Detall

Conferenciant: Fèlix Campelo (ICFO).

Resum: Cells secrete proteins – such as neurotransmitters, cytokines, or collagens – to regulate many aspects of human physiology, from endocrine signaling, to synaptic transmission or the building of tissues. In this talk, I will present two examples of how biophysics can help us get a better understanding of this fundamental cellular process. First, I will describe a mechanism by which tension and mechanical forces can modulate the shaping of intracellular membranes to mediate the export of large secretory proteins. And second, I will briefly discuss how advanced fluorescence microscopy tools can reveal details of protein secretion.