An article published in the Journal of Medicinal Chemistry shows a new family of molecules with high affinity to join imidazoline receptors, which are altered in the brain of those patients with neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s. According to the preclinical study, the merge of these specific ligands to I2 receptors improves cognitive skills and some biomarkers which are indicators of brain neurodegenerative processes in murine models.

The new study is coordinated by the lecturer M. Carmen Escolano, from the Faculty of Pharmacy and Food Sciences, and counts on the participation of Mercè Pallàs (UBNeuro), Javier Luque (IBUB-IQTCUB) and Pilar Pérez-Lozano (Unit of Pharmaceutic Technology), among other researchers from the same Faculty.

Other collaborators in this research were Julia García-Fuster and Jesús A. García-Fuster (UIB), Belén Pérez (UAB), Elies Molins (Institute of Materials Sciences of Barcelona, ICMAB-CSIC), Luis F. Callado (UPV), and other experts from the University of Santiago de Compostela, the University of Belgrade (Serbia) and Leuven University (Belgium).

More