Plasticidad neuronal en enfermedades neurodegenerativas. IP: Jordi Alberch Vié

Jordi Alberch Vié
Professor Catedràtic d’Universitat
alberch@ub.edu

Mercè Masana Nadal
Profesora Lectora
mmasana@ub.edu

Sara Fernández García
Becaria Pre-doctoral
sarafernandez@ub.edu

Ened Rodríguez Urgelles
Investigadora Pre-doctoral
enedrodriguez@ub.edu

Alfonso Gerardo García Diaz-Barriga
Investigadora Pre-doctoral
gerardogarcia@ub.edu

• Implicación del sistema BDNF/TrkB/p75 en los mecanismos de plasticidad neuronal en la enfermedad de Huntington.
• Control del balance excitador/inhibidor de las redes neuronales corticales y estriatales y su implicación en los procesos neurodegenerativos.
• Estudio de optogenética para valorar la afectación de la vía directa e indirecta en los ganglios basales en la coordinación motora alterada en la enfermedad de Huntington.
• Identificación de nuevos fármacos que recuperen la conectividad funcional (glutamato-dopamina-acetilcolina-gaba) de los circuitos neuronales los ganglios basales.

• Identificar los mecanismos convergentes activados por la huntingtina mutada y la falta de VPS13A responsables de la neurodegeneraciónselectiva de las neuronas estriatales par

Referencia del proyecto: PID2020-119386RB-I00
Investigador principal: Jordi Alberch Vié / Manuel J. Rodríguez Allué
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: Ministerio de Ciencia e Innovación (NBME)
Duración: 01/09/2021 - 31/08/2024
Financiación recibida: euros

• Una finestra al Cervell

Premis Barcelona 2020
Investigador principal: Jordi Alberch Vié
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: Ajuntament de Barcelona
Duración: 01/02/2021 - 31/12/2021
Financiación recibida: euros

• Modulación de la Dinámica de las Redes Neuronales como Estrategia Terpeutica para Recuperar la Disfunción de los Ganglios Basales enlas Enfermedades del Movimiento

Referencia del proyecto: SAF2017-88076-R
Investigador principal: Jordi Alberch Vié
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: Ministerio de Economía y Competitividad
Duración: 1/1/2018 - 31/12/2020
Financiación recibida: 326.700 euros

• Modulación de la plasticidad sináptica como estrategia terapéutica en la enfermedad de Huntington

Referencia del proyecto: SAF2014-57160-R
Investigador principal: Jordi Alberch Vié / Cristina Malagelada Grau
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: Ministerio de Economía y Competitividad
Duración: 1/1/2015 - 31/12/2017
Financiación recibida: 270.000 euros

• Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine (MESO_BRAIN)

Referencia del proyecto: 713140
Investigador principal: Jordi Soriano Fradera
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: HORIZON 2020. PILLAR 1-EXCELLENT SCIENCE. FET. Future and Emerging Technologies.
Duración: 1/1/2016 - 31/12/2019
Financiación recibida:  466.236 euros

• European Training Network for Cell-Based Regenerative Medicine (Training4CRM)

Referencia del proyecto: 722779
Investigador principal: Jordi Alberch Vié / Josep M Canals
Entidad de afiliación: Universidad de Barcelona
Entidad financiadora: HORIZON 2020. PILLAR 1-EXCELLENT SCIENCE. MCA. Marie Sklodowska-Curie Actions.
Duración: 1/1/2016 - 31/12/2020
Financiación recibida: 247.872 euros

• Enfermedades neurodegenerativas: enfermedad de Huntington

Referencia del proyecto: CIBER en enfermedades neurodegenerativas (CIBERNED)
Investigador principal: Jordi Alberch Vié
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: Instituto de Salud Carlos III
Duración: 2006 - 2019
Financiación recibida: 672.683 euros

• Fisiopatología y Tratamiento de las enfermedades neurodegenerativas

Referencia del proyecto: 2014 SGR 968
Investigador principal: Jordi Alberch Vié
Entidad de afiliación: Universitat de Barcelona
Entidad financiadora: Generalitat de Catalunya
Duración: 2014 - 2016
Financiación recibida: 30.000 euros

• Red temática de terapia celular

Referència del projecte: RD06/0010/0006
Investigador principal: Josep Maria Canals Coll
Entidad de afiliación: Instituto de Investigaciones Biomédicas August i Pi Sunyer (IDIBAPS)
Entidad financiadora: Instituto de Salud Carlos III
Duración: 2007-2017
Financiación recibida: 408.000 euros

• Modulation of synaptic plasticity deficits as therapeutic strategy in Huntington’s disease

Investigador Principal: Jordi Alberch Vié / Isabel Pérez Otaño
Entitat d’afiliació: Universitat de Barcelona
Entidad financiadora: Fundació La Marató de TV3
Duración: 2015 - 2017
Financiación recibida: 299.375 euros

 

Contratos, méritos tecnológicos o de transferencia

• Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis

Investigador responsable: Jordi Alberch Vié
Entidad financiadora: Fundación ChAc
Referencia: 309965
Duración: 2018 - 2020
Financiación recibida: 25.677 euros

• Desarrollo experimental del tratamiento con AAT-1 como terapia antiinflamatoria en la isquemia neonatal (el Estudio A) y Ensayo de la AAT-1 en la lesión aguda de la médula espinal

Investigador responsable: Jordi Alberch Vié
Entidad financiadora/s: Instituto Grifols, S.A
Referencia: 307272                                                               
Duración: 2013 - 2018
Financiación recibida: 52.973 euros

Para más información sobre las publicaciones del IP del grupo pueden visitar el siguiente enlace:
ORCID: https://orcid.org/0000-0002-8684-2721
ResearcherID: http://www.researcherid.com/rid/K-5702-2014
Scopus Author ID: https://www.scopus.com/authid/detail.uri?authorId=7003644890

 

Pérez-Sisqués, L.; Solana-Balaguer, J.; Campoy-Campos, G.; Martín-Flores, N.; Sancho-Balsells, A.; Vives-Isern, M.; Soler-Palazón, F.; Garcia-Forn, M.; Masana, M.; Alberch, J.; Pérez-Navarro, E.; Giralt, A.; Malagelada, C. Rtp801/redd1 is involved in neuroinflammation and modulates cognitive dysfunction in huntingtons disease. Biomolecules 2021 Dec 27; 12(1): 34. doi: 10.3390/ biom12010034. PMID: 35053183

García‐García, E.; Chaparro‐Cabanillas, N.; Coll‐Manzano, A.; Carreras‐Caballé, M.; Giralt, A.; Del Toro, D.; Alberch, J.; Masana, M.; Rodríguez, M.J. Unraveling the spatiotemporal distribution of VPS13A in the mouse brain. Int J Mol Sci. 2021 Dec 1; 22(23): 13018. doi: 10.3390/ ijms222313018. PMID: 34884823

Pérez-Sisqués, L.; Martín-Flores, N.; Masana, M.; Solana-Balaguer, J.; Llobet, A.; Romaní-Aumedes, J.; Canal, M.; Campoy-Campos, G.; García-García, E.; Sánchez-Fernández, N.; Fernández-García, S.; Gilbert, J.P.; Rodríguez, M.J.; Man, H.Y.; Feinstein, E.; Williamson, D.L.; Soto, D.; Gasull, X.; Alberch, J.; Malagelada, C. RTP801 regulates motor cortex synaptic transmission and learning. Exp Neurol. 2021 Aug;342: 113755. doi: 10.1016/ j.expneurol. 2021.113755. Epub 2021 May 11. PMID: 33984337

Pérez-Sisqués, L.; Sancho-Balsells, A.; Solana-Balaguer, J.; Campoy-Campos, G.; Vives-Isern, M.; Soler-Palazón, F.; Anglada-Huguet, M.; López-Toledano, MÁ.; Mandelkow, EM.; Alberch, J.; Giralt, A.; Malagelada, C. RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease. Cell Death Dis. 2021 Jun 15; 12(6): 616. doi: 10.1038/ s41419-021-03899-y. PMID: 34131105

Masana, M.; Rodriguez M.J.; Alberch, J. Proceedings of the tenth international meeting on neuroacanthocytosis syndromes. Tremor Other Hyperkinet Mov (NY) 2021 May 21; 11:19. doi: 10.5334/ tohm.622. PMID: 34046249

Fernández-García S, Conde-Berriozábal S, García-García E, Gort-Paniello C, Bernal-Casas D, García-Díaz Barriga G, López-Gil J, Muñoz-Moreno E, Sòria G, Campa L, Artigas F, Rodríguez-Allué MJ, Alberch J and Masana M. M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's Disease. Elife. 2020 Oct 5; 9:e57017. doi: 10.7554/ eLife.57017. PMID: 33016873

Vidal-Sancho, L.; Fernández-García, S.; Solés-Tarrés, I.; Alberch, J.; Xifró, X. Decreased Myocyte Enhancer Factor 2 Levels in the Hippocampus of Huntington's Disease Mice Are Related to Cognitive Dysfunction. Mol Neurobiol. 2020 Nov; 57(11): 4549-4562. doi: 10.1007/ s12035-020-02041-x. Epub 2020 Aug 5. PMID: 32757160

Martín-Flores,N.; Pérez-Sisqués, L.; Creus-Muncunill, J.; Masana, M.; Ginés, S.; Alberch, J.; Pérez-Navarro, E.; Malagelada, C. Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease. Cell Death Dis. 2020 Jul 30; 11(7):569. doi: 10.1038/ s41419-020-02775-5. PMID: 32732871

Kim, A.; García-García, E.; Straccia, M.; Comella-Bolla, A.; Miguez, A.; Masana, M.; Alberch, J.; Canals, J.M.; Rodríguez, M.J. Reduced fractalkine levels lead to striatal synaptic plasticity deficits in Huntington's disease. Front Cell Neurosci. 2020 Jun 18; 14:163. doi: 10.3389/ fncel.2020.00163. eCollection 2020. PMID: 32625064

Comella-Bolla, A.; Orlandi, J. A.; Miguez, A.; Straccia, M.; García-Bravo, M.; Bombau, G.; Galofré, M.; Sanders, P.; Carrere, J.; Segovia, J. C.; Blasi, J.; Allen, N. D.; Alberch, J.; Soriano, J.; Canals, J. M. Human pluripotent stem cell-derived neurons are functionally mature in vitro and integrate into the mouse striatum following transplantation. Mol Neurobiol. 2020 Jun;57(6): 2766-2798. doi: 10.1007/ s12035-020-01907-4. Epub 2020 Apr 30. PMID: 32356172

Moreno-Delgado, D.; Puigdellívol, M.; Moreno, E.; Rodríguez-Ruiz, M.; Botta, K.; Gasperini, P.; Chiarlone, A.; Howell, L.A.; Scarselli, M.; Casado, V.; Cortés, A.; Ferré, S.; Guzmán, M.; Lluís, C.; Alberch, J.; Canela, E.I.; Ginés, S.; McCormick, P.J. Modulation of dopamine D 1 receptors via histamine H 3 receptors is a novel therapeutic target for Huntington's disease. Elife. 2020 Jun 9; 9:e51093. doi: 10.7554/ eLife.51093. PMID: 32513388

Fernandez-Garcia, S.; Sancho-Balsells, A.; Longueville, S; Herve, D; Gruart, A; Delgado-Garcia MJ; Alberch, J; Giralt, A. Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy. Cell Death Dis. 2020 Jun 1;11 (6):411. doi: 10.1038/ s41419-020-2615-9. PMID: 32483154

Fernández-García, S.; Orlandi, J.G.; García-Díaz Barriga, G.A.; Rodríguez, M.J.; Masana, M.; Soriano, J.; Alberch, J. Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease. BMC Biol. 2020 May 28;18(1):58. doi: 10.1186/s12915-020-00794-4. PMID: 32466798

Sancho-Balsells, A.; Brito, V.; Fernández,B.; Pardo, M.; Straccia, M.; Ginés, S.; Alberch, J.; Hernández, I.; Arranz, B.; Canals, J.M.; Giralt, A. Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1. Front Cell Neurosci. 2020 May 14; 14:93. doi: 10.3389/ fncel.2020.00093. eCollection 2020. PMID: 32477064

Llorach-Pares, L.; Rodriguez-Urgelles, E.; Nonell-Canals, A.; Alberch, J.; Avila, C.; Sanchez-Martinez, M.; Giralt, A. Meridianins and Lignarenone B as potential GSK3β inhibitors and inductors of structural neuronal plasticity. Biomolecules 2020 Apr 21; 10(4):639. doi: 10.3390/ biom10040639. PMID: 32326204

Giralt, A.; Brito, V.; Pardo, M.; Rubio, S.E.; Marion-Poll, L.; Martín-Ibáñez, R.; Zamora-Moratalla, A.; Bosch, C.; Ballesteros, J.J.; Blasco, E.; García-Torralba, A.; Pascual, M.; Pumarola, M.; Alberch, J.; Ginés, S.; Martín, E.D.; Segovia, J.; Soriano, E.; Canals, J.M. Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation. Exp Neurol. 2020 Jan; 323:113095. doi: 10.1016/ j.expneurol.2019.113095. Epub 2019 Nov 8. PMID: 31712124

Creus-Muncunill, J.; Badillos-Rodríguez, R.; Garcia-Forn, M.; Masana, M.; Garcia-Díaz Barriga, G.; Guisado-Corcoll, A.; Alberch, J.; Malagelada, C.; Delgado-García, J.M.; Gruart, A.; Pérez-Navarro, E. Increased translation as a novel pathogenic mechanism in Huntington's disease. Brain. 2019 Oct 1; 142(10): 3158-3175. doi: 10.1093/ brain/ awz230. PMID: 31365052

Brito, V; Giralt, A; Masana, M; Royes, A; Espina, M; Sieiro, E; Alberch, J; Castane, A; Girault, JA; Gines, S. Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens. Biol Psychiatry. 2019 Aug 1; 86(3): 196-207. doi: 10.1016/ j.biopsych. 2019.03.001. Epub 2019 Mar 13. PMID: 31060804

Blázquez G, Castañé A, Saavedra A, Masana M, Alberch J, Pérez-Navarro E. Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase. Front Behav Neurosci. 2019 Jan 25;12:317. doi: 10.3389/ fnbeh.2018.00317.  eCollection 2018. PMID: 30760987

de Pins B, Cifuentes-Díaz C, Farah AT, López-Molina L, Montalban E, Sancho-Balsells A, López A, Ginés S, Delgado-García JM, Alberch J, Gruart A, Girault JA, Giralt A. Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease. J Neurosci. 2019 Mar 27; 39(13): 2441-2458. doi: 10.1523/ JNEUROSCI. 2121-18.2019. Epub 2019 Jan 30. PMID: 30700530

Montalban E, Al-Massadi O, Sancho-Balsells A, Brito V, de Pins B, Alberch J, Ginés S, Girault JA, Giralt A. Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes. Transl Psychiatry. 2019 Jan 15; 9(1):3. doi: 10.1038/ s41398-018-0352-y. PMID: 30664624

Siegert AM, García Díaz-Barriga G, Esteve-Codina A, Navas-Madroñal M, Gorbenko Del Blanco D, Alberch J, Heath S, Galán M, Egea G. A FBN1 3'UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in Marfan syndrome. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):107-114. doi: 10.1016/ j.bbadis.2018.10.029. Epub 2018 Oct 30. PMID: 30385411

García-Forn M, Martínez-Torres S, García-Díaz Barriga G, Alberch J, Milà M, Azkona G, Pérez-Navarro E. Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease. Neurobiol Dis. 2018 Dec;120:88-97. doi: 10.1016/j.nbd.2018.08.024. Epub 2018 Aug 31. PMID: 30176350

Saavedra A, Ballesteros JJ, Tyebji S, Martínez-Torres S, Blázquez G, López-Hidalgo R, Azkona G, Alberch J, Martín ED, Pérez-Navarro E. Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning. Mol Neurobiol. 2019 Feb;56(2):1475-1487. doi: 10.1007/s12035-018-1170-1. Epub 2018 Jun 12. PMID: 29948948

Cabezas-Llobet N, Camprubí S, García B, Alberch J, Xifró X. Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1852-1861. doi: 10.1016/j.bbagen.2018.05.017. Epub 2018 May 30. PMID: 29857082

Suelves N, Miguez A, López-Benito S, Barriga GG, Giralt A, Alvarez-Periel E, Arévalo JC, Alberch J, Ginés S, Brito V. Early Downregulation of p75NTR by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice. Mol Neurobiol. 2019 Feb;56(2):935-953. doi: 10.1007/s12035-018-1126-5. Epub 2018 May 27. PMID: 29804232

Saavedra A, García-Díaz Barriga G, Pérez-Navarro E, Alberch J. Huntington's disease: novel therapeutic perspectives hanging in the balance. Expert Opin Ther Targets. 2018 May;22(5):385-399. doi: 10.1080/14728222.2018.1465930. Epub 2018 Apr 26. Review. PMID: 29671352

Creus-Muncunill J, Rué L, Alcalá-Vida R, Badillos-Rodríguez R, Romaní-Aumedes J, Marco S, Alberch J, Perez-Otaño I, Malagelada C, Pérez-Navarro E. Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration. Mol Neurobiol. 2018 Oct;55(10):7728-7742. doi: 10.1007/s12035-018-0956-5. Epub 2018 Feb 19. PMID: 29460266

Alvarez-Periel E, Puigdellívol M, Brito V, Plattner F, Bibb JA, Alberch J, Ginés S. Cdk5 Contributes to Huntington's Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates. Mol Neurobiol. 2018 Aug;55(8):6250-6268. doi: 10.1007/s12035-017-0828-4. Epub 2017 Dec 29. PMID: 29288339

Cases S, Saavedra A, Tyebji S, Giralt A, Alberch J, Pérez-Navarro E. Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF. Mol Cell Neurosci. 2018 Jan;86:41-49. doi: 10.1016/j.mcn.2017.11.003. Epub 2017 Nov 6. PMID: 29122705

Giralt A, Gómez-Climent MÁ, Alcalá R, Bretin S, Bertrand D, María Delgado-García J, Pérez-Navarro E, Alberch J, Gruart A. The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice. Neuropharmacology. 2017 Sep 1; 123:395-409. doi: 10.1016/ j.neuropharm. 2017.06.009. Epub 2017 Jun 8. PMID: 28603025

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA. Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model. Nat Commun. 2017 May 30;8:15592. doi: 10.1038/ncomms15592. PMID: 28555636

García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J. 7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway. Hum Mol Genet. 2017 Aug 15;26(16): 3144-3160. doi: 10.1093/ hmg/ ddx198. PMID: 28541476

HD iPSC Consortium. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci. 2017 May;  20(5): 648-660. doi: 10.1038/ nn.4532. Epub 2017 Mar 20. PMID: 28319609

Martín-Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion-Poll L, Herranz C, Esgleas M, Garcia-Díaz Barriga G, Edel MJ, Vicario-Abejón C, Alberch J, Girault JA, Chan S, Kastner P, Canals JM. Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons. Development. 2017 Apr 15; 144(8): 1566-1577. doi: 10.1242/ dev. 138248. Epub 2017 Mar 13. PMID: 28289129

Saavedra A, Fernández-García S, Cases S, Puigdellívol M, Alcalá-Vida R, Martín-Flores N, Alberch J, Ginés S, Malagelada C, Pérez-Navarro E. Chelerythrine promotes Ca(2+)-dependent calpain activation in neuronal cells in a PKC-independent manner. Biochim Biophys Acta Gen Subj. 2017 Apr; 1861(4): 922-935. doi: 10.1016/ j.bbagen. 2017.01.021. Epub 2017 Jan 24. PMID: 28130160

Canal M, Martín-Flores N, Pérez-Sisqués L, Romaní-Aumedes J, Altas B, Man HY,  Kawabe H, Alberch J, Malagelada C. Loss of NEDD4 contributes to RTP801 elevation  and neuron toxicity: implications for Parkinson's disease. Oncotarget. 2016 Sep 13; 7(37): 58813-58831. doi: 10.18632/ oncotarget. 11020. PMID: 27494837

Anglada-Huguet M, Giralt A, Rué L, Alberch J, Xifró X. Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease. Biochim Biophys Acta. 2016 Jul; 1862(7): 1255-66. doi: 10.1016/ j.bbadis. 2016.04.002. Epub 2016 Apr 6. PMID: 27063456

Pont L, Benavente F, Jaumot J, Tauler R, Alberch J, Ginés S, Barbosa J, Sanz-Nebot V. Metabolic profiling for the identification of Huntington biomarkers by on-line solid-phase extraction capillary electrophoresis mass spectrometry combined with advanced data analysis tools. Electrophoresis. 2016 Mar; 37(5-6): 795-808. doi: 10.1002/ elps. 201500378. Epub 2016 Feb 8.. PMID: 26685060

Fernández-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez-Danés A, Vilarrasa-Blasi R, Sánchez-Pla A, Mosquera JL, Soriano J, López-Barneo J, Canals JM, Alberch J, Raya Á, Vila M, Consiglio A, Martín-Subero  JI, Ezquerra M, Tolosa E. Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients. EMBO Mol Med. 2015 Dec; 7(12): 1529-46. doi: 10. 15252/ emmm. 201505439. PMID: 26516212

Puigdellívol M, Cherubini M, Brito V, Giralt A, Suelves N, Ballesteros J, Zamora-Moratalla A, Martín ED, Eipper BA, Alberch J, Ginés S. A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease. Hum Mol Genet. 2015 Dec 20; 24(25): 7265-85. doi: 10. 1093/ hmg/ ddv426. Epub 2015 Oct 12. PMID: 26464483

Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, Rosser AE, Canals JM. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Mol Ther Methods Clin Dev. 2015 Sep 16; 2:15030. doi: 10.1038/ mtm. 2015.30. eCollection 2015. PMID: 26417608

Anglada-Huguet M, Vidal-Sancho L, Giralt A, García-Díaz Barriga G, Xifró X, Alberch J. Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity. Neurobiol Dis. 2016 Nov; 95: 22-34. doi: 10.1016/ j.nbd. 2015.09.001. Epub 2015 Sep 11. PMID: 26369879

Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman  JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E. Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition. Pain. 2016 Feb;157(2):377-86. PMID: 26270590

Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E. BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome. Mol Neurobiol. 2016 Aug; 53(6): 4261-4273. doi: 10.1007/ s12035- 015-9335-7. Epub 2015 Jul 30. PMID: 26223799

Puigdellívol-Sánchez A, Giralt A, Casanovas A, Alberch J, Prats-Galino A. Cryostat Slice Irregularities May Introduce Bias in Tissue Thickness Estimation: Relevance for Cell Counting Methods. Microsc Microanal. 2015 Aug; 21(4): 893-901. doi: 10.1017/ S143192761501380X. Epub 2015 Jul 15. PMID: 26173483

Cherubini M, Puigdellívol M, Alberch J, Ginés S. Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A): 2145-60. doi: 10.1016/ j.bbadis. 2015.06.025. Epub 2015 Jul 2. PMID: 26143143

Fernández-Nogales M, Hernández F, Miguez A, Alberch J, Ginés S, Pérez-Navarro E, Lucas JJ. Decreased glycogen synthase kinase-3 levels and activity contribute  to Huntington's disease. Hum Mol Genet. 2015 Sep 1; 24(17): 5040-52. doi: 10.1093/ hmg/ ddv224. Epub 2015 Jun 16. PMID: 26082469

Miguez A, García-Díaz Barriga G, Brito V, Straccia M, Giralt A, Ginés S, Canals JM, Alberch J. Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation  and astrocyte-mediated inflammation. Hum Mol Genet. 2015 Sep 1; 24(17): 4958-70. doi: 10.1093/ hmg/ ddv218. Epub 2015 Jun 10. PMID: 26063761

Martín-Flores N, Romaní-Aumedes J, Rué L, Canal M, Sanders P, Straccia M, Allen ND, Alberch J, Canals JM, Pérez-Navarro E, Malagelada C. RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death. Mol Neurobiol. 2016 Jul; 53(5): 2857-2868. doi: 10.1007/ s12035-015- 9166-6. Epub 2015 Apr 16. PMID: 25876513

Xifró X, Vidal-Sancho L, Boadas-Vaello P, Turrado C, Alberch J, Puig T, Verdú E. Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice. PLoS One. 2015 Apr 9; 10(4): e0123122. doi: 10.1371/ journal. pone. 0123122. eCollection 2015. PMID: 25855977

Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-García JM, Alberch J, Cunha RA, Gruart A, Pérez-Navarro E. Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease. Neurobiol Dis. 2015 Feb; 74: 41-57. doi: 10.1016/ j.nbd. 2014.11.004. Epub 2014 Nov 11. PMID: 25449908

Brito V, Giralt A, Enriquez-Barreto L, Puigdellívol M, Suelves N, Zamora-Moratalla A, Ballesteros JJ, Martín ED, Dominguez-Iturza N, Morales M, Alberch J, Ginés S. Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction. J Clin Invest. 2014 Oct; 124(10): 4411-28. doi: 10.1172/ JCI74809. Epub 2014 Sep 2. PMID: 25180603

Romaní-Aumedes J, Canal M, Martín-Flores N, Sun X, Pérez-Fernández V, Wewering S, Fernández-Santiago R, Ezquerra M, Pont-Sunyer C, Lafuente A, Alberch  J, Luebbert H, Tolosa E, Levy OA, Greene LA, Malagelada C. Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease. Cell Death Dis. 2014 Aug 7; 5: e1364. doi: 10.1038/ cddis. 2014. 333. PMID: 25101677

Moreno B, Lopez I, Fernández-Díez B, Gottlieb M, Matute C, Sánchez-Gómez MV,  Domercq M, Giralt A, Alberch J, Collon KW, Zhang H, Parent JM, Teixido M, Giralt  E, Ceña V, Posadas I, Martínez-Pinilla E, Villoslada P, Franco R. Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. PLoS One. 2014 Mar 5; 9(3): e90671. doi: 10.1371/ journal. pone. 0090671. eCollection 2014. PMID: 24599318

Anglada-Huguet M, Xifró X, Giralt A, Zamora-Moratalla A, Martín ED, Alberch J. Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease. Mol Neurobiol. 2014 Apr; 49(2): 784-95. doi: 10.1007/ s12035-013-8556-x. Epub 2013 Nov 7. PMID: 24198227

Saavedra A, Giralt A, Arumí H, Alberch J, Pérez-Navarro E. Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease. PLoS One. 2013 Sep 5; 8(9): e73664. doi: 10.1371/ journal. pone. 0073664. eCollection 2013. PMID: 24040016

Rué L, Alcalá-Vida R, López-Soop G, Creus-Muncunill J, Alberch J, Pérez-Navarro E. Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease. Neuromolecular Med. 2014 Mar; 16(1): 25-37. doi: 10.1007/ s12017- 013- 8248-8. Epub 2013 Jul 30. PMID: 23896721

Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I. Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nat Med. 2013 Aug; 19(8): 1030-8. doi: 10.1038/ nm. 3246. Epub 2013 Jul 14. PMID: 23852340

30: Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux  T, Déglon N, Beal MF, Brouillet E. A role of mitochondrial complex II defects in  genetic models of Huntington's disease expressing N-terminal fragments of mutant  huntingtin. Hum Mol Genet. 013 Oct 1; 22(19): 3869-82. doi: 10.1093/ hmg/ ddt242. Epub 2013 May 29. PMID: 23720495

Giralt A, Sanchis D, Cherubini M, Ginés S, Cañas X, Comella JX, Alberch J. Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety. Exp Neurol. 2013 Sep; 247: 122-9. doi: 10.1016/ j.expneurol. 2013.03. 028. Epub 2013 Apr 18.. PMID: 23603365

Brito V, Puigdellívol M, Giralt A, del Toro D, Alberch J, Ginés S. Imbalance  of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies. Cell Death Dis. 2013 Apr 18; 4: e595. doi: 10.1038/ cddis. 2013.116. PMID: 23598407

Giralt A, Saavedra A, Carretón O, Arumí H, Tyebji S, Alberch J, Pérez-Navarro E. PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model. Hippocampus. 2013 Aug; 23(8): 684-95. doi: 10. 1002/ hipo. 22128. Epub 2013 Apr 29. PMID: 23576401

Barroso E, del Valle J, Porquet D, Vieira Santos AM, Salvadó L, Rodríguez-Rodríguez R, Gutiérrez P, Anglada-Huguet M, Alberch J, Camins A, Palomer X, Pallàs M, Michalik L, Wahli W, Vázquez-Carrera M. Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice. Biochim Biophys Acta. 2013 Aug; 1832(8): 1241-8. doi: 10.1016/ j.bbadis. 2013.03.006. Epub 2013 Mar 16. PMID: 23507144

Rué L, López-Soop G, Gelpi E, Martínez-Vicente M, Alberch J, Pérez-Navarro E. Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease. Neurobiol Dis. 2013 Apr; 52: 219-28. doi: 10. 1016/ j.nbd. 2012.12. 008. Epub 2013 Jan 4. PMID: 23295856

Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F. Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression. Gene. 2012 Oct 25; 508(2): 199-205. doi: 10. 1016/ j.gene. 2012.07. 074. Epub 2012 Aug 7. PMID: 22892378

Carretón O, Giralt A, Torres-Peraza JF, Brito V, Lucas JJ, Ginés S, Canals JM, Alberch J. Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels. Exp Neurol. 2012 Oct; 237(2): 335-45. doi: 10.1016/ j.expneurol. 2012.06. 033. Epub 2012 Jul 6. PMID: 22776425

Ruiz C, Casarejos MJ, Rubio I, Gines S, Puigdellivol M, Alberch J, Mena MA, de Yebenes JG. The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins. Brain Res. 2012 Jun 12; 1459: 100-12. doi: 10.1016/ j.brainres. 2012. 04.021. Epub 2012 Apr 21. PMID: 22560595

Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Caig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol Med. 2012 May; 4(5): 380-95. doi: 10.1002/ emmm. 201200215. Epub 2012 Mar 8. PMID: 22407749

Giralt A, Saavedra A, Alberch J, Pérez-Navarro E. Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms. J Huntingtons Dis. 2012; 1(2): 155-73. doi: 10.3233/ JHD- 120023. PMID: 25063329

Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM. Helios transcription factor expression depends on Gsx2  and Dlx1&2 function in developing striatal matrix neurons. Stem Cells Dev. 2012 Aug 10; 21(12): 2239-51. doi: 10.1089/ scd. 2011. 0607. Epub 2012 Jan 26. PMID: 22142223

Giralt A, Puigdellívol M, Carretón O, Paoletti P, Valero J, Parra-Damas A, Saura CA, Alberch J, Ginés S. Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity. Hum Mol Genet. 2012 Mar 15; 21(6): 1203-16. doi: 10. 1093/ hmg/ ddr552. Epub 2011 Nov 24. PMID: 22116937

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