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Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation
Posted June 8th, 2010 by pschmidtke
| Title | Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Avino, A, Morales JC, Frieden M, de la Torre BG, Garcia RG, Cubero E, Luque FJ, Orozco M, Azorin F, Eritja R |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 11 |
| Issue | 13 |
| Pagination | 1761 - 1763 |
| Date Published | 2001/07/09/ |
| Keywords | Base, DNA, Probes;, Purines/chemistry, Sequence; |
| Abstract | We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure. |
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