Molècules de la membrana i immunomodulació viral. IP: Ana Angulo Aguado i Pablo Engel Rocamora

Ana Angulo Aguado 
Catedràtica d'Universitat
aangulo@ub.edu

Pablo Engel Rocamora
Professor Titular 
pengel@ub.edu

 

EQUIP

 

Olga Bautista Cerecero
Tècnic de laboratori
olgabautistacerecero@ub.edu

 

Javier Fernández Calles
Tècnic de laboratori
jfernandezc@clinic.cat 

 

Rebeca Gutiérrez Cozar
Investigadora predoctoral
rebeca.gutierrez@ub.edu

 

Pablo Hernández Luis
Investigador predoctoral
pablo_hernandez_luis@ub.edu

 

Julen Merino Aboitiz
Investigador predoctoral
julenmerino20@ub.edu

 

Judit Pelegrín Pérez
Investigadora predoctoral
juditpelegrinperez@ub.edu

• Estudi de l'estructura i la funció de les famílies de molècules leucocitàries SLAM (Molècula senyalitzadora d'activació dels limfòcits) i SAP (proteïna associada a SLAM).
• Anàlisi del rol de les molècules SLAM en autoimmunitat i càncer.
• Estudi de la modulació de la resposta immune pel CMV i estratègies d'immunoevasió viral.
• Identificació i caracterització de funcions codificades pel CMV.

• CD229 en Mieloma Múltiple: Biología y diana terapéutica

Entitat finançadora: Ministerio de Ciencia e Innovación
Codi Projecte: PID2021-125734OB-I00
Investigador principal: Pablo Engel Rocamora  
Durada: 01/09/2022-31/08/2024 

• Nuevos mecanismos de inmunoevasión utilizados por herpesvirus

Entitat finançadora: Ministerio de Ciencia e Innovación
Codi Projecte: PID2020-116918RB-I00
Investigador principal: Ana Angulo Aguado 
Quantia de la subvenció: 250.000 €
Durada: 01/09/2021 - 31/08/2024

• Repertorio, inmunopatología y terapia dirigida a los linfocitos B en la enfermedad autoinmune, Síndrome de Sjögren

Entitat finançadora: Ministerio de Economia y Competitividad
Codi Projecte: RTI2018-094440-B-I00
Investigador principal: Pablo Engel Rocamora  
Quantia de la subvenció: 242.000,00 €
Durada: 2019-2021

• Manipulación de inmunoreceptores de la superfície celular por citomegalovirus

Entitat finançadora: Ministerio de Economia y Competitividad
Codi Projecte: SAF 2017
Investigador principal: Ana Angulo Aguado   
Quantia de la subvenció: 181.500 €
Durada: 2018-2020

• CoViproteHCt

Entitat finançadora: HORIZON 2020. European Inst. of Innovation and Technol.
Codi Projecte: 8PM KIC Health (codi UE 20877)
Investigador principal: Ana Angulo Aguado
Investigadors secundaris: Pablo Engel  Rocamora i Pablo Hernández Luis
Quantia de la subvenció: 599.671 €
Durada: 15/04/2020 - 31/12/2020

• Estudio de la homeostasis de las células B de la zona marginal y su papel en la autoinmunidad y linfomagénesis

Entitat finançadora: Ministerio de Economia y Competitividad
Codi Projecte: SAF 2015-69829-R
Investigador principal: Pablo Engel Rocamora     
Quantia de la subvenció: 190.000 €
Durada: 2016-2018

• Caracterización funcional de nuevas proteínas del citomegalovirus que interfieren con la respuesta inmune del huésped

Entitat finançadora: Ministerio de Economia y Competitividad
Codi Projecte: SAF 2014-55683-R
Investigador principal: Ana Angulo Aguado
Quantia de la subvenció: 190.000 €
Durada: 2015-2017

• SLAM Gene Family Controlled Pathways to SLE

Entitat finançadora: National Institutes of Health
Codi Projecte: 2P01AI065587-06A1
Investigador principal: Cox Terhost/Pablo Engel (co-IP)
Quantia de la subvenció: 400.000 $ (cost directe; part corresponent al grup de Pablo Engel)
Durada: 2012-2017

Recombinant fusion proteins targeting P-selectin, and methods of use thereof for treating diseases and disorders

Inventors / autors: Tomlison, Stephen; Alawieh, Ali; Engel, Pablo
Data Sol·licitud: 01/06/2021
Codi Territori: Països membres del Tractat de Cooperació en Matèria de Patents
Entitats titulars: MUSCA - Medical University of South Carolina / USGOV - The United States Government / UBAR - Universitat de Barcelona
Número de sol.licitud: PCT/US2021/035128
Tipus: Sol·licitud PCT

Recombinant fusion proteins targeting P-selectin, and methods of use thereof for treating diseases and disorders

Inventors / autors: Tomlison, Stephen; Alawieh, Ali; Engel, Pablo
Data Sol·licitud: 01/06/2021
Codi Territori: US - ESTATS UNITS D'AMÈRICA
Entitats titulars: MUSCA - Medical University of South Carolina / USGOV - The United States Government / UBAR - Universitat de Barcelona
Número de sol.licitud: US17/335355
Tipus: Fase Nacional

CD22 targeting-moiety for the treatment of B-cell acute lymphoblastic leukemia (B-ALL)

Inventors / autors: Menéndez Buján, Pablo; Velasco Hernández, Talía; Romina Zanetti, Samanta; Engel Rocamora, Pablo; Sánchez Martínez, Diego; Gutiérrez Agüera, Francisco; Fernández Martín, Adrián
Data Sol·licitud: 11/03/2021
Codi Territori: Països Membres de la Convenció Europea de Patents
Entitats titulars: FIJC - Fundació Institut de Recerca contra la Leucèmia Josep Carreras / FICR - Fundació Institució Catalana de Recerca i Estudis Avançats (ICREA) / UBAR - Universitat de Barcelona / 15188 - Fundació Institut D'Investigació en Ciències de la Salut Germans Trias i Pujol
Número de sol.licitud: PCT/EP2021/056262
Tipus: Sol·licitud PCT

Recombinant fusion proteins targeting P-selectin, and methods of use thereof for treating diseases and disorders

Inventors / autors: Tomlison, Stephen; Alawieh, Ali; Engel, Pablo
Data Sol·licitud: 16/02/2021
Codi Territori: US - ESTATS UNITS D'AMÈRICA
Entitats titulars: MUSCA - Medical University of South Carolina / USGOV - The United States Government / UBAR - Universitat de Barcelona
Número de sol.licitud: US63/149725
Tipus: Sol·licitud prioritària

Anticossos Monoclonals(clone psel.ko.2.3) (CD62P)

Inventors / autors: Pablo Engel
Data Sol·licitud: 28/12/2020
Codi Territori: ES - ESPANYA
Entitats titulars: UBAR - Universitat de Barcelona
Número de sol.licitud: 69g
Tipus: Tangibles

Recombinant fusion proteins targeting P-selectin, and methods of use thereof for treating diseases and disorders

Inventors / autors: Tomlison, Stephen; Alawieh, Ali; Engel, Pablo
Data Sol·licitud: 01/06/2020
Codi Territori: US - ESTATS UNITS D'AMÈRICA
Entitats titulars: MUSCA - Medical University of South Carolina / USGOV - The United States Government / UBAR - Universitat de Barcelona
Número de sol.licitud: US63/032934
Tipus: Sol·licitud prioritària

Anticossos Monoclonals(clon hsF6.4.20 (Human SLAMF6) Hibridomes productors d’anticossos monoclonals dirigits contra la molècula Human SLAMF6

Inventors / autors: Pablo Engel; Ana Angulo Aguado
Data Sol·licitud: 27/02/2020
Codi Territori: ES - ESPANYA
Entitats titulars: UBAR - Universitat de Barcelona
Número de sol.licitud: 69f
Tipus: Tangibles

CD22 targeting-moiety for the treatment of B-cell acute lymphoblastic leukemia (B-ALL)

Inventors / autors: Menéndez Buján, Pablo; Velasco Hernández, Talía; Romina Zanetti, Samanta; Engel Rocamora, Pablo; Sánchez Martínez, Diego; Gutiérrez Agüera, Francisco
Data Sol·licitud: 11/03/2020
Codi Territori: Països Membres de la Convenció Europea de Patents
Entitats titulars: FIJC - Fundació Institut de Recerca contra la Leucèmia Josep Carreras / FICR - Fundació Institució Catalana de Recerca i Estudis Avançats (ICREA) / UBAR - Universitat de Barcelona
Número de sol.licitud: EP20382175.6
Tipus: Sol·licitud prioritària

Anticossos Monoclonals CD69 2.2

Inventors / autors: Pablo Engel
Data Sol·licitud: 21/11/2019
Codi Territori: ES - ESPANYA
Entitats titulars: UBAR - Universitat de Barcelona
Número de sol.licitud: 069e
Tipus: Tangibles

Títol: Anti-C3d antibody conjugates and methods of detecting complement activation

Inventors / autors: Tomlinson, Stephen; Holers, V. Michael; Engel Rocamora, Pablo
Data Sol·licitud: 16/09/2019
Codi Territori: US - ESTATS UNITS D'AMÈRICA
Entitats titulars: MUSCA - Medical University of South Carolina / VETAF - Dept of Veterans Affairs /
COLO - University of Colorado, The Regents of / UBAR - Universitat de Barcelona
Número de sol.licitud: US16/572260
Tipus: Fase Nacional

Anticossos Monoclonals clone p-sel.ko.2.7

Inventors / autors: Pablo Engel
Data Sol·licitud: 01/07/2018
Codi Territori: ES - ESPANYA
Entitats titulars: UBAR - Universitat de Barcelona
Número de sol.licitud: 69d
Tipus: Tangibles

Anticossos Monoclonals

Inventors / autors: Pablo Engel
Data Sol·licitud: 01/12/2016
Codi Territori: ES - ESPANYA
Entitats titulars: UBAR - Universitat de Barcelona
Número de sol.licitud: 69c
Tipus: Tangibles

Anticossos Monoclonals (hSF6.4.20)

Inventors / autors: Pablo Engel; Ana Angulo Aguado
Data Sol·licitud: 12/07/2015
Codi Territori: ES - ESPANYA
Entitats titulars: UBAR - Universitat de Barcelona
Número de sol.licitud: 0295
Tipus: Tangibles

Per a més informació sobre les publicacions de l’IP del grup podeu visitar el següent l’enllaç:
IP: Pablo Engel Rocamora
ORCID: https://orcid.org/0000-0001-8410-252X
IP: Ana Angulo Aguado
ORCID: https://orcid.org/0000-0002-5792-1164

 

de Pablo N, Meana C, Martínez-García J, Martínez-Vicente P, Albert M, Guerra S, Angulo A, Balsinde J, Balboa MA. Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon. EMBO Rep. 2023 Dec 6;24(12):e57238. doi: 10.15252/embr.202357238. Epub 2023 Nov 6. PMID: 37929625; PMCID: PMC10702840.

Andrade LEC, Chan EKL, Vieths S, Engel P, Kirschfink M. Editorial: Contemporary challenges in immunologic testing in clinical and research laboratories. Front Immunol. 2023 Jul 27;14:1259823. doi: 10.3389/fimmu.2023.1259823. PMID: 37575258; PMCID: PMC10415069.

Aguilar R, Li X, Crowell CS, Burrell T, Vidal M, Rubio R, Jiménez A, Hernández-Luis P, Hofmann D, Mijočević H, Jeske S, Christa C, D'Ippolito E, Lingor P, Knolle PA, Roggendorf H, Priller A, Yazici S, Carolis C, Mayor A, Schreiner P, Poppert H, Beyer H, Schambeck SE, Izquierdo L, Tortajada M, Angulo A, Soutschek E, Engel P, Garcia-Basteiro A, Busch DH, Moncunill G, Protzer U, Dobaño C, Gerhard M. RBD-Based ELISA and Luminex Predict Anti-SARS-CoV-2 Surrogate-Neutralizing Activity in Two Longitudinal Cohorts of German and Spanish Health Care Workers. Microbiol Spectr. 2023 Feb 14;11(1): e0316522. doi: 10.1128/ spectrum.03165-22. Epub 2023 Jan 9. PMID: 36622140; PMCID: PMC9927417.

Martínez-Vicente P, Poblador F, Leitner J, Farré D, Steinberger P, Engel P, Angulo A. Discovery of the first PD-1 ligand encoded by a pathogen. Front Immunol. 2022 Sep 13;13: 1007334. doi: 10.3389/ fimmu.2022.1007334. PMID: 36177035; PMCID: PMC9514091.

Casadó-Llombart S, Velasco-de Andrés M, Català C, Leyton-Pereira A, Gutiérrez-Cózar R, Suárez B, Armiger N, Carreras E, Esteller M, Ricart E, Ordás I, Gisbert JP, Chaparro M, Esteve M, Márquez L, Busquets D, Iglesias E, García-Planella E, Martín-Arranz MD, Lohmann J, Ayata CK, Niess JH, Engel P, Panés J, Salas A, Domènech E, Lozano F. Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease. Front Immunol. 2022 Sep 21;13: 966184. doi: 10.3389/ fimmu.2022.966184. PMID: 36211446; PMCID: PMC9532939.

Català C, Velasco-de Andrés M, Leyton-Pereira A, Casadó-Llombart S, Sáez Moya M, Gutiérrez-Cózar R, García-Luna J, Consuegra-Fernández M, Isamat M, Aranda F, Martínez-Florensa M, Engel P, Mourglia-Ettlin G, Lozano F. CD6 deficiency impairs early immune response to bacterial sepsis. iScience. 2022 Sep 5;25(10): 105078. doi: 10.1016/ j.isci.2022.105078. PMID: 36157587; PMCID: PMC9490029.

Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A. Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis. Autophagy. 2023 Mar;19(3): 904-925. doi: 10.1080/ 15548627.2022. 2111081. Epub 2022 Aug 25. Erratum in: Autophagy. 2022 Sep 14;:1. PMID: 35947488; PMCID: PMC9980505.

Roncador G, Puñet-Ortiz J, Maestre L, Rodríguez-Lobato LG, Jiménez S, Reyes-García AI, García-González Á, García JF, Piris MÁ, Montes-Moreno S, Rodríguez-Justo M, Mena MP, Fernández de Larrea C, Engel P. CD229 (Ly9) a Novel Biomarker for B-Cell Malignancies and Multiple Myeloma. Cancers (Basel). 2022 Apr 26;14(9): 2154. doi: 10.3390/ cancers 14092154. PMID: 35565280; PMCID: PMC9101303.

Autio A, Wang H, Velázquez F, Newton G, Parkos CA, Engel P, Engelbertsen D, Lichtman AH, Luscinskas FW. SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen. PLoS One. 2022 Apr 12;17(4): e0266566. doi: 10.1371/ journal.pone.0266566. PMID: 35413056

Hernández-Luis P, Aguilar R, Pelegrin-Pérez J, Ruiz-Olalla G, García-Basteiro AL, Tortajada M, Moncunill G, Dobaño C, Angulo A, Engel P. Decreased and Heterogeneous Neutralizing Antibody Responses Against RBD of SARS-CoV-2 Variants After mRNA Vaccination. Front Immunol. 2022 Apr 6;13: 816389. doi: 10.3389/ fimmu.2022.816389. PMID: 35464418

Kužílková D, Puñet-Ortiz J, Aui PM, Fernández J, Fišer K, Engel P, van Zelm MC, Kalina T. Standardization of Workflow and Flow Cytometry Panels for Quantitative Expression Profiling of Surface Antigens on Blood Leukocyte Subsets: An HCDM CDMaps Initiative. Front Immunol. 2022 Feb 11;13: 827898. doi: 10.3389/ fimmu.2022.827898. PMID: 35222411

Moncunill, G.; Aguilar, R.; Ribes, M.; Ortega, N.; Rubio, R.; Salmerón, G.; Molina, MJ.; Vidal, M.; Barrios, D.; Mitchell, RA.; Jiménez, A.; Castellana, C.; Hernández-Luis, P.; Rodó, P.; Méndez, S.; Llupià, A.; Puyol, L.; Rodrigo Melero, N.; Carolis, C.; Mayor, A.; Izquierdo, L.; Varela, P.; Trilla, A.; Vilella, A.; Barroso, S.; Angulo, A.; Engel, P.; Tortajada, M.; García-Basteiro, AL.; Dobaño, C. Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers. EBioMedicine. 2022 Jan;75: 103805. doi: 10.1016/ j.ebiom.2021. 103805. Epub 2022 Jan 12. PMID: 35032961

Zheng C, Ricci J, Zhang Q, Alawieh A, Yang X, Nadig S, He S, Engel P, Jin J, Atkinson C, Tomlinson S. Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation. Front Immunol. 2021 Nov 25;12: 785229. doi: 10.3389/ fimmu.2021.785229. PMID: 34899752; PMCID: PMC8654931

Balsas P, Veloza L, Clot G, Sureda-Gómez M, Rodríguez ML, Masaoutis C, Frigola G, Navarro A, Beà S, Nadeu F, Giné E, López-Guillermo A, Martínez A, Ribera-Cortada I, Engel P, Quintanilla-Martínez L, Klapper W, Campo E, Amador V. SOX11, CD70, and Treg cells configure the tumor-immune microenvironment of aggressive mantle cell lymphoma. Blood. 2021 Dec 2;138(22):2202-2215. doi: 10.1182/blood.2020010527. PMID: 34189576; PMCID: PMC8641098.

Ortega N, Ribes M, Vidal M, Rubio R, Aguilar R, Williams S, Barrios D, Alonso S, Hernández-Luis P, Mitchell RA, Jairoce C, Cruz A, Jimenez A, Santano R, Méndez S, Lamoglia M, Rosell N, Llupià A, Puyol L, Chi J, Melero NR, Parras D, Serra P, Pradenas E, Trinité B, Blanco J, Mayor A, Barroso S, Varela P, Vilella A, Trilla A, Santamaria P, Carolis C, Tortajada M, Izquierdo L, Angulo A, Engel P, García-Basteiro AL, Moncunill G, Dobaño C. Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses. Nat Commun. 2021 Aug 6;12(1): 4740. doi: 10.1038/ s41467-021- 24979-9. PMID: 34362897; PMCID: PMC8346582.

Sáez Moya M, Gutiérrez-Cózar R, Puñet-Ortiz J, Rodríguez de la Concepción ML, Blanco J, Carrillo J, Engel P. Autoimmune B Cell Repertoire in a Mouse Model of Sjögren's Syndrome. Front Immunol. 2021 Apr 23;12: 666545. doi: 10.3389/ fimmu.2021.666545. PMID: 33968069; PMCID: PMC8103202.

Angulo G, Zeleznjak J, Martínez-Vicente P, Puñet-Ortiz J, Hengel H, Messerle M, Oxenius A, Jonjic S, Krmpotic A, Engel P, Angulo A. Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion. Elife. 2021 Jan 18;10:e59350. doi: 10.7554/eLife.59350. Epub ahead of print. PMID: 33459589.

van Zelm MC, Ziegler-Heitbrock L, Collins AM, Chan SK, Engel P. Editorial: Nomenclature - Avoiding Babylonian Speech Confusion in Present Day Immunology. Front Immunol. 2020 Dec 14;11:621100. doi: 10.3389/ fimmu. 2020.621100. PMID: 33381126; PMCID: PMC7767845.

Velasco-Hernandez T, Zanetti SR, Roca-Ho H, Gutierrez-Aguera F, Petazzi P, Sánchez-Martínez D, Molina O, Baroni ML, Fuster JL, Ballerini P, Bueno C, Fernandez-Fuentes N, Engel P, Menendez P. Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope. J Immunother Cancer. 2020 Aug;8(2):e000896. doi: 10.1136/jitc-2020-000896. PMID: 32788237; PMCID: PMC7422657.

Martínez-Vicente P, Farré D, Engel P, Angulo A. Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family. Viruses. 2020 Jul 28;12(8):813. doi: 10.3390/v12080813. PMID: 32731344; PMCID: PMC7472110.

Huerga Encabo H, Traveset L, Argilaguet J, Angulo A, Nistal-Villán E, Jaiswal  R, Escalante CR, Gekas C, Meyerhans A, Aramburu J, López-Rodríguez C. The transcription factor NFAT5 limits infection-induced type I interferon responses.  J Exp Med. 2020 Mar 2;217 (3). pii: e20190449. doi: 10.1084/ jem.20190449. PMID: 31816635

Strazic Geljic I, Kucan Brlic P, Angulo G, Brizic I, Lisnic B, Jenus T, Juranic Lisnic V, Pietri GP, Engel P, Kaynan N, Zeleznjak J, Schu P, Mandelboim O, Krmpotic A, Angulo A, Jonjic S, Lenac Rovis T. Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion. Elife. 2020 Jan 13;9. pii: e50803. doi: 10.7554/eLife.50803. PMID: 31928630

Engel, P. Órganos y células del sistema inmunitario. Sección XX. Inmunología. Farreras-Rozman. Medicina Interna (19ª ed). ed. Rozman C; Cardellach F. Editorial: Elsevier. Capítol de llibre, Volum: 2, Pàgina inicial: 2580 - Pàgina final: 2586. Ciutat: Barcelona. Dipòsit legal: ISBN: 9788491135449. Any: 2020.

Kalina T, Fišer K, Pérez-Andrés M, Kuzílková D, Cuenca M, Bartol SJW, Blanco E, Engel P, van Zelm MC. CD Maps-Dynamic Profiling of CD1-CD100 Surface Expression on Human Leukocyte and Lymphocyte Subsets. Front Immunol. 2019 Oct 23;10:2434. doi: 10.3389/fimmu.2019.02434. PMID: 31708916; PMCID: PMC6820661.

Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107. PMID: 31633216; PMCID: PMC7350392.

Kalina T, Lundsten K, Engel P. Relevance of Antibody Validation for Flow Cytometry. Cytometry A. 2020 Feb;97(2):126-136. doi: 10.1002/cyto.a.23895. Epub 2019 Oct 2. PMID: 31577065.

Wang N, Yigit B, van der Poel CE, Cuenca M, Carroll MC, Herzog RW, Engel P, Terhorst C. The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease. Front Immunol. 2019 Apr 17;10:831. doi: 10.3389/fimmu.2019.00831. PMID: 31057553; PMCID: PMC6482334.

Martínez-Vicente P, Farré D, Sánchez C, Alcamí A, Engel P, Angulo A. Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor. PLoS Pathog. 2019 Apr 4;15(4):e1007658. doi: 10.1371/journal.ppat.1007658. eCollection 2019 Apr. PMID: 30947296

Sanchez LR, Godoy GJ, Gorosito Serrán M, Breser ML, Fiocca Vernengo F, Engel P, Motrich RD, Gruppi A, Rivero VE. IL-10 Producing B Cells Dampen Protective T Cell Response and Allow Chlamydia muridarumInfection of the Male Genital Tract. Front Immunol. 2019 Mar 1;10:356. doi: 10.3389/fimmu.2019.00356. eCollection 2019. PMID: 30881362

Angulo A, Cuenca M, Martínez-Vicente P, Engel P. Viral CD229 (Ly9) homologs as new manipulators of host immunity. J Leukoc Biol. 2019 Feb 21. doi: 10.1002/JLB.2MR1018-413R. [Epub ahead of print]. Review. PMID: 30791129

Castella M, Boronat A, Martín-Ibáñez R, Rodríguez V, Suñé G, Caballero M, Marzal B, Pérez-Amill L, Martín-Antonio B, Castaño J, Bueno C, Balagué O, González-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua Á, Yagüe J, Pérez-Galán P, Rives S, Delgado J, Juan M. Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions. Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15. PMID: 30623002

Cuenca M, Sintes J, Lányi Á, Engel P. CD84 cell surface signaling molecule: An emerging biomarker and target for cancer and autoimmune disorders. Clin Immunol. 2018 Oct 26. pii: S1521-6616(18)30567-9. doi: 10.1016/j.clim.2018.10.017. [Epub ahead of print] Review. PMID: 30522694

Pérez-Carmona N, Martínez-Vicente P, Farré D, Gabaev I, Messerle M, Engel P, Angulo A.. A Prominent Role of the Human Cytomegalovirus UL8 Glycoprotein in Restraining Proinflammatory Cytokine Production by Myeloid Cells at Late Times during Infection.J Virol. 2018 Apr 13;92(9). pii: e02229-17. doi: 10.1128/JVI.02229-17. Print 2018 May 1. PMID: 29467314

Agod Z, Pazmandi K, Bencze D, Vereb G, Biro T, Szabo A, Rajnavolgyi E, Bacsi A, Engel P, Lanyi A.. Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.Front Immunol. 2018 Jan 26;9:62. doi: 10.3389/fimmu.2018.00062. eCollection 2018. PMID: 29434592

Cuenca M, Puñet-Ortiz J, Ruart M, Terhorst C, Engel P.. Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice. Eur J Immunol. 2018 Jan;48(1):99-105. doi: 10.1002/eji.201746925. Epub 2017 Nov 7. PMID: 28980301

Pupuleku A, Costa-García M, Farré D, Hengel H, Angulo A, Muntasell A, López-Botet M.. Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System. Front Immunol. 2017 Oct 24;8:1317. doi: 10.3389/fimmu.2017.01317. eCollection 2017. PMID: 29114247 

Dantoft W, Martínez-Vicente P, Jafali J, Pérez-Martínez L, Martin K, Kotzamanis K, Craigon M, Auer M, Young NT, Walsh P, Marchant A, Angulo A, Forster T, Ghazal P. Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses. Front Immunol. 2017 Sep 25;8:1146. doi: 10.3389/fimmu.2017.01146. eCollection 2017. PMID: 28993767

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available

Consuegra-Fernández M, Martínez-Florensa M, Aranda F, de Salort J, Armiger-Borràs N, Lozano T, Casares N, Lasarte JJ, Engel P, Lozano F. Relevance of CD6-Mediated Interactions in the Regulation of Peripheral T-Cell Responses and Tolerance. Front Immunol. 2017 May 30;8:594. doi: 10.3389/fimmu.2017.00594. eCollection 2017. PMID: 28611770

Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, Talbot S, Haas J, Dölken L, Griffiths WJ, Wang Y, Angulo A, Ghazal P. An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLoS Biol. 2016 Mar 3;14(3):e1002364. doi: 10.1371 /journal. pbio.1002364. eCollection 2016 Mar. PMID: 26938778

Wang N, Keszei M, Halibozek P, Yigit B, Engel P, Terhorst C. Slamf6 negatively regulates autoimmunity. Clin Immunol. 2016 Dec;173:19-26. doi: 10.1016/j.clim.2016.06.009. Epub 2016 Jun 29. PMID: 27368806

Yigit B, Halibozek PJ, Chen SS, O'Keeffe MS, Arnason J, Avigan D, Gattei V, Bhan A, Cen O, Longnecker R, Chiorazzi N, Wang N, Engel P, Terhorst C. A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells.Oncotarget. 2016 May 3;7(18):26346-60. doi: 10.18632/oncotarget.8378. PMID: 27029059.

Clark G, Stockinger H, Balderas R, van Zelm MC, Zola H, Hart D, Engel P. Nomenclature of CD molecules from the Tenth Human Leucocyte Differentiation Antigen Workshop. Clin Transl Immunology. 2016 Jan 22;5(1):e57. doi: 10.1038/cti.2015.38. eCollection 2016 Jan. No abstract available. PMID: 26900471

van Driel BJ, Liao G, Engel P, Terhorst C. Responses to Microbial Challenges by SLAMF Receptors. Front Immunol. 2016 Jan 20;7:4. doi: 10.3389/fimmu.2016.00004. eCollection 2016. Review. PMID: 26834746

Cuenca M, Romero X, Sintes J, Terhorst C, Engel P. Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses. J Immunol. 2016 Jan 15;196(2):726-37. doi: 10.4049/jimmunol.1501266. Epub 2015 Dec 14. PMID: 26667173

Engel P, Boumsell L, Balderas R, Bensussan A, Gattei V, Horejsi V, Jin BQ, Malavasi F, Mortari F, Schwartz-Albiez R, Stockinger H, van Zelm MC, Zola H, Clark G. CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology. J Immunol. 2015 Nov 15;195(10):4555-63. doi: 10.4049/ jimmunol.1502033. PMID: 26546687

Roncador G, Engel P, Maestre L, Anderson AP, Cordell JL, Cragg MS, Šerbec VČ, Jones M, Lisnic VJ, Kremer L, Li D, Koch-Nolte F, Pascual N, Rodríguez-Barbosa JI, Torensma R, Turley H, Pulford K, Banham AH. The European antibody network's practical guide to finding and validating suitable antibodies for research. MAbs. 2016;8(1):27-36. doi: 10.1080/19420862.2015.1100787. Epub 2015 Sep 29. PMID: 26418356

Pérez-Carmona N, Farré D, Martínez-Vicente P, Terhorst C, Engel P, Angulo A. Signaling Lymphocytic Activation Molecule Family Receptor Homologs in New World Monkey Cytomegaloviruses. J Virol. 2015 Nov;89(22):11323-36. doi: 10.1128/JVI.01296-15. Epub 2015 Sep 2. PMID: 26339044

Kropp KA, Hsieh WY, Isern E, Forster T, Krause E, Brune W, Angulo A, Ghazal P. A temporal gate for viral enhancers to co-opt Toll-like-receptor transcriptional activation pathways upon acute infection. PLoS Pathog. 2015 Apr 9;11(4):e1004737. doi: 10.1371/journal.ppat.1004737. eCollection 2015 Apr. PMID: 25856589

Kotzamanis K, Angulo A, Ghazal P. Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection. Med Microbiol Immunol. 2015 Jun;204(3):395-407. doi: 10.1007/ s00430-015-0402-5. Epub 2015 Mar 24. Review. PMID: 25800350

Romero X, Sintes J, Engel P. Role of SLAM family receptors and specific adapter SAP in innate-like lymphocytes. Crit Rev Immunol. 2014;34(4):263-99. Review. PMID: 24941157

De Calisto J, Wang N, Wang G, Yigit B, Engel P, Terhorst C. SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors. Front Immunol. 2014 Apr 23;5:186. doi:  10.3389/ fimmu.2014. 00186. eCollection 2014. PMID: 24795728

Romero X, Cañete JD, Engel P. Determination of soluble tumor necrosis factor receptor 2 produced by alternative splicing.Methods Mol Biol. 2014;1155:187-99. doi: 10.1007/978-1-4939-0669-7_16. PMID: 24788183

Zarama A, Pérez-Carmona N, Farré D, Tomic A, Borst EM, Messerle M, Jonjic S, Engel P, Angulo A. Cytomegalovirus m154 hinders CD48 cell-surface expression and promotes viral escape from host natural killer cell control. PLoS Pathog. 2014 Mar 13;10(3):e1004000. doi: 10.1371/journal.ppat.1004000. eCollection 2014 Mar. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004121. PMID: 24626474

Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P, Lozano F. Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses. PLoS One. 2014 Jan 15;9(1):e84895. doi: 10.1371/journal.pone.0084895. eCollection 2014. PMID: 24454761

Liao G, van Driel B, Magelky E, O'Keeffe MS, de Waal Malefyt R, Engel P, Herzog RW, Mizoguchi E, Bhan AK, Terhorst C. Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine. FASEB J. 2014 Jan;28(1):474-84. doi: 10.1096/fj.13-236505. Epub 2013 Oct 9. PMID: 24107315.

Kropp KA, Angulo A, Ghazal P. Viral enhancer mimicry of host innate-immune promoters. PLoS Pathog. 2014 Feb 6;10(2):e1003804. doi: 10.1371/journal.ppat.1003804. eCollection 2014 Feb. Review. No abstract available. PMID: 24516378

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