Inflamació en malaltia hepàtica. IP: Joan Clària Enrich

Presentació

El nostre grup està principalment interessat en l'estudi dels mecanismes moleculars implicats en els processos inflamatoris que acompanyen un gran nombre de malalties hepàtiques. Una de les àrees prioritàries de la nostra recerca es caracteritzar el component genètic que modifica aquesta resposta inflamatòria en els pacients amb hepatopatia crònica. En aquest sentit, el nostre grup ha identificat un nombre de polimorfismes en gens que codifiquen per mediadors d’inflamació com son ara les citoquines (p. ex. interleucina-1 (IL-1) i antagonista del receptor de la IL-1 (IL-1ra)), així com en factors anti-inflamatoris i pro-resolutius com per exemple el receptor chemR23. El nostre grup desenvolupa la seva recerca en l'àrea de les malalties del fetge tant a nivell basic com traslacional. A més d’estudiar en pacients la influència del component genètic en les malalties hepàtiques, el nostre grup investiga aspectes mecanístics de la resposta inflamatòria en els diferents tipus cel·lulars, especialment en macròfags. D'altra banda, el nostre grup disposa de nombrosos models experimentals de malaltia hepàtica d'origen metabòlic (per exemple en models d’obesitat i esteatohepatitis) amb l’objectiu d’avaluar noves aproximacions terapèutiques orientades a atenuar la resposta inflamatòria en aquestes condicions.

Joan Clària Enrich
Professor agregat
jclaria@clinic.cat

Esther Titos Rodriguez
Professora Associada
esther.titos@ciberehd.org

Cristina López Vicario
Investigadora Postdoctoral
clopezv@clinic.cat

Roger Flores Costa
Investigador Postdoctoral
roflores@clinic.cat

Nayra Rico Santana
Especialista Sènior
nrico@clinic.cat

Mireia Casulleras Olivé
Investigadora Predoctoral
mcasulleras@clinic.cat

Marta Duran Güell
Investigadora Predoctoral
madurang@clinic.cat

Albert Salvatella
Tècnic de Laboratori
salvatella@clinic.cat

Ingrid Wei Zhang
Investigadora Postdoctoral
ingrid-wei.zhang@charite.de

Sanchez Rodriguez, Maria Belén
Tècnic de Laboratori
Sanchez11@clinic.cat

Bryan Javier Contreras Herrera
Tècnic de Laboratori
bjcontreras@clinic.cat

  • Inflamació hepàtica associada a l’obesitat
  • Gens i vies moleculars implicades en la inflamació
  • Factors genètics modificadors de la resposta inflamatòria
  • Mediadors d’inflamació de naturalesa lipídica

DECISION (Decompensated cirrhosis: identification of new combinatorial therapies based on systems approaches) grant agreement N. 847949

Comissió Europea programa Horizon2020
2020-2025
396.722 €

MICROB-PREDICT (MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response) grant agreement N. 825694

Comissió Europea programa Horizon2020
2019-2024
171.742 €

Cellular mechanisms underlying the anti-inflamatory effects of albumin

European Foundation for the Study of Chronic Liver Failure
2020-2022
250.000 €

Mecanismos responsables de una respuesta inflamatoria inadecuada y de fallo organico multiple en pacientes con enfermedad hepatica avanzada: papel de los mediadores lipidicos (PID2019-105240RB-I00)

Ministerio de Ciencia e Innovación
2019-2022
290.400 €

In vitro, ex vivo and in vivo evaluation of the anti-inflammatory effects of human albumin

European Foundation €for the Study of Chronic Liver Failure
2019-2021
250.000

Grup Investigació hepática: recerca bàsica i experimental. Beca Grup de Recerca Consolidat (2017SGR1449)

AGAUR (Generalitat de Catalunya)
2017-2019
31.224,60 €

Avaluació in vitro, ex vivo i in vivo dels efectes antiinflamatoris de l'albúmina humana

European Foundation for the Study of Chronic Liver Failure
2018
210.000 €

Els efectes anti-inflamatoris i anti-fibrogènics d'un nou estimulador de la guanilat-ciclasa soluble, sol o en combinació amb àcid obeticholic, en ratolins amb esteatohepatitis no alcohòlica

Ironwood Pharmaceuticals
2018-2019
64.990 €

Avaluació de la capacitat terapèutica d'un nou estimulador de la guanilat-ciclasa soluble sobre la inflamació i la fibrosi en teixits sensibles a la insulina

Ironwood Pharmaceuticals
2017-2018
77.000 €

Identificació de nous perfils lipidòmics ("eicosanomic") en pacients cirròtics descompensats amb insuficiència hepàtica aguda sobre crònica

European Foundation for the Study of Chronic Liver Failure
2017-2019
18.000 €

Efectes de les formes d'albúmina natives (reduïdes) i oxidades sobre la funció de leucòcits humans

Grifols Institute
2017-1019
50.000 €

Mecanismos moleculares determinantes de la resolución inadecuada de la inflamación en tejido adiposo obeso. Nuevas oportunidades en la prevención de comorbilidades metabólicas

Ministerio de Economía y Competitividad (SAF 15/63674-R)
2015-2018
210.000 €

Per a més informació sobre les publicacions de l’IP del grup podeu visitar el següent l’enllaç:
ORCID: https://orcid.org/0000-0003-4333-7749
ResearcherID:https://www.scopus.com/authid/detail.uri?authorId=36770842900

 

Zhang IW, Curto A, López-Vicario C, Casulleras M, Duran-Güell M, Flores-Costa R, Colsch B, Aguilar F, Aransay AM, Lozano JJ, Hernández-Tejero M, Toapanta D, Fernández J, Arroyo V, Clària J. Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure. J Hepatol 2022 Jan;76(1): 93-106. doi: 10.1016/ j.jhep.2021.08.009. Epub 2021 Aug 25. PMID: 34450236.

Clària J, Curto A, Moreau R, Colsch B, López-Vicario C, Lozano JJ, Aguilar F, Castelli FA, Fenaille F, Junot C, Zhang I, Vinaixa M, Yanes O, Caraceni P, Trebicka J, Fernández J, Angeli P, Jalan R, Arroyo V. Untargeted lipidomics uncovers lipid signatures distinguishing severe versus moderate forms of acutely decompensated cirrhosis. J Hepatol. 2021 Nov;75(5): 1116-1127. doi: 10.1016/ j.jhep.2021.06.043. Epub 2021 Jul 7. PMID: 34245803

Zhang IW, López-Vicario C, Duran-Güell M, Clària J. Mitochondrial dysfunction in advanced liver disease: Emerging Concepts. Front Mol Biosci. 2021 Nov 23; 8:772174. doi: 10.3389/ fmolb.2021.772174. eCollection 2021. PMID: 34888354

Clària J, Flores-Costa R, Duran-Güell M, López-Vicario C. Proresolving lipid mediators and liver disease. BBA - Molecular and Cell Biology of Lipids 2021 Nov; 1866(11): 159023. doi: 10.1016/ j.bbalip.2021.159023. Epub 2021 Aug 2. PMID: 34352389

Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M. Pathophysiology of decompensated cirrhosis: portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction. J Hepatol 2021 Jul; 75 Suppl 1:S49-S66. doi: 10.1016 /j.jhep.2021.01.002. PMID: 34039492

Arroyo V, Angeli P, Moreau R, Jalan R, Clària J, Trebicka J, Fernández J, Gustot T, Caraceni P, Bernardi M.  The Systemic Inflammation Hypothesis: Towards a New Paradigm of Acute Decompensation and Multiorgan Failure in Cirrhosis. J Hepatol 2021 Mar;74(3): 670-685. doi: 10.1016 j.jhep.2020.11.048. Epub 2020 Dec 7.  PMID: 33301825

Weiss E, de la Grange P, Defaye M, Lozano JJ, Aguilar F, Hegde P, Jolly A, Moga L, Sukriti S, Agarwal B, Gurm H, Tanguy M, Poisson J, Clària J, Abback PS, Périanin A, Mehta G, Jalan R, Francoz C, Rautou PE, Lotersztajn S, Arroyo V, Durand F, Moreau R. Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF. Front Immunol 2021 Feb 5;11: 619039. doi: 10.3389/ fimmu. 2020.619039. eCollection 2020. PMID: 33613548

Duran-Güell M, Flores-Costa R, Casulleras M, López-Vicario C, Titos E, Díaz A, Alcaraz-Quiles J, Horrillo R, Costa M, Fernández J, Arroyo V, Clària J. Albumin protects the liver from tumor necrosis factor α-induced immunopathology. FASEB J. 2021 Feb; 35(2): e21365. doi: 10.1096/ fj.202001615RRR. PMID: 33496031

Zaccherini G, Aguilar F, Caraceni P, Clària J, Lozano JJ, Fenaille F, Castelli F, Junot C, Curto A, Formentin C, Weiss E, Bernardi M, Jalan R, Angeli P, Moreau R, Arroyo V. Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF. J Hepatol 2021 May; 74(5):1117-1131. doi: 10.1016/ j.jhep.2020.11.035. Epub 2020 Dec 1. PMID: 33276029

Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jansen C, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Jarcuska P, Steib C, Reiberger T, Acevedo J, Gatti P, Shawcross DL, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Danielsen KV, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solé C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Kani HT, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia-Lopez E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Praktiknjo M, Curto A, Pitarch C, Putignano A, Moreno E, Bernal W, Aguilar F, Clària J, Ponzo P, Vitalis Z, Zaccherini G, Balogh B, Gerbes A, Vargas V, Alessandria C, Bernardi M, Ginès P, Moreau R, Angeli P, Jalan R, Arroyo V; PREDICT STUDY group of the EASL-CLIF CONSORTIUM. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis. J Hepatol. 2021 May; 74(5): 1097-1108. doi: 10.1016/ j.jhep.2020.11.019. Epub 2020 Nov 20. PMID: 33227350

Flores-Costa R, Duran-Güell M, Casulleras M, López-Vicario C, Alcaraz-Quiles J, Diaz A, Lozano JJ, Titos E, Hall K, Sarno R, Masferrer JL, Clària J. Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit. Proc Natl Acad Sci USA. 2020 Nov 10;117(45): 28263-28274. doi: 10.1073/ pnas.2000466117. Epub 2020 Oct 26. PMID: 33106416

Casulleras M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E, López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P, Moreau R, Arroyo V, Clària J. Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis. Sci Transl Med. 2020 Oct 21; 12(566): eaax5135. doi: 10.1126/ scitranslmed.aax513. PMID: 33087502

Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M, Ioan-Facsinay A. Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid. J Immunol. 2020 Nov 15;205(10): 2840-2849. doi: 10.4049/ jimmunol.1801653. Epub 2020 Oct 2. PMID: 33008950

Casulleras M, Zhang IW, López-Vicario C, Clària J. Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure. Cells 2020 Dec 8;9(12):2632. doi: 10.3390/cells9122632. PMID: 33302342

Nielsen MC, Gantzel RH, Clària J, Trebicka J, Møller HJ, Grønbæk H. Macrophage activation markers, sCD163 and sCD206, in Acute-on-Chronic Liver Failure. Cells 2020 May 9;9(5): 1175. doi: 10.3390/ cells9051175. PMID: 32397365

Bernardi M, Angeli P, Claria J, Moreau R, Gines P, Jalan R, Caraceni P, Fernandez J, Gerbes AL, O'Brien AJ, Trebicka J, Thevenot T, Arroyo V. Albumin in decompensated cirrhosis: new concepts and perspectives. Gut 2020 Jun; 69(6): 1127-1138. doi: 10.1136/ gutjnl-2019-318843. Epub 2020 Feb 26. PMID: 32102926

Fernandez J, Gratacos-Ginès J, Olivas P, Costa M, Nieto S, Mateo D, Sánchez MB, Aguilar F, Bassegoda O, Ruiz P, Caballol B, Pocurull A, Llach J, Mustieles MJ, Cid J, Reverter E, Toapanta ND, Hernández-Tejero M, Martínez JA, Claria J, Fernández C, Mensa J, Arroyo V, Castro P, Lozano M; Covid Clinic Critical Care (CCCC) Group. Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection. Crit Care Med. 2020 Dec;48(12):e1350-e1355. doi: 10.1097/ CCM. 0000000000004613. PMID: 32833695

Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Janicko M, Steib C, Reiberger T, Acevedo J, Gatti P, Bernal W, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Bendtsen F, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solè C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Özdogan OC, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Curto A, Pitarch C, Putignano A, Moreno E, Shawcross D, Aguilar F, Clària J, Ponzo P, Jansen C, Vitalis Z, Zaccherini G, Balogh B, Vargas V, Montagnese S, Alessandria C, Bernardi M, Ginès P, Jalan R, Moreau R, Angeli P, Arroyo V; PREDICT STUDY group of the EASL-CLIF Consortium. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology. J Hepatol. 2020; Oct;73(4): 842-854. doi: 10.1016/ j.jhep.2020.06.013. Epub 2020 Jul 13. PMID: 32673741

Schierwagen R, Uschner FE, Ortiz C, Torres S, Brol MJ, Tyc O, Gu W, Grimm C, Zeuzem S, Plamper A, Pfeifer P, Zimmer S, Welsch C, Schaefer L, Rheinwalt KP, Clària J, Arroyo V, Trebicka J, Klein S. The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease. Frontiers in Immunology 2020 Jul 7; 11:1352. doi: 10.3389/ fimmu.2020.01352. eCollection 2020. PMID: 32733451

Pal A, Al-Shaer AE, Guesdon W, Torres MJ, Armstrong M, Quinn K, Davis T, Reisdorph N, Neufer PD, Spangenburg EE, Carroll I, Bazinet RP, Halade GV, Clària J, Shaikh SR. Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner. FASEB J 2020 Aug; 34(8): 10640-10656. doi: 10.1096/ fj.202000830R. Epub 2020 Jun 24. PMID: 32579292

López-Vicario C, Checa A, Urdangarin A, Aguilar F, Alcaraz-Quiles J, Caraceni P, Amorós A, Pavesi M, Gómez-Cabrero D, Trebicka J, Oettl K, Moreau R, Planell N, Arroyo V, Wheelock CE, Clària J. Targeted Lipidomics Reveals Extensive Changes in the Blood Lipid Mediator Profile in Acutely Decompensated Cirrhosis. J Hepatol 2020 Oct;73(4): 817-828. doi: 10.1016/ j.jhep.2020.03.046. Epub 2020 Apr 12. PMID: 32294533

Monteiro S, Grandt J, Uschner F, Kimer N, Lysgaard-Madsen J, Schierwagen R, Klein S, Welsch C, Schäfer L, Jansen C, Clària J, Alcaraz-Quiles J, Arroyo V, Moreau R, Fernández J, Bendtsen F, Mehta G, Møller S, Gluud LL, Møller S, Praktiknjo M, Trebicka J. Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation. Gut 2021 Feb;70(2):379-387. doi: 10.1136/ gutjnl-2019-320170. Epub 2020 Apr 2. PMID: 32241903

Trieb M, Rainer F, Stadlbauer V, Douschan P, Horvath A, Binder L, Trakaki A, Knuplez E, Scharnagl H, Stojakovic T, Heinemann Á, Mandorfer M, Paternostro R, Reiberger T, Pitarch C, Amorós A, Gerbes A, Caraceni P, Alessandria C, Moreau R, Clària J, Marsche G, Stauber RE. HDL-related biomarkers are robust predictors of survival in patients with chronic liver failure. J Hepatol. 2020 Jul;73(1): 113-120. doi: 10.1016/ j.jhep.2020.01.026. Epub 2020 Feb 14. PMID: 32061870

Schaapman JJ, Amoros À, van der Reijden JJ, Laleman W, Zeuzem S, Bañares R, Jalan R, Arroyo V, Clària J, Verspaget HW, Coenraad MJ. Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection. Liver Int. 2020 Mar;40(3): 646-653. doi: 10.1111/ liv.14392. Epub 2020 Feb 16. PMID: 31991025

Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot C, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin N, Hautbergue T, Cholet S, Castelli F, Jansen C, Steib C, Campion D, Mookerjee R, Rodríguez-Gandía M, Soriano G, Durand F, Benten D, Bañares R, Stauber RE, Gronbaek H, Coenraad MJ, Ginès P, Gerbes A, Jalan R, Bernardi M, Arroyo V, Angeli P; CANONIC Study Investigators of the EASL Clif Consortium; Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif). Correction to 'Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF. J Hepatol. 2020 Jun; 72(6): 1218-1220. doi: 10.1016/ j.jhep.2020.03.002. Epub 2020 Mar 17. PMID: 32192825

Moreau R, Clària J, Aguilar F, Fenaille F, Lozano J, Junot C, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldasarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin N, Hautbergue T, Cholet S, Castelli F, Jansen C, Steib C, Campion D, Mookerjee R, Rodríguez-Gandía M, Soriano G, Durand F, Benten D, Bañares R, Stauber RE, Gronbaek H, Coenraad MJ, Ginès P, Gerbes A, Jalan R, Bernardi M, Arroyo V, Angeli P; CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair and EFClif. Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF. J Hepatol. 2020; Apr;72(4):688-701. doi: 10.1016/ j.jhep.2019.11.009. Epub 2019 Nov 25. PMID: 31778751

Fernández J, Angeli P, Trebicka J, Merli M, Gustot T, Alessandria C, Aagaard NK, de Gottardi A, Welzel TM, Gerbes A, Soriano G, Vargas V, Albillos A, Salerno F, Durand F, Bañares R, Stauber R, Prado V, Arteaga M, Hernández-Tejero M, Aziz F, Morando F, Jansen C, Lattanzi B, Moreno C, Campion D, Gronbaek H, Garcia R, Sánchez C, García E, Amorós A, Pavesi M, Clària J, Moreau R, Arroyo V. Efficacy of Albumin Treatment for Patients with Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis. Clin Gastroenterol Hepatol. 2020Apr;18(4):963-973.e14. doi: 10.1016/ j.cgh. 2019.07.055. Epub 2019 Aug 5. PMID: 31394283

Queck A, Thomas D, Jansen C, Schreiber Y, Rüschenbaum S, Praktiknjo M, Schwarzkopf KM, Mücke MM, Schierwagen R, Uschner FE, Meyer C, Clària J, Zeuzem S, Geisslinger G, Trebicka J, Lange CM. Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. PLoS One. 2019 Oct 23; 14(10): e0222840. doi: 10.1371/ journal.pone.0222840. eCollection 2019. PMID: 31644538

Fernández J, Clària J, Amorós A, Aguilar F, Castro M, Casulleras M, Acevedo J, Duran-Güell M, Nuñez L, Costa M, Torres M, Horrillo R, Ruiz-Del-Árbol L, Villanueva C, Prado V, Arteaga M, Trebicka J, Angeli P, Merli M, Alessandria C, Aagaard NK, Soriano G, Durand F, Gerbes A, Gustot T, Welzel TM, Salerno F, Bañares R, Vargas V, Albillos A, Silva A, Morales-Ruiz M, Pavesi M, Jalan R, Bernardi M, Moreau R, Páez A, Arroyo V. Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis. Gastroenterology. 2019 Mar 21. pii: S0016-5085 (19)33576-0. doi: 10.1053/ j.gastro.2019.03.021. [Epub ahead of print]. PMID: 30905652

López-Vicario C, Titos E, Walker ME, Alcaraz-Quiles J, Casulleras M, Durán-Güell M, Flores-Costa R, Pérez-Romero N, Forné M, Dalli J, Clària J. Leukocytes from obese individuals exhibit an impaired SPM signature. FASEB J. 2019 Mar 6:fj201802587R. doi: 10.1096/ fj. 201802587R. [Epub ahead of print]. PMID: 30840838

Trebicka J, Amoros A, Pitarch C, Titos E, Alcaraz-Quiles J, Schierwagen R, Deulofeu C, Fernandez-Gomez J, Piano S, Caraceni P, Oettl K, Sola E, Laleman W, McNaughtan J, Mookerjee RP, Coenraad MJ, Welzel T, Steib C, Garcia R, Gustot T, Rodriguez Gandia MA, Bañares R, Albillos A, Zeuzem S, Vargas V, Saliba F, Nevens F, Alessandria C, de Gottardi A, Zoller H, Ginès P, Sauerbruch T, Gerbes A, Stauber RE, Bernardi M, Angeli P, Pavesi M, Moreau R, Clària J, Jalan R, Arroyo V. Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis. Front Immunol. 2019 Mar 19;10:476. doi: 10.3389/ fimmu.2019.00476. eCollection 2019. PMID: 30941129

Alvarez-Silva C, Schierwagen R, Pohlmann A, Magdaleno F, Uschner FE, Ryan P, Vehreschild MJGT, Claria J, Latz E, Lelouvier B, Arumugam M, Trebicka J. Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis. Front Immunol. 2019 Feb 8;10:69. doi: 10.3389/ fimmu.2019.00069. eCollection 2019. PMID: 30800122

Carracedo M, Artiach G, Witasp A, Clària J, Carlström M, Laguna-Fernandez A, Stenvinkel P, Bäck M. The G-protein coupled receptor ChemR23 determines smooth muscle cell phenotypic switching to enhance high phosphate-induced vascular calcification. Cardiovasc Res. 2018 Dec 28. doi: 10.1093/cvr/cvy316. [Epub ahead of print] PMID: 30597013

Artiach G, Carracedo M, Clària J, Laguna-Fernandez A, Bäck M. Opposing Effects on Vascular Smooth Muscle Cell Proliferation and Macrophage-induced Inflammation Reveal a Protective Role for the Proresolving Lipid Mediator Receptor ChemR23 in Intimal Hyperplasia. Front Pharmacol. 2018 Nov 20;9: 1327. doi: 10.3389/ fphar.2018. 01327. eCollection 2018. PMID: 30515096

Laleman W, Claria J, Van der Merwe S, Moreau R, Trebicka J. Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough. Can J Gastroenterol Hepatol. 2018 Aug 1;2018: 1027152. doi: 10.1155/2018 /1027152. eCollection 2018. Review. PMID: 30155448

Clària J, Moreau R, Fenaille F, Amorós A, Junot C, Gronbaek H, Coenraad MJ, Pruvost A, Ghettas A, Chu-Van E, López-Vicario C, Oettl K, Caraceni P, Alessandria C, Trebicka J, Pavesi M, Deulofeu C, Albillos A, Gustot T, Welzel TM, Fernández J, Stauber RE, Saliba F, Butin N, Colsch B, Moreno C, Durand F, Nevens F, Bañares R, Benten D, Ginès P, Gerbes A, Jalan R, Angeli P, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif). Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis. Hepatology. 2019 Apr; 69(4): 1686-1701. doi: 10.1002/ hep.30363. Epub 2019 Mar 19. PMID: 30521097

Lopategi A, Flores-Costa R, Rius B, López-Vicario C, Alcaraz-Quiles J, Titos E, Clària J. Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome. J Leukoc Biol. 2019 Jan;105(1): 25-36. doi: 10.1002/ JLB.3HI0517- 206RR. Epub 2018 Mar 30. PMID: 29601102

Alcaraz-Quiles J, Casulleras M, Oettl K, Titos E, Flores-Costa R, Duran-Güell M, López-Vicario C, Pavesi M, Stauber RE, Arroyo V, Clària J. Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen-Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis. Hepatology. 2018 Nov;68(5):1937-1952. doi: 10.1002/hep.30135. Epub 2018 Oct 13. PMID: 30070728

Flores-Costa R, Alcaraz-Quiles J, Titos E, López-Vicario C, Casulleras M, Duran-Güell M, Rius B, Diaz A, Hall K, Shea C, Sarno R, Currie M, Masferrer JL, Clària J. The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis. Br J Pharmacol. 2018 Mar; 175(6): 953-967. doi: 10.1111/ bph.14137. Epub 2018 Jan 31. PMID: 29281143

Arroyo V, Clària J. Acute-on-Chronic Liver Failure, Human Serum Albumin, and Immune Modulation: The Beginning of an Exciting Adventure. Clin Gastroenterol Hepatol. 2018 May; 16(5): 633-636. doi: 10.1016/ j.cgh.2017.12.008. Epub 2017 Dec 12. No abstract available. PMID: 29246698

López-Vicario C, Rius B, Alcaraz-Quiles J, González-Périz A, Martínez-Puchol AI, Casulleras M, Duran-Güell M, Ibarzabal A, Corcelles R, Laguna-Fernández A, Back M, Titos E, Clària J. Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals. Sci Rep. 2017 Nov 16;7(1): 15724. doi: 10.1038/ s41598- 017-15951-z. PMID: 29146976

Steinhilber D, Uydeş-Doğan BS, Topal G, Clària J, Norel X, Schebb NH, Bannenberg G. Editorial-Special issue of the 6th European Workshop on Lipid Mediators. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:1-3. doi: 10.1016/ j.prostaglandins.2017.10.005. Epub 2017 Nov 4. No abstract available. PMID: 29113951

Lehmann JM, Claus K, Jansen C, Pohlmann A, Schierwagen R, Meyer C, Thomas D, Manekeller S, Claria J, Strassburg CP, Trautwein C, Wasmuth HE, Berres ML, Trebicka J. Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality. Liver Int. 2018 May;38 (5):875- 884. doi: 10.1111/ liv.13610. Epub 2017 Nov 6. PMID: 29105936

Rius B, Duran-Güell M, Flores-Costa R, López-Vicario C, Lopategi A, Alcaraz-Quiles J, Casulleras M, Lozano JJ, Titos E, Clària J. The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress. FASEB J. 2017 Dec; 31(12): 5384-5398. doi: 10.1096/ fj.201700394R. Epub 2017 Aug 2. PMID: 28768719

Alcaraz-Quiles J, Titos E, Casulleras M, López-Vicario C, Rius B, Lopategi A, Pavesi M, de Gottardi A, Graziadei I, Gronbaek H, Ginès P, Bernardi M, Arroyo V, Clària J. Polymorphisms in the interleukin (IL)-1 gene cluster influence systemic inflammation in patients with acute-on-chronic liver failure. Hepatology 2017 Jan;65(1):202-216. doi: 10.1002/hep.28896. Epub 2016 Nov 28.

Berzigotti A, Albillos A, Villanueva C, Genescà J, Ardevol A, Augustín S, Calleja JL, Bañares R, García-Pagán JC, Mesonero F, Bosch J on behalf of the Ciberehd SportDiet Collaborative Group. Effects of an Intensive Lifestyle Intervention Program on Portal Hypertension in Patients With Cirrhosis and Obesity: The SportDiet Study. Hepatology 2017 Apr;65(4):1293-1305. doi: 10.1002/hep.28992. Epub 2017 Mar 6.

Clària J, López-Vicario C, Rius B, Titos E. Pro-resolving actions of SPM in adipose tissue biology. Mol Aspects Med. 2017 Dec; 58:83-92. doi: 10.1016/ j.mam.2017. 03.004. Epub 2017 Mar 25. Review. PMID: 28341541

Clària J, Arroyo V and Moreau R. The acute-on-chronic liver failure syndrome or when the innate immune system goes astray. J. Immunol. 2016:197:3755-3761.

Daniel J Klionsky et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition). Autophagy 2016; 12:1-222. 

Clària J, Stauber RE, Coenraad MJ, Moreau R, Jalan R, Pavesi M, Amorós A, Titos E, Alcaraz-Quiles J, Oettl K, Morales-Ruiz M, Angeli P, Domenicali M, Alessandria C, Gerbes A, Wendon J, Nevens F, Trebicka J, Laleman W, Saliba F, Welzel TM, Albillos A, Gustot T, Benten D, Durand F, Ginès P, Bernardi M and Arroyo V, for the CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (EF-CLIF). Systemic inflammation in decompensated cirrhosis. Characterization and role in acute-on-chronic liver failure. Hepatology 2016; 64:1249-64.

Titos E, Rius B, López-Vicario C, García-Alonso V, Lopategi A, Alcaraz-Quiles J, Dalli J, Lozano JJ, Arroyo V, Delgado S, Serhan CN and Clària J. p38 Mitogen-Activated Protein Kinase Signals the Immuno Resolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. J Immunol 2016; 197:3360-3370.

García-Alonso V, Titos E, Alcaraz-Quiles J, Rius B, Lopategi A, López-Vicario C, Jakobsson PJ, Delgado S, Lozano J and Clària J. Prostaglandin E2 exerts multiple regulatory actions on human obese adipose tissue remodeling, inflammation, adaptive thermogenesis and lipolysis. PLos One  2016; 11:e015375.

Blaya D, Vila-Casadesus M, Coll M, Rodrigo-Torres D, Affò S, Altamirano J, Morales-Ibanez O, Graupera I, Perea L, Lozano JJ, Clària J, Arroyo V, Bataller R, Caballería J, Ginès P, Sancho-Bru P. Integrative MicroRNA Profiling in Alcoholic Hepatitis Reveals a Role for microRNA-182 in Liver Injury and Inflammation. Gut 2016; 65: 1535-45.

Lopategi A, López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Titos E and Clària J. Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction. Mol Cell Endocrinol 2016; 419:44-59

López-Vicario C, Rius B, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Titos E and Clària J. Pro-resolving mediators produced from EPA and DHA: Overview of pathways involved and of their mechanisms in metabolic syndrome and related liver diseases. Eur J Pharmacol 2016:785:133-143.

Smith T, Hutchison P, Schrör K, Clària J, Lanas A, Patrignani P, Chan AT, Din F, Langley R, Elwood P, Freedman A, Eccles R. Aspirin in the 21st century-common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK. Ecancermedicalscience 2015 Oct 13;9:581

López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Hwang SE, Titos E, Lopategi A, Hammock B, Arroyo V, Clària J. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver. Role for omega-3 epoxides. Proc Natl Acad Sci USA 2015; 112:536-41.

Rius B, Titos E, Morán-Salvador E, López-Vicario C, García-Alonso V, González-Périz A, Arroyo V, Clària J. Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis. FASEB J 2014; 28:836-48

López-Vicario C, González-Périz A, Rius B, Morán-Salvador E, García-Alonso V, Lozano JJ, Bataller R, Cofán M, Kang JX, Arroyo V, Clària J, Titos E. A regulatory loop between desaturases and omega-3 fatty acids exerts protective actions in obesity-induced fatty liver disease. Gut 2014; 63:344-55

García-Alonso V and Clària J. Prostaglandin E2 signals white-to-brown adipogenic differentiation. Adipocyte 2014; 3:290-296

Spite M, Clària J and Serhan C.N. Resolvins, Specialized Pro-Resolving Lipid Mediators and their Potential Roles in Metabolic Syndrome. Cell Metab. 2014; 19:21-36

Titos E and Clària J. Omega-3-Derived Mediators Counteract Obesity-Induced Adipose Tissue Inflammation. Prostaglandins Other Lipid Mediat 2013; 107:77-84

García-Alonso V, López-Vicario C, Titos E, Morán-Salvador E, González-Périz A, Rius B, Parrizas M, Werz O, Arroyo V, Clària J. Coordinate functional regulation between microsomal prostaglandin E synthase-1 and PPARγ in the conversion of white-to-brown adipocytes. J Biol Chem 2013; 288;28230-28242

Morán-Salvador E, Titos E, González-Périz A, Rius B, García-Alonso V, López-Vicario C, Miquel R, Barak Y, Arroyo V, Clària J. Cell-specific knockout mice establish anti-inflammatory and anti-fibrogenic properties for PPARg in non-parenchymal liver cells. J Hepatol 2013; 59:1045-1053

Clària J, Nguyen BT, Madenci A, Ozaki CK, Serhan CN. Diversity of lipid mediators in human adipose tissue depots. Am J Physiol (Cell Physiol) 2013; 304:C1141-9

Noguera A, Gómez C, Faner R, Cosío B, González-Périz A, Clària J, Carvajal A, Agustí A. Investigation of the resolution of inflammation (catabasis) in COPD. Respir Res 2012; 13:101

Clària J, Dalli J, Yacoubian S, Gao F, Serhan CN. Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat. J Immunol 2012; 189:2597-2605

Rius B, López-Vicario C, González-Périz A, Morán-Salvador E, García-Alonso V, Clària J, Titos E. Resolution of inflammation in obesity-induced liver disease. Front. Immunol. 2012 10.3389/fimmu.2012.00257

  • Ofertes de la Universitat de Barcelona:

Feina UB

  • Ofertes del Grup de Recerca:

Doctoral INPhINIT Fellowships Programme - Incoming. Call for applications 2022
Identification of molecular signatures associated with systemic inflammation and organ failures
https://finder.lacaixafellowships.org/finder?position=5078