Rational design of reversible acetylcholinesterase inhibitors

TitleRational design of reversible acetylcholinesterase inhibitors
Publication TypeJournal Article
Year of Publication2002
AuthorsBarril, X, Kalko SG, Orozco M, Luque FJ
JournalMini reviews in medicinal chemistry
Pagination27 - 36
Date Published2002/02//
KeywordsAcetylcholinesterase/drug effects/metabolism; Alzheimer Disease/drug therapy; Animals; Cholinergic Agents/chemical synthesis/pharmacology/therapeutic use; Cholinesterase Inhibitors/chemical synthesis/pharmacology/therapeutic use; Drug Design; Humans; Mode, Molecular
AbstractA large amount of structural information on AChE and AChE-inhibitor complexes is currently available. Based on that, molecular modeling studies can be intensively used to gain insight into the mechanism of action of the enzyme and the molecular determinants that modulate the potency of inhibitors. In turn, this knowledge can be exploited to design new compounds leading to more effective cholinergic strategies. This manuscript reviews recent developments in the design of reversible acetylcholinesterase inhibitors.