Muñoz-Torrero, D.; Schopfer, L. M.; Lockridge, O.
Chlorpyrifos oxon activates glutamate and lysine for protein cross-linking
Chem. Res. Toxicol. 2023, 36, 112–121. Open access article
Gandini, A.; Gonçalves, A. E.; Strocchi, S.; Albertini, C.; Janočková, J.; Tramarin, A.; Grifoni, D.; Poeta, E.; Soukup, O.; Muñoz-Torrero, D.; Monti, B.; Sabaté, R.; Bartolini, M.; Legname, G.; Bolognesi, M. L.
Discovery of dual Aβ/tau inhibitors and evaluation of their therapeutic effect on a Drosophila model of Alzheimer’s disease
ACS Chem. Neurosci. 2022, 13, 3314–3329. Open access article
Bouzón-Arnáiz, I.; Avalos-Padilla, Y.; Biosca, A.; Caño-Prades, O.; Román-Álamo, L.; Valle, J.; Andreu, D.; Moita, D.; Prudêncio, M.; Arce, E.M.; Muñoz-Torrero, D.; Fernàndez-Busquets, X.
The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures
BMC Biology 2022, 20, 197. Open access article
Codony, S.; Pont, C.; Griñán-Ferré, C.; Di Pede-Mattatelli, A.; Calvó-Tusell, C.; Feixas, F.; Osuna, S.; Jarné-Ferrer, J.; Naldi, M.; Bartolini, M.; Loza, M. I.; Brea, J.; Pérez, B.; Bartra, C.; Sanfeliu, C.; Juárez-Jiménez, J.; Morisseau, C.; Hammock, B. D.; Pallàs, M.; Vázquez, S.; Muñoz-Torrero, D.
Discovery and in vivo proof of concept of a highly potent dual inhibitor of soluble epoxide hydrolase and acetylcholinesterase for the treatment of Alzheimer’s disease
J. Med. Chem. 2022, 65, 4909-4925. Open access article
Jarne-Ferrer, J.; Griñán-Ferré, C.; Bellver-Sanchis, A.; Vázquez, S.; Muñoz-Torrero, D.; Pallàs, M.
A combined chronic low-dose soluble epoxide hydrolase and acetylcholinesterase pharmacological inhibition promotes memory reinstatement in Alzheimer's disease mice models
Pharmaceuticals 2022, 15, 908. Open access article
Sampietro, A.; Pérez-Areales, F. J.; Martínez, P.; Arce, E. M.; Galdeano, C.; Muñoz-Torrero, D.
Unveiling the multitarget anti-Alzheimer drug discovery landscape: A bibliometric analysis
Pharmaceuticals 2022, 15, 545. Open access article
Chemat, F.; Cirillo, G.; Muñoz-Torrero, D.; Dembinski, R. (eds.)
Molecules in 2022 (Special issue, 12 papers)
Molecules 2022, 27. Open Access Issue
Pont, C.; Ginex, T.; Griñan-Ferre, C.; Scheiner, M.; Mattellone, A.; Martínez, N.; Arce, E.M.; Soriano-Fernandez, Y.; Naldi, M.; De Simone, A.; Barenys, M.; Gómez-Catalán, J.; Perez, B.; Sabate, R.; Andrisano, V.; Loza, M.I.; Brea, J.; Bartolini, M.; Bolognesi, M.L.; Decker, M.; Pallas, M.; Luque, F.J.; Muñoz-Torrero, D.
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
Eur. J. Med. Chem. 2021, 225, 113779. Open access article
Zambrano, P.; Suwalsky, M.; Jemiola-Rzeminska, M.; Gallardo-Nelson, M.J.; Strzalka, K.; Muñoz-Torrero, D.
Protective role of a donepezil-huprine hybrid against the beta-amyloid (1-42) effect on human erythrocytes
Int. J. Mol. Sci. 2021, 22, 9563. Open access article
García Palmer, H.; Puig Borreil, I.; Tabernero Caturla, J.; Galdeano Cantador, C.; Muñoz-Torrero López-Ibarra, D.; Barril Alonso, X.; Ruiz Carmona, S.
Compounds for use in the treatment of hyperproliferative disorders
Patent EP21382343.8 Date of priority: 2021
Main institution: Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron (VHIO) / Universitat de Barcelona / Fundació Institució Catalana de Recerca i Estudis Avançats (ICREA)
Fernàndez Busquets, X.; Biosca Romanillos, A.; Bouzón Arnáiz, I.; Muñoz-Torrero López-Ibarra, D.
Compounds for the treatment of malaria
Patent EP21382949.2 Date of priority: 2021
Main institution: Fundació Institut de Bioenginyeria de Catalunya (IBEC) / Fundació ISGlobal - Institut de Salut Global Barcelona / Universitat de Barcelona
Muñoz-Torrero, D.; Rapposelli, S.; Gütschow, M.; Matos, M.J.; de Sousa, M.E.; Saso, L. (eds.)
Molecules Medicinal Chemistry Reviews 2021 (Special issue, 34 papers)
Molecules 2021, 26-27. Open Access Issue
Muñoz-Torrero, D.; Osborn, H.; Doerksen, R.J.; Socorro, S. (eds.)
Featured Papers in Medicinal Chemistry (Special issue, 25 papers)
Molecules 2021, 26-27. Open Access Issue
Giménez-Llort, L.; Santana-Santana, M.; Ratia, M.; Pérez, B.; Camps, P.; Muñoz-Torrero, D.; Badia, A.; Clos, M.V.
Clock/sleep-dependent learning and memory in male 3xTg-AD mice at advanced disease stages and extrinsic effects of huprine X and the novel multitarget agent AVCRI104P3
Brain Sci. 2021, 11, 426. Open access article
Muñoz-Torrero, D.
The cream of the crop of the Medicinal Chemistry section of Molecules - 2019
Molecules 2021, 26, 1053. Open access editorial
Viayna, E.; Coquelle, N.; Cieslikiewicz-Bouet, M.; Cisternas, P.; Oliva, C. A.; Sánchez-López, E.; Ettcheto, M.; Bartolini, M.; De Simone, A.; Ricchini, M.; Rendina, M.; Pons, M.; Firuzi, O.; Pérez, B.; Saso, L.; Andrisano, V.; Nachon, F.; Brazzolotto, X.; García, M. L.; Camins, A.; Silman, I.; Jean, L.; Inestrosa, N. C.; Colletier, J.-P.; Renard, P.-Y.; Muñoz-Torrero, D.
Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates Alzheimer-like pathology in old APP/PS1 mice
J. Med. Chem. 2021, 64, 812-839
Pérez-Areales, F. J.; Garrido, M.; Aso, E.; Bartolini, M.; De Simone, A.; Espargaró, A.; Ginex, T.; Sabate, R.; Pérez, B.; Andrisano, V.; Puigoriol-Illamola, D.; Pallàs, M.; Luque, F. J.; Loza, M. I.; Brea, J.; Ferrer, I.; Ciruela, F.; Messeguer, A.; Muñoz-Torrero, D.
Centrally active multitarget anti-Alzheimer agents derived from the antioxidant lead CR-6
J. Med. Chem. 2020, 63, 9360-9390
Guzman, L.; Besa, G.; Linares, D.; González, L.; Pont, C.; Bartolini, M.; Haigis, A.-C.; Legradi, J.; Muñoz-Torrero, D.; Gómez-Catalán, J.; Barenys, M.
Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment
Environ. Sci. Eur. 2020, 32, 145. Open access article
Muñoz-Torrero, D.; De Pascual-Teresa, B. (eds.)
25th Anniversary of Molecules - Recent advances in medicinal chemistry (Special issue, 28 papers)
Molecules 2020, 25-26. Open Access Issue
Muñoz-Torrero, D. (ed.)
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes - 2020 (Special issue, 10 papers)
Molecules 2020, 25. Open Access Issue
Chemad, F.; Muñoz-Torrero, D.; Quirino, J.P.; Gauld, J.; Soloshonok, V.A.; Dembinski, R.; McPhee, D.J.; Schmidt, T.J.; von Itzstein, M. (eds.)
Feature papers to celebrate Molecules reaches 20,000 articles milestone (Special issue, 15 papers)
Molecules 2020, 25. Open Access Issue
Gütschow, M.; Vanden Eynde, J. J.; Jampilek, J.; Kang, C.; Mangoni, A. A.; Fossa, P.; Karaman, R.; Trabocchi, A.; Scott, P. J. H.; Reynisson, J.; Rapposelli, S.; Galdiero, S.; Winum, J.-Y.; Brullo, C.; Prokai-Tatrai, K.; Sharma, A. K.; Schapira, M.; Azuma, Y.-T.; Cerchia, L.; Spetea, M.; Torri, G.; Collina, S.; Geronikaki, A.; García-Sosa, A. T.; Vasconcelos, M. H.; Sousa, M. E.; Kosalec, I.; Tuccinardi, T.; Duarte, I. F.; Salvador, J. A. R.; Bertinaria, M.; Pellecchia, M.; Amato, J.; Rastelli, G.; Gomes, P. A. C.; Guedes, R. C.; Sabatier, J.-M.; Estévez-Braun, A.; Pagano, B.; Mangani, S.; Ragno, R.; Kokotos, G.; Brindisi, M.; González, F. V.; Borges, F.; Miloso, M.; Rautio, J.; Muñoz-Torrero, D. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7
Molecules 2020, 25, 2968. Open access article
Pérez-Areales, F. J.; Turcu, A. L.; Barniol-Xicota, M.; Pont, C.; Pivetta, D.; Espargaró, A.; Bartolini, M.; De Simone, A.; Andrisano, V.; Pérez, B.; Sabate, R.; Sureda, F. X.; Vázquez, S.; Muñoz-Torrero, D.
A novel class of multitarget anti-Alzheimer benzohomoadamantane_chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
Eur. J. Med. Chem. 2019, 180, 613-626.
Vanden Eynde, J. J.; Mangoni, A. A.; Rautio, J.; Leprince, J.; Azuma, Y.-T.; García-Sosa, A. T.; Hulme, C.; Jampilek, J.; Karaman, R.; Li, W.; Gomes, P. A. C.; Hadjipavlou-Litina, D.; Capasso, R.; Geronikaki, A.; Cerchia, L.; Sabatier, J.-M.; Ragno, R.; Tuccinardi, T.; Trabocchi, A.; Winum, J.-Y.; Luque, F. J.; Prokai-Tatrai, K.; Spetea, M.; Gütschow, M.; Kosalec, I.; Guillou, C.; Vasconcelos, M. H.; Kokotos, G.; Rastelli, G.; de Sousa, M. E.; Manera, C.; Gemma, S.; Mangani, S.; Siciliano, C.; Galdiero, S.; Liu, H.; Scott, P. J. H.; de los Ríos, C.; Agrofoglio, L. A.; Collina, S.; Guedes, R. C.; Muñoz-Torrero, D.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6
Molecules 2019, 25, 119. Open access article
Mangoni, A. A.; Vanden Eynde, J. J.; Jampilek, J.; Hadjipavlou-Litina, D.; Liu, H.; Reynisson, J.; Sousa, M. E.; Gomes, P. A. C.; Prokai-Tatrai, K.; Tuccinardi, T.; Sabatier, J.-M.; Luque, F. J.; Rautio, J.; Karaman, R.; Vasconcelos, M. H.; Gemma, S.; Galdiero, S.; Hulme, C.; Collina, S.; Gütschow, M.; Kokotos, G.; Siciliano, C.; Capasso, R.; Agrofoglio, L. A.; Ragno, R.; Muñoz-Torrero, D.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5
Molecules 2019, 24, 2415. Open access article
Muñoz-Torrero, D.; Vázquez, S.; Pont, C.; Codony, S
Multitarget compounds for the treatment of Alzheimer’s disease
Patent PCT/EP2020/057914 Date of priority: 2019
Main institution: Universitat de Barcelona
Muñoz-Torrero, D.; Lavilla, R.; Pérez-Areales, F.J.; Ghashghaei, O.
Multicomponent reactions: A mighty journey partner for infectious tropical disease drug discovery
In Annual Reports in Medicinal Chemistry: Medicinal Approaches to Malaria and Other Tropical Disease, Part 2 Volume 53; Chibale, K. (ed.); Elsevier, 2019, 181-217.
Pérez-Areales, F.J.; Muñoz-Torrero, D.
Development of hybrid compounds to tackle Alzheimer's disease
in Recent Advances in Pharmaceutical Sciences VIII; Muñoz-Torrero, D.; Cajal, Y.; Llobet, J.M. (eds.); Transworld Research Network, 2019, chapter 3, pp. 43-58. Open access E-book chapter
Muñoz-Torrero, D.; Decker, M. (eds.)
Molecules against Alzheimer II (Special issue, 7 papers)
Molecules 2019, 23-24. Open Access Issue
Caballero, A. B.; Espargaró, A.; Pont, C.; Busquets, M. A.; Estelrich, J.; Muñoz-Torrero, D.; Gamez, P.; Sabate, R.
Bacterial inclusion bodies for anti-amyloid drug discovery: Current and future screening methods
Curr. Protein Pept. Sci. 2019, 20, 563-576.
Espargaró, A.; Pont, C.; Gamez, P.; Muñoz-Torrero, D.; Sabate, R.
Amyloid pan-inhibitors: One family of compounds to cope with all conformational diseases
ACS Chem. Neurosci. 2019, 10, 1311-1317.
Mangoni, A. A.; Guillou, C.; Vanden Eynde, J. J.; Hulme, C.; Jampilek, J.; Li, W.; Prokai-Tatrai, K.; Rautio, J.; Collina, S.; Tuccinardi, T.; Sousa, M. E.; Sabatier, J.-M.; Galdiero, S.; Karaman, R.; Kokotos, G.; Torri, G.; Luque, F. J.; Vasconcelos, M. H.; Hadjipavlou-Litina, D.; Siciliano, C.; Gütschow, M.; Ragno, R.; Gomes, P. A. C.; Agrofoglio, L. A.; Muñoz-Torrero, D.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-4
Molecules 2019, 24, 130. Open Access Article
Barniol-Xicota, M.; Ruiz Santa Quiteria Saavedra, M.; Muñoz-Torrero, D. (eds.)
Present and Future of Medicinal Chemistry Research: A Young Researchers' Perspective (Special issue, 9 papers)
Molecules 2018, 23-24. Open Access Issue
Relat, J.; Come, J.; Perez, B.; Camps, P.; Muñoz-Torrero, D.; Badia, A.; Gimenez-Llort, L.; Clos, M. V.
Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice
Int. J. Mol. Sci. 2018, 19, 2615. Open Access Article
Mangoni, A. A.; Tuccinardi, T.; Collina, S.; Vanden Eynde, J. J.; Muñoz-Torrero, D.; Karaman, R.; Siciliano, C.; de Sousa, M. E.; Prokai-Tatrai, K.; Rautio, J.; Guillou, C.; Gütschow, M.; Galdiero, S.; Liu, H.; Agrofolio, L. A.; Sabatier, J.-M.; Hulme, C.; Kokotos, G.; You, Q.; Gomes, P. A. C.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3
Molecules 2018, 23, 1596. Open Access Article
Alencar, N.; Sola, I.; Linares, M.; Juárez-Jiménez, J.; Pont, C.; Viayna, A.; Vílchez, D.; Sampedro, C.; Abad, P.; Pérez-Benavente, S.; Lameira, J.; Bautista, J. M.; Muñoz-Torrero, D.; Luque, F. J.
First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents
Eur. J. Med. Chem. 2018, 146, 108-122.
Galdeano, C.; Coquelle, N.; Cieslikiewicz-Bouet, M.; Bartolini, M.; Pérez, B.; Clos, M.V.; Silman, I.; Jean, L.; Colletier, J.-P.; Renard, P.-Y.; Muñoz-Torrero, D.
Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis
Molecules 2018, 23, 634. Open Access Article
Ghashghaei, O.; Kielland, N.; Revés, M.; Taylor, M.C.; Kelly, J.M.; Di Pietro, O.; Muñoz-Torrero, D.; Pérez, B.; Lavilla, R.
Tetrasubstituted imidazolium salts as potent antiparasitic agents against African and American trypanosomiases
Molecules 2018, 23, 177. Open Access Article
Artigas, A.; Sola, I.; Taylor, M.C.; Clos, M.V.; Pérez, B.; Kelly, J.M.; Muñoz-Torrero, D.
Synthesis and biological evaluation of heteroarylnonanenitriles as potential antitrypanosomal agents: Serendipitous discovery of novel anticholinesterase hits
Lett. Org. Chem. 2018, 15, 455-461. (Special Issue dedicated to Prof. Miguel Yus, University of Alicante)
Relat, J.; Pérez, B.; Camps, P.; Muñoz-Torrero, D.; Badia, A.; Clos, M. V.
Huprine X attenuates the neurotoxicity induced by kainic acid, especially brain inflammation
Basic Clin. Pharmacol. Toxicol. 2018, 122, 94-103. Open Access Article
Muñoz-Torrero, D.; Mangoni, A. A.; Liu, H.; Hulme, C.; Rautio, J.; Karaman, R.; de Sousa, M. E.; Prokai-Tatrai, K.; Sabatier, J.-M.; Siciliano, C.; Luque, F. J.; Kokotos, G.; Ragno, R.; Collina, S.; Guillou, C.; Gütschow, M.; Agrofolio, L. A.
Editorial: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2
Molecules 2018, 23, 65. Open Access Article
Muñoz-Torrero, D.
Multitarget anti-Alzheimer hybrid compounds: Do they work in vivo?
in Design of Hybrid Molecules for Drug Development; Decker, M. (ed.); Elsevier, 2017, chapter 6, pp. 165-190.
Muñoz-Torrero, D.; Chibale, K. (eds.)
Emerging Drug Discovery Approaches against Infectious Diseases (Special issue, 27 papers)
Molecules 2017, 22-23. Open Access Issue
Muñoz-Torrero, D.; Lavilla, R.; Hulme, C. (eds.)
Multicomponent Reaction-Based Synthesis of Bioactive Molecules (Special issue, 7 papers)
Molecules 2017, 22-23. Open Access Issue
Muñoz-Torrero, D. (Ed.)
Proceedings of the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain
MDPI Proceedings 2017, 1(6). Open Access Issue
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Pérez-Areales, F. J.; Betari, N.; Viayna, A.; Pont, C.; Espargaró, A.; Bartolini, M.; De Simone, A.; Rinaldi Alvarenga, J. F.; Pérez, B.; Sabate, R.; Lamuela-Raventós, R. M.; Andrisano, V.; Luque, F. J.; Muñoz-Torrero, D.
Design, synthesis, and multitarget biological profiling of second generation anti-Alzheimer rhein-huprine hybrids
Fut. Med. Chem. 2017, 9, 965-981.
Di Pietro, O.; Juárez-Jiménez, J.; Muñoz-Torrero, D.; Laughton, C. A.; Luque, F. J.
Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors
PLoS One 2017, 12, e0177683. Open Access Article
Muñoz-Torrero, D.; Mangoni, A. A.; Guillou, C.; Collina, S.; Vanden Eynde, J. J.; Rautio, J.; Keseru, G. M.; Hulme, C.; Chibale, K.; Luque, F. J.; Karaman, R.; Gütschow, M.; Liu, H.; Ragno, R.
Editorial: Breakthroughs in Medicinal Chemistry: New targets and mechanisms, new drugs, new hopes
Molecules 2017, 22, 743. Open Access Article
Espargaró, A.; Ginex, T.; Vadell, M. M.; Busquets, M. A.; Estelrich, J.; Muñoz-Torrero, D.; Luque, F. J.; Sabate, R.
Combined in vitro cell-based/in silico screening of naturally occurring flavonoids and phenolic compounds as potential anti-Alzheimer drugs
J. Nat. Prod. 2017, 80, 278-289.
Giménez-Llort, L.; Ratia, M.; Pérez, B.; Camps, P.; Muñoz-Torrero, D.; Badia, A.; Clos, M. V.
Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer’s disease
Behav. Pharmacol. 2017, 28, 124-131.
Decker, M.; Muñoz-Torrero, D. (eds.)
Molecules against Alzheimer (Special issue, 16 papers)
Molecules 2016, 20-21. Open Access Issue
Sola, I.; Artigas, A.; Taylor, M. C.; Pérez-Areales, F. J.; Viayna, E.; Clos, M. V.; Pérez, B.; Wright, C. W.; Kelly, J. M.; Muñoz-Torrero, D.
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents
Bioorg. Med. Chem. 2016, 24, 5162-5171. Open Access Article
Di Pietro, O.; Alencar, N.; Esteban, G.; Viayna, E.; Szalaj, N.; Vázquez, J.; Juárez-Jiménez, J.; Sola, I.; Pérez, B.; Solé, M.; Unzeta, M.; Muñoz-Torrero, D.; Luque, F. J.
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors
Bioorg. Med. Chem. 2016, 24, 4835-4854.
Kishore, K. G.; Ghashghaei, O.; Estarellas, C.; Mestre, M. M.; Monturiol, C.; Kielland, N.; Kelly, J. M.; Fortes Francisco, A.; Jayawardhana, S.; Muñoz-Torrero, D.; Pérez, B.; Luque, F. J.; Gámez-Montaño, R.; Lavilla, R.
Insertion of isocyanides into N-Si bonds: Multicomponent reactions with azines leading to potent antiparasitic compounds
Angew. Chem. Int. Ed. 2016, 55, 8994-8998.
Espargaró, A.; Medina, A.; Di Pietro, O.; Muñoz-Torrero, D.; Sabate, R.
Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs
Sci. Rep. 2016, 6, 23349. Open Access Article
Serrano, F. G.; Tapia-Rojas, C.; Carvajal, F. J.; Cisternas, P.; Viayna, E.; Sola, I.; Muñoz-Torrero, D.; Inestrosa, N. C.
Rhein-huprine derivatives reduce cognitive impairment, synaptic failure and amyloid pathology in AβPPswe/PS-1 mice of different ages
Curr. Alzheimer Res. 2016, 13, 1017-1029.
Navarro, S.; Carija, A.; Muñoz-Torrero, D.; Ventura, S.
A fast and specific method to screen for intracellular amyloid inhibitors using bacterial model systems
Eur. J. Med. Chem. 2016, 121, 785-792.
Sola, I.; Aso, E.; Frattini, D.; López-González, I.; Espargaró, A.; Sabaté, R.; Di Pietro, O.; Luque, F. J.; Clos, M. V.; Ferrer, I.; Muñoz-Torrero, D.
Novel levetiracetam derivatives that are effective against the Alzheimer-like phenotype in mice: synthesis, in vitro, ex vivo and in vivo efficacy studies
J. Med. Chem. 2015, 58, 6018-6032.
Di Pietro, O.; Vicente-García, E.; Taylor, M. C.; Berenguer, D.; Viayna, E.; Lanzoni, A.; Sola, I.; Sayago, H.; Riera, C.; Fisa, R.; Clos, M. V.; Pérez, B.; Kelly, J. M.; Lavilla, R.; Muñoz-Torrero, D.
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity
Eur. J. Med. Chem. 2015, 105, 120-137. Open Access Article
Sola, I.; Castellà, S.; Viayna, E.; Galdeano, C.; Taylor, M. C.; Gbedema, S. Y.; Pérez, B.; Clos, M. V.; Jones, D. C.; Fairlamb, A. H.; Wright, C. W.; Kelly, J. M.; Muñoz-Torrero, D.
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity
Bioorg. Med. Chem. 2015, 23, 5156-5167 (Special issue New Developments in Antiinfectives Research).
Sola, I.; Viayna, E.; Gómez, T.; Galdeano, C.; Cassina, M.; Camps, P.; Romeo, M.; Diomede, L.; Salmona, M.; Franco, P.; Schaeffer, M.; Colantuono, D.; Robin, D.; Brunner, D.; Taub, N.; Hutter-Paier, B.; Muñoz-Torrero, D.
Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound
Molecules 2015, 20, 4492-4515. Open Access Article
Torrent, J.; Vilchez-Acosta, A.; Muñoz-Torrero, D.; Trovaslet, M.; Nachon, F.; Chatonnet, A.; Grznarova, K.; Acquatella-Tran Van Ba, I.; Le Goffic, R.; Herzog, L.; Béringue, V.; Rezaei, H.;
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases
Acta Neuropathol. Commun. 2015, 3:18 Open Access Article
Giménez-Llort, L.; Ratia, M.; Pérez, B.; Camps, P.; Muñoz-Torrero, D.; Badia, A.; Clos, M.V.
AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxyolitic actitivies: Studies in cognitively poor middle-aged mice
Behav. Brain Res. 2015, 286, 97-103.
Viayna, E.; Sola, I.; Bartolini, M.; De Simone, A.; Tapia-Rojas, C.; Serrano, F. G.; Sabaté, R.; Juárez-Jiménez, J.; Pérez, B.; Luque, F. J.; Andrisano, V.; Clos, M. V.; Inestrosa, N. C.; Muñoz-Torrero, D.
Synthesis and multi-target biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents
J. Med. Chem. 2014, 57, 2549-2567.
Sola, I.; Artigas, A.; Taylor, M. C.; Gbedema, S. Y.; Pérez, B.; Clos, M. V.; Wright, C. W.; Kelly, J. M.; Muñoz-Torrero, D.
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines
Bioorg. Med. Chem. Lett. 2014, 24, 5435-5438.
Pérez-Areales, F. J.; Di Pietro. O.; Espargaró, A.; Vallverdú-Queralt, A.; Galdeano, C.; Ragusa, I. M.; Viayna, E.; Guillou, C.; Clos, M. V.; Pérez, B.; Sabaté, R.; Lamuela-Raventós, R. M.; Luque, F. J.; Muñoz-Torrero, D.
Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties
Bioorg. Med. Chem. 2014, 22, 5298-5307.
Di Pietro, O.; Pérez-Areales, F.J.; Juárez-Jiménez, J.; Espargaró, A.; Clos, M.V.; Pérez, B.; Lavilla, R.; Sabaté, R.; Luque, F.J.; Muñoz-Torrero, D.
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies
Eur. J. Med. Chem. 2014, 84, 107-117.
Di Pietro, O.; Viayna, E.; Vicente-García, E.; Bartolini, M.; Ramón, R.; Juárez-Jiménez, J.; Clos, M.V.; Pérez, B.; Andrisano, V.; Luque, F.J.; Lavilla, R.; Muñoz-Torrero, D.
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies
Eur. J. Med. Chem. 2014, 73, 141-152.
Pouplana, S.; Espargaró, A.; Galdeano, C.; Viayna, E.; Sola, I.; Ventura, S.; Muñoz-Torrero, D.; Sabate, R.
Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors
Curr. Med. Chem. 2014, 21, 1152-1159.
Muñoz-Torrero, D.; Ferrer, I.; Sola, I.; Aso, E.
Multi-target drug compounds for the treatment of neurodegenerative disorders
Patent WO2014206877 A1 Date of priority: 2014
Main institution: Universitat de Barcelona / Institut d'Investigació Biomèdica de Bellvitge IDIBELL
Pera, M.; Camps, P.; Muñoz-Torrero, D.; Perez, B.; Badia, A.; Clos Guillen, M.V
Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide
PLoS One 2013, 8, e74344. Open Access Article
Viayna, E.; Sabate, R.; Muñoz-Torrero, D.
Dual inhibitors of beta-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates
Curr. Top. Med. Chem. 2013, 13, 1820-1842.
Editor: Muñoz-Torrero, D.
Complexity against complexity: Multitarget drugs (Hot Topic issue, 12 chapters)
Curr. Med. Chem. 2013, 20, 1621-1799.
Viayna, E.; Sola, I.; Di Pietro, O.; Muñoz-Torrero, D.
Human disease and drug pharmacology, complex as real life
Curr. Med. Chem. 2013, 20, 1623-1634.
Ratia, M.; Giménez-Llort, L.; Camps, P.; Muñoz-Torrero, D.; Pérez, B.; Clos, M.V.; Badia, A.
Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD)
Neurodegener. Dis. 2013, 11, 129-140.
Muñoz-Torrero, D.; Inestrosa, N.C.; Viayna, E.; Sola, I.; Vázquez, S.
Beta-amyloid-directed multitarget compounds for the treatment of Alzheimer’s disease
Patent PCT/EP2013/059683; US 9,238,626 B2. Date of priority: 2013
Main institution: Universitat de Barcelona / Pontificia Universidad Católica de Chile
Galdeano, C.; Viayna, E.; Sola, I.; Formosa, X.; Camps, P.; Badia, A.; Clos, M. V.; Relat, J.; Ratia, M.; Bartolini, M.; Mancini, F.; Andrisano, V.; Salmona, M.; Minguillón, C.; González-Muñoz, G. C.; Rodríguez-Franco, M. I.; Bidon-Chanal, A.; Luque, F. J.; Muñoz-Torrero, D.
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer’s and prion diseases
J. Med. Chem. 2012, 55, 661-669.
Muñoz-Torrero, D.; Pera, M.; Relat, J.; Ratia, M.; Galdeano, C.; Viayna, E.; Sola, I.; Formosa, X.; Camps, P.; Badia, A.; Clos, M. V.
Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents
Neurodegener. Dis. 2012, 10, 96-99.
