteliales como terapia celular para estimular la capacidad regenerativa de los hígados cirróticos.
• Modulación de los macrófagos al daño hepático, regeneración y cáncer mediante nanopartículas funcionalizadas y terapia génica.

• Incorporación de la espectrometría de masas en las pruebas de endocrinología y nutrición

  IP: Gregori Casals
  Entidad financiadora: Sociedad Española de Endocrinología y Nutrición
  Ref.: Investigación Clínica en Endocrinología General y Metabolismo
  Importe: 10.000,00 €
  15/10/21 a 15/10/22

  Effect of long term administration of a specific cb2 agonist on hepatic collagen content in rats with fibrosis

  IP:Wladimiro Jiménez Povedano
  Entidad financiadora: ABALON BIO INC.
  2021

  Effect of a new formulation of human serum albumin on systemic hemodynamics, inflammatory mediators and oxidative stress in rats with cirrhosis and ascites

  IP: Wladimiro Jiménez Povedano
  Entidad financiadora: European Foundation for the Study of Chronic Liver Failure
  09/05/2016 continua en vigor

  THERANANO: Determining the therapeutic use in liver diseases of advanced antioxidant conjugates based on cerium oxide nanoparticles

  IPs: Gregori Casals Mercadal i Guillermo Fernández Varo
  Entidad financiadora: Instituto de Salud Carlos III
  Ref: PI19-00774
  Importe: 147.620 €
  01/01/2020 a 31/12/2022

  Identification of  novel serological biomarkers pf liver fibrosis resolution in rats with CCl4 Induced fibrosis

  IP:Wladimiro Jiménez Povedano
  Entidad financiadoraa: Nordic Bioscience
  2021

  Utilidad terapeutica y de nuevos tratamientos para las enfermedades hepáticas. RNA de interferencia para PTTG1. Nanoparticulas de carbono grafito y donadores de óxido nítrico

  IP: Wladimiro Jiménez Povedano
  Entidad financiadoraa: Ministerio de Ciencia, Innovación y Universidades
  Ref.: RTI2018-094734-B-C21
  Importe: 190.000 €
  04/10/2016 a 31/12/2021

  Effect of a new CD6-Derived peptide (SEP3) on systemic  hemodynamics in endotexemic rats induced by lipopolysaccharide (LPS) administration

  IP:Wladimiro Jiménez Povedano
  Entidad financiadora: Sepsia Therapeutics SL
  2020-2021

  Development and application of ceria nanoparticles in the treatment of hepatocellular carcinoma

  IP: Wladimiro Jiménez Povedano
  Entidad financiadora: Agència de gestió d’ajuts universitaris i de recerca. Ayudas de industria de Conocimiento (Llavor i Producte)
  Ref.: 2018_PROD_00187
  Importe: 41.850 €
  01/05/2019 a 31/01/2021

  Nuevos mecanismos moleculares y nuevas estrategias terapéuticas aplicables a la conservación de la función hepática y a la mejora de la enfermedad hepática crónica

  IP: Manuel Morales-Ruiz
  Entidad financiadora: Agencia Estatal de Investigación, Ministerio de Ciencia  Innovación
  Ref.: PID2019-105502RB-100
  01/01/2019-31/12/2020

  Ceria nanoparticles for use in the treatment of hepatocellular carcinoma

  IPs: Wladimiro Jimenez Povedano y Victor Franco Puntes.
  Entidad financiadora: CERCA-GINJOL
  Ref.: 2017-02-002-CeNPsHCC-IDIBAPS
  01/01/2017 a 31/12/2019

  Evaluación de las propiedades antioxidantes y antiinflamatorias de las nanopartículas de óxido de cerio como nueva estrategia terapéutica en la esteatosis hepática

  IP: Gregori Casals Mercadal
  Entidad financiadora: Instituto de Salud Carlos III
  Ref.: PI15/00777
  Importe: 56.265 €
  01/01/2016 a 31/12/2018

  Utilidad terapéutica de las nanopartículas de óxido de cerio en las enfermedades hepáticas

  IPs: Wladimiro Jiménez Povedano y Guillermo Fernández Varo
  Entidad financiadora: Ministerio de Economía y Competitividad
  Ref.: SAF2015-64126-R
  Importe: 180.000 €
  01/01/2016 a 31/12/2018

  Utilitat terapèutica de les nanopartícules d’óxid de ceri en la malaltia hepàtica

  IP: Wladimiro Jiménez Povedano
  Entidad financiadora: PERIS
  Ref.: 2016-2020 SLT002/16/0034
  01/04/2017 a 31/08/2018

Para más información sobre las publicaciones del IP del grupo pueden visitar el siguiente enlace:

ORCID Wladimiro Jimenez: 0000-0002-9376-0214
ORCID Manuel Morales: 0000-0002-9074-2272
ORCID Gregori Casals: 0000-0002-3271-1371
ORCID Pedro Melgar: 0000-0002-2009-5911
ORCID Guillermo Fernandez-Varo: 0000-0002-7776-3300

 

Fernández-Galán E, Badenas C, Fondevila C, Jiménez W, Navasa M, Puig-Butillé JA, Brunet M. Monitoring of Donor-Derived Cell-Free DNA by Short Tandem Repeats: Concentration of Total Cell-Free DNA and Fragment Size for Acute Rejection Risk Assessment in Liver Transplantation. Liver Transpl. 2022 Feb; 28(2): 257-268. doi: 10.1002/ lt.26272. Epub 2021 Oct 4. PMID: 34407295

Meritxell Perramón, Silvia Carvajal, Vedrana Reichenbach, Guillermo Fernández-Varo, Loreto Boix Laura Macias-Muñoz, Pedro Melgar-Lesmes,| Jordi Bruix, Shlomo Melmed, Santiago Lamas, Wladimiro Jiménez. The pituitary tumor‐transforming gene 1 / delta like homolog 1 pathway plays a key role in liver fibrogenesis Liver International Wiley. Liver int. 2022 Jan 20. doi: 10.1111/liv.15165. Online ahead of print. PMID: 35050550

Juanola A, Graupera I, Elia C, Piano S, Solé C, Carol M, Pérez-Guasch M, Bassegoda O, Escudé L, Rubio AB, Cervera M, Napoleone L, Avitabile E, Ma AT, Fabrellas N, Pose E, Morales-Ruiz M, Jiménez W, Torres F, Crespo G, Solà E, Ginès P. Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis. J Hepatol. 2022 Jan; 76(1): 107-114. doi: 10.1016/ j.jhep.2021.08.031. Epub 2021 Sep 13. PMID: 34530063

García-Eguren G, González-Ramírez M, Vizán P, Giró O, Vega-Beyhart A, Boswell L, Mora M, Halperin I, Carmona F, Gracia M, Casals G, Squarcia M, Enseñat J, Vidal O, Di Croce L, Hanzu FA. Glucocorticoid-induced Fingerprints on Visceral Adipose Tissue Transcriptome and Epigenome. J Clin Endocrinol Metab. 2022 Jan 1;107(1):150-166. doi: 10.1210/clinem/dgab662. PMID: 34487152

Ribera J, Portolés I, Córdoba-Jover B, Rodríguez-Vita J, Casals G, González-de la Presa B, Graupera M, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernández-Checa JC, Soria G, Tudela R, Esteve-Codina A, Espadas G, Sabidó E, Jiménez W, Sessa WC, Morales-Ruiz M. The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice. Commun Biol. 2021 Oct 15; 4(1): 1192. doi: 10.1038/ s42003-021-02722-w. PMID: 34654883

Zeng M, Shu Y, Parra-Robert M, Desai D, Zhou H, Li Q, Rong Z, Karaman DŞ, Yang H, Peng J, Fernandez-Varo G, Jiménez W, Casals G, Puntes V, Rosenholm JM, Casals E. Scalable synthesis of multicomponent multifunctional inorganic core@mesoporous silica shell nanocomposites. Mater Sci Eng C Mater Biol Appl. 2021 Sep; 128: 112272. doi: 10.1016/ j.msec.2021.112272. Epub 2021 Jun 24. PMID: 34474831

Guerra Ruiz, Armando Raúl, Crespo, Javier, López Martínez, Rosa Maria, Iruzubieta, Paula, Casals Mercadal, Gregori, Lalana Garcés, Marta, Lavin, Bernardo and Morales Ruiz, Manuel. Measurement and clinical usefulness of bilirubin in liver disease. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, vol. 2, no. 3, 2021, pp. 352-361.

Vega-Beyhart A, Iruarrizaga M, Pané A, García-Eguren G, Giró O, Boswell L, Aranda G, Flores V, Casals G, Alonso C, Mora M, Halperin I, Carmona F, Enseñat J, Vidal O, Hu T, Rojo G, Gomis R, Hanzu FA. Endogenous cortisol excess confers a unique lipid signature and metabolic network. J Mol Med (Berl). 2021 Aug;99(8): 1085-1099. doi: 10.1007/ s00109-021-02076-0. Epub 2021 Apr 21. PMID: 33881561.

Medrano-Bosch M, Moreno-Lanceta A, Melgar-Lesmes P. Nanoparticles to Target and Treat Macrophages: The Ockham's Concept? Pharmaceutics. 2021 Aug 26; 13(9):1340. doi: 10.3390/ pharmaceutics13091340. PMID: 34575416 

Parra-Robert M, Zeng M, Shu Y, Fernández-Varo G, Perramón M, Desai D, Chen J, Guo D, Zhang X, Morales-Ruiz M, Rosenholm JM, Jiménez W, Puntes V, Casals E, Casals G. Mesoporous silica coated CeO2 nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats. Nanoscale. 2021 May 14; 13(18): 8452-8466. doi: 10.1039/ d1nr00790d. Epub 2021 Apr 14. PMID: 33984104

Wijngaard R, Perramón M, Parra-Robert M, Hidalgo S, Butrico G, Morales-Ruiz M, Zeng M, Casals E, Jiménez W, Fernández-Varo G, Shulman GI, Cline GW, Casals G. Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate / Acetoacetate in Biological Samples. Int J Mol Sci. 2021 Apr 30; 22(9). doi: 10.3390/ ijms22094752. PMID: 33946157

Ribera J, Vilches C, Sanz V, de Miguel I, Portolés I, Córdoba-Jover B, Prat E, Nunes V, Jiménez W, Quidant R, Morales-Ruiz M. Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia. ACS Nano. 2021 Apr 27; 15(4): 7547-7562. doi: 10.1021/ acsnano.1c00988. Epub 2021 Mar 15. PMID: 33720693. 

Casals G, Perramón M, Casals E, Portolés I, Fernández-Varo G, Morales-Ruiz M, Puntes V, Jiménez W. Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases. Antioxidants (Basel). 2021 Apr 24; 10(5). doi: 10.3390/ antiox10050660. Review. PMID: 33923136

Araujo-Castro M, Valderrábano P, Escobar-Morreale HF, Hanzu FA, Casals G. Urine steroid profile as a new promising tool for the evaluation of adrenal tumors. Literature review. Endocrine. 2021 Apr; 72(1):40-48. doi: 10.1007 /s12020-020-02544-6. Epub 2020 Nov 21. PMID: 33219921.

Guerra-Ruiz, Armando R., Casals, Gregori, Iruzubieta, Paula, Lalana, Marta, Leis, Alba, López, Rosa María, Crespo, Javier and Morales-Ruiz, Manuel. Biochemical assessment of metabolic associated fatty liver disease. 2021 March. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, vol. 2, no. 2, 2021, pp. 199-208. doi; 10.1515/almed-2021-0009.

Macias-Muñoz L, Wijngaard R, González-de la Presa B, Bedini JL, Morales-Ruiz M, Jiménez W. Value of clinical laboratory test for early prediction of mortality in patients with COVID-19: the BGM score. J Circ Biomark. 2021 Feb 8; 10:1-8. doi: 10.33393/ jcb.2021.2194. eCollection Jan-Dec 2021. PMID: 33717357

Leitner S, Solans C, García-Celma MJ, Morral-Ruíz G, Melgar-Lesmes P, Calderó G. Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms. Mater Sci Eng C Mater Biol Appl. 2021 Jan; 120:111682. doi: 10.1016  /j.msec.2020.111682. Epub 2020 Oct 27. PMID: 33545844 

Fernández-Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, Oller L, Macías-Muñoz L, Marfà S, Casals G, Morales-Ruiz M, Casado P, Cutillas PR, Bruix J, Navasa M, Fuster J, Garcia-Valdecasas JC, Pavel MC, Puntes V, Jiménez W. Bespoken Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma. Hepatology. 2020 Oct; 72(4): 1267-1282. doi: 10.1002/ hep.31139. PMID: 31961955

Bosch X, Jáuregui B, Villamor N, Morales-Ruiz M, Ortiz-Pérez JT, Borràs R, Penela D, Soto-Iglesias D, Perea RJ, Doltra A, Prat-González S, Jiménez W, Mira Á, Lasalvia L, Berruezo A. Monocyte Subsets Are Differently Associated with Infarct Size, Left Ventricular Function, and the Formation of a Potentially Arrhythmogenic Scar in Patients with Acute Myocardial Infarction. J Cardiovasc Transl Res. 2020 Oct; 13(5): 722-730. doi: 10.1007/ s12265-019- 09944-8. Epub 2019 Dec 12. PMID: 31833003 

Moreno-Lanceta A, Medrano-Bosch M, Melgar-Lesmes P.. Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer. Pharmaceutics. 2020 Sep 7;12(9):850. doi: 10.3390/ pharmaceutics12090850. PMID: 32906852 

Casals G, Hanzu FA. Cortisol Measurements in Cushing's Syndrome: Immunoassay or Mass Spectrometry? Ann Lab Med. 2020 Jul; 40(4): 285-296. doi: 10.3343/ alm.2020.40.4.285. PMID: 32067427

Casals E, Zeng M, Parra-Robert M, Fernández-Varo G, Morales-Ruiz M, Jiménez W, Puntes V, Casals G. Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration. Small. 2020 May; 16(20) :e1907322. doi: 10.1002/ smll.201907322. Epub 2020 Apr 24. Review. PMID: 32329572

Jáuregui B, Soto-Iglesias D, Penela D, Acosta J, Fernández-Armenta J, Linhart M, Terés C, Syrovnev V, Zaraket F, Hervàs V, Prat-González S, Perea RJ, Morales-Ruiz M, Jiménez W, Lasalvia L, Bosch X, Ortiz-Pérez JT, Berruezo A. Follow-Up After Myocardial Infarction to Explore the Stability of Arrhythmogenic Substrate: The Footprint Study. JACC Clin Electrophysiol. 2020 Feb; 6(2): 207-218. doi: 10.1016/ j.jacep.2019.10.002. Epub 2019 Nov 27. PMID: 32081225.

Carvajal S, Perramón M, Casals G, Oró D, Ribera J, Morales-Ruiz M, Casals E, Casado P, Melgar-Lesmes P, Fernández-Varo G, Cutillas P, Puntes V, Jiménez W. Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes. Int J Mol Sci. 2019 Nov 27; 20(23). doi: 10.3390 /ijms20235959. PMID: 31783479

Córdoba-Jover B, Arce-Cerezo A, Ribera J, Pauta M, Oró D, Casals G, Fernández-Varo G, Casals E, Puntes V, Jiménez W, Morales-Ruiz M. Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats. J Nanobiotechnology. 2019 Oct 31; 17(1): 112. doi: 10.1186/ s12951- 019-0544-5. PMID: 31672158

Melgar-Lesmes P, Perramon M, Jiménez W. Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis. Cells. 2019 Oct 24; 8(11). doi: 10.3390/cells8111311. Review. PMID: 31653030

Carvajal S, Perramón M, Oró D, Casals E, Fernández-Varo G, Casals G, Parra M, González de la Presa B, Ribera J, Pastor Ó, Morales-Ruíz M, Puntes V, Jiménez W. Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease. Sci Rep. 2019 Sep 6; 9(1): 12848. doi: 10.1038/ s41598-019-49262-2. PMID: 31492960

Parra-Robert M, Casals E, Massana N, Zeng M, Perramón M, Fernández-Varo G, Morales-Ruiz M, Puntes V, Jiménez W, Casals G. Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis. Biomolecules. 2019 Aug 29; 9(9). doi: 10.3390 /biom9090425. PMID: 31470518

Huelin P, Solà E, Elia C, Solé C, Risso A, Moreira R, Carol M, Fabrellas N, Bassegoda O, Juanola A, de Prada G, Albertos S, Piano S, Graupera I, Ariza X, Napoleone L, Pose E, Filella X, Morales-Ruiz M, Rios J, Fernández J, Jiménez W, Poch E, Torres F, Ginès P. Neutrophil Gelatinase-Associated Lipocalin for Assessment of Acute Kidney Injury in Cirrhosis: A Prospective Study. Hepatology. 2019 Jul; 70(1): 319-333. doi: 10.1002/ hep.30592. Epub 2019 Apr 25. PMID: 30810244.

Solé C, Solà E, Huelin P, Carol M, Moreira R, Cereijo U, Mas JM, Graupera I, Pose E, Napoleone L, dePrada G, Juanola A, Fabrellas N, Torres F, Morales-Ruiz M, Farrés J, Jiménez W, Ginès P. Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival. Liver Int. 2019 Jul; 39(7): 1246-1255. doi: 10.1111/ liv.14037. Epub 2019 Feb 17. PubMed PMID: 30597709

Ribera J, Rodríguez-Vita J, Cordoba B, Portolés I, Casals G, Casals E, Jiménez W, Puntes V, Morales-Ruiz M. Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats. PLoS One. 2019 Jun 24; 14(6): e0218716. doi: 10.1371/ journal.pone.0218716. eCollection 2019. PMID: 31233564 

Lopez-Moya M, Melgar-Lesmes P, Kolandaivelu K, de la Torre Hernández JM, Edelman ER, Balcells M.Tweaking glutaraldehyde-fixed tissue heart valves with chondroitin sulfate hydrogel for endothelialization and shield against deterioration. Biomacromolecules. 2018 Apr 9;19(4):1234-1244. doi: 10.1021/ acs.biomac.8b00077. Epub 2018 Mar 20. PMID: 29539266

Lopez-Moya M, Melgar-Lesmes P, Kolandaivelu K, de la Torre Hernández JM, Edelman ER, Balcells M. Optimizing Glutaraldehyde-Fixed Tissue Heart Valves with Chondroitin Sulfate Hydrogel for Endothelialization and Shielding against Deterioration. Biomacromolecules. 2018 Apr 9;19(4): 1234-1244. doi: 10.1021/ acs.biomac. 8b00077. Epub 2018 Mar 20. PMID: 29539266

Auge JM, Rodriguez C, Espanyol O, Rivero L, Sandalinas S, Grau J, Jimenez W, Castells A. An evaluation of the SENTiFIT 270 analyser for quantitation of faecal haemoglobin in the investigation of patients with suspected colorectal cancer. Clin Chem Lab Med. 2018 Mar 28; 56(4): 625-633. doi: 10.1515/cclm- 2017-0605. PMID: 29150989

Aranda G, Fernandez-Ruiz R, Palomo M, Romo M, Mora M, Halperin I, Casals G, Enseñat J, Vidal O, Diaz-Ricart M, Hanzu FA. Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing syndrome after remission. Clin Endocrinol (Oxf). 2018 Mar; 88(3):415-424. doi: 10.1111/ cen.13521. Epub 2017 Dec 17. PMID: 29154455

Miró Ò, González de la Presa B, Herrero-Puente P, Fernández Bonifacio R, Möckel M, Mueller C, Casals G, Sandalinas S, Llorens P, Martín-Sánchez FJ, Jacob J, Bedini JL, Gil V. The GALA study: relationship between galectin-3 serum levels and short- and long-term outcomes of patients with acute heart failure. Biomarkers. 2017 Dec; 22(8): 731-739. doi: 10.1080/1354750X. 2017.1319421. Epub 2017 May 2. PMID: 28406038

Ribera J, Pauta M, Melgar-Lesmes P, Córdoba B, Bosch A, Calvo M, Rodrigo-Torres D, Sancho-Bru P, Mira A, Jiménez W, Morales-Ruiz M. A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5): G492-G504. doi: 10.1152/ ajpgi.00428. 2016. Epub 2017 Aug 10. PMID: 28798084

Aranda G, Lopez C, Fernandez-Ruiz R, Esteban Y, Garcia-Eguren G, Mora M, Halperin I, Casals G, Enseñat J, Hanzu FA. Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers. Int J Endocrinol. 2017; 2017: 2912763. doi: 10.1155/ 2017/2912763. Epub 2017 Sep 20. PMID: 29213284

Casals E, Gusta MF, Piella J, Casals G, Jiménez W, Puntes V. Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide. Front Immunol. 2017 Aug 14;8:970. doi: 10.3389/ fimmu. 2017.00970. eCollection 2017. Review. Erratum in: Front Immunol. 2017 Dec 22;8:1891. PMID: 28855907

Garcia-Polite F, Martorell J, Del Rey-Puech P, Melgar-Lesmes P, O'Brien CC, Roquer J, Ois A, Principe A, Edelman ER, Balcells M. Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium. J Cereb Blood Flow Metab. 2017 Jul; 37(7): 2614-2625. doi: 10.1177/ 0271678X16672482. Epub 2016 Jan 1. PMID: 27702879

Melgar-Lesmes P, Balcells M, Edelman ER. Implantation of healthy matrix-embedded endothelial cells rescues dysfunctional endothelium and ischaemic tissue in liver engraftment. Gut. 2017 Jul; 66(7): 1297-1305. doi: 10.1136/ gutjnl- 2015-310409. Epub 2016 Feb 5. PMID: 26851165

Pericàs JM, García-de-la-Mària C, Brunet M, Armero Y, García-González J, Casals G, Almela M, Quintana E, Falces C, Ninot S, Fuster D, Llopis J, Marco F, Moreno A, Miró JM; Hospital Clinic Endocarditis Study Group. Early in vitro development of daptomycin non-susceptibility in high-level aminoglycoside-resistant Enterococcus faecalis predicts the efficacy of the combination of high-dose daptomycin plus ampicillin in an in vivo model of experimental endocarditis. J. Antimicrob Chemother. 2017 Jun 1;72(6): 1714-1722. doi: 10.1093 /jac/dkx016. PMID: 28204495

Graupera I, Coll M, Pose E, Elia C, Piano S, Solà E, Blaya D, Huelin P, Solé C, Moreira R, de Prada G, Fabrellas N, Juanola A, Morales-Ruiz M, Sancho-Bru P, Villanueva C, Ginès P. Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes. Sci Rep. 2017 May 12;7(1): 1829. doi: 10.1038/ s41598-017-01709-0. PMID: 28500294

Solà E, Sanchez-Cabús S, Rodriguez E, Elia C, Cela R, Moreira R, Pose E, Sánchez-Delgado J, Cañete N, Morales-Ruiz M, Campos F, Balust J, Guevara M, García-Valdecasas JC, Ginès P. Effects of alfapump™ system on kidney and circulatory function in patients with cirrhosis and refractory ascites. Liver Transpl. 2017 May; 23(5): 583-593. doi: 10.1002/ lt.24763. PMID: 28318147

Soto M, Sampietro-Colom L, Lasalvia L, Mira A, Jiménez W, Navasa M. Cost-effectiveness of enhanced liver fibrosis test to assess liver fibrosis in chronic hepatitis C virus and alcoholic liver disease patients. World Journal of Gastroenterology, 2017 May 7;23(17): 3163-3173. doi: 10.3748/ wjg.v23.i17.3163. PMID. 28533673

Penela D, Acosta J, Andreu D, Ortiz-Perez JT, Bosch X, Perea RJ, de Caralt TM, Fernández-Armenta J, Soto-Iglesias D, Prat-Gonzalez S, Borràs R, Mont L, Hervas V, Morales-Ruiz M, Jiménez W, Mira A, Donnelly J, Ekinci O, Lasalvia L, Berruezo A. Identification of the potentially arrhythmogenic substrate in the acute phase of ST-segment elevation myocardial infarction. Heart Rhythm. 2017 Apr; 14(4): 592-598. doi: 10.1016/j.hrthm. 2017.01.019. Epub 2017 Jan 17. PMID: 28104481

Sans-Roselló J, Casals G, Rossello X, González de la Presa B, Vila M, Duran-Cambra A, Morales-Ruiz M, Ferrero-Gregori A, Jiménez W, Sionis A. Prognostic value of plasma apelin concentrations at admission in patients with ST-segment elevation acute myocardial infarction. Clin Biochem. 2017 Apr; 50(6): 279-284. doi: 10.1016/ j.clinbiochem. 2016.11.018. Epub 2016 Nov 24. PMID: 27889567

Reyes A, Marti J, Marfà S, Jiménez W, Reichenbach V, Pelegrina A, Fondevila C, Garcia Valdecasas JC, Fuster J. Prognostic prediction by liver tissue proteomic profiling in patients with colorectal liver metastases. Future Oncol. 2017 Apr; 13(10): 875-882. doi: 10.2217/ fon-2016-0461. Epub 2017 Jan 16.

Morales-Ruiz M, Santel A, Ribera J, Jiménez W. The Role of Akt in Chronic Liver Disease and Liver Regeneration. Semin Liver Dis. 2017 Feb; 37(1): 11-16. doi: 10.1055/ s-0036- 1597819. Epub 2017 Feb 15. PMID: 28201844

Escoté X, Aranda GB, Mora M, Casals G, Enseñat J, Vidal O, Esteban Y, Halperin I, Hanzu FA. Zinc alpha-2 glycoprotein is overproduced in Cushing's syndrome. Endocrinol Diabetes Nutr. 2017 Jan; 64(1):26-33. doi: 10.1016/ j.endinu. 2016.10.002. Epub 2017 Jan 18. English, Spanish. PMID: 28440767

Solà E, Kerbert AJ, Verspaget HW, Moreira R, Pose E, Ruiz P, Cela R, Morales-Ruiz M, López E, Graupera I, Solé C, Huelin P, Navarro AA, Ariza X, Jalan R, Fabrellas N, Benten D, de Prada G, Durand F, Jimenez W, van der Reijden JJ, Fernandez J, van Hoek B, Coenraad MJ, Ginès P. Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis. J Hepatol. 2016 Nov; 65(5):914-920. doi: 10.1016 /j.jhep. 2016.07.003. Epub 2016 Jul 12. PMID: 27422752

Perea RJ, Morales-Ruiz M, Ortiz-Perez JT, Bosch X, Andreu D, Borras R, Acosta J, Penela D, Prat-González S, de Caralt TM, Martínez M, Morales-Romero B, Lasalvia L, Donnelly J, Jiménez W, Mira A, Mont L, Berruezo A. Utility of galectin-3 in predicting post-infarct remodeling after acute myocardial infarction based on extracellular volume fraction mapping. Int J Cardiol. 2016 Nov 15;223:458-464. doi: 10.1016/j.ijcard.2016.08.070. Epub 2016 Aug 8. PMID: 27544605

Marfà S, Marti J, Reyes A, Casals G, Fernández-Varo G, Carvajal S, García-Valdecasas JC, Fuster J, Jiménez W. Metastatic Tissue Proteomic Profiling Predicts 5-Year Outcomes in Patients with Colorectal Liver Metastases. Transl Oncol. 2016 Oct; 9(5): 445-452. doi: 10.1016/ j.tranon. 2016.08.002. PMID: 27751349

Aranda G, Careaga M, Hanzu FA, Patrascioiu I, Ríos P, Mora M, Morales-Romero B, Jiménez W, Halperin I, Casals G. Accuracy of immunoassay and mass spectrometry urinary free cortisol in the diagnosis of Cushing's syndrome. Pituitary 2016 Oct; 19(5): 496-502. doi: 10.1007/ s11102-016-0730-5. PMID: 27259502

Solé C, Solà E, Morales-Ruiz M, Fernàndez G, Huelin P, Graupera I, Moreira R, de Prada G, Ariza X, Pose E, Fabrellas N, Kalko SG, Jiménez W, Ginès P. Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis. Sci Rep. 2016 Aug 31; 6:32341. doi: 10.1038/srep32341. PMID: 27578545

X.Ariza, I.Graupera, M.Coll, R.Barreto, E.García, R. Moreira, C.Elia, M.Morales-Ruiz,, M.Llopis, P.Huelin, C.Solé, N.Fabrellas, E.Weiss, F.Nevens, A.Gerbes, J.Trebicka, F.Saliba, C.Fondevila, V.Hernández-Gea, J.Fernández, W.Jiménez, C.Deulofeu, M.Pavesi, P.Angeli, R.Jalan, R.Moreau, M.Bernardi, V.Arroyo, P.Sancho-Bru, and P.Ginès. Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis. Journal Hepatology, 2016 Jul; 65(1): 57-65. doi:   10.1016/ j.jhep.2016.03.002. PMID: 26988732

G.Crespo, M.Gambato, O.Millán, G.Casals, P.Ruiz, M.C.Londoño, A.Mira, X.Forns, M.Brunet, W.Jimenez, M.Navasa. Early non-invasive selection of patients at high risk of severe hepatitis C recurrence after liver transplantation. Transplant Infectious Disease, 2016 Jun;18(3):471-9. doi: 10.1111/tid.12526. PMID: 26992003

Crespo G, Gambato M, Millán O, Casals G, Ruiz P, Londoño MC, Mira A, Forns X, Brunet M, Jiménez W, Navasa M. Early non-invasive selection of patients at high risk of severe hepatitis C recurrence after liver transplantation. Transpl Infect Dis. 2016 Jun; 18(3): 471-9. doi: 10.1111/ tid.12526. Epub 2016 May 30. PMID: 26992003

Graupera I, Solà E, Fabrellas N, Moreira R, Solé C, Huelin P, de la Prada G, Pose E, Ariza X, Risso A, Albertos S, Morales-Ruiz M, Jiménez W, Ginès P. Urine Monocyte Chemoattractant Protein-1 Is an Independent Predictive Factor of Hospital Readmission and Survival in Cirrhosis. PLoS One. 2016 Jun 30;11(6): e0157371. doi: 10.1371/ journal.pone. 0157371. PMID: 27359339

Marfà S, Morales-Ruiz M, Oró D, Ribera J, Fernández-Varo G, Jiménez W. Sipa1l1 is an early biomarker of liver fibrosis in CCl4-treated rats. Biol Open. 2016 Jun 15; 5(6): 858-65. doi: 10.1242/ bio.018887. PMID: 27230648

M.Pauta, N.Rotllan, A. Fernandez-Hernando, C. Langhi, J.Ribera, L.Boix, J.Bruix, W.Jiménez, Y.Suarez, D.A.Ford, A.Baldan, M.Birnbaum, M.Morales-Ruiz, C.Fernandez-Hernando. Akt-mediated FoxO1 inhibition is required for liver regeneration after partial hepatectomy in mice. Hepatology, 2016 May; 63(5):1660-74.  doi: 10.1002/hep.28286. PMC: 5177729

Oró D, Yudina T, Fernández-Varo G, Casals E, Reichenbach V, Casals G, González de la Presa B, Sandalinas S, Carvajal S, Puntes V, Jiménez W. Cerium oxide nanoparticles reduce steatosis, portal hypertension and display antiinflammatory properties in rats with liver fibrosis. Journal Hepatology , 2016 Mar; 64(3):691-8. doi: 10.1016/ j.jhep. 2015.10.020. Epub 2015 Oct 28. PMID: 26519601

G.Fernández-Varo, D.Oró, E.E.Cable, V. Reichenbach, S. Carvajal, B. González de la Presa, K. Wiśniewski, P. Ginés, G. Harris, W. Jiménez. Vasopressin 1α receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats. Hepatology, 2016 Jan; 63(1):207-16. doi: 10.1002/ hep.28250. Epub 2015 Nov 4. PMID: 26403564

Auge JM, Fraser CG, Rodriguez C, Roset A, Lopez-Ceron M, Grau J, Castells A,  Jimenez W. Clinical utility of one versus two faecal immunochemical test samples in the detection of advanced colorectal neoplasia in symptomatic patients. Clin Chem Med Lab, 2016 Jan; 54(1): 125-32. doi: 10.1515/ cclm-2015-0388. PMID: 26124057

Melgar-Lesmes P,  Edelman ER. Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse. J Hepatol. 2015 Oct; 63(4): 917-25. doi: 10.1016 /j.jhep.2015.05.011. Epub 2015 May 27. PMID: 26022689

Ariza X, Solà E, Elia C, Barreto R, Moreira R, Morales-Ruiz M, Graupera I, Rodríguez E, Huelin P, Solé C, Fernández J, Jiménez W, Arroyo V, Ginès P. Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis. PLoS One. 2015, Jun 4;10(6):e0128145. doi: 10.1371/ journal.pone. 0128145. PMID: 26042740

Pauta M, Ribera J, Melgar-Lesmes P, Casals G, Rodríguez-Vita J, Reichenbach V, Fernandez-Varo G, Morales-Romero B, Bataller R, Michelena J, Altamirano J, Jiménez W, Morales-Ruiz M. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. Liver International. 2015 Apr; 35(4): 1383-92. doi: 10.1111/ liv.12505. Epub 2014 Mar 11. PMID: 24612347

Fabregat A,  Marcos J,  Ventura R, Casals G, Jimenez W, Reichenbach V, Segura J, Pozo OJ. Formation of Δ(1) and Δ(6) testosterone metabolites by human hepatocytes. Steroids 2015 Mar; 95:66-72. doi: 10.1016/ j.steroids.2014.12.006. Epub 2014 Dec 23. PMID: 25541059

Marfà S, Crespo G, Reichenbach V, Forns X, Casals G, Morales-Ruiz M, Navasa M, Jiménez W. Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease. PLoS One. 2014 Oct 2;9(10): e109254. doi: 10.1371/ journal.pone.0109254. eCollection 2014. PMID: 25275549

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A; 2014 Sep 2; 111(35): 12865-70. doi: 10.1073/ pnas.1408472111. Epub 2014 Aug 18. PMID: 25136137

Auge JM, Pellise M, Escudero JM, Hernandez C, Andreu M, Grau J, Buron A, López-Cerón M, Bessa X, Serradesanferm A, Piracés M, Macià F, Guayta R, Filella X, Molina R, Jimenez W, Castells A. Risk stratification for advanced colorectal neoplasia according to fecal hemoglobin concentration in a colorectal cancer screening program. Gastroenterology 2014 Sep; 147(3): 628-636.e1. doi: 10.1053/ j.gastro.2014.06.008. Epub 2014 Jun 14. PMID: 24937264

Filella X, Foj L, Alcover J, Augé JM, Molina R, Jiménez W. The influence of prostate volume in prostate health index performance in patients with total PSA lower than 10μg/L. Clin Chim Acta. 2014 Sep 25; 436:303-7. doi: 10.1016/ j.cca.2014.06.019. Epub 2014 Jun 27. PMID: 24978824

Foj L, Milà M, Mengual L, Luque P, Alcaraz A, Jiménez W, Filella X. Real-time PCR PCA3 assay is a useful test measured in urine to improve prostate cancer detection. Clin Chim Acta. 2014 Aug 5; 435:53-8. doi: 10.1016/ j.cca.2014.04.025. Epub 2014 May 5. PMID: 24803095

Barreto R, Elia C, Solà E, Moreira R, Ariza X, Rodríguez E, Graupera I, Alfaro I, Morales-Ruiz M, Poch E, Guevara M, Fernández J, Jiménez W,  Arroyo V, Ginès P. Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections. J Hepatol. 2014 Jul; 61(1):35-42. doi: 10.1016/ j.jhep.2014.02.023. Epub 2014 Mar 5. PMID: 24613364

Casals G,  Oscar J.M., Pozo J., Alcaraz J, Martínez de Osaba MJ,  Jiménez W. Microwave-assisted derivatization: application to steroid profiling by gas chromatography/mass spectrometry. J Chromatography B 2014 Jun 1;960: 8-13. doi: 10.1016/ j.jchromb. 2014.04.015. Epub 2014 Apr 13. PMID: 24780701

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